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1A3K
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X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION
Descriptor:GALECTIN-3, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE
Authors:Seetharaman, J., Kanigsberg, A., Slaaby, R., Leffler, H., Barondes, S.H., Rini, J.M.
Deposit date:1998-01-22
Release date:1998-07-15
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.
J.Biol.Chem., 273, 1998
1HLC
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X-RAY CRYSTAL STRUCTURE OF THE HUMAN DIMERIC S-LAC LECTIN, L-14-II, IN COMPLEX WITH LACTOSE AT 2.9 ANGSTROMS RESOLUTION
Descriptor:HUMAN LECTIN, BETA-D-GALACTOSE, BETA-D-GLUCOSE
Authors:Lobsanov, Y.D., Gitt, M.A., Leffler, H., Barondes, S., Rini, J.M.
Deposit date:1993-10-13
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.
J.Biol.Chem., 268, 1993
3M2M
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RAT GALECTIN-1 COMPLEX WITH LACTOSE
Descriptor:Galectin-1, BETA-LACTOSE
Authors:Lobsanov, Y.D., Rini, J.M., Leffler, H.
Deposit date:2010-03-07
Release date:2010-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Monovalent interactions of galectin-1.
Biochemistry, 49, 2010
1KJL
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HIGH RESOLUTION X-RAY STRUCTURE OF HUMAN GALECTIN-3 IN COMPLEX WITH LACNAC
Descriptor:Galectin-3, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sorme, P., Arnoux, P., Kahl-Knutsson, B., Leffler, H., Rini, J.M., Nilsson, U.J.
Deposit date:2001-12-04
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction.
J.Am.Chem.Soc., 127, 2005
1KJR
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CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CRD IN COMPLEX WITH A 3'-DERIVATIVE OF N-ACETYLLACTOSAMINE
Descriptor:Galectin-3, 2,3,5,6-TETRAFLUORO-4-METHOXY-BENZAMIDE, BETA-D-GALACTOSE, ...
Authors:Sorme, P., Arnoux, P., Kahl-Knutsson, B., Leffler, H., Rini, J.M., Nilsson, U.J.
Deposit date:2001-12-05
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction.
J.Am.Chem.Soc., 127, 2005
2XG3
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HUMAN GALECTIN-3 IN COMPLEX WITH A BENZAMIDO-N-ACETYLLACTOSEAMINE INHIBITOR
Descriptor:Galectin-3, CHLORIDE ION, BENZAMIDE, ...
Authors:Diehl, C., Engstrom, O., Delaine, T., Hakansson, M., Genheden, S., Modig, K., Leffler, H., Ryde, U., Nilsson, U., Akke, M.
Deposit date:2010-05-30
Release date:2010-10-13
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3.
J. Am. Chem. Soc., 132, 2010
3ZSJ
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH LACTOSE AT 0.86 ANGSTROM RESOLUTION
Descriptor:GALECTIN-3, BETA-LACTOSE
Authors:Saraboji, K., Hakansson, M., Diehl, C., Nilsson, U.J., Leffler, H., Akke, M., Logan, D.T.
Deposit date:2011-06-28
Release date:2011-12-14
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (0.86 Å)
Cite:The Carbohydrate-Binding Site in Galectin-3 is Pre-Organized to Recognize a Sugar-Like Framework of Oxygens: Ultra-High Resolution Structures and Water Dynamics.
Biochemistry, 51, 2012
3ZSK
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD WITH GLYCEROL BOUND AT 0.90 ANGSTROM RESOLUTION
Descriptor:GALECTIN-3, GLYCEROL
Authors:Saraboji, K., Hakansson, M., Diehl, C., Nilsson, U.J., Leffler, H., Akke, M., Logan, D.T.
Deposit date:2011-06-28
Release date:2011-12-14
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:The Carbohydrate-Binding Site in Galectin-3 is Pre-Organized to Recognize a Sugar-Like Framework of Oxygens: Ultra-High Resolution Structures and Water Dynamics.
Biochemistry, 51, 2012
3ZSL
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CRYSTAL STRUCTURE OF APO HUMAN GALECTIN-3 CRD AT 1.08 ANGSTROM RESOLUTION, AT CRYOGENIC TEMPERATURE
Descriptor:GALECTIN-3
