Author results

5COR
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X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) N-TERMINAL-SWITCH POLYMER
Descriptor:C-C motif chemokine 3, HEXANE-1,6-DIOL, ACETATE ION
Authors:Liang, W.G., Tang, W.
Deposit date:2015-07-20
Release date:2016-04-13
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.548 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
3OVP
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CRYSTAL STRUCTURE OF HRPE
Descriptor:Ribulose-phosphate 3-epimerase, FE (II) ION, 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL
Authors:Liang, W.G., Ouyang, S.Y., Shaw, N., Joachimiak, A., Zhang, R.G., Liu, Z.J.
Deposit date:2010-09-16
Release date:2011-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.695 Å)
Cite:Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE
Faseb J., 25, 2011
3OVQ
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CRYSTAL STRUCTURE OF HRPE AND D-RIBULOSE-5-PHOSPATE COMPLEX
Descriptor:Ribulose-phosphate 3-epimerase, FE (II) ION, RIBULOSE-5-PHOSPHATE, ...
Authors:Liang, W.G., Ouyang, S.Y., Shaw, N., Joachimiak, A., Zhang, R.G., Liu, Z.J.
Deposit date:2010-09-17
Release date:2011-03-09
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE
Faseb J., 25, 2011
3OVR
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CRYSTAL STRUCTURE OF HRPE AND D-XYLULOSE 5-PHOSPHATE COMPLEX
Descriptor:Ribulose-phosphate 3-epimerase, FE (II) ION, 5-O-phosphono-D-xylulose, ...
Authors:Liang, W.G., Ouyang, S.Y., Shaw, N., Joachimiak, A., Zhang, R.G., Liu, Z.J.
Deposit date:2010-09-17
Release date:2011-03-09
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE
Faseb J., 25, 2011
4MHE
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CRYSTAL STRUCTURE OF CC-CHEMOKINE 18
Descriptor:C-C motif chemokine 18, ACETATE ION
Authors:Liang, W.G., Tang, W.-J.
Deposit date:2013-08-29
Release date:2014-09-03
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4RA8
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STRUCTURE ANALYSIS OF THE MIP1A P8A MUTANT
Descriptor:C-C motif chemokine 3
Authors:Liang, W.G., Ren, M., Guo, Q., Tang, W.J.
Deposit date:2014-09-09
Release date:2014-09-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
4RAL
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME IN COMPLEX WITH MACROPHAGE INFLAMMATORY PROTEIN 1 BETA
Descriptor:Insulin-degrading enzyme, C-C motif chemokine 4, ZINC ION
Authors:Liang, W.G., Ren, M., Guo, Q., Tang, W.J.
Deposit date:2014-09-10
Release date:2015-05-13
Method:X-RAY DIFFRACTION (3.148 Å)
Cite:Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
J.Mol.Biol., 427, 2015
5CMD
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OLIGOMER CRYSTAL STRUCTURE OF CC CHEMOKINE 5 (CCL5)
Descriptor:C-C motif chemokine 5, SULFATE ION
Authors:Liang, W.G., Tang, W.-J.
Deposit date:2015-07-16
Release date:2016-04-13
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (3.086 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5COY
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CRYSTAL STRUCTURE OF CC CHEMOKINE 5 (CCL5)
Descriptor:C-C motif chemokine 5, PHOSPHATE ION, alpha-D-fructofuranosyl alpha-D-glucopyranoside, ...
Authors:Liang, W.G., Tang, W.
Deposit date:2015-07-20
Release date:2016-04-13
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (1.443 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5D65
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X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) WITH HEPARIN COMPLEX
Descriptor:C-C motif chemokine 3, BETA-D-GLUCOSE, CHLORIDE ION, ...
Authors:Liang, W.G., Hwang, D.Y., Zulueta, M.M., Hung, S.C., Tang, W.
Deposit date:2015-08-11
Release date:2016-04-20
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DNF
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CRYSTAL STRUCTURE OF CC CHEMOKINE 5 (CCL5) OLIGOMER IN COMPLEX WITH HEPARIN
Descriptor:C-C motif chemokine 5, ALPHA D-GALACTOSE, BETA-D-GLUCOSE, ...
