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5COR
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BU of 5cor by Molmil
X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) N-TERMINAL-SWITCH POLYMER
Descriptor: ACETATE ION, C-C motif chemokine 3, HEXANE-1,6-DIOL
Authors:Liang, W.G, Tang, W.
Deposit date:2015-07-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
4RA8
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BU of 4ra8 by Molmil
Structure analysis of the Mip1a P8A mutant
Descriptor: C-C motif chemokine 3
Authors:Liang, W.G, Ren, M, Guo, Q, Tang, W.J.
Deposit date:2014-09-09
Release date:2014-09-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4RAL
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BU of 4ral by Molmil
Crystal structure of insulin degrading enzyme in complex with macrophage inflammatory protein 1 beta
Descriptor: C-C motif chemokine 4, Insulin-degrading enzyme, ZINC ION
Authors:Liang, W.G, Ren, M, Guo, Q, Tang, W.J.
Deposit date:2014-09-10
Release date:2015-05-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.148 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
3OVR
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BU of 3ovr by Molmil
Crystal Structure of hRPE and D-Xylulose 5-Phosphate Complex
Descriptor: 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, 5-O-phosphono-D-xylulose, FE (II) ION, ...
Authors:Liang, W.G, Ouyang, S.Y, Shaw, N, Joachimiak, A, Zhang, R.G, Liu, Z.J.
Deposit date:2010-09-17
Release date:2011-03-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE
Faseb J., 25, 2011
3OVP
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BU of 3ovp by Molmil
Crystal Structure of hRPE
Descriptor: 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, FE (II) ION, Ribulose-phosphate 3-epimerase
Authors:Liang, W.G, Ouyang, S.Y, Shaw, N, Joachimiak, A, Zhang, R.G, Liu, Z.J.
Deposit date:2010-09-16
Release date:2011-03-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.695 Å)
Cite:Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE
Faseb J., 25, 2011
3OVQ
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BU of 3ovq by Molmil
Crystal Structure of hRPE and D-Ribulose-5-Phospate Complex
Descriptor: 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, FE (II) ION, RIBULOSE-5-PHOSPHATE, ...
Authors:Liang, W.G, Ouyang, S.Y, Shaw, N, Joachimiak, A, Zhang, R.G, Liu, Z.J.
Deposit date:2010-09-17
Release date:2011-03-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE
Faseb J., 25, 2011
6XLY
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BU of 6xly by Molmil
CRYOEM STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ZINC METALLOPROTEASE ZMP1 IN OPEN STATE
Descriptor: Probable zinc metalloprotease Zmp1, ZINC ION
Authors:Liang, W.G, Zhao, M, Tang, W.
Deposit date:2020-06-29
Release date:2020-12-23
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states.
Structure, 29, 2021
6XOU
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BU of 6xou by Molmil
CryoEM structure of human presequence protease in open state
Descriptor: Presequence protease, mitochondrial
Authors:Liang, W.G, Zhao, M, Tang, W.
Deposit date:2020-07-07
Release date:2021-07-07
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
6XOV
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BU of 6xov by Molmil
CryoEM structure of human presequence protease in partial closed state 1
Descriptor: Amyloid-beta precursor protein, Presequence protease, mitochondrial
Authors:Liang, W.G, Zhao, M, Tang, W.
Deposit date:2020-07-07
Release date:2021-07-07
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
6XOW
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BU of 6xow by Molmil
CryoEM structure of human presequence protease in partial close state 2, induced by presequence of citrate synthase
Descriptor: Presequence protease, mitochondrial
Authors:Liang, W.G, Tang, W.
Deposit date:2020-07-07
Release date:2021-07-07
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:CryoEM structure of human presequence protease in partial open state 2, induced by presequence of citrate synthase
To Be Published
6XOT
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BU of 6xot by Molmil
CryoEM structure of human presequence protease in partial open state 2
Descriptor: Presequence protease, mitochondrial
Authors:Liang, W.G, Zhao, M, Tang, W.
Deposit date:2020-07-07
Release date:2021-07-07
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
6XOS
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BU of 6xos by Molmil
CryoEM structure of human presequence protease in partial open state 1
Descriptor: Presequence protease, mitochondrial
Authors:Liang, W.G, Zhao, M, Tang, W.
