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5F59
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THE CRYSTAL STRUCTURE OF MLL3 SET DOMAIN
Descriptor:Histone-lysine N-methyltransferase 2C, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-04
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F5E
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THE CRYSTAL STRUCTURE OF MLL1 SET DOMAIN WITH N3816I/Q3867L MUTATION
Descriptor:Histone-lysine N-methyltransferase 2A, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-04
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6K
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CRYSTAL STRUCTURE OF THE MLL3-ASH2L-RBBP5 COMPLEX
Descriptor:Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ...
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-06
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.411 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6L
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THE CRYSTAL STRUCTURE OF MLL1 (N3861I/Q3867L) IN COMPLEX WITH RBBP5 AND ASH2L
Descriptor:Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, ...
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-06
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
1HQR
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CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II
Descriptor:HLA-DR ALPHA CHAIN, HLA-DR BETA CHAIN, MYELIN BASIC PROTEIN, ...
Authors:Li, Y., Li, H., Dimasi, N., Schlievert, P., Mariuzza, R.
Deposit date:2000-12-19
Release date:2001-01-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.
Immunity, 14, 2001
1XGR
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STRUCTURE FOR ANTIBODY HYHEL-63 Y33I MUTANT COMPLEXED WITH HEN EGG LYSOZYME
Descriptor:antibody kappa light chain, antibody kappa heavy chain, Lysozyme C
Authors:Li, Y., Huang, Y., Swaminathan, C.P., Smith-Gill, S.J., Mariuzza, R.A.
Deposit date:2004-09-17
Release date:2005-09-06
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces
Structure, 13, 2005
1XGU
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STRUCTURE FOR ANTIBODY HYHEL-63 Y33F MUTANT COMPLEXED WITH HEN EGG LYSOZYME
Descriptor:antibody kappa light chain, antibody kappa heavy chain, Lysozyme C
Authors:Li, Y., Huang, Y., Swaminathan, C.P., Smith-Gill, S.J., Mariuzza, R.A.
Deposit date:2004-09-17
Release date:2005-09-06
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces
Structure, 13, 2005
2N7G
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STRUCTURE OF THE CYCLIC NUCLEOTIDE-BINDING HOMOLOGY DOMAIN OF THE HERG CHANNEL
Descriptor:Potassium voltage-gated channel subfamily H member 2
Authors:Li, Y., Ng, H., Li, Q., Kang, C.
Deposit date:2015-09-10
Release date:2016-05-18
Method:SOLUTION NMR
Cite:Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrome
Sci Rep, 6, 2016
2N7Q
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STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF HUMAN NICASTRIN IN SDS MICELLES
Descriptor:Nicastrin
Authors:Li, Y., Liew, L., Li, Q., Kang, C.
Deposit date:2015-09-17
Release date:2016-04-27
Method:SOLUTION NMR
Cite:Structure of the transmembrane domain of human nicastrin-a component of gamma-secretase
Sci Rep, 6, 2016
2N7R
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STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF HUMAN NICASTRIN IN DPC MICELLES
Descriptor:Nicastrin
Authors:Li, Y., Liew, L., Li, Q., Kang, C.
Deposit date:2015-09-17
Release date:2016-04-27
Method:SOLUTION NMR
Cite:Structure of the transmembrane domain of human nicastrin-a component of gamma-secretase
Sci Rep, 6, 2016
4P5A
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CRYSTAL STRUCTURE OF A UMP/DUMP METHYLASE POLB FROM STREPTOMYCES CACAOI BOUND WITH 5-BR UMP
Descriptor:Thymidylate synthase ThyX, FLAVIN-ADENINE DINUCLEOTIDE, 5-BROMO-URIDINE-5'-MONOPHOSPHATE
Authors:Li, Y., Chen, W., Li, J., Xia, Z., Deng, Z., Zhou, J.
Deposit date:2014-03-15
Release date:2015-12-09
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi with 5-Br UMP
To Be Published
4P5B
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CRYSTAL STRUCTURE OF A UMP/DUMP METHYLASE POLB FROM STREPTOMYCES CACAOI BOUND WITH 5-BR DUMP
Descriptor:Thymidylate synthase ThyX, FLAVIN-ADENINE DINUCLEOTIDE, 5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ...
Authors:Li, Y., Chen, W., Li, J., Xia, Z., Deng, Z., Zhou, J.
Deposit date:2014-03-15
Release date:2015-12-09
Method:X-RAY DIFFRACTION (2.274 Å)
Cite:Crystal structure of a UMP/dUMP methylase PolB form Streptomyces cacaoi bound with 5-Br dUMP
To Be Published
5ZN9
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CRYSTAL STRUCTURE OF PX DOMAIN
Descriptor:Sorting nexin-27, SULFATE ION
Authors:Li, Y., Zhu, Z., Li, F., Liao, S., Xu, C.
