Author results

2LFB
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HOMEODOMAIN FROM RAT LIVER LFB1/HNF1 TRANSCRIPTION FACTOR, NMR, 20 STRUCTURES
Descriptor:LFB1/HNF1 TRANSCRIPTION FACTOR
Authors:Schott, O., Billeter, M., Leiting, B., Wider, G., Wuthrich, K.
Deposit date:1996-12-12
Release date:1997-03-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The NMR solution structure of the non-classical homeodomain from the rat liver LFB1/HNF1 transcription factor.
J.Mol.Biol., 267, 1997
1BLJ
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NMR ENSEMBLE OF BLK SH2 DOMAIN, 20 STRUCTURES
Descriptor:P55 BLK PROTEIN TYROSINE KINASE
Authors:Metzler, W.J., Leiting, B., Pryor, K., Mueller, L., Farmer II, B.T.
Deposit date:1996-03-26
Release date:1997-03-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The three-dimensional solution structure of the SH2 domain from p55blk kinase.
Biochemistry, 35, 1996
1BLK
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NMR ENSEMBLE OF BLK SH2 DOMAIN USING CHEMICAL SHIFT REFINEMENT, 20 STRUCTURES
Descriptor:P55 BLK PROTEIN TYROSINE KINASE
Authors:Metzler, W.J., Leiting, B., Pryor, K., Mueller, L., Farmer II, B.T.
Deposit date:1996-03-26
Release date:1997-03-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The three-dimensional solution structure of the SH2 domain from p55blk kinase.
Biochemistry, 35, 1996
1X70
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Kim, D., Wang, L., Beconi, M., Eiermann, G.J., Fisher, M.H., He, H., Hickey, G.J., Leiting, B., Lyons, K.
Deposit date:2004-08-12
Release date:2005-01-18
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
J.Med.Chem., 48, 2005
2FJP
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH AN INHIBITOR
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM
Authors:Scapin, G., Patel, S.B., Becker, J.W.
Deposit date:2006-01-03
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J.Med.Chem., 49, 2006
2IIT
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HUMAN DIPEPTIDYL PEPTIDASE 4 IN COMPLEX WITH A DIAZEPAN-2-ONE INHIBITOR
Descriptor:Dipeptidyl peptidase 4 soluble form, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G., Biftu, T., Weber, A.E.
Deposit date:2006-09-28
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem.Lett., 17, 2007
2IIV
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HUMAN DIPEPTIDYL PEPTIDASE 4 IN COMPLEX WITH A DIAZEPAN-2-ONE INHIBITOR
Descriptor:Dipeptidyl peptidase 4 soluble form, N-ACETYL-D-GLUCOSAMINE, (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE
Authors:Scapin, G., Weber, A.E., Biftu, T.
Deposit date:2006-09-28
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem.Lett., 17, 2007
1GG4
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI UDPMURNAC-TRIPEPTIDE D-ALANYL-D-ALANINE-ADDING ENZYME (MURF) AT 2.3 ANGSTROM RESOLUTION
Descriptor:UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,6-DIAMINOPIMELATE-D-ALANYL-D-ALANYL LIGASE
Authors:Yan, Y., Munshi, S., Chen, Z.
Deposit date:2000-07-12
Release date:2000-12-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution.
J.Mol.Biol., 304, 2000
2HHA
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THE STRUCTURE OF DPP4 IN COMPLEX WITH AN OXADIAZOLE INHIBITOR
Descriptor:Hypothetical protein DPP4, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G.
Deposit date:2006-06-28
Release date:2006-09-19
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
2OPH
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH AN ALPHA AMINO ACID INHIBITOR
Descriptor:Dipeptidyl peptidase 4 soluble form, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G., Weber, A.E., Duffy, J.L.
Deposit date:2007-01-29
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.
Bioorg.Med.Chem.Lett., 17, 2007
2QOE
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A TRIAZOLOPIPERAZINE-BASED BETA AMINO ACID INHIBITOR
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, SODIUM ION, ...
Authors:Scapin, G.
Deposit date:2007-07-20
Release date:2007-11-06
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
2QT9
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH A 4-ARYL CYCLOHEXYLALANINE INHIBITOR
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, SODIUM ION, ...
Authors:Scapin, G.
Deposit date:2007-08-01
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
Bioorg.Med.Chem.Lett., 17, 2007
2QTB
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH A 4-ARYL CYCLOHEXYLALANINE INHIBITOR
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, SODIUM ION, ...
Authors:Scapin, G.
Deposit date:2007-08-01
Release date:2007-11-06
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
Bioorg.Med.Chem.Lett., 17, 2007
3C43
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH A FLOUROOLEFIN INHIBITOR
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G., Edmondson, S.D., Weber, A.E.
Deposit date:2008-01-29
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3C45
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH A FLUOROOLEFIN INHIBITOR
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G., Edmondson, S.D., Weber, A.E.
Deposit date:2008-01-29
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3D4L
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH A NOVEL INHIBITOR
Descriptor:Dipeptidyl peptidase 4 soluble form, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G.
Deposit date:2008-05-14
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.
Bioorg.Med.Chem.Lett., 18, 2008
2F00
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ESCHERICHIA COLI MURC
Descriptor:UDP-N-acetylmuramate--L-alanine ligase, MAGNESIUM ION
Authors:Deva, T., Baker, E.N., Squire, C.J., Smith, C.A.
Deposit date:2005-11-10
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Escherichia coliUDP-N-acetylmuramoyl:L-alanine ligase (MurC).
Acta Crystallogr.,Sect.D, 62, 2006