Author results

5F8U
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LIGAND OCCUPANCY IN CRYSTAL STRUCTURE OF BETA1-ADRENERGIC RECEPTOR PREVIOUSLY SUBMITTED BY HUANG ET AL
Descriptor:Beta-1 adrenergic receptor, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
Authors:Leslie, A.G.W., Warne, A., Tate, C.G.
Deposit date:2015-12-09
Release date:2015-12-23
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Ligand occupancy in crystal structure of Beta1 adrenergic G protein coupled receptor
Nat.Struct.Mol.Biol., 22, 2015
4CLA
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ALTERNATIVE BINDING MODES FOR CHLORAMPHENICOL AND 1-SUBSTITUTED CHLORAMPHENICOL ANALOGUES REVEALED BY SITE-DIRECTED MUTAGENESIS AND X-RAY CRYSTALLOGRAPHY OF CHLORAMPHENICOL ACETYLTRANSFERASE
Descriptor:TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE, COBALT (II) ION, CHLORAMPHENICOL
Authors:Leslie, A.G.W.
Deposit date:1990-10-23
Release date:1992-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and X-ray crystallography of chloramphenicol acetyltransferase.
Biochemistry, 30, 1991
3CLA
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REFINED CRYSTAL STRUCTURE OF TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE AT 1.75 ANGSTROMS RESOLUTION
Descriptor:TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE, COBALT (II) ION, CHLORAMPHENICOL
Authors:Leslie, A.G.W.
Deposit date:1990-07-09
Release date:1990-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Refined crystal structure of type III chloramphenicol acetyltransferase at 1.75 A resolution.
J.Mol.Biol., 213, 1990
1QCA
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QUADRUPLE MUTANT Q92C, N146F, Y168F, I172V TYPE III CAT COMPLEXED WITH FUSIDIC ACID. CRYSTALS GROWN AT PH 6.3. X-RAY DATA COLLECTED AT ROOM TEMPERATURE
Descriptor:TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE, COBALT (II) ION, FUSIDIC ACID
Authors:Leslie, A.G.W.
Deposit date:1995-08-03
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Steroid recognition by chloramphenicol acetyltransferase: engineering and structural analysis of a high affinity fusidic acid binding site.
J.Mol.Biol., 254, 1995
1CIA
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REPLACEMENT OF CATALYTIC HISTIDINE-195 OF CHLORAMPHENICOL ACETYLTRANSFERASE: EVIDENCE FOR A GENERAL BASE ROLE FOR GLUTAMATE
Descriptor:CHLORAMPHENICOL ACETYLTRANSFERASE, COBALT (II) ION, BETA-MERCAPTOETHANOL
Authors:Leslie, A.G.W., Gibbs, M.R.
Deposit date:1993-07-19
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Replacement of catalytic histidine-195 of chloramphenicol acetyltransferase: evidence for a general base role for glutamate.
Biochemistry, 33, 1994
1QGT
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HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)
Descriptor:PROTEIN (HBV CAPSID PROTEIN)
Authors:Leslie, A.G.W., Wynne, S.A., Crowther, R.A.
Deposit date:1999-05-05
Release date:1999-06-25
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The crystal structure of the human hepatitis B virus capsid.
Mol.Cell, 3, 1999
1W0J
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BERYLLIUM FLUORIDE INHIBITED BOVINE F1-ATPASE
Descriptor:ATP SYNTHASE ALPHA CHAIN HEART ISOFORM, MITOCHONDRIAL PRECURSOR, ATP SYNTHASE BETA CHAIN, ...
Authors:Kagawa, R., Montgomery, M.G., Braig, K., Walker, J.E., Leslie, A.G.W.
Deposit date:2004-06-08
Release date:2004-07-08
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of Bovine F1-ATPase Inhibited by Adp and Beryllium Fluoride
Embo J., 23, 2004
1W0K
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ADP INHIBITED BOVINE F1-ATPASE
Descriptor:ATP SYNTHASE ALPHA CHAIN HEART ISOFORM, MITOCHONDRIAL PRECURSOR, ATP SYNTHASE BETA CHAIN, ...
Authors:Kagawa, R., Montgomery, M.G., Braig, K., Walker, J.E., Leslie, A.G.W.
Deposit date:2004-06-08
Release date:2004-07-08
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Structure of Bovine F1-ATPase Inhibited by Adp and Beryllium Fluoride
Embo J., 23, 2004
2CK3
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AZIDE INHIBITED BOVINE F1-ATPASE
Descriptor:ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL, ATP SYNTHASE SUBUNIT BETA, ...
Authors:Bowler, M.W., Montgomery, M.G., Leslie, A.G.W., Walker, J.E.
Deposit date:2006-04-10
Release date:2006-05-08
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:How Azide Inhibits ATP Hydrolysis by the F-Atpases.
Proc.Natl.Acad.Sci.USA, 103, 2006
1H8E
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(ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)
Descriptor:BOVINE MITOCHONDRIAL F1-ATPASE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Menz, R.I., Walker, J.E., Leslie, A.G.W.
Deposit date:2001-02-02
Release date:2001-08-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Bovine Mitochondrial F1-ATPase with Nucleotide Bound to All Three Catalytic Sites: Implications for the Mechanism of Rotary Catalysis
Cell(Cambridge,Mass.), 106, 2001
1CLA
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EVIDENCE FOR TRANSITION-STATE STABILIZATION BY SERINE-148 IN THE CATALYTIC MECHANISM OF CHLORAMPHENICOL ACETYLTRANSFERASE
Descriptor:TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE, COBALT (II) ION, CHLORAMPHENICOL
Authors:Gibbs, M.R., Leslie, A.G.W.
