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2A5H
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2.1 ANGSTROM X-RAY CRYSTAL STRUCTURE OF LYSINE-2,3-AMINOMUTASE FROM CLOSTRIDIUM SUBTERMINALE SB4, WITH MICHAELIS ANALOG (L-ALPHA-LYSINE EXTERNAL ALDIMINE FORM OF PYRIDOXAL-5'-PHOSPHATE).
Descriptor:L-lysine 2,3-aminomutase, ZINC ION, SULFATE ION, ...
Authors:Lepore, B.W., Ruzicka, F.J., Frey, P.A., Ringe, D.
Deposit date:2005-06-30
Release date:2005-10-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The X-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale.
Proc.Natl.Acad.Sci.Usa, 102, 2005
3LQS
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COMPLEX STRUCTURE OF D-AMINO ACID AMINOTRANSFERASE AND 4-AMINO-4,5-DIHYDRO-THIOPHENECARBOXYLIC ACID (ADTA)
Descriptor:D-alanine aminotransferase, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ACETIC ACID
Authors:Lepore, B.W., Liu, D., Peng, Y., Fu, M., Yasuda, C., Manning, J.M., Silverman, R.B., Ringe, D.
Deposit date:2010-02-10
Release date:2010-03-16
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Chiral discrimination among aminotransferases: inactivation by 4-amino-4,5-dihydrothiophenecarboxylic acid.
Biochemistry, 49, 2010
3PGR
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ASP348ARG MUTANT OF ECFADL
Descriptor:Long-chain fatty acid transport protein, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE
Authors:Lepore, B.W., van den Berg, B., Indic, M., Hearn, E., Patel, D., Pham, H.
Deposit date:2010-11-02
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PGU
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PHE3GLU MUTANT OF ECFADL
Descriptor:Long-chain fatty acid transport protein, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, NONAETHYLENE GLYCOL, ...
Authors:Lepore, B.W., Indic, M., Pham, H., Hearn, E., Patel, D., van den Berg, B.
Deposit date:2010-11-02
Release date:2011-05-25
Last modified:2015-01-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
1G2W
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E177S MUTANT OF THE PYRIDOXAL-5'-PHOSPHATE ENZYME D-AMINO ACID AMINOTRANSFERASE
Descriptor:D-ALANINE AMINOTRANSFERASE, ACETATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Lepore, B.W., Ringe, D.
Deposit date:2000-10-21
Release date:2000-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on an Active Site Residue, E177, That Affects Binding of the Coenzyme in D-Amino Acid Transaminase, and Mechanistic Studies on a Suicide Substrate
Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins, 10th Annual International Symposium on Vitamin B6, 2000
2R89
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CRYSTAL STRUCTURE OF THE LONG-CHAIN FATTY ACID TRANSPORTER FADL MUTANT DELTA N3
Descriptor:Long-chain fatty acid transport protein
Authors:Hearn, E.M., Patel, D.R., Lepore, B.W., Indic, M., van den Berg, B.
Deposit date:2007-09-10
Release date:2008-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
2R8A
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CRYSTAL STRUCTURE OF THE LONG-CHAIN FATTY ACID TRANSPORTER FADL MUTANT DELTA N8
Descriptor:Long-chain fatty acid transport protein, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE
Authors:Hearn, E.M., Patel, D.R., Lepore, B.W., Indic, M., van den Berg, B.
Deposit date:2007-09-10
Release date:2008-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PF1
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E. COLI FADL ASP348ALA MUTANT
Descriptor:Long-chain fatty acid transport protein, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, LAURYL DIMETHYLAMINE-N-OXIDE
Authors:Vandenberg, B., Lepore, B.W., Hearn, E.M., Indic, M., Patel, D.
Deposit date:2010-10-27
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PGS
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PHE3GLY MUTANT OF ECFADL
Descriptor:Long-chain fatty acid transport protein, CALCIUM ION, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ...
Authors:van den Berg, B., Lepore, B.W.
