Author results

5XSG
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ULTRAHIGH RESOLUTION STRUCTURE OF FUS (37-42) SYSGYS DETERMINED BY MICROED
Descriptor:RNA-binding protein FUS
Authors:Luo, F., Gui, X., Zhou, H., Li, D., Li, X., Liu, C.
Deposit date:2017-06-14
Release date:2018-04-04
Last modified:2018-04-18
Method:ELECTRON CRYSTALLOGRAPHY (0.73 Å)
Cite:Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation.
Nat. Struct. Mol. Biol., 25, 2018
3IP0
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CRYSTAL STRUCTURE OF E. COLI HPPK IN COMPLEX WITH MGAMPCPP AND 6-HYDROXYMETHYLPTERIN/6-CARBOXYPTERIN
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Blaszczyk, J., Ji, X.
Deposit date:2009-08-15
Release date:2009-08-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (0.89 Å)
Cite:Dynamic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydroptein pyrophosphokinase: Crystallographic studies
Biochemistry, 42, 2003
5ZGL
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HNRNP A1 SEGMENT GGGYGGS (RESIDUES 234-240)
Descriptor:7-mer peptide from Heterogeneous nuclear ribonucleoprotein A1
Authors:Xie, M., Luo, F., Gui, X., Zhao, M., He, J., Li, D., Liu, C.
Deposit date:2018-03-09
Release date:2019-04-03
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
6J60
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HNRNP A1 REVERSIBLE AMYLOID CORE GFGGNDNFG (RESIDUES 209-217)
Descriptor:9-mer peptide (GFGGNDNFG) from Heterogeneous nuclear ribonucleoprotein A1
Authors:Luo, F., Zhou, H., Gui, X., Li, D., Li, X., Liu, C.
Deposit date:2019-01-12
Release date:2019-04-03
Last modified:2019-10-16
Method:ELECTRON CRYSTALLOGRAPHY (0.96 Å)
Cite:Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
4TXR
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CRYSTAL STRUCTURE OF LIP5 N-TERMINAL DOMAIN COMPLEXED WITH CHMP1B MIM AND CHMP5 MIM
Descriptor:Charged multivesicular body protein 1b, Vacuolar protein sorting-associated protein VTA1 homolog, Charged multivesicular body protein 5, ...
Authors:Vild, C.J., Xu, Z.
Deposit date:2014-07-04
Release date:2015-02-11
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1 Å)
Cite:A Novel Mechanism of Regulating the ATPase VPS4 by Its Cofactor LIP5 and the Endosomal Sorting Complex Required for Transport (ESCRT)-III Protein CHMP5.
J.Biol.Chem., 290, 2015
5I86
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO THE BENZODIAZEPINONE G02778174
Descriptor:CREB-binding protein, 1,2-ETHANEDIOL, THIOCYANATE ION, ...
Authors:Jayaram, H., Poy, F., Setser, J.W., Bellon, S.F.
Deposit date:2016-02-18
Release date:2016-04-20
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Acs Med.Chem.Lett., 7, 2016
2O90
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ATOMIC RESOLUTION CRYSTAL STRUCTURE OF E.COLI DIHYDRONEOPTERIN ALDOLASE IN COMPLEX WITH NEOPTERIN
Descriptor:Dihydroneopterin aldolase, L-NEOPTERIN
Authors:Blaszczyk, J., Ji, X., Yan, H.
Deposit date:2006-12-12
Release date:2007-12-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Crystallographic and molecular dynamics simulation analysis of Escherichia coli dihydroneopterin aldolase.
Cell Biosci, 4, 2014
5I89
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP BOUND TO THE BENZODIAZEPINONE G02857790
Descriptor:CREB-binding protein, ACETATE ION, CALCIUM ION, ...
Authors:Setser, J.W., Poy, F., Bellon, S.F.
