Author results

6KS6
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TRIC AT 0.2 MM ADP-ALFX, CONFORMATION 1, 0.2-C1
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KS7
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TRIC AT 0.1 MM ADP-ALFX, CONFORMATION 1, 0.1-C1
Descriptor:T-complex protein 1 subunit eta, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (4.62 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KS8
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TRIC AT 0.1 MM ADP-ALFX, CONFORMATION 4, 0.1-C4
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (4.69 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KRD
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TRIC AT 0.05 MM ADP-ALFX, CONFORMATION 4, 0.05-C4
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-21
Release date:2019-09-18
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (4.38 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KRE
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TRIC AT 0.05 MM ADP-ALFX, CONFORMATION 2, 0.05-C2
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-21
Release date:2019-09-18
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (4.45 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6Q2J
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CRYO-EM STRUCTURE OF EXTRACELLULAR DIMERIC COMPLEX OF RET/GFRAL/GDF15
Descriptor:Growth/differentiation factor 15, GDNF family receptor alpha-like, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2N
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CRYO-EM STRUCTURE OF RET/GFRA1/GDNF EXTRACELLULAR COMPLEX
Descriptor:Glial cell line-derived neurotrophic factor, GDNF family receptor alpha-1, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2O
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CRYO-EM STRUCTURE OF RET/GFRA2/NRTN EXTRACELLULAR COMPLEX. THE 3D REFINEMENT WAS APPLIED WITH C2 SYMMETRY.
Descriptor:Neurturin, GDNF family receptor alpha-2, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2R
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CRYO-EM STRUCTURE OF RET/GFRA2/NRTN EXTRACELLULAR COMPLEX IN THE TETRAMERIC FORM
Descriptor:Neurturin, GDNF family receptor alpha-2, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6Q2S
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CRYO-EM STRUCTURE OF RET/GFRA3/ARTN EXTRACELLULAR COMPLEX. THE 3D REFINEMENT WAS APPLIED WITH C2 SYMMETRY.
Descriptor:Ubiquitin-like protein SMT3,Artemin, GDNF family receptor alpha-3, Proto-oncogene tyrosine-protein kinase receptor Ret, ...
Authors:Li, J., Shang, G.J., Chen, Y.J., Brautigam, C.A., Liou, J., Zhang, X.W., Bai, X.C.
Deposit date:2019-08-08
Release date:2019-10-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
6PYH
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CRYO-EM STRUCTURE OF FULL-LENGTH IGF1R-IGF1 COMPLEX. ONLY THE EXTRACELLULAR REGION OF THE COMPLEX IS RESOLVED.
Descriptor:Insulin-like growth factor 1 receptor, Insulin-like growth factor I
Authors:Li, J., Choi, E., Yu, H.T., Bai, X.C.
Deposit date:2019-07-29
Release date:2019-10-23
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of the activation of type 1 insulin-like growth factor receptor.
Nat Commun, 10, 2019
6KKR
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HUMAN KCC1 STRUCTURE DETERMINED IN KCL AND DETERGENT GDN
Descriptor:Solute carrier family 12 member 4, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Liu, S., Chang, S., Ye, S., Bai, X., Guo, J.
Deposit date:2019-07-27
Release date:2019-10-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 2019
6KKT
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HUMAN KCC1 STRUCTURE DETERMINED IN KCL AND LIPID NANODISC
Descriptor:Solute carrier family 12 member 4, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Liu, S., Chang, S., Ye, S., Bai, X., Guo, J.
Deposit date:2019-07-27
Release date:2019-10-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 2019
6KKU
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HUMAN KCC1 STRUCTURE DETERMINED IN NACL AND GDN
Descriptor:Solute carrier family 12 member 4, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Liu, S., Chang, S., Ye, S., Bai, X., Guo, J.
Deposit date:2019-07-27
Release date:2019-10-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 2019
6PFM
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CRYSTAL STRUCTURE OF GDC-0927 BOUND TO ESTROGEN RECEPTOR ALPHA
Descriptor:Estrogen receptor, (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-6-ol
Authors:Kiefer, J.R., Vinogradova, M., Liang, J., Zhang, B., Wang, X., Zbieg, J.R., Labadie, S.S., Li, J., Ray, N.C., Ortwine, D.
Deposit date:2019-06-21
Release date:2019-07-17
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
Bioorg.Med.Chem.Lett., 29, 2019
6PET
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CRYSTAL STRUCTURE OF 8-HYDROXYCHROMENE COMPOUND 30 BOUND TO ESTROGEN RECEPTOR ALPHA
Descriptor:Estrogen receptor, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-8-ol, ...