Deposit date:1989-10-16
Release date:1990-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Evidence for transition-state stabilization by serine-148 in the catalytic mechanism of chloramphenicol acetyltransferase.
Biochemistry, 29, 1990
2CLA
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CRYSTAL STRUCTURE OF THE ASP-199-ASN MUTANT OF CHLORAMPHENICOL ACETYLTRANSFERASE TO 2.35 ANGSTROMS RESOLUTION. STRUCTURAL CONSEQUENCES OF DISRUPTION OF A BURIED SALT-BRIDGE
Descriptor:CHLORAMPHENICOL ACETYLTRANSFERASE, COBALT (II) ION
Authors:Gibbs, M.R., Moody, P.C.E., Leslie, A.G.W.
Deposit date:1990-04-05
Release date:1990-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the aspartic acid-199----asparagine mutant of chloramphenicol acetyltransferase to 2.35-A resolution: structural consequences of disruption of a buried salt bridge.
Biochemistry, 29, 1990
1E79
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BOVINE F1-ATPASE INHIBITED BY DCCD (DICYCLOHEXYLCARBODIIMIDE)
Descriptor:ATP SYNTHASE ALPHA CHAIN HEART ISOFORM, ATP SYNTHASE BETA CHAIN, ATP SYNTHASE GAMMA CHAIN, ...
Authors:Gibbons, C., Montgomery, M.G., Leslie, A.G.W., Walker, J.E.
Deposit date:2000-08-25
Release date:2000-11-03
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of the Central Stalk in Bovine F(1)-ATPase at 2.4 A Resolution.
Nat.Struct.Biol., 7, 2000
1OHH
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BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH THE INHIBITOR PROTEIN IF1
Descriptor:ATP synthase subunit alpha, mitochondrial, ATP synthase subunit beta, ...
Authors:Cabezon, E., Montgomery, M.G., Leslie, A.G.W., Walker, J.E.
Deposit date:2003-05-27
Release date:2003-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of Bovine F1-ATPase in Complex with its Regulatory Protein If1
Nat.Struct.Biol., 10, 2003
1E1Q
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BOVINE MITOCHONDRIAL F1-ATPASE AT 100K
Descriptor:BOVINE MITOCHONDRIAL F1-ATPASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Braig, K., Menz, R.I., Montgomery, M.G., Leslie, A.G.W., Walker, J.E.
Deposit date:2000-05-10
Release date:2000-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of Bovine Mitochondrial F1-ATPase Inhibited by Mg2+Adp and Aluminium Fluoride
Structure, 8, 2000
1E1R
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BOVINE MITOCHONDRIAL F1-ATPASE INHIBITED BY MG2+ADP AND ALUMINIUM FLUORIDE
Descriptor:BOVINE MITOCHONDRIAL F1-ATPASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Braig, K., Menz, R.I., Montgomery, M.G., Leslie, A.G.W., Walker, J.E.
Deposit date:2000-05-10
Release date:2000-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Bovine Mitochondrial F1-ATPase Inhibited by Mg2+Adp and Aluminium Fluoride
Structure, 8, 2000
1H8H
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BOVINE MITOCHONDRIAL F1-ATPASE CRYSTALLISED IN THE PRESENCE OF 5MM AMPPNP
Descriptor:BOVINE MITOCHONDRIAL F1-ATPASE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Braig, K., Menz, R.I., Montgomery, M.G., Leslie, A.G.W., Walker, J.E.
Deposit date:2001-02-06
Release date:2001-04-15
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Structure and Nucleotide Occupancy of Bovine Mitochondrial F(1)-ATPase are not Influenced by Crystallisation at High Concentrations of Nucleotide
FEBS Lett., 494, 2001
1QO1
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MOLECULAR ARCHITECTURE OF THE ROTARY MOTOR IN ATP SYNTHASE FROM YEAST MITOCHONDRIA
Descriptor:ATP SYNTHASE ALPHA CHAIN, ATP SYNTHASE BETA CHAIN, ATP SYNTHASE GAMMA CHAIN, ...
Authors:Stock, D., Leslie, A.G.W., Walker, J.E.
Deposit date:1999-11-01
Release date:1999-11-04
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Molecular Architecture of the Rotary Motor in ATP Synthase
Science, 286, 1999
2CLY
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SUBCOMPLEX OF THE STATOR OF BOVINE MITOCHONDRIAL ATP SYNTHASE
Descriptor:ATP SYNTHASE B CHAIN, MITOCHONDRIAL, ATP SYNTHASE D CHAIN, ...
Authors:Kane Dickson, V., Silvester, J.A., Fearnley, I.M., Leslie, A.G.W., Walker, J.E.
Deposit date:2006-05-03
Release date:2006-06-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:On the Structure of the Stator of the Mitochondrial ATP Synthase.
Embo J., 25, 2006
2Y00
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92)
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y01
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB102)
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-03-30
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y02
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST CARMOTEROL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y03
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST ISOPRENALINE
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
2Y04
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TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST SALBUTAMOL
Descriptor:BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, HEGA-10, ...
Authors:Warne, A., Moukhametzianov, R., Baker, J.G., Nehme, R., Edwards, P.C., Leslie, A.G.W., Schertler, G.F.X., Tate, C.G.
Deposit date:2010-11-30
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:The Structural Basis for Agonist and Partial Agonist Action on a Beta1-Adrenergic Receptor
Nature, 469, 2011
5G53
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STRUCTURE OF THE ADENOSINE A2A RECEPTOR BOUND TO AN ENGINEERED G PROTEIN
Descriptor:ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, ...
Authors:Carpenter, B., Nehme, R., Warne, T., Leslie, A.G.W., Tate, C.G.
Deposit date:2016-05-19
Release date:2016-08-03
Last modified:2017-03-08
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein
Nature, 536, 2016
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