Deposit date:2010-11-02
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:From the Cover: Ligand-gated diffusion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
1M54
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CYSTATHIONINE-BETA SYNTHASE: REDUCED VICINAL THIOLS
Descriptor:CYSTATHIONINE BETA-SYNTHASE, PYRIDOXAL-5'-PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Taoka, S., Lepore, B.W., Kabil, O., Ojha, S., Ringe, D., Banerjee, R.
Deposit date:2002-07-08
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:HUMAN CYSTATHIONINE BETA-SYNTHASE IS A HEME SENSOR PROTEIN. EVIDENCE THAT THE REDOX SENSOR IS HEME AND NOT THE VICINAL CYSTEINES IN THE CXXC MOTIF SEEN IN THE CRYSTAL STRUCTURE OF THE TRUNCATED ENZYME
BIOCHEMISTRY, 41, 2002
2A7M
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1.6 ANGSTROM RESOLUTION STRUCTURE OF THE QUORUM-QUENCHING N-ACYL HOMOSERINE LACTONE HYDROLASE OF BACILLUS THURINGIENSIS
Descriptor:N-acyl homoserine lactone hydrolase, ZINC ION, GLYCEROL
Authors:Liu, D., Lepore, B.W., Petsko, G.A., Thomas, P.W., Stone, E.M., Fast, W., Ringe, D.
Deposit date:2005-07-05
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis
Proc.Natl.Acad.Sci.Usa, 102, 2005
2R4L
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CRYSTAL STRUCTURE OF THE LONG-CHAIN FATTY ACID TRANSPORTER FADL MUTANT P34A
Descriptor:Long-chain fatty acid transport protein, LAURYL DIMETHYLAMINE-N-OXIDE
Authors:Hearn, E.M., Patel, D.R., Lepore, B.W., Indic, M., van den Berg, B.
Deposit date:2007-08-31
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Transmembrane passage of hydrophobic compounds through a protein channel wall
Nature, 458, 2009
2R4N
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CRYSTAL STRUCTURE OF THE LONG-CHAIN FATTY ACID TRANSPORTER FADL MUTANT N33A
Descriptor:Long-chain fatty acid transport protein, LAURYL DIMETHYLAMINE-N-OXIDE
Authors:Hearn, E.M., Patel, D.R., Lepore, B.W., Indic, M., van den Berg, B.
Deposit date:2007-08-31
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Transmembrane passage of hydrophobic compounds through a protein channel wall
Nature, 458, 2009
2R4O
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CRYSTAL STRUCTURE OF THE LONG-CHAIN FATTY ACID TRANSPORTER FADL MUTANT DELTA NPA
Descriptor:Long-chain fatty acid transport protein, LAURYL DIMETHYLAMINE-N-OXIDE
Authors:Hearn, E.M., Patel, D.R., Lepore, B.W., Indic, M., van den Berg, B.
Deposit date:2007-08-31
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Transmembrane passage of hydrophobic compounds through a protein channel wall
Nature, 458, 2009
2R4P
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CRYSTAL STRUCTURE OF THE LONG-CHAIN FATTY ACID TRANSPORTER FADL MUTANT G212E
Descriptor:Long-chain fatty acid transport protein, LAURYL DIMETHYLAMINE-N-OXIDE
Authors:Hearn, E.M., Patel, D.R., Lepore, B.W., Indic, M., van den Berg, B.
Deposit date:2007-08-31
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Transmembrane passage of hydrophobic compounds through a protein channel wall
Nature, 458, 2009
2R88
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CRYSTAL STRUCTURE OF THE LONG-CHAIN FATTY ACID TRANSPORTER FADL MUTANT DELTA S3 KINK
Descriptor:Long-chain fatty acid transport protein
Authors:Hearn, E.M., Patel, D.R., Lepore, B.W., Indic, M., van den Berg, B.
