Author results

1LBG
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LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY
Descriptor:DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), PROTEIN (LACTOSE OPERON REPRESSOR)
Authors:Lewis, M., Chang, G., Horton, N.C., Kercher, M.A., Pace, H.C., Lu, P.
Deposit date:1996-01-03
Release date:1996-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.8 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
1LBH
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INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG
Descriptor:INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG, ISOPROPYL-1-BETA-D-THIOGALACTOSIDE
Authors:Lewis, M., Chang, G., Horton, N.C., Kercher, M.A., Pace, H.C., Lu, P.
Deposit date:1996-02-17
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
1LBI
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LAC REPRESSOR
Descriptor:LAC REPRESSOR
Authors:Lewis, M., Chang, G., Horton, N.C., Kercher, M.A., Pace, H.C., Lu, P.
Deposit date:1996-02-17
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
2FJR
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CRYSTAL STRUCTURE OF BACTERIOPHAGE 186
Descriptor:Repressor protein CI
Authors:Lewis, M.
Deposit date:2006-01-03
Release date:2006-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The structural basis of cooperative regulation at an alternate genetic switch
Mol.Cell, 21, 2006
2FKD
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF BACTERIOPHAGE 186 REPRESSOR
Descriptor:Repressor protein CI
Authors:Lewis, M.
Deposit date:2006-01-04
Release date:2006-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis of cooperative regulation at an alternate genetic switch.
Mol.Cell, 21, 2006
1LRP
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COMPARISON OF THE STRUCTURES OF CRO AND LAMBDA REPRESSOR PROTEINS FROM BACTERIOPHAGE LAMBDA
Descriptor:LAMBDA REPRESSOR
Authors:Pabo, C., Lewis, M.
Deposit date:1987-12-04
Release date:1989-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Comparison of the structures of cro and lambda repressor proteins from bacteriophage lambda.
J.Mol.Biol., 169, 1983
1AFS
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RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE
Descriptor:3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TESTOSTERONE
Authors:Bennett, M.J., Albert, R.H., Jez, J.M., Ma, H., Penning, T.M., Lewis, M.
Deposit date:1997-03-13
Release date:1997-10-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
Structure, 5, 1997
1EFA
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CRYSTAL STRUCTURE OF THE LAC REPRESSOR DIMER BOUND TO OPERATOR AND THE ANTI-INDUCER ONPF
Descriptor:DNA (5'-D(*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), LAC REPRESSOR, ORTHONITROPHENYL-BETA-D-FUCOPYRANOSIDE
Authors:Bell, C.E., Lewis, M.
Deposit date:2000-02-07
Release date:2000-03-06
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A closer view of the conformation of the Lac repressor bound to operator.
Nat.Struct.Biol., 7, 2000
1LWI
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3-ALPHA-HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE FROM RATTUS NORVEGICUS
Descriptor:3-ALPHA-HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bennett, M.J., Schlegel, B.P., Jez, J.M., Penning, T.M., Lewis, M.
Deposit date:1996-02-24
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.
Biochemistry, 35, 1996
1F39
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CRYSTAL STRUCTURE OF THE LAMBDA REPRESSOR C-TERMINAL DOMAIN
Descriptor:REPRESSOR PROTEIN CI
Authors:Bell, C.E., Frescura, P., Hochschild, A., Lewis, M.
Deposit date:2000-06-01
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding.
Cell(Cambridge,Mass.), 101, 2000
1IHI
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CRYSTAL STRUCTURE OF HUMAN TYPE III 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE/BILE ACID BINDING PROTEIN (AKR1C2) COMPLEXED WITH NADP+ AND URSODEOXYCHOLATE
Descriptor:3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISO-URSODEOXYCHOLIC ACID
Authors:Jin, Y., Stayrook, S.E., Albert, R.H., Palackal, N.T., Penning, T.M., Lewis, M.
Deposit date:2001-04-19
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.
Biochemistry, 40, 2001
1JWL
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STRUCTURE OF THE DIMERIC LAC REPRESSOR/OPERATOR O1/ONPF COMPLEX
Descriptor:5'-D(*AP*GP*AP*AP*T*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*T)-3', 5'-D(*TP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', Lactose Operon Repressor, ...
Authors:Bell, C.E., Lewis, M.
Deposit date:2001-09-04
Release date:2001-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystallographic analysis of Lac repressor bound to natural operator O1.
J.Mol.Biol., 312, 2001
1JYE
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STRUCTURE OF A DIMERIC LAC REPRESSOR WITH C-TERMINAL DELETION AND K84L SUBSTITUTION
Descriptor:Lactose Operon Repressor, GLYCEROL
Authors:Bell, C.E., Barry, J., Matthews, K.S., Lewis, M.
Deposit date:2001-09-12
Release date:2001-10-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator.
J.Mol.Biol., 313, 2001
1JYF
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STRUCTURE OF THE DIMERIC LAC REPRESSOR WITH AN 11-RESIDUE C-TERMINAL DELETION.
Descriptor:Lactose Operon Repressor, GLYCEROL
Authors:Bell, C.E., Barry, J., Matthews, K.S., Lewis, M.
Deposit date:2001-09-12
Release date:2001-10-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a variant of lac repressor with increased thermostability and decreased affinity for operator.
J.Mol.Biol., 313, 2001
1KCA
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CRYSTAL STRUCTURE OF THE LAMBDA REPRESSOR C-TERMINAL DOMAIN OCTAMER
Descriptor:REPRESSOR PROTEIN CI
Authors:Bell, C.E., Lewis, M.
Deposit date:2001-11-07
Release date:2001-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Crystal structure of the lambda repressor C-terminal domain octamer.
