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Structure of Rivax: A Human Ricin Vaccine
Descriptor:	Ricin A chain, SULFATE ION
Authors:	Legler, P.M, Millard, C.B.
Deposit date:	2011-07-07
Release date:	2011-08-03
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.14 Å)
Cite:	Structure of RiVax: a recombinant ricin vaccine. Acta Crystallogr.,Sect.D, 67, 2011

3C6B

Reaction product of paraoxon and S-formylglutathione hydrolase W197I mutant
Descriptor:	S-formylglutathione hydrolase
Authors:	Legler, P.M, Millard, C.B.
Deposit date:	2008-02-04
Release date:	2008-08-12
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.17 Å)
Cite:	Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase. Biochemistry, 47, 2008

5BWC

ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA IN COMPLEX WITH THE BIS-PYRIDINIUM OXIME ORTHO-7
Descriptor:	1,7-HEPTYLENE-BIS-N,N'-SYN-2-PYRIDINIUMALDOXIME, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase
Authors:	Legler, P.M, Millard, C.B.
Deposit date:	2015-06-07
Release date:	2015-09-09
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oxime. Acta Crystallogr.,Sect.D, 71, 2015

5BWB

ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA IN COMPLEX WITH THE BIS-IMIDAZOLIUM OXIME 2BIM-7
Descriptor:	(Z,Z)-[heptane-1,7-diylbis(1H-imidazol-1-yl-2-ylidene)]bis(N-hydroxymethanamine), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Legler, P.M, Millard, C.B.
Deposit date:	2015-06-07
Release date:	2015-09-09
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.57 Å)
Cite:	A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oxime. Acta Crystallogr.,Sect.D, 71, 2015

4IDL

Low melting temperature Anti-Cholera Toxin Llama VHH domain
Descriptor:	Single Domain Antibody VHH A9
Authors:	Legler, P.M, Lam, A, Hol, W.G.J.
Deposit date:	2012-12-12
Release date:	2013-02-13
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.09 Å)
Cite:	Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain. Acta Crystallogr.,Sect.F, 69, 2013

4FOL

S-formylglutathione hydrolase Variant H160I
Descriptor:	S-formylglutathione hydrolase
Authors:	Legler, P.M, Millard, C.B.
Deposit date:	2012-06-20
Release date:	2012-09-05
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.07 Å)
Cite:	A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: Evidence for an oxidation sensitive motif. Arch.Biochem.Biophys., 528, 2012

4FLM

S-formylglutathione Hydrolase W197I Variant containing Copper
Descriptor:	COPPER (II) ION, S-formylglutathione hydrolase
Authors:	Legler, P.M, Millard, C.B.
Deposit date:	2012-06-14
Release date:	2012-09-05
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.41 Å)
Cite:	A role for His-160 in peroxide inhibition of S. cerevisiae S-formylglutathione hydrolase: Evidence for an oxidation sensitive motif. Arch.Biochem.Biophys., 528, 2012

3MK9

Stabilized Ricin Immunogen 1-33/44-198
Descriptor:	Ricin, SULFATE ION
Authors:	Legler, P.M, Compton, J.R, Millard, C.B.
Deposit date:	2010-04-14
Release date:	2010-11-10
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen. Proteins, 79, 2011

1VKR

STRUCTURE OF IIB DOMAIN OF THE MANNITOL-SPECIFIC PERMEASE ENZYME II
Descriptor:	mannitol-specific PTS system enzyme IIABC components
Authors:	Clore, G.M, Legler, P.M, Cai, M.
Deposit date:	2004-06-14
Release date:	2004-09-21
Last modified:	2023-12-27
Method:	SOLUTION NMR
Cite:	Three-dimensional Solution Structure of the Cytoplasmic B Domain of the Mannitol Transporter II-Mannitol of the Escherichia coli Phosphotransferase System. J.Biol.Chem., 279, 2004

4TYU

Homodimeric Single Domain Antibody (sdAb) against Staphylococcal enterotoxin B (SEB)
Descriptor:	SULFATE ION, Single Domain Antibody
Authors:	Legler, P.M.
Deposit date:	2014-07-09
Release date:	2014-09-03
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.13 Å)
Cite:	Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding. Proteins, 82, 2014

4U7S

Homodimeric Single Domain Antibody (sdAb) against Staphylococcal enterotoxin B (SEB) Crystallized for 5 months
Descriptor:	SULFATE ION, sdAb A3
Authors:	Legler, P.M.
Deposit date:	2014-07-31
Release date:	2014-09-03
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.07 Å)
Cite:	Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding. Proteins, 82, 2014

4U05

Homodimeric Single Domain Antibody (sdAb) against Staphylococcal enterotoxin B (SEB) S74A Variant
Descriptor:	SULFATE ION, Single Domain Antibody
Authors:	Legler, P.M.
Deposit date:	2014-07-11
Release date:	2014-09-03
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding. Proteins, 82, 2014

5EZS

Venezuelan Equine Encephalitis Virus (VEEV) Nonstructural Protein 2 (nsP2) Cysteine Protease Inhibited by E64d
Descriptor:	Non-structural Protein 2 Cysteine Protease, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate
Authors:	Legler, P.M.
Deposit date:	2015-11-26
Release date:	2016-04-13
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.16 Å)
Cite:	Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. Biochemistry, 55, 2016