Deposit date:2007-09-10
Release date:2008-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Transmembrane passage of hydrophobic compounds through a protein channel wall
Nature, 458, 2009
3DWN
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CRYSTAL STRUCTURE OF THE LONG-CHAIN FATTY ACID TRANSPORTER FADL MUTANT A77E/S100R
Descriptor:Long-chain fatty acid transport protein, LAURYL DIMETHYLAMINE-N-OXIDE
Authors:Hearn, E.M., Patel, D.R., Lepore, B.W., Indic, M., van den Berg, B.
Deposit date:2008-07-22
Release date:2008-12-16
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Transmembrane passage of hydrophobic compounds through a protein channel wall.
Nature, 458, 2009
3DWO
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CRYSTAL STRUCTURE OF A PSEUDOMONAS AERUGINOSA FADL HOMOLOGUE
Descriptor:Probable outer membrane protein, SULFATE ION, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE
Authors:Hearn, E.M., Patel, D.R., Lepore, B.W., Indic, M., van den Berg, B.
Deposit date:2008-07-22
Release date:2008-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Transmembrane passage of hydrophobic compounds through a protein channel wall.
Nature, 458, 2009
2Q7W
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STRUCTURAL STUDIES REVEALS THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE (S)-4,5-AMINO-DIHYDRO-2-THIOPHENECARBOXYLIC ACID (SADTA) VIA TWO MECHANISMS AT PH 6.0
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-07
Release date:2007-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inactivation of Escherichia coli l-Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid Reveals "A Tale of Two Mechanisms".
Biochemistry, 46, 2007
2QA3
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STRUCTURAL STUDIES REVEAL THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE BY (S)-4,5-AMINO-DIHYDRO-2-THIOPHENECARBOXYLIC ACID (SADTA) VIA TWO MECHANISMS (AT PH6.5)
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-14
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Biochemistry, 46, 2007
2QB2
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STRUCTURAL STUDIES REVEAL THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE BY (S)-4,5-DIHYDRO-2THIOPHENECARBOYLIC ACID (SADTA) VIA TWO MECHANISMS (AT PH 7.0).
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-15
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Biochemistry, 46, 2007
2QB3
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STRUCTURAL STUDIES REVEAL THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE BY (S)-4,5-DIHYDRO-2-THIOPHENECARBOXYLIC ACID (SADTA) VIA TWO MECHANISMS (AT PH 7.5)
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-15
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms".
Biochemistry, 46, 2007
2QBT
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STRUCTURAL STUDIES REVEAL THE INACTIVATION OF E. COLI L-ASPARTATE AMINOTRANSFERASE BY (S)-4,5-AMINO-DIHYDRO-2-THIOPHENECARBOXYLIC ACID (SADTA) VIA TWO MECHANISMS (AT PH 8.0)
Descriptor:Aspartate aminotransferase, SULFATE ION, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]THIOPHENE-2-CARBOXYLIC ACID, ...
Authors:Liu, D., Pozharski, E., Lepore, B., Fu, M., Silverman, R.B., Petsko, G.A., Ringe, D.
Deposit date:2007-06-18
Release date:2007-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inactivation of Escherichia coli l-Aspartate Aminotransferase by (S)-4-Amino-4,5-dihydro-2-thiophenecarboxylic Acid Reveals "A Tale of Two Mechanisms".
Biochemistry, 46, 2007
3SY7
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IMPROVED CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA OPRD
Descriptor:Porin D, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE
Authors:van den Berg, B., Eren, E.
Deposit date:2011-07-15
Release date:2012-02-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Substrate Specificity within a Family of Outer Membrane Carboxylate Channels.
Plos Biol., 10, 2012
3SY9
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA OCCD2 (OPDC)
Descriptor:Histidine porin OpdC, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, B-OCTYLGLUCOSIDE
Authors:van den Berg, B., Eren, E.
Deposit date:2011-07-16
Release date:2012-02-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate Specificity within a Family of Outer Membrane Carboxylate Channels.
Plos Biol., 10, 2012
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