J.Mol.Biol., 314, 2001
1M3W
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CRYSTAL STRUCTURE OF A MOLECULAR MAQUETTE SCAFFOLD
Descriptor:H10H24, MERCURY (II) ION
Authors:Huang, S.S., Gibney, B.R., Stayrook, S.E., Dutton, P.L., Lewis, M.
Deposit date:2002-07-01
Release date:2003-02-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray Structure of a Maquette Scaffold
J.Mol.Biol., 326, 2003
1RAL
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THREE-DIMENSIONAL STRUCTURE OF RAT LIVER 3ALPHA-HYDROXYSTEROID(SLASH)DIHYDRODIOL DEHYDROGENASE: A MEMBER OF THE ALDO-KETO REDUCTASE SUPERFAMILY
Descriptor:3-ALPHA-HYDROXYSTEROID DEHYDROGENASE
Authors:Hoog, S.S., Pawlowski, J.E., Alzari, P.M., Penning, T.M., Lewis, M.
Deposit date:1994-02-04
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.
Proc.Natl.Acad.Sci.USA, 91, 1994
2PE5
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CRYSTAL STRUCTURE OF THE LAC REPRESSOR BOUND TO ONPG IN REPRESSED STATE
Descriptor:DNA (5'-D(*DAP*DAP*DTP*DTP*DGP*DTP*DGP*DAP*DGP*DCP*DGP*DCP*DTP*DCP*DAP*DCP*DAP*DAP*DTP*DT)-3'), Lactose operon repressor, 1-O-[O-NITROPHENYL]-BETA-D-GALACTOPYRANOSE
Authors:Daber, R., Stayrook, S.E., Rosenberg, A., Lewis, M.
Deposit date:2007-04-02
Release date:2008-03-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural analysis of lac repressor bound to allosteric effectors
J.Mol.Biol., 370, 2007
2YNN
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YEAST BETAPRIME COP 1-304 WITH KTKTN MOTIF
Descriptor:COATOMER SUBUNIT BETA', KTKTN MOTIF, SULFATE ION
Authors:Jackson, L.P., Lewis, M., Kent, H.M., Edeling, M.A., Evans, P.R., Duden, R., Owen, D.J.
Deposit date:2012-10-17
Release date:2012-12-12
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (1.782 Å)
Cite:Molecular Basis for Recognition of Dilysine Trafficking Motifs by Copi.
Dev.Cell, 23, 2012
2YNO
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YEAST BETAPRIME COP 1-304H6
Descriptor:COATOMER SUBUNIT BETA', POLY ALA
Authors:Jackson, L.P., Lewis, M., Kent, H.M., Edeling, M.A., Evans, P.R., Duden, R., Owen, D.J.
Deposit date:2012-10-17
Release date:2012-12-12
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis for Recognition of Dilysine Trafficking Motifs by Copi.
Dev.Cell, 23, 2012
2YNP
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YEAST BETAPRIME COP 1-604 WITH KTKTN MOTIF
Descriptor:COATOMER SUBUNIT BETA', KTKTN MOTIF
Authors:Jackson, L.P., Lewis, M., Kent, H.M., Edeling, M.A., Evans, P.R., Duden, R., Owen, D.J.
Deposit date:2012-10-17
Release date:2012-12-12
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (2.962 Å)
Cite:Molecular Basis for Recognition of Dilysine Trafficking Motifs by Copi.
Dev.Cell, 23, 2012
3BDN
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CRYSTAL STRUCTURE OF THE LAMBDA REPRESSOR
Descriptor:DNA (5'-D(*DAP*DAP*DTP*DAP*DCP*DCP*DAP*DCP*DTP*DGP*DGP*DCP*DGP*DGP*DTP*DGP*DAP*DTP*DAP*DT)-3'), DNA (5'-D(*DTP*DAP*DTP*DAP*DTP*DCP*DAP*DCP*DCP*DGP*DCP*DCP*DAP*DGP*DTP*DGP*DGP*DTP*DAP*DT)-3'), Lambda Repressor
Authors:Stayrook, S.E., Jaru-Ampornpan, P., Hochschild, A., Lewis, M.
Deposit date:2007-11-15
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.909 Å)
Cite:Crystal structure of the lambda repressor and a model for pairwise cooperative operator binding
Nature, 452, 2008
4BV4
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STRUCTURE AND ALLOSTERY IN TOLL-SPATZLE RECOGNITION
Descriptor:PROTEIN SPAETZLE C-106, PROTEIN TOLL, VARIABLE LYMPHOCYTE RECEPTOR B CHIMERA, ...
Authors:Lewis, M.F., Arnot, C.J., Beeston, H., McCoy, A., Ashcroft, A.E., Gay, N.J., Gangloff, M.
Deposit date:2013-06-24
Release date:2013-12-04
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Cytokine Spatzle Binds to the Drosophila Immunoreceptor Toll with a Neurotrophin-Like Specificity and Couples Receptor Activation.
Proc.Natl.Acad.Sci.USA, 110, 2013
1AAQ
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HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS
Descriptor:HIV-1 PROTEASE, methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate
Authors:Lewis, M.
Deposit date:1992-04-13
Release date:1994-06-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.
Biochemistry, 31, 1992
3MO7
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CRYSTAL STRUCTURE OF HUMAN OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE COVALENTLY MODIFIED BY 2'-FLUORO-6-IODO-UMP
Descriptor:Uridine 5'-monophosphate synthase, 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate), GLYCEROL
Authors:Liu, Y., Kotra, L.P., Pai, E.F.
Deposit date:2010-04-22
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.
J.Med.Chem., 54, 2011
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