3GEL

O-Methylphosphorylated Torpedo Acetylcholinesterase Obtained by Reaction with Methyl Paraoxon (AGED)
Descriptor:	Acetylcholinesterase
Authors:	Legler, P.M, Millard, C.B.
Deposit date:	2009-02-25
Release date:	2010-09-22
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.39 Å)
Cite:	O-Methylphosphorylated Torpedo Acetylcholinesterase Obtained by Reaction with Methyl Paraoxon (AGED) To be Published

4IMV

Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N
Descriptor:	Ricin, SULFATE ION
Authors:	Legler, P.M, Compton, J.R, Millard, C.B.
Deposit date:	2013-01-03
Release date:	2013-02-13
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198. Toxins (Basel), 5, 2013

5SV4

Anti-Ricin A-chain Single Domain Antibody A3C8
Descriptor:	SULFATE ION, Single Domain Antibody A3C8
Authors:	Compton, J.R, Legler, P.M.
Deposit date:	2016-08-04
Release date:	2016-10-19
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Stability of isolated antibody-antigen complexes as a predictive tool for selecting toxin neutralizing antibodies. MAbs, 9, 2017

5SV3

RTA1-33/44-198 (RVEC) bound to Single Domain Antibody A3C8
Descriptor:	Anti-Ricin A-chain Single Domain Antibody (sdAb) A3C8, Ricin, SULFATE ION
Authors:	Compton, J.R, Legler, P.M.
Deposit date:	2016-08-04
Release date:	2016-10-19
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.73 Å)
Cite:	Stability of isolated antibody-antigen complexes as a predictive tool for selecting toxin neutralizing antibodies. MAbs, 9, 2017

8T8N

Venezuelan Equine Encephalitis Virus (VEEV) Nonstructural Protein 2 (nsP2) Cysteine Protease Inhibited with CA074
Descriptor:	Protease nsP2, [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE
Authors:	Compton, J.R, Legler, P.M.
Deposit date:	2023-06-22
Release date:	2023-08-09
Method:	X-RAY DIFFRACTION (2.32 Å)
Cite:	In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. Viruses, 15, 2023

3LC9

Ricin A-chain variant 1-33/44-198 with engineered disulfide bond
Descriptor:	Ricin A chain, SULFATE ION
Authors:	Compton, J.R, Legler, P.M, Millard, C.B.
Deposit date:	2010-01-10
Release date:	2010-11-10
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.28 Å)
Cite:	Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen. Proteins, 79, 2011

4W68

Cytoplasmically Produced Homodimeric Single Domain Antibody (sdAb) C22A/C99V variant against Staphylococcal enterotoxin B (SEB)
Descriptor:	SULFATE ION, Single domain antibody
Authors:	George, J, Legler, P.M.
Deposit date:	2014-08-20
Release date:	2014-11-05
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding. Proteins, 82, 2014

4W70

Periplasmically Produced Monomeric Single Domain Antibody (sdAb) C22A/C99V variant against Staphylococcal enterotoxin B (SEB) at pH 7.0
Descriptor:	SULFATE ION, Single Domain Antibody
Authors:	George, J, Legler, P.M.
Deposit date:	2014-08-21
Release date:	2014-11-05
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.28 Å)
Cite:	Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding. Proteins, 82, 2014

4W81

Periplasmically Produced Monomeric Single Domain Antibody (sdAb) C22A/C99V variant against Staphylococcal enterotoxin B (SEB) at pH 8.0
Descriptor:	SULFATE ION, Single Domain Antibody
Authors:	George, J, Legler, P.M.
Deposit date:	2014-08-22
Release date:	2014-11-05
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Structural and mutational analysis of a monomeric and dimeric form of a single domain antibody with implications for protein misfolding. Proteins, 82, 2014

6WIA

CRYSTAL STRUCTURE OF HUMAN PROTECTIVE PROTEIN/CATHEPSIN A, DFP-INHIBITED (AGED)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CADMIUM ION, ...
Authors:	Compton, J.R, Legler, P.M.
Deposit date:	2020-04-09
Release date:	2020-04-29
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.21 Å)
Cite:	Structural and kinetic evidence of aging after organophosphate inhibition of human Cathepsin A. Biochem. Pharmacol., 177, 2020

6BCM

Structure of a Self-inhibited N475A variant of the Venezuelan Equine Encephalitis Virus (VEEV) nsP2 cysteine protease
Descriptor:	GLYCEROL, Protease nsP2, SODIUM ION
Authors:	Compton, J.R, Legler, P.M.
Deposit date:	2017-10-20
Release date:	2017-11-08
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State. Biochemistry, 56, 2017

5EZQ

Venezuelan Equine Encephalitis Virus (VEEV) Nonstructural protein 2 (nsP2) Cysteine Protease
Descriptor:	Non-structural Protein 2 Cysteine Protease
Authors:	Compton, J.R, Legler, P.M.
Deposit date:	2015-11-26
Release date:	2016-04-13
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.66 Å)
Cite:	Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. Biochemistry, 55, 2016

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Displayed results:	25
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