Author results

3BJV
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THE CRYSTAL STRUCTURE OF A PUTATIVE PTS IIA(PTXA) FROM STREPTOCOCCUS MUTANS
Descriptor:RmpA
Authors:Lei, J., Liang, Y.H., Su, X.D.
Deposit date:2007-12-04
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of phosphotransferase system enzymes PtxB (IIB(Asc)) and PtxA (IIA(Asc)) from Streptococcus mutans
J.Mol.Biol., 386, 2009
3CZC
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THE CRYSTAL STRUCTURE OF A PUTATIVE PTS IIB(PTXB) FROM STREPTOCOCCUS MUTANS
Descriptor:RmpB
Authors:Lei, J., Su, X.D.
Deposit date:2008-04-29
Release date:2009-03-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal structures of phosphotransferase system enzymes PtxB (IIB(Asc)) and PtxA (IIA(Asc)) from Streptococcus mutans
J.Mol.Biol., 386, 2009
3L8R
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THE CRYSTAL STRUCTURE OF PTCA FROM S. MUTANS
Descriptor:Putative PTS system, cellobiose-specific IIA component
Authors:Lei, J., Liu, X., Li, L.
Deposit date:2010-01-03
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of PtcA from Streptococcus mutans
To be Published
3RK6
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CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN PAIP1
Descriptor:Polyadenylate-binding protein-interacting protein 1
Authors:Lei, J., Mesters, J.R., Hilgenfeld, R.
Deposit date:2011-04-17
Release date:2011-05-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1.
Biochem.Biophys.Res.Commun., 408, 2011
4P16
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CRYSTAL STRUCTURE OF THE PAPAIN-LIKE PROTEASE OF MIDDLE-EAST RESPIRATORY SYNDROME CORONAVIRUS
Descriptor:ORF1a, ZINC ION
Authors:Lei, J., Mesters, J.R., Ma, Q., Hilgenfeld, R.
Deposit date:2014-02-25
Release date:2014-05-07
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features.
Antiviral Res., 109C, 2014
4WUR
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THE CRYSTAL STRUCTURE OF THE MERS-COV PAPAIN-LIKE PROTEASE (C111S) WITH HUMAN UBIQUITIN
Descriptor:Papain-like protease, Polyubiquitin-B, ISOPROPYL ALCOHOL, ...
Authors:Lei, J., Hilgenfeld, R.
Deposit date:2014-11-03
Release date:2014-11-26
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.
Virol Sin, 31, 2016
5HIH
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CRYSTAL STRUCTURE OF THE MACRO DOMAIN IN MIDDLE-EAST RESPIRATORY SYNDROME CORONAVIRUS
Descriptor:ORF1a
Authors:Lei, J., Hilgenfeld, R.
Deposit date:2016-01-11
Release date:2016-01-20
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin.
Virol Sin, 31, 2016
5HOL
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THE CRYSTAL STRUCTURE OF THE MERS-COV MACRO DOMAIN WITH ADP-RIBOSE
Descriptor:ORF1a, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Lei, J., Hilgenfeld, R.
Deposit date:2016-01-19
Release date:2016-01-27
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.
Antiviral Res., 149, 2018
5LC0
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CRYSTAL STRUCTURE OF ZIKA VIRUS NS2B-NS3 PROTEASE IN COMPLEX WITH A BORONATE INHIBITOR
Descriptor:NS2B-NS3 protease,NS2B-NS3 protease, N-((S)-3-(4-(aminomethyl)phenyl)-1-(((R)-4-guanidino-1-(5-hydroxy-1,3,2-dioxaborinan-2-yl)butyl)amino)-1-oxopropan-2-yl)benzamide
Authors:Lei, J., Hansen, G., Zhang, L.L., Hilgenfeld, R.
Deposit date:2016-06-18
Release date:2016-07-06
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.
Science, 353, 2016
3D3F
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CRYSTAL STRUCTURE OF YVGN AND COFACTOR NADPH FROM BACILLUS SUBTILIS
Descriptor:YvgN protein, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhou, Y.F., Lei, J., Su, X.D.
Deposit date:2008-05-10
Release date:2009-04-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis
Protein Sci., 18, 2009
3F7J
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B.SUBTILIS YVGN
Descriptor:YvgN protein, NITRATE ION, POTASSIUM ION
Authors:Zhou, Y.F., Lei, J., Liang, Y.H., Su, X.-D.
Deposit date:2008-11-09
Release date:2008-11-25
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis
Protein Sci., 18, 2009
5NGN
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LYBATIDE 2, A CYSTINE-RICH PEPTIDE FROM LYCIUM BARBARUM
Descriptor:lybatide 2, GLYCEROL, ACETONITRILE, ...
Authors:Lei, J., Tan, W.L., Sakai, N., Hilgenfeld, R.
Deposit date:2017-03-18
Release date:2017-07-26
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold.
Sci Rep, 7, 2017
4CSU
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CRYO-EM STRUCTURES OF THE 50S RIBOSOME SUBUNIT BOUND WITH OBGE
Descriptor:50S RIBOSOMAL PROTEIN L28, 50S RIBOSOMAL PROTEIN L29, 50S RIBOSOMAL PROTEIN L30, ...
Authors:Feng, B., Mandava, C.S., Guo, Q., Wang, J., Cao, W., Li, N., Zhang, Y., Zhang, Y., Wang, Z., Wu, J., Sanyal, S., Lei, J., Gao, N.
Deposit date:2014-03-10
Release date:2014-06-04
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structural and Functional Insights Into the Mode of Action of a Universally Conserved Obg Gtpase.
Plos Biol., 12, 2014
4V6K
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STRUCTURAL INSIGHTS INTO COGNATE VS. NEAR-COGNATE DISCRIMINATION DURING DECODING.