Authors:Kiefer, J.R., Vinogradova, M., Liang, J., Wang, X., Zbieg, J., Labadie, S.S., Zhang, B., Li, J., Liang, W.
Deposit date:2019-06-20
Release date:2019-07-17
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
Bioorg.Med.Chem.Lett., 29, 2019
6P46
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CRYO-EM STRUCTURE OF TMEM16F IN DIGITONIN WITH CALCIUM BOUND
Descriptor:Anoctamin-6, CALCIUM ION
Authors:Feng, S., Dang, S., Han, T.W., Ye, W., Jin, P., Cheng, T., Li, J., Jan, Y.N., Jan, L.Y., Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6P47
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CRYO-EM STRUCTURE OF TMEM16F IN DIGITONIN WITHOUT CALCIUM
Descriptor:Anoctamin-6
Authors:Feng, S., Dang, S., Han, T.W., Ye, W., Jin, P., Cheng, T., Li, J., Jan, Y.N., Jan, L.Y., Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6P48
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CRYO-EM STRUCTURE OF CALCIUM-BOUND TMEM16F IN NANODISC WITH SUPPLEMENT OF PIP2 IN CL1
Descriptor:Anoctamin-6, CALCIUM ION
Authors:Feng, S., Dang, S., Han, T.W., Ye, W., Jin, P., Cheng, T., Li, J., Jan, Y.N., Jan, L.Y., Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6P49
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CRYO-EM STRUCTURE OF CALCIUM-BOUND TMEM16F IN NANODISC WITH SUPPLEMENT OF PIP2 IN CL2
Descriptor:Anoctamin-6, CALCIUM ION
Authors:Feng, S., Dang, S., Han, T.W., Ye, W., Jin, P., Cheng, T., Li, J., Jan, Y.N., Jan, L.Y., Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6JRL
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CRYSTAL STRUCTURE OF DROSOPHILA ALPHA METHYLDOPA-RESISTANT PROTEIN/3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE
Descriptor:3,4-dihydroxyphenylacetaldehyde synthase
Authors:Wei, S., Vavrick, C.J., Guan, H., Liao, C., Robinson, H., Liang, J., Wang, D., Han, Q., Li, J.
Deposit date:2019-04-04
Release date:2019-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the bifunctional mechanism of Drosophila alpha methyldopa-resistant protein/3,4-dihydroxyphenylacetaldehyde synthase
To Be Published
6JRF
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CRYSTAL STRUCTURE OF ZMMOC1-HOLLIDAY JUNCTION COMPLEX IN THE PRESENCE OF CALCIUM
Descriptor:Monokaryotic chloroplast 1, DNA (33-MER), CALCIUM ION, ...
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2019-04-03
Release date:2019-10-23
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1
Nat.Chem.Biol., 2019
6JRG
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CRYSTAL STRUCTURE OF ZMMOC1 H253A MUTANT IN COMPLEX WITH HOLLIDAY JUNCTION
Descriptor:Monokaryotic chloroplast 1, DNA (33-MER), DNA (32-MER), ...
Authors:Lin, Z., Lin, H., Zhang, D., Yuan, C.
Deposit date:2019-04-03
Release date:2019-10-23
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural basis of sequence-specific Holliday junction cleavage by MOC1
Nat.Chem.Biol., 2019
6JPJ
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CRYSTAL STRUCTURE OF FGF401 IN COMPLEX OF FGFR4
Descriptor:Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION
Authors:Zhou, Z., Chen, X., Chen, Y.
Deposit date:2019-03-27
Release date:2019-05-15
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.638 Å)
Cite:Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.
Chem.Commun.(Camb.), 55, 2019
6OD3
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HUMAN TCF4 C-TERMINAL BHLH DOMAIN IN COMPLEX WITH 13-BP OLIGONUCLEOTIDE CONTAINING E-BOX SEQUENCE
Descriptor:Transcription factor 4, DNA (5'-D(*CP*AP*TP*AP*CP*AP*CP*GP*TP*GP*TP*AP*T)-3'), 1,2-ETHANEDIOL, ...
Authors:Horton, J.R., Cheng, X., Yang, J.
Deposit date:2019-03-25
Release date:2019-05-29
Method:X-RAY DIFFRACTION (1.494 Å)
Cite:Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine.
Nucleic Acids Res., 2019