4F5A
| Triple mutant Src SH2 domain bound to phosphate ion | Descriptor: | PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src | Authors: | Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. | Deposit date: | 2012-05-12 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
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4F59
| Triple mutant Src SH2 domain | Descriptor: | Proto-oncogene tyrosine-protein kinase Src | Authors: | Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. | Deposit date: | 2012-05-12 | Release date: | 2012-10-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
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4F5B
| Triple mutant Src SH2 domain bound to phosphotyrosine | Descriptor: | O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src | Authors: | Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. | Deposit date: | 2012-05-12 | Release date: | 2012-10-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
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1H3H
| Structural Basis for Specific Recognition of an RxxK-containing SLP-76 peptide by the Gads C-terminal SH3 domain | Descriptor: | GRB2-RELATED ADAPTOR PROTEIN 2, LYMPHOCYTE CYTOSOLIC PROTEIN 2 | Authors: | Liu, Q, Berry, D, Nash, P, Pawson, T, McGlade, C.J, Li, S.S. | Deposit date: | 2002-09-03 | Release date: | 2003-03-06 | Last modified: | 2013-07-24 | Method: | SOLUTION NMR | Cite: | Structural Basis for Specific Binding of the Gads SH3 Domain to an Rxxk Motif-Containing Slp-76 Peptide: A Novel Mode of Peptide Recognition Mol.Cell, 11, 2003
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3MAZ
| Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide | Descriptor: | CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 | Authors: | Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. | Deposit date: | 2010-03-24 | Release date: | 2010-05-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
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4GXB
| Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin | Descriptor: | GLYCEROL, P-selectin, Sorting nexin-17 | Authors: | Ghai, R, Bugarcic, A, Liu, H, Norwood, S.J, Li, S.S, Teasdale, R.D, Collins, B.M. | Deposit date: | 2012-09-04 | Release date: | 2013-03-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc.Natl.Acad.Sci.USA, 110, 2013
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7CQI
| Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex | Descriptor: | ORM1-like protein 3, Serine palmitoyltransferase 1, Serine palmitoyltransferase 2, ... | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | Deposit date: | 2020-08-11 | Release date: | 2021-02-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. Nat.Struct.Mol.Biol., 28, 2021
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7CQK
| Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex | Descriptor: | ORM1-like protein 3, Serine palmitoyltransferase 1, Serine palmitoyltransferase 2, ... | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | Deposit date: | 2020-08-11 | Release date: | 2021-02-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. Nat.Struct.Mol.Biol., 28, 2021
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6M4N
| Cryo-EM structure of the dimeric SPT-ORMDL3 complex | Descriptor: | ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ... | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | Deposit date: | 2020-03-07 | Release date: | 2021-02-10 | Last modified: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. Nat.Struct.Mol.Biol., 28, 2021
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6M4O
| Cryo-EM structure of the monomeric SPT-ORMDL3 complex | Descriptor: | ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ... | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | Deposit date: | 2020-03-08 | Release date: | 2021-02-10 | Last modified: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. Nat.Struct.Mol.Biol., 28, 2021
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7M6T
| Crystal structure of SOCS2/ElonginB/ElonginC bound to a non-canonical peptide that enhances phospho-peptide binding | Descriptor: | Elongin-B, Elongin-C, Non-canonical peptide F3, ... | Authors: | Kershaw, N.J, Li, K, Linossi, E.M, Nicholson, S.E. | Deposit date: | 2021-03-26 | Release date: | 2021-10-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.194 Å) | Cite: | Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nat Commun, 12, 2021
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6E8M
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6E8I
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6E8H
| Legionella Longbeachae LeSH (Llo2327) | Descriptor: | CHLORIDE ION, LeSH (Llo2327) | Authors: | Kaneko, T, Li, S.S.C. | Deposit date: | 2018-07-29 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
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6E8K
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2NNZ
| Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus | Descriptor: | Hypothetical protein | Authors: | Ai, X, Semesib, A, Yee, A, Arrowsmith, C.H, Li, S.S.C, Choy, W.Y, Ontario Centre for Structural Proteomics (OCSP) | Deposit date: | 2006-10-24 | Release date: | 2007-08-28 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold. J.Biomol.Nmr, 38, 2007
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2LAS
| Molecular Determinants of Paralogue-Specific SUMO-SIM Recognition | Descriptor: | M-IR2_peptide, Small ubiquitin-related modifier 1 | Authors: | Namanja, A, Li, Y, Su, Y, Wong, S, Lu, J, Colson, L, Wu, C, Li, S, Chen, Y. | Deposit date: | 2011-03-20 | Release date: | 2011-12-14 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealed by a Combination of NMR and Peptide Array Analysis. J.Biol.Chem., 287, 2012
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2VIF
| Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide | Descriptor: | 1,2-ETHANEDIOL, MAST/STEM CELL GROWTH FACTOR RECEPTOR, SUPPRESSOR OF CYTOKINE SIGNALLING 6 | Authors: | Bullock, A, Pike, A.C.W, Savitsky, P, Keates, T, Pilka, E.S, von Delft, F, Edwards, A, Weigelt, J, Arrowsmith, C.H, Knapp, S. | Deposit date: | 2007-11-30 | Release date: | 2007-12-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase. J.Biol.Chem., 286, 2011
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2I5O
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2I50
| Solution Structure of Ubp-M Znf-UBP domain | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 16, ZINC ION | Authors: | Pai, M.-T. | Deposit date: | 2006-08-23 | Release date: | 2007-08-07 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. J.Mol.Biol., 370, 2007
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3JZN
| Structure of EED in apo form | Descriptor: | Polycomb protein EED | Authors: | Xu, C, Bian, C.B, Ouyang, H, Qiu, W, MacKenzie, F, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-23 | Release date: | 2009-12-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3K27
| Complex structure of EED and trimethylated H3K9 | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-29 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3JPX
| EED: A Novel Histone Trimethyllysine Binder Within The EED-EZH2 Polycomb Complex | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-04 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3JZG
| Structure of EED in complex with H3K27me3 | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-23 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3K26
| Complex structure of EED and trimethylated H3K4 | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-29 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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