Descriptor:ribosomal RNA 5S, ribosomal RNA 23S, 50S ribosomal protein L1, ...
Authors:Agirrezabala, X., Schreiner, E., Trabuco, L.G., Lei, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J.
Deposit date:2011-01-07
Release date:2014-07-09
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (8.25 Å)
Cite:Structural insights into cognate versus near-cognate discrimination during decoding.
Embo J., 30, 2011
4V6L
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STRUCTURAL INSIGHTS INTO COGNATE VS. NEAR-COGNATE DISCRIMINATION DURING DECODING.
Descriptor:16S ribosomal RNA, A/T-site tRNA Phe, Elongation factor Tu 2, ...
Authors:Agirrezabala, X., Schreiner, E., Trabuco, L.G., Lei, J., Ortiz-Meoz, R.F., Schulten, K., Green, R., Frank, J.
Deposit date:2011-01-07
Release date:2014-07-09
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (13.2 Å)
Cite:Structural insights into cognate versus near-cognate discrimination during decoding.
Embo J., 30, 2011
1A94
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STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
Descriptor:PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T.
Deposit date:1998-04-16
Release date:1999-01-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
1BAI
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CRYSTAL STRUCTURE OF ROUS SARCOMA VIRUS PROTEASE IN COMPLEX WITH INHIBITOR
Descriptor:PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
Authors:Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T.
Deposit date:1998-04-17
Release date:1999-01-13
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
3J3R
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STRUCTURAL DYNAMICS OF THE MECA-CLPC COMPLEX REVEALED BY CRYO-EM
Descriptor:Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB
Authors:Liu, J., Mei, Z., Li, N., Qi, Y., Xu, Y., Shi, Y., Wang, F., Lei, J., Gao, N.
Deposit date:2013-04-18
Release date:2013-05-15
Last modified:2014-10-22
Method:ELECTRON MICROSCOPY (9.4 Å)
Cite:Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine
J.Biol.Chem., 288, 2013
3J3S
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STRUCTURAL DYNAMICS OF THE MECA-CLPC COMPLEX REVEALED BY CRYO-EM
Descriptor:Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB
Authors:Liu, J., Mei, Z., Li, N., Qi, Y., Xu, Y., Shi, Y., Wang, F., Lei, J., Gao, N.
Deposit date:2013-04-18
Release date:2013-05-15
Last modified:2015-01-21
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine.
J.Biol.Chem., 288, 2013
3J3T
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STRUCTURAL DYNAMICS OF THE MECA-CLPC COMPLEX REVEALED BY CRYO-EM
Descriptor:Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB
Authors:Liu, J., Mei, Z., Li, N., Qi, Y., Xu, Y., Shi, Y., Wang, F., Lei, J., Gao, N.
Deposit date:2013-04-18
Release date:2013-05-15
Last modified:2015-01-21
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine.
J.Biol.Chem., 288, 2013
3J3U
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STRUCTURAL DYNAMICS OF THE MECA-CLPC COMPLEX REVEALED BY CRYO-EM
Descriptor:Adapter protein MecA 1, Negative regulator of genetic competence ClpC/MecB
Authors:Liu, J., Mei, Z., Li, N., Qi, Y., Xu, Y., Shi, Y., Wang, F., Lei, J., Gao, N.
Deposit date:2013-04-18
Release date:2013-05-15
Last modified:2015-01-21
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine.
J.Biol.Chem., 288, 2013
3J8G
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ELECTRON CRYO-MICROSCOPY STRUCTURE OF ENGA BOUND WITH THE 50S RIBOSOMAL SUBUNIT
Descriptor:5S rRNA, 23S rRNA, 50S ribosomal protein L28, ...
Authors:Zhang, X., Yan, K., Zhang, Y., Li, N., Ma, C., Li, Z., Zhang, Y., Feng, B., Liu, J., Sun, Y., Xu, Y., Lei, J., Gao, N.
Deposit date:2014-10-24
Release date:2014-11-26
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structural insights into the function of a unique tandem GTPase EngA in bacterial ribosome assembly
Nucleic Acids Res., 2014
3O5Z
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CRYSTAL STRUCTURE OF THE SH3 DOMAIN FROM P85BETA SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE (PI3K)
Descriptor:Phosphatidylinositol 3-kinase regulatory subunit beta, CHLORIDE ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Chen, S., Xiao, Y., Ponnusamy, R., Tan, J., Lei, J., Hilgenfeld, R.
Deposit date:2010-07-28
Release date:2011-08-10
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85 beta subunit
Acta Crystallogr.,Sect.F, 67, 2011
5XJC
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CRYO-EM STRUCTURE OF THE HUMAN SPLICEOSOME JUST PRIOR TO EXON LIGATION AT 3.6 ANGSTROM
Descriptor:Pre-mRNA-processing-splicing factor 8, U5 snRNA, 116 kDa U5 small nuclear ribonucleoprotein component, ...
Authors:Zhang, X., Yan, C., Hang, J., Finci, I.L., Lei, J., Shi, Y.
Deposit date:2017-04-30
Release date:2017-07-05
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:An Atomic Structure of the Human Spliceosome
Cell, 169, 2017
5YLC
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CRYSTAL STRUCTURE OF MCR-1 CATALYTIC DOMAIN
Descriptor:Probable phosphatidylethanolamine transferase Mcr-1, ZINC ION
Authors:Wei, P.C., Song, G.J., Shi, M.Y., Zhou, Y.F., Liu, Y., Lei, J., Chen, P., Yin, L.
Deposit date:2017-10-17
Release date:2017-11-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.
FASEB J., 32, 2018
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