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5Z18
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THE CRYSTAL STRUCTURE OF RUMINOCOCCUS GNAVUS BETA-GLUCURONIDASE
分子名称:Beta-glucuronidase
著者Dashnyam, P., Lin, H.Y., Lin, C.H.
登録日2017-12-25
公開日2018-12-12
実験手法X-RAY DIFFRACTION (2.495 Å)
主引用文献Dissection of the substrate preference and structure of gut microbial beta-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
5Z19
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THE CRYSTAL STRUCTURE OF RUMINOCOCCUS GNAVUS BETA-GLUCURONIDASE IN COMPLEX WITH URONIC ISOFAGOMINE
分子名称:Beta-glucuronidase, (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid
著者Dashnyam, P., Lin, H.Y., Lin, C.H.
登録日2017-12-25
公開日2018-12-12
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Dissection of the substrate preference and structure of gut microbial beta-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
5Z1A
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THE CRYSTAL STRUCTURE OF BACTEROIDES FRAGILIS BETA-GLUCURONIDASE IN COMPLEX WITH URONIC ISOFAGOMINE
分子名称:Putative beta-galactosidase, (3S,4R,5R)-4,5-dihydroxypiperidine-3-carboxylic acid
著者Dashnyam, P., Lin, H.Y., Lin, C.H.
登録日2017-12-25
公開日2018-12-12
実験手法X-RAY DIFFRACTION (1.859 Å)
主引用文献Dissection of the substrate preference and structure of gut microbial-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
5Z1B
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STRUCTURE OF BIFIDOBACTERIUM DENTIUM BETA-GLUCURONIDASE COMPLEXED WITH COUMARIN-3-O-GLUCURONIDE
分子名称:Glycosyl hydrolase family 2, TIM barrel domain protein, BETA-D-GLUCOPYRANURONIC ACID, ...
著者Dashnyam, P., Lin, H.Y., Lin, C.H.
登録日2017-12-25
公開日2018-12-12
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Dissection of the substrate preference and structure of gut microbial-glucuronidases identifies the major bacteria causing xenobiotic toxicity
To Be Published
5H9P
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH TD139
分子名称:Galectin-3, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
著者Hsieh, T.J., Lin, H.Y., Lin, C.H.
登録日2015-12-29
公開日2016-06-29
最終更新日2016-07-27
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6, 2016
5H9Q
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH TD139
分子名称:Galectin-7, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
著者Hsieh, T.J., Lin, H.Y., Lin, C.H.
登録日2015-12-29
公開日2016-06-29
最終更新日2016-07-27
実験手法X-RAY DIFFRACTION (1.931 Å)
主引用文献Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6, 2016
5H9R
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH TAZTDG
分子名称:Galectin-3, (2~{S},3~{R},4~{S},5~{R},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol
著者Hsieh, T.J., Lin, H.Y., Lin, C.H.
登録日2015-12-29
公開日2016-06-29
最終更新日2016-07-27
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6, 2016
5H9S
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH TAZTDG
分子名称:Galectin-7, (2~{S},3~{R},4~{S},5~{R},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol
著者Hsieh, T.J., Lin, H.Y., Lin, C.H.
登録日2015-12-29
公開日2016-06-29
最終更新日2016-07-27
実験手法X-RAY DIFFRACTION (1.821 Å)
主引用文献Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors
Sci Rep, 6, 2016
4ZHT
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CRYSTAL STRUCTURE OF UDP-GLCNAC 2-EPIMERASE
分子名称:Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, URIDINE-5'-DIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE-5-N-ACETYLNEURAMINIC ACID, ...
著者Chen, S.C., Yang, C.S., Ko, T.P., Chen, Y.
登録日2015-04-27
公開日2016-06-01
最終更新日2016-11-09
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Mechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis.
Sci Rep, 6, 2016
4Y1U
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COMPLEX OF HUMAN GALECTIN-1 AND GALBETA1-4GLCNAC
分子名称:Galectin-1, BETA-D-GALACTOSE, BETA-METHYL-N-ACETYL-D-GLUCOSAMINE
著者Lin, H.Y., Hsieh, T.J., Lin, C.H.
登録日2015-02-09
公開日2016-04-06
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y1V
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COMPLEX OF HUMAN GALECTIN-1 AND GALBETA1-3GLCNAC
分子名称:Galectin-1, BETA-METHYL-N-ACETYL-D-GLUCOSAMINE, BETA-D-GALACTOSE
著者Lin, H.Y., Hsieh, T.J., Lin, C.H.