Deposit date:2016-02-18
Release date:2016-04-20
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Acs Med.Chem.Lett., 7, 2016
4K12
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STRUCTURAL BASIS FOR HOST SPECIFICITY OF FACTOR H BINDING BY STREPTOCOCCUS PNEUMONIAE
Descriptor:Complement factor H, Choline binding protein A
Authors:Liu, A., Achila, D., Banerjee, R., Martinez-Hackert, E., Li, Y., Yan, H.
Deposit date:2013-04-04
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.079 Å)
Cite:Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae.
Biochem.J., 465, 2015
5KTW
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CREBBP BROMODOMAIN IN COMPLEX WITH CPD 44 (3-((5-ACETYL-1-(CYCLOPROPYLMETHYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-3-YL)AMINO)-N-ISOPROPYLBENZAMIDE)
Descriptor:CREB-binding protein, 3-[[1-(cyclopropylmethyl)-5-ethanoyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]amino]-~{N}-propan-2-yl-benzamide, 1,2-ETHANEDIOL
Authors:Murray, J.M., Boenig, G.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.087 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
2HXS
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CRYSTAL STRUCTURE OF RAB28A GTPASE IN THE INACTIVE (GDP-3'P-BOUND) FORM
Descriptor:Ras-related protein Rab-28, MAGNESIUM ION, GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE
Authors:Lee, S.H., Li, Y., Dominguez, R.
Deposit date:2006-08-03
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The Crystal Structure of Rab28 GTPase in Active and Inactive Forms
To be Published
3HD2
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CRYSTAL STRUCTURE OF E. COLI HPPK(Q50A) IN COMPLEX WITH MGAMPCPP AND PTERIN
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-05-06
Release date:2010-05-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Role of loop coupling in enzymatic catalysis and conformational dynamics
To be Published
3ILO
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CRYSTAL STRUCTURE OF E. COLI HPPK(D97A) IN COMPLEX WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
Descriptor:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-08-07
Release date:2010-08-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural and functional roles of residues D95 and D97 in E. coli HPPK
To be Published
5MSZ
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LYTIC POLYSACCHARIDE MONOOXYGENASE AA15 FROM THERMOBIA DOMESTICA IN THE CU(I) STATE
Descriptor:Thermobia domestica domestica AA15, 1,2-ETHANEDIOL, COPPER (I) ION
Authors:Hemsworth, G.R., Sabbadin, F., Ciano, L., Henrissat, B., Dupree, P., Tryfona, T., Besser, K., Elias, L., Pesante, G., Li, Y., Dowle, A., Bates, R., Gomez, L., Hallam, R., Davies, G.J., Walton, P.H., Bruce, N.C., McQueen-Mason, S.
Deposit date:2017-01-06
Release date:2018-02-28
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion.
Nat Commun, 9, 2018
3HSG
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CRYSTAL STRUCTURE OF E. COLI HPPK(Y53A) IN COMPLEX WITH MGAMPCPP
Descriptor:HPPK, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-06-10
Release date:2010-06-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK
To be Published
4IPM
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CRYSTAL STRUCTURE OF A GH7 FAMILY CELLOBIOHYDROLASE FROM LIMNORIA QUADRIPUNCTATA IN COMPLEX WITH THIOCELLOBIOSE
Descriptor:GH7 family protein, THIOCELLOBIOSE, CALCIUM ION, ...
Authors:McGeehan, J.E., Martin, R.N.A., Streeter, S.D., Cragg, S.M., Guille, M.J., Schnorr, K.M., Kern, M., Bruce, N.C., McQueen-Mason, S.J.
Deposit date:2013-01-10
Release date:2013-06-12
Last modified:2014-09-03
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Structural characterization of a unique marine animal family 7 cellobiohydrolase suggests a mechanism of cellulase salt tolerance.
Proc.Natl.Acad.Sci.USA, 110, 2013
5KU3
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BRD4 BROMODOMAIN IN COMPLEX WITH CPD59 ((S)-1-(3-((2-FLUORO-4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)AMINO)-1-(TETRAHYDROFURAN-3-YL)-6,7-DIHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-5(4H)-YL)ETHANONE)
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
Authors:Murray, J.M., Huang, W.
