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2ISA
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CRYSTAL STRUCTURE OF VIBRIO SALMONICIDA CATALASE
Descriptor:Catalase, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ...
Authors:Riise, E.K., Lorentzen, M.S., Helland, R., Smalas, A.O., Leiros, H.K.S., Willassen, N.P.
Deposit date:2006-10-17
Release date:2007-01-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The first structure of a cold-active catalase from Vibrio salmonicida at 1.96A reveals structural aspects of cold adaptation
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
2IUC
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STRUCTURE OF ALKALINE PHOSPHATASE FROM THE ANTARCTIC BACTERIUM TAB5
Descriptor:ALKALINE PHOSPHATASE, ZINC ION, MAGNESIUM ION, ...
Authors:Wang, E., Koutsioulis, D., Leiros, H.K.S., Andersen, O.A., Bouriotis, V., Hough, E., Heikinheimo, P.
Deposit date:2006-06-01
Release date:2006-11-28
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Alkaline Phosphatase from the Antarctic Bacterium Tab5.
J.Mol.Biol., 366, 2007
5ACU
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VIM-2-NAT, DISCOVERY OF NOVEL INHIBITOR SCAFFOLDS AGAINST THE METALLO- BETA-LACTAMASE VIM-2 BY SPR BASED FRAGMENT SCREENING
Descriptor:BETA-LACTAMASE, HYDROXIDE ION, ZINC ION, ...
Authors:Christopeit, T., Carlsen, T.J.O., Helland, R., Leiros, H.K.S.
Deposit date:2015-08-18
Release date:2015-11-04
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening
J.Med.Chem., 58, 2015
5ACV
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VIM-2-OX, DISCOVERY OF NOVEL INHIBITOR SCAFFOLDS AGAINST THE METALLO- BETA-LACTAMASE VIM-2 BY SPR BASED FRAGMENT SCREENING
Descriptor:BETA-LACTAMASE, HYDROXIDE ION, ZINC ION, ...
Authors:Christopeit, T., Carlsen, T.J.O., Helland, R., Leiros, H.K.S.
Deposit date:2015-08-18
Release date:2015-11-04
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.963 Å)
Cite:Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening
J.Med.Chem., 58, 2015
5ACW
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VIM-2-1, DISCOVERY OF NOVEL INHIBITOR SCAFFOLDS AGAINST THE METALLO- BETA-LACTAMASE VIM-2 BY SPR BASED FRAGMENT SCREENING
Descriptor:BETA-LACTAMASE, ZINC ION, 4-methyl-5-(trifluoromethyl)-1,2,4-triazole-3-thiol, ...
Authors:Christopeit, T., Carlsen, T.J.O., Helland, R., Leiros, H.K.S.
Deposit date:2015-08-18
Release date:2015-11-04
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening
J.Med.Chem., 58, 2015
5ACX
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VIM-2-2, DISCOVERY OF NOVEL INHIBITOR SCAFFOLDS AGAINST THE METALLO- BETA-LACTAMASE VIM-2 BY SPR BASED FRAGMENT SCREENING
Descriptor:BETA-LACTAMASE, ZINC ION, 2-(4-fluorophenyl)carbonylbenzoic acid, ...
Authors:Christopeit, T., Carlsen, T.J.O., Helland, R., Leiros, H.K.S.
Deposit date:2015-08-18
Release date:2015-11-04
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening
J.Med.Chem., 58, 2015
5ODZ
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CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-163
Descriptor:Beta-lactamase, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Lund, B.A., Carlsen, T.J.O., Leiros, H.K.S.
Deposit date:2017-07-07
Release date:2017-10-18
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5OE0
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CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-181
Descriptor:Beta-lactamase, CHLORIDE ION, SULFATE ION
Authors:Lund, B.A., Carlsen, T.J.O., Leiros, H.K.S., Thomassen, A.M.
Deposit date:2017-07-07
Release date:2017-08-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.050008 Å)
Cite:Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5OE2
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CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-245
Descriptor:Beta-lactamase, CHLORIDE ION, SODIUM ION
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-07
Release date:2017-08-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis.
Acta Crystallogr F Struct Biol Commun, 73, 2017
6Q5B
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OXA-48_P68A-AVI. EVOLUTIONARY TRADE-OFFS OF OXA-48 MEDIATED CEFTAZIDIME-AVIBACTAM RESISTANCE
Descriptor:Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, CARBON DIOXIDE, ...
Authors:Frohlich, C., Sorum, V., Thomassen, A.M., Johnsen, P.J., Leiros, H.K.S., Samuelsen, O.
Deposit date:2018-12-07
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance
To be published
5OFT
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STRUCTURAL BASIS FOR OXA-48 DIMERIZATION
Descriptor:Beta-lactamase
Authors:Lund, B.A., Nesheim, B.H.B., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-08-01
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The biological assembly of OXA-48 reveals a dimer interface with high charge complementarity and very high affinity.
FEBS J., 285, 2018
5QA5
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OXA-48 IN COMPLEX WITH COMPOUND 3B
Descriptor:Beta-lactamase, 3-(3-methylphenyl)benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA6
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OXA-48 IN COMPLEX WITH COMPOUND 4A
Descriptor:Beta-lactamase, 3-(2-hydroxyphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA7
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OXA-48 IN COMPLEX WITH COMPOUND 4B
Descriptor:Beta-lactamase, 3-(3-hydroxyphenyl)benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA8
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OXA-48 IN COMPLEX WITH COMPOUND 4C
Descriptor:Beta-lactamase, 3-(4-hydroxyphenyl)benzoic acid, CHLORIDE ION
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QA9
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OXA-48 IN COMPLEX WITH COMPOUND 5
Descriptor:Beta-lactamase, 3-[3-(hydroxymethyl)phenyl]benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAA
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OXA-48 IN COMPLEX WITH COMPOUND 6A
Descriptor:Beta-lactamase, 3-(2-methoxyphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAB
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OXA-48 IN COMPLEX WITH COMPOUND 6B
Descriptor:Beta-lactamase, 3-(3-methoxyphenyl)benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAC
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OXA-48 IN COMPLEX WITH COMPOUND 6C
Descriptor:Beta-lactamase, 3-(4-methoxyphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAD
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OXA-48 IN COMPLEX WITH COMPOUND 8A
Descriptor:Beta-lactamase, 3-(2-fluorophenyl)benzoic acid, 1,2-ETHANEDIOL, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAE
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OXA-48 IN COMPLEX WITH COMPOUND 8B
Descriptor:Beta-lactamase, 3-(3-fluorophenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAF
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OXA-48 IN COMPLEX WITH COMPOUND 8C
Descriptor:Beta-lactamase, 3-(4-fluorophenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAG
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OXA-48 IN COMPLEX WITH COMPOUND 9A
Descriptor:Beta-lactamase, 3-(2-methoxycarbonylphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAH
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OXA-48 IN COMPLEX WITH COMPOUND 9B
Descriptor:Beta-lactamase, 3-(3-methoxycarbonylphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
5QAI
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OXA-48 IN COMPLEX WITH COMPOUND 12A
Descriptor:Beta-lactamase, 3-(3-methylsulfonylphenyl)benzoic acid, CHLORIDE ION, ...
Authors:Lund, B.A., Leiros, H.K.S.
Deposit date:2017-07-11
Release date:2018-01-10
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145, 2018
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