Author results

5XHZ
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CRYSTAL STRUCTURE ANALYSIS OF CIN85-SH3B IN COMPLEX WITH ARAP1-P2
分子名称:SH3 domain-containing kinase-binding protein 1, Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1, ...
著者Liu, W., Yang, W.
登録日2017-04-25
公開日2018-04-11
最終更新日2018-04-25
実験手法X-RAY DIFFRACTION (1.319 Å)
主引用文献Biochemical and Structural Studies of the Interaction between ARAP1 and CIN85.
Biochemistry, 57, 2018
5GM9
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CRYSTAL STRUCTURE OF A GLYCOSIDE HYDROLASE IN COMPLEX WITH CELLOBIOSE
分子名称:Glycoside hydrolase family 45 protein, 4-O-beta-D-glucopyranosyl-alpha-D-glucopyranose, CELLOBIOSE
著者Gao, J., Liu, W.D., Zheng, Y.Y., Chen, C.C., Guo, R.T.
登録日2016-07-13
公開日2017-04-19
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-beta-endoglucanase from Thielavia terrestris
Enzyme Microb. Technol., 99, 2017
3ZCL
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X-RAY STRUCTURE OF C-MET KINASE IN COMPLEX WITH INHIBITOR (S)-3-(1-(1H-PYRROLO(2,3-B)PYRIDIN-3-YL)ETHYL)-N-ISOPROPYL-(1,2,4)TRIAZOLO(4,3- B)PYRIDAZIN-6-AMINE
分子名称:HEPATOCYTE GROWTH FACTOR RECEPTOR, (S)-3-(1-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-N-isopropyl-(1,2,4)triazolo(4,3-b)pyridazin-6-amine
著者McTigue, M., Grodsky, N., Ryan, K.
登録日2012-11-20
公開日2013-11-27
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Lessons from (S)-6-(1-(6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2, 4]Triazolo[4,3-B]Pyridazin-3-Yl)Ethyl)Quinoline (Pf-04254644), an Inhibitor of Receptor Tyrosine Kinase C-met with High Protein Kinase Selectivity But Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats.
J.Med.Chem., 56, 2013
6EGE
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CRYSTAL STRUCTURE OF THE UNPHOSPHORYLATED IRAK4 KINASE DOMAIN BOUND TO A TYPE I INHIBITOR
分子名称:Interleukin-1 receptor-associated kinase 4, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide
著者Ferrao, R., Liu, Q., Wu, H.
登録日2018-08-19
公開日2019-02-13
最終更新日2019-08-28
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
J.Biol.Chem., 294, 2019
5GLX
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CRYSTAL STRUCTURE OF A GLYCOSIDE HYDROLASE FROM THIELAVIA TERRESTRIS NRRL 8126
分子名称:Glycoside hydrolase family 45 protein
著者Gao, J., Liu, W.D., Zheng, Y.Y., Chen, C.C., Guo, R.T.
登録日2016-07-12
公開日2017-04-19
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-beta-endoglucanase from Thielavia terrestris
Enzyme Microb. Technol., 99, 2017
3FSS
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STRUCTURE OF THE TANDEM PH DOMAINS OF RTT106
分子名称:Histone chaperone RTT106, GLYCEROL, MALONIC ACID
著者Su, D., Thompson, J.R., Mer, G.
登録日2009-01-11
公開日2009-12-22
最終更新日2015-04-29
実験手法X-RAY DIFFRACTION (1.432 Å)
主引用文献Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.
Nature, 483, 2012
3U91
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STRUCTURAL DETERMINANTS OF TRIMERIZATION SPECIFICITY IN HIV-1 GP41 PROTEIN
分子名称:Gp41, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
著者Liu, J., Lu, M.
登録日2011-10-17
公開日2013-04-24
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein
To be Published
3SAL
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS NEURAMINIDASE N5
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Wang, M.Y., Qi, J.X., Liu, Y., Vavricka, C.J., Wu, Y., Li, Q., Gao, G.F.
登録日2011-06-03
公開日2011-08-10
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Influenza a virus n5 neuraminidase has an extended 150-cavity
J.Virol., 85, 2011
4GHI
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CRYSTAL STRUCTURE OF THE HIGH AFFINITY HETERODIMER OF HIF2 ALPHA AND ARNT C-TERMINAL PAS DOMAINS IN COMPLEX WITH A BENZOXADIAZOLE ANTAGONIST
分子名称:Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
著者Scheuermann, T.H., Key, J., Tambar, U.K., Bruick, R.K., Gardner, K.H.
登録日2012-08-07
公開日2013-02-27
最終更新日2013-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Nat.Chem.Biol., 9, 2013
4H53
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INFLUENZA N2-TYR406ASP NEURAMINIDASE IN COMPLEX WITH BETA-NEU5AC
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Liu, Y., Kiyota, H., Sriwilaijaroen, N., Qi, J., Tanaka, K., Wu, Y., Li, Q., Li, Y., Yan, J., Suzuki, Y., Gao, G.F.
登録日2012-09-18
公開日2013-02-20
最終更新日2013-07-31
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors
Nat Commun, 4, 2013
4RFR
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COMPLEX STRUCTURE OF ALKB/RHEIN
分子名称:Alpha-ketoglutarate-dependent dioxygenase AlkB, 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, MANGANESE (II) ION
著者Li, Q., Huang, Y., Li, J.F., Yang, C.-G.
登録日2014-09-27
公開日2016-04-06
最終更新日2016-09-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage.