Deposit date:2018-04-08
Release date:2019-04-10
Method:X-RAY DIFFRACTION (1.776 Å)
Cite:Crystal structure of PX domain
To Be Published
1XGP
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STRUCTURE FOR ANTIBODY HYHEL-63 Y33A MUTANT COMPLEXED WITH HEN EGG LYSOZYME
Descriptor:antibody kappa light chain, antibody kappa heavy chain, Lysozyme C
Authors:Li, Y., Mariuzza, R.A.
Deposit date:2004-09-17
Release date:2005-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces
Structure, 13, 2005
1XGQ
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STRUCTURE FOR ANTIBODY HYHEL-63 Y33V MUTANT COMPLEXED WITH HEN EGG LYSOZYME
Descriptor:antibody kappa light chain, antibody kappa heavy chain, Lysozyme C
Authors:Li, Y., Mariuzza, R.A.
Deposit date:2004-09-17
Release date:2005-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces
Structure, 13, 2005
1XGT
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STRUCTURE FOR ANTIBODY HYHEL-63 Y33L MUTANT COMPLEXED WITH HEN EGG LYSOZYME
Descriptor:antibody kappa light chain, antibody kappa heavy chain, Lysozyme C
Authors:Li, Y., Mariuzza, R.A.
Deposit date:2004-09-17
Release date:2005-09-06
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces
Structure, 13, 2005
3ETL
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RADA RECOMBINASE FROM METHANOCOCCUS MARIPALUDIS IN COMPLEX WITH AMPPNP
Descriptor:DNA repair and recombination protein radA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Li, Y., He, Y., Luo, Y.
Deposit date:2008-10-08
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conservation of a conformational switch in RadA recombinase from Methanococcus maripaludis.
Acta Crystallogr.,Sect.D, 65, 2009
3EW9
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RADA RECOMBINASE FROM METHANOCOCCUS MARIPALUDIS IN COMPLEX WITH AMPPNP AND POTASSIUM IONS
Descriptor:DNA repair and recombination protein radA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Li, Y., He, Y., Luo, Y.
Deposit date:2008-10-14
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conservation of a conformational switch in RadA recombinase from Methanococcus maripaludis.
Acta Crystallogr.,Sect.D, 65, 2009
3EWA
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RADA RECOMBINASE FROM METHANOCOCCUS MARIPALUDIS IN COMPLEX WITH AMPPNP AND AMMONIUM IONS
Descriptor:DNA repair and recombination protein radA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Li, Y., He, Y., Luo, Y.
Deposit date:2008-10-14
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conservation of a conformational switch in RadA recombinase from Methanococcus maripaludis.
Acta Crystallogr.,Sect.D, 65, 2009
3FYH
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RECOMBINASE IN COMPLEX WITH ADP AND METATUNGSTATE
Descriptor:DNA repair and recombination protein radA, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Li, Y., He, Y., Luo, Y.
Deposit date:2009-01-22
Release date:2009-09-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of an archaeal Rad51 homologue in complex with a metatungstate inhibitor.
Biochemistry, 48, 2009
5DO2
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COMPLEX STRUCTURE OF MERS-RBD BOUND WITH 4C2 ANTIBODY
Descriptor:S protein, 4C2 heavy chain, 4C2 light chain, ...
Authors:Li, Y., Wan, Y., Liu, P., Zhao, J., Lu, G., Qi, J., Wang, Q., Lu, X., Wu, Y., Liu, W., Yuen, K.Y., Perlman, S., Gao, G.F., Yan, J.
Deposit date:2015-09-10
Release date:2015-10-14
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.
Cell Res., 25, 2015
6A3V
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COMPLEX STRUCTURE OF HUMAN 4-1BB AND 4-1BBL
Descriptor:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, N-ACETYL-D-GLUCOSAMINE
Authors:Li, Y., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
Deposit date:2018-06-17
Release date:2018-10-10
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (3.391 Å)
Cite:Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
6A3W
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COMPLEX STRUCTURE OF 4-1BB AND UTOMILUMAB
Descriptor:utomilumab VH, utomilumab VL, Tumor necrosis factor receptor superfamily member 9, ...
Authors:Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
Deposit date:2018-06-17
Release date:2018-10-10
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
1ZGL
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CRYSTAL STRUCTURE OF 3A6 TCR BOUND TO MBP/HLA-DR2A
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, major histocompatibility complex, ...
Authors:Li, Y., Huang, Y., Lue, J., Quandt, J.A., Martin, R., Mariuzza, R.A.
Deposit date:2005-04-21
Release date:2005-10-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.
Embo J., 24, 2005
2M19
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SOLUTION STRUCTURE OF THE HALOFERAX VOLCANII HVO 2177 PROTEIN
Descriptor:Molybdopterin converting factor subunit 1
Authors:Li, Y., Maciejewski, M.W., Martin, J., Jin, K., Zhang, Y., Lu, M., Maupin-Furlow, J.A., Hao, B.
Deposit date:2012-11-21
Release date:2013-08-07
Last modified:2013-10-02
Method:SOLUTION NMR
Cite:Crystal structure of the ubiquitin-like small archaeal modifier protein 2 from Haloferax volcanii.
Protein Sci., 22, 2013