登録日2015-02-09
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y1X
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COMPLEX OF HUMAN GALECTIN-1 AND GALBETA1-4(6OSO3)GLCNAC
分子名称:Galectin-1, BETA-D-GALACTOSE, methyl 2-(acetylamino)-2-deoxy-6-O-sulfo-beta-D-glucopyranoside
著者Lin, H.Y., Hsieh, T.J., Lin, C.H.
登録日2015-02-09
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y1Y
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COMPLEX OF HUMAN GALECTIN-1 AND (6OSO3)GALBETA1-3GLCNAC
分子名称:Galectin-1, BETA-D-GALACTOSE, methyl 2-(acetylamino)-2-deoxy-6-O-sulfo-beta-D-glucopyranoside
著者Lin, H.Y., Hsieh, T.J., Lin, C.H.
登録日2015-02-09
公開日2016-04-06
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y1Z
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COMPLEX OF HUMAN GALECTIN-1 AND GALBETA1-4(6CO2)GLCNAC
分子名称:Galectin-1, BETA-D-GALACTOSE, methyl 2-(acetylamino)-2-deoxy-beta-D-glucopyranosiduronic acid
著者Lin, H.Y., Hsieh, T.J., Lin, C.H.
登録日2015-02-09
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y20
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COMPLEX OF HUMAN GALECTIN-1 AND NEUACALPHA2-3GALBETA1-4GLC
分子名称:Galectin-1, 5-(ACETYLAMINO)-3,5-DIDEOXYNON-2-ULOPYRANONOSYL-(2->3)-BETA-D-LYXO-HEXOPYRANOSYL-(1->4)HEXOPYRANOSE
著者Lin, H.Y., Hsieh, T.J., Lin, C.H.
登録日2015-02-09
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.204 Å)
主引用文献Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y22
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COMPLEX OF HUMAN GALECTIN-1 AND (3OSO3)GALBETA1-3GLCNAC
分子名称:Galectin-1, O3-SULFONYLGALACTOSE, BETA-METHYL-N-ACETYL-D-GLUCOSAMINE
著者Lin, H.Y., Hsieh, T.J., Lin, C.H.
登録日2015-02-09
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4Y24
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COMPLEX OF HUMAN GALECTIN-1 AND TD-139
分子名称:Galectin-1, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
著者Lin, H.Y., Hsieh, T.J., Lin, C.H.
登録日2015-02-09
公開日2016-04-27
最終更新日2016-08-03
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors.
Sci Rep, 6, 2016
4Y26
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COMPLEX OF HUMAN GALECTIN-7 AND GALBETA1-3(6OSO3)GLCNAC
分子名称:Galectin-7, BETA-D-GALACTOSE, methyl 2-(acetylamino)-2-deoxy-6-O-sulfo-beta-D-glucopyranoside
著者Lin, H.Y., Hsieh, T.J., Lin, C.H.
登録日2015-02-09
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.611 Å)
主引用文献Structural basis of human galectin-1 inhibition with Ki values in the micro- to nanomolar range
To Be Published
4XBL
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH TYPE 1 N-ACETYLLACTOSAMINE
分子名称:Galectin-1, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE
著者Hsieh, T.J., Lin, H.Y., Lin, C.H.
登録日2014-12-17
公開日2015-05-20
実験手法X-RAY DIFFRACTION (1.931 Å)
主引用文献Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Gal beta 1-3/4GlcNAc.
Plos One, 10, 2015
4XBN
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH TYPE 1 N-ACETYLLACTOSAMINE
分子名称:Galectin-3, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE
著者Hsieh, T.J., Lin, H.Y., Lin, C.H.
登録日2014-12-17
公開日2015-05-20
実験手法X-RAY DIFFRACTION (2.208 Å)
主引用文献Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Gal beta 1-3/4GlcNAc.
Plos One, 10, 2015
4XBQ
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH TYPE 1 N-ACETYLLACTOSAMINE
分子名称:Galectin-7, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE
著者Hsieh, T.J., Lin, H.Y., Lin, C.H.
登録日2014-12-17
公開日2015-05-20
実験手法X-RAY DIFFRACTION (2.234 Å)
主引用文献Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Gal beta 1-3/4GlcNAc.