J.Biol.Chem., 291, 2016
6IJ1
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CRYSTAL STRUCTURE OF A PROTEIN FROM ACTINOPLANES
分子名称:Prenylcyclase, IMIDAZOLE, ACETATE ION
著者Yang, Z.Z., Zhang, L.L., Liu, W.D., Chen, C.C., Guo, R.T.
登録日2018-10-08
公開日2019-09-11
最終更新日2019-09-18
実験手法X-RAY DIFFRACTION (1.521 Å)
主引用文献Crystal structure of TchmY from Actinoplanes teichomyceticus.
Acta Crystallogr.,Sect.F, 75, 2019
4LGJ
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CRYSTAL STRUCTURE AND MECHANISM OF A TYPE III SECRETION PROTEASE
分子名称:Uncharacterized protein, ZINC ION
著者Li, W.Q., Liu, Y.X., Sheng, X.L., Yan, C.Y., Wang, J.W.
登録日2013-06-28
公開日2014-01-15
最終更新日2015-02-25
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structure and mechanism of a type III secretion protease, NleC
Acta Crystallogr.,Sect.D, 70, 2014
6BTD
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CRYSTAL STRUCTURE OF DEOXYRIBOSE-PHOSPHATE ALDOLASE FROM BACILLUS THURINGIENSIS INVOLVED IN DISPATCHING THE UBIQUITOUS RADICAL SAM ENZYME BYPRODUCT 5-DEOXYRIBOSE
分子名称:Fuculose phosphate aldolase, SULFATE ION, MANGANESE (II) ION
著者Li, Q., Bruner, S.D.
登録日2017-12-06
公開日2018-07-04
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.551 Å)
主引用文献Salvage of the 5-deoxyribose byproduct of radical SAM enzymes.
Nat Commun, 9, 2018
4HLR
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STRUCTURAL DETERMINANTS OF TRIMERIZATION SPECIFICITY IN HIV-1 GP41 PROTEIN
分子名称:Gp41, HEXANE-1,6-DIOL
著者Liu, J., Lu, M.
登録日2012-10-17
公開日2013-10-30
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein
To be Published
5GLY
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CRYSTAL STRUCTURE OF A GLYCOSIDE HYDROLASE IN COMPLEX WITH CELLOTETROSE FROM THIELAVIA TERRESTRIS NRRL 8126
分子名称:Glycoside hydrolase family 45 protein, beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranose, CELLOTRIOSE
著者Gao, J., Liu, W.D., Zheng, Y.Y., Chen, C.C., Guo, R.T.
登録日2016-07-12
公開日2017-04-19
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Characterization and crystal structure of a thermostable glycoside hydrolase family 45 1,4-beta-endoglucanase from Thielavia terrestris
Enzyme Microb. Technol., 99, 2017
5GM3
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CRYSTAL STRUCTURE OF FI-CMCASE FROM ASPERGILLUS ACULEATUS F-50
分子名称:Endoglucanase-1, ZINC ION, CACODYLATE ION
著者Huang, J.W., Liu, W.D., Zheng, Y.Y., Chen, C.C., Guo, R.T.
登録日2016-07-12
公開日2017-05-17
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50
Biochem. Biophys. Res. Commun., 478, 2016
4HZY
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CRYSTAL STRUCTURE OF INFLUENZA A NEURAMINIDASE N3-H274Y
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
著者Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
登録日2012-11-16
公開日2013-11-06
実験手法X-RAY DIFFRACTION (1.598 Å)
主引用文献Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87, 2013
3SAN
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS NEURAMINIDASE N5 COMPLEXED WITH ZANAMIVIR
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Wang, M.Y., Qi, J.X., Liu, Y., Vavricka, C.J., Wu, Y., Li, Q., Gao, G.F.
登録日2011-06-03
公開日2011-08-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Influenza a virus n5 neuraminidase has an extended 150-cavity
J.Virol., 85, 2011
4I00
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CRYSTAL STRUCTURE OF INFLUENZA A NEURAMINIDASE N3-H274Y COMPLEXED WITH ZANAMIVIR
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
著者Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
登録日2012-11-16
公開日2013-11-13
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87, 2013
6G3C
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CRYSTAL STRUCTURE OF JAK2-V617F PSEUDOKINASE DOMAIN IN COMPLEX WITH COMPOUND 2
分子名称:Tyrosine-protein kinase, 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one, 1,2-ETHANEDIOL
著者Dekker, C., Hinniger, A.
登録日2018-03-24
公開日2019-03-27
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
Acs Chem.Biol., 14, 2019
3PFT
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CRYSTAL STRUCTURE OF UNTAGGED C54A MUTANT FLAVIN REDUCTASE (DSZD) IN COMPLEX WITH FMN FROM MYCOBACTERIUM GOODII
分子名称:Flavin reductase, FLAVIN MONONUCLEOTIDE
著者Li, Q., Xu, P., Ma, C., Gu, L., Liu, X., Zhang, C., Li, N., Su, J., Li, B., Liu, S.
登録日2010-10-29
公開日2011-11-02
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献The flavin reductase DSZD from a desulfurizing mycobacterium goodii strain: systemic manipulation and investigation based on the crystal structure
To be Published
3TI8
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS NEURAMINIDASE N5 COMPLEXED WITH LANINAMIVIR
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
4HZZ
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CRYSTAL STRUCTURE OF INFLUENZA NEURAMINIDASE N3-H274Y COMPLEXED WITH OSELTAMIVIR
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
著者Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
登録日2012-11-16
公開日2013-11-06
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87, 2013
3TI4
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011