Deposit date:2020-07-07
Release date:2021-07-07
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
5UOE
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BU of 5uoe by Molmil
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
Descriptor: FAB Heavy chain with engineered elbow, FAB light chain, Insulin-degrading enzyme
Authors:Liang, W.G, Bailey, L, Kossiakoff, T, Tang, W.J.
Deposit date:2017-01-31
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
To Be Published
7K1E
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BU of 7k1e by Molmil
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646
Descriptor: 1,4-DIETHYLENE DIOXIDE, 3,4-difluoro-N-[(1S)-1-{1-[(2R)-4-(hydroxyamino)-4-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}ethyl]benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Liang, W.G, Deprez, R, Bosc, D, Tang, W.
Deposit date:2020-09-07
Release date:2021-09-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 3
To Be Published
7K1F
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BU of 7k1f by Molmil
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88558
Descriptor: 1,4-DIETHYLENE DIOXIDE, 3,4-difluoro-N-({1-[(2R)-4-(hydroxyamino)-4-oxo-1-(quinolin-7-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Liang, W.G, Deprez, R, Bosc, D, Tang, W.
Deposit date:2020-09-07
Release date:2021-09-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 4
To Be Published
7K1D
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BU of 7k1d by Molmil
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_77291
Descriptor: (3R)-3-{4-[(3R)-4-(3,4-difluorobenzene-1-carbonyl)morpholin-3-yl]-1H-1,2,3-triazol-1-yl}-N-hydroxy-4-(naphthalen-2-yl)butanamide, 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Liang, W.G, Deprez, R, Bosc, D, Tang, W.
Deposit date:2020-09-07
Release date:2021-09-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 2
To Be Published
5COY
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BU of 5coy by Molmil
Crystal structure of CC chemokine 5 (CCL5)
Descriptor: C-C motif chemokine 5, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ...
Authors:Liang, W.G, Tang, W.
Deposit date:2015-07-20
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.443 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CMD
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BU of 5cmd by Molmil
Oligomer crystal structure of CC chemokine 5 (CCL5)
Descriptor: C-C motif chemokine 5, SULFATE ION
Authors:Liang, W.G, Tang, W.-J.
Deposit date:2015-07-16
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.086 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5D65
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BU of 5d65 by Molmil
X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) WITH HEPARIN COMPLEX
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, C-C motif chemokine 3, CHLORIDE ION, ...
Authors:Liang, W.G, Hwang, D.Y, Zulueta, M.M, Hung, S.C, Tang, W.
Deposit date:2015-08-11
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DNF
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BU of 5dnf by Molmil
Crystal structure of CC chemokine 5 (CCL5) oligomer in complex with heparin
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, C-C motif chemokine 5, ...
Authors:Liang, W.G, Tang, W.
Deposit date:2015-09-10
Release date:2016-04-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.549 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
6C6D
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BU of 6c6d by Molmil
20mer crystal structure of CC chemokine 5 (CCL5)
Descriptor: C-C motif chemokine 5
Authors:Liang, W.G, Tang, W.J.
Deposit date:2018-01-18
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:20mer crystal structure of CC chemokine 5 (CCL5)
To Be Published
4MHE
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BU of 4mhe by Molmil
Crystal structure of CC-chemokine 18
Descriptor: ACETATE ION, C-C motif chemokine 18
Authors:Liang, W.G, Tang, W.-J.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4RE9
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BU of 4re9 by Molmil
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-5-yl}methyl)benzamide, ...
Authors:Liang, W.G, Deprez, R, Deprez, B, Tang, W.J.
Deposit date:2014-09-22
Release date:2015-09-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.908 Å)
Cite:Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
5CJO
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BU of 5cjo by Molmil
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FAB Heavy chain with engineered elbow, FAB light chain, ...
Authors:liang, w.g, bailey, L, tang, w.j.
Deposit date:2015-07-14
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.287 Å)
Cite:Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 2017
4IFH
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BU of 4ifh by Molmil
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
Descriptor: Insulin-degrading enzyme, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide, ZINC ION
Authors:Liang, W.G, Guo, Q, Deprez, R, Deprez, B, Tang, W.
Deposit date:2012-12-14
Release date:2013-12-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.286 Å)
Cite:Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015

 

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