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5H3O
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STRUCTURE OF A EUKARYOTIC CYCLIC NUCLEOTIDE-GATED CHANNEL
Descriptor:Cyclic nucleotide-gated cation channel, CYCLIC GUANOSINE MONOPHOSPHATE, SODIUM ION
Authors:Li, M., Zhou, X., Wang, S., Michailidis, I., Gong, Y., Su, D., Li, H., Li, X., Yang, J.
Deposit date:2016-10-26
Release date:2017-01-25
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of a eukaryotic cyclic-nucleotide-gated channel.
Nature, 542, 2017
5TJA
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I-II LINKER OF TRPML1 CHANNEL AT PH 6
Descriptor:Mucolipin-1
Authors:Li, M., Zhang, W.K., Benvin, N.M., Zhou, X., Su, D., Li, H., Wang, S., Michailidis, I.E., Tong, L., Li, X., Yang, J.
Deposit date:2016-10-04
Release date:2017-01-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
5TJB
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I-II LINKER OF TRPML1 CHANNEL AT PH 4.5
Descriptor:Mucolipin-1
Authors:Li, M., Zhang, W.K., Benvin, N.M., Zhou, X., Su, D., Li, H., Wang, S., Michailidis, I.E., Tong, L., Li, X., Yang, J.
Deposit date:2016-10-04
Release date:2017-01-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
5TJC
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I-II LINKER OF TRPML1 CHANNEL AT PH 7.5
Descriptor:Mucolipin-1
Authors:Li, M., Zhang, W.K., Benvin, N.M., Zhou, X., Su, D., Li, H., Wang, S., Michailidis, I.E., Tong, L., Li, X., Yang, J.
Deposit date:2016-10-04
Release date:2017-01-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel.
Nat. Struct. Mol. Biol., 24, 2017
5Z3L
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX IN APO STATE
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (4.31 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
5Z3O
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX IN ADP STATE
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
5Z3U
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX AT SHL2 IN ADP BEFX STATE
Descriptor:Transcription regulatory protein SNF2, Histone H3.2, Histone H4, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-05-22
Method:ELECTRON MICROSCOPY (4.31 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
5Z3V
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX AT SHL-2 IN ADP BEFX STATE
Descriptor:Transcription regulatory protein SNF2, Histone H3.2, Histone H4, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-05-22
Method:ELECTRON MICROSCOPY (4.22 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
6IY2
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STRUCTURE OF SNF2-MMTV-A NUCLEOSOME COMPLEX AT SHL2 IN ADP STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-12-12
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
6IY3
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STRUCTURE OF SNF2-MMTV-A NUCLEOSOME COMPLEX AT SHL-2 IN ADP STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-12-12
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
5Z3T
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX IN ADP BEFX STATE
Descriptor:Transcription regulatory protein SNF2, Histone H3.2, Histone H4, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (4.06 Å)
Cite:The structures of Snf2-nucleosome complex in the ADP and ADP-BeFx states
To Be Published
1AER
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DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH BETA-TAD
Descriptor:EXOTOXIN A, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE, 2-(1,5-DIDEOXYRIBOSE)-4-AMIDO-THIAZOLE, ...
Authors:Li, M., Dyda, F., Benhar, I., Pastan, I., Davies, D.R.
Deposit date:1995-12-11
Release date:1996-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation
Proc.Natl.Acad.Sci.USA, 93, 1996
1GGP
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CRYSTAL STRUCTURE OF TRICHOSANTHES KIRILOWII LECTIN-1 AND ITS RELATION TO THE TYPE 2 RIBOSOME INACTIVATING PROTEINS
Descriptor:PROTEIN (LECTIN 1 A CHAIN), PROTEIN (LECTIN 1 B CHAIN)
Authors:Li, M., Chai, J.J., Wang, Y.P., Wang, K.Y., Bi, R.C.
Deposit date:2000-09-07
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Trichosanthes Kirilowii Lectin-1 and its Relation to the Type 2 Ribosome Inactivating Proteins
PROTEIN PEPT.LETT., 8, 2003
1DP5
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THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT INHIBITOR
Descriptor:PROTEINASE A, PROTEINASE INHIBITOR IA3, BETA-D-MANNOSE, ...
Authors:Li, M., Phylip, H.L., Lees, W.E., Winther, J.R., Dunn, B.M., Wlodawer, A., Kay, J., Guschina, A.