Deposit date:2016-07-12
Release date:2016-11-02
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J. Med. Chem., 59, 2016
3BFO
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CRYSTAL STRUCTURE OF IG-LIKE C2-TYPE 2 DOMAIN OF THE HUMAN MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1
Descriptor:Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Isoform 2)
Authors:Walker, J.R., Akutsu, M., Littler, D.R., Li, Y., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-11-22
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure of the Ig-like C2-type 2 domain of the human Mucosa-associated lymphoid tissue lymphoma translocation protein 1.
To be Published
4HRO
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CRYSTAL STRUCTURE OF H. VOLCANII SMALL ARCHAEAL MODIFIER PROTEIN 1
Descriptor:Small archaeal modifier protein 1, CALCIUM ION
Authors:Hao, B.
Deposit date:2012-10-28
Release date:2013-10-30
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Crystal structure of H. volcanii small archaeal modifier protein 1
To be Published
3HSJ
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CRYSTAL STRUCTURE OF E. COLI HPPK(N55A)
Descriptor:HPPK, ACETATE ION, GLYCEROL
Authors:Blaszczyk, J., Li, Y., Yan, H., Ji, X.
Deposit date:2009-06-10
Release date:2010-06-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK
To be Published
6DUB
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CRYSTAL STRUCTURE OF A METHYLTRANSFERASE
Descriptor:Alpha N-terminal protein methyltransferase 1B, RCC1, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Dong, C., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-06-20
Release date:2018-07-25
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.
Commun Biol, 1, 2018
6I6M
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PAPAVER SOMNIFERUM O-METHYLTRANSFERASE 1
Descriptor:O-methyltransferase 1, (13aS)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,9-diol, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Cabry, M.P., Offen, W.A., Winzer, T., Li, Y., Graham, I.A., Davies, G.J., Saleh, P.
Deposit date:2018-11-15
Release date:2019-03-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure of Papaver somniferum O-Methyltransferase 1 Reveals Initiation of Noscapine Biosynthesis with Implications for Plant Natural Product Methylation
Acs Catalysis, 2019
5X5M
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CRYSTAL STRUCTURE OF A HYDROLASE ENCODED BY LIN2189 FROM LISTERIA INNOCUA
Descriptor:Lin2189 protein, DIMETHYL SULFOXIDE, (+)-Yatakemycin
Authors:Zhang, J.
Deposit date:2017-02-16
Release date:2017-12-06
Method:X-RAY DIFFRACTION (1.211 Å)
Cite:GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection
Nat Commun, 8, 2017
1HQ2
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E.COLI HPPK(R82A) WITH MGAMPCPP AND 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 1.25 ANGSTROM RESOLUTION
Descriptor:6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Blaszczyk, J., Ji, X.
Deposit date:2000-12-13
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Dynamic Roles of Arginine Residues 82 and 92 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase: Crystallographic Studies
Biochemistry, 42, 2003
1RWH
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CRYSTAL STRUCTURE OF ARTHROBACTER AURESCENS CHONDROITIN AC LYASE IN COMPLEX WITH CHONDROITIN TETRASACCHARIDE
Descriptor:chondroitin AC lyase, 2,6-ANHYDRO-3-DEOXY-D-ERYTHRO-HEX-2-ENONIC ACID, 2-DEOXY-2-ACETAMIDO-BETA-D-GALACTOSE-4-SULFATE, ...
Authors:Lunin, V.V., Li, Y., Miyazono, H., Kyogashima, M., Bell, A.W., Cygler, M.
Deposit date:2003-12-16
Release date:2004-04-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:High-resolution crystal structure of Arthrobacter aurescens chondroitin AC lyase: an enzyme-substrate complex defines the catalytic mechanism
J.Mol.Biol., 337, 2004