Plos One, 10, 2015
2MIV
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NMR STUDIES OF N2-GUANINE ADDUCTS DERIVED FROM THE TUMORIGEN DIBENZO[A,L]PYRENE IN DNA: IMPACT OF ADDUCT STEREOCHEMISTRY, SIZE, AND LOCAL DNA STRUCTURE ON SOLUTION CONFORMATIONS
分子名称:DNA_(5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3'), DNA_(5'-D(*GP*GP*TP*AP*GP*GP*AP*TP*GP*G)-3'), (11R,12R,13R)-11,12,13,14-tetrahydronaphtho[1,2,3,4-pqr]tetraphene-11,12,13-triol
著者Rodriguez, F.A., Liu, Z., Lin, C.H., Ding, S., Cai, Y., Kolbanovskiy, A., Kolbanovskiy, M., Amin, S., Broyde, S., Geacintov, N.E.
登録日2013-12-20
公開日2014-04-02
最終更新日2014-04-09
実験手法SOLUTION NMR
主引用文献Nuclear Magnetic Resonance Studies of an N(2)-Guanine Adduct Derived from the Tumorigen Dibenzo[a,l]pyrene in DNA: Impact of Adduct Stereochemistry, Size, and Local DNA Sequence on Solution Conformations.
Biochemistry, 53, 2014
2MIW
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NUCLEAR MAGNETIC RESONANCE STUDIES OF N2-GUANINE ADDUCTS DERIVED FROM THE TUMORIGEN DIBENZO[A,L]PYRENE IN DNA: IMPACT OF ADDUCT STEREOCHEMISTRY, SIZE, AND LOCAL DNA STRUCTURE ON SOLUTION CONFORMATIONS
分子名称:DNA_(5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3'), DNA_(5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3'), (11R,12R,13R)-11,12,13,14-tetrahydronaphtho[1,2,3,4-pqr]tetraphene-11,12,13-triol
著者Rodriguez, F.A., Liu, Z., Lin, C.H., Ding, S., Cai, Y., Kolbanovskiy, A., Kolbanovskiy, M., Amin, S., Broyde, S., Geacintov, N.E.
登録日2013-12-20
公開日2014-04-02
最終更新日2014-04-09
実験手法SOLUTION NMR
主引用文献Nuclear Magnetic Resonance Studies of an N(2)-Guanine Adduct Derived from the Tumorigen Dibenzo[a,l]pyrene in DNA: Impact of Adduct Stereochemistry, Size, and Local DNA Sequence on Solution Conformations.
Biochemistry, 53, 2014
2LZK
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NMR SOLUTION STRUCTURE OF AN N2-GUANINE DNA ADDUCT DERIVED FROM THE POTENT TUMORIGEN DIBENZO[A,L]PYRENE: INTERCALATION FROM THE MINOR GROOVE WITH RUPTURED WATSON-CRICK BASE PAIRING
分子名称:DNA (5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3'), (11S,12S,13S)-11,12,13,14-tetrahydronaphtho[1,2,3,4-pqr]tetraphene-11,12,13-triol
著者Tang, Y., Liu, Z., Ding, S., Lin, C.H., Cai, Y., Rodriguez, F.A., Sayer, J.M., Jerina, D.M., Amin, S., Broyde, S., Geacintov, N.E.
登録日2012-10-04
公開日2012-11-21
最終更新日2013-02-20
実験手法SOLUTION NMR
主引用文献Nuclear Magnetic Resonance Solution Structure of an N(2)-Guanine DNA Adduct Derived from the Potent Tumorigen Dibenzo[a,l]pyrene: Intercalation from the Minor Groove with Ruptured Watson-Crick Base Pairing.
Biochemistry, 51, 2012
3UYY
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CRYSTAL STRUCTURES OF BRANCHED-CHAIN AMINOTRANSFERASE FROM DEINOCOCCUS RADIODURANS COMPLEXES WITH ALPHA-KETOISOCAPROATE AND L-GLUTAMATE SUGGEST ITS RADIO-RESISTANCE FOR CATALYSIS
分子名称:Branched-chain-amino-acid aminotransferase, PYRIDOXAL-5'-PHOSPHATE
著者Chen, C.D., Huang, Y.C., Chuankhayan, P., Hsieh, Y.C., Huang, T.F., Lin, C.H., Guan, H.H., Liu, M.Y., Chang, W.C., Chen, C.J.
登録日2011-12-07
公開日2012-12-12
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of Complexes of the Branched-Chain Aminotransferase from Deinococcus radiodurans with alpha-Ketoisocaproate and L-Glutamate Suggest the Radiation Resistance of This Enzyme for Catalysis
J.Bacteriol., 194, 2012
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