Deposit date:1999-12-23
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nat.Struct.Biol., 7, 2000
1DPJ
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THE STRUCTURE OF PROTEINASE A COMPLEXED WITH IA3 PEPTIDE INHIBITOR
Descriptor:PROTEINASE A, PROTEINASE INHIBITOR IA3 PEPTIDE, BETA-D-MANNOSE, ...
Authors:Li, M., Phylip, H.L., Lees, W.E., Winther, J.R., Dunn, B.M., Wlodawer, A., Kay, J., Guschina, A.
Deposit date:1999-12-27
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nat.Struct.Biol., 7, 2000
2B7F
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CRYSTAL STRUCTURE OF HUMAN T-CELL LEUKEMIA VIRUS PROTEASE, A NOVEL TARGET FOR ANTI-CANCER DESIGN
Descriptor:HTLV protease, (ACE)APQV(STA)VMHP peptide, PHOSPHATE ION
Authors:Li, M., Laco, G.S., Jaskolski, M., Rozycki, J., Alexandratos, J., Wlodawer, A., Gustchina, A.
Deposit date:2005-10-04
Release date:2005-12-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design
Proc.Natl.Acad.Sci.Usa, 102, 2005
3TLH
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
Descriptor:PROTEIN (PROTEASE), benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-03
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
5C9B
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CRYSTAL STRUCTURE OF A RETROPEPSIN-LIKE ASPARTIC PROTEASE FROM RICKETTSIA CONORII
Descriptor:ApRick protease
Authors:Li, M., Gustchina, A., Cruz, R., Simoes, M., Curto, P., Martinez, J., Faro, C., Simoes, I., Wlodawer, A.
Deposit date:2015-06-26
Release date:2015-10-14
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
5C9D
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CRYSTAL STRUCTURE OF A RETROPEPSIN-LIKE ASPARTIC PROTEASE FROM RICKETTSIA CONORII
Descriptor:ApRick protease, SODIUM ION
Authors:Li, M., Gustchina, A., Cruz, R., Simoes, M., Curto, P., Martinez, J., Faro, C., Simoes, I., Wlodawer, A.
Deposit date:2015-06-26
Release date:2015-10-14
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease
Acta Crystallogr.,Sect.D, 71, 2015
5C9F
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CRYSTAL STRUCTURE OF A RETROPEPSIN-LIKE ASPARTIC PROTEASE FROM RICKETTSIA CONORII
Descriptor:ApRick protease, CHLORIDE ION, SODIUM ION
Authors:Li, M., Gustchina, A., Cruz, R., Simoes, M., Curto, P., Martinez, J., Faro, C., Simoes, I., Wlodawer, A.
Deposit date:2015-06-26
Release date:2015-10-14
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
5DZK
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CRYSTAL STRUCTURE OF THE ACTIVE FORM OF THE PROTEOLYTIC COMPLEX CLPP1 AND CLPP2
Descriptor:ATP-dependent Clp protease proteolytic subunit 2, BEZ-LEU-LEU, ATP-dependent Clp protease proteolytic subunit 1
Authors:LI, M., Wlodawer, A., Maurizi, M.
Deposit date:2015-09-25
Release date:2016-02-17
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
5E0S
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CRYSTAL STRUCTURE OF THE ACTIVE FORM OF THE PROTEOLYTIC COMPLEX CLPP1 AND CLPP2
Descriptor:ATP-dependent Clp protease proteolytic subunit 2, ATP-dependent Clp protease proteolytic subunit 1
Authors:LI, M., Wlodawer, A., Maurizi, M.
Deposit date:2015-09-29
Release date:2016-02-17
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
5FIV
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STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
Descriptor:RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M., Lee, T., Morris, G., Laco, G., Wong, C., Olson, A., Elder, J., Wlodawer, A., Gustchina, A.
Deposit date:1998-12-02
Release date:1998-12-09
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
6DWF
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CRYSTAL STRUCTURE OF COMPLEX OF BBKI MUTANT, L55R WITH BOVINE TRYPSIN
Descriptor:Cationic trypsin, Kunitz-type inihibitor
Authors:Li, M., Wlodawer, A., Gustchina, A.
Deposit date:2018-06-26
Release date:2019-01-30
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes.
Acta Crystallogr D Struct Biol, 75, 2019
6DWH
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CRYSTAL STRUCTURE OF COMPLEX OF BBKI AND BOVINE TRYPSIN
Descriptor:Cationic trypsin, Kunitz-type inihibitor, SODIUM ION, ...
Authors:Li, M., Wlodawer, A.
Deposit date:2018-06-26
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes.
Acta Crystallogr D Struct Biol, 75, 2019