Authors:Liang, W.G., Tang, W.
Deposit date:2015-09-10
Release date:2016-04-13
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.549 Å)
Cite:Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
5UOE
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CRYSTAL STRUCTURE ANALYSIS OF ELBOW-ENGINEERED-FAB-BOUND HUMAN INSULIN DEGRADING ENZYME (IDE)
Descriptor:Insulin-degrading enzyme, FAB Heavy chain with engineered elbow, FAB light chain
Authors:Liang, W.G., Bailey, L., Kossiakoff, T., Tang, W.J.
Deposit date:2017-01-31
Release date:2018-02-07
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
To Be Published
6C6D
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20MER CRYSTAL STRUCTURE OF CC CHEMOKINE 5 (CCL5)
Descriptor:C-C motif chemokine 5
Authors:Liang, W.G., Tang, W.J.
Deposit date:2018-01-18
Release date:2019-01-23
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:20mer crystal structure of CC chemokine 5 (CCL5)
To Be Published
4IFH
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPOUND BDM44619
Descriptor:Insulin-degrading enzyme, ZINC ION, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide
Authors:Liang, W.G., Guo, Q., Deprez, R., Deprez, B., Tang, W.
Deposit date:2012-12-14
Release date:2013-12-18
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (3.286 Å)
Cite:Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
4NXO
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME IN COMPLEX WITH BDM44768
Descriptor:Insulin-degrading enzyme, ZINC ION, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide, ...
Authors:Liang, W.G., Deprez, R., Deprez, B., Tang, W.
Deposit date:2013-12-09
Release date:2015-10-07
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
4RE9
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH COMPOUND 71290
Descriptor:Insulin-degrading enzyme, ZINC ION, 4-fluoro-N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-5-yl}methyl)benzamide, ...
Authors:Liang, W.G., Deprez, R., Deprez, B., Tang, W.J.
Deposit date:2014-09-22
Release date:2015-09-30
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.908 Å)
Cite:Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
5CJO
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CRYSTAL STRUCTURE ANALYSIS OF ELBOW-ENGINEERED-FAB-BOUND HUMAN INSULIN DEGRADING ENZYME (IDE) IN COMPLEX WITH INSULIN
Descriptor:Insulin-degrading enzyme, FAB Heavy chain with engineered elbow, FAB light chain, ...
Authors:liang, w.g., bailey, L., tang, w.j.
Deposit date:2015-07-14
Release date:2016-07-20
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.287 Å)
Cite:Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 2017
6B3Q
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH INSULIN
Descriptor:Insulin-degrading enzyme, Insulin
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-09-22
Release date:2017-11-22
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6B70
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11-E HEAVY CHAIN, FAB H11-E LIGHT CHAIN AND INSULIN
Descriptor:Insulin-degrading enzyme, FAB H11-E heavy chain, FAB H11-E light chain, ...
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-03
Release date:2017-12-27
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6B7Y
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME
Descriptor:Insulin-degrading enzyme
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-05
Release date:2017-11-08
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6B7Z
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11 HEAVY CHAIN AND FAB H11 LIGHT CHAIN
Descriptor:Insulin-degrading enzyme, FAB H11 heavy chain, FAB H11 light chain
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-05
Release date:2018-01-10
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BF6
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME
Descriptor:Insulin-degrading enzyme
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-26
Release date:2018-02-07
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BF7
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11-E HEAVY CHAIN, FAB H11-E LIGHT CHAIN
Descriptor:Insulin-degrading enzyme, Fab H11-E heavy chain, Fab H11-E light chain
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-26
Release date:2018-02-07
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BF8
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH INSULIN
Descriptor:Insulin-degrading enzyme
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-26
Release date:2018-04-04
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BF9
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CRYO-EM STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH FAB H11-E HEAVY CHAIN, FAB H11-E LIGHT CHAIN
Descriptor:Insulin-degrading enzyme, Fab H11-E heavy chain, Fab H11-E light chain
Authors:Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
Deposit date:2017-10-26
Release date:2018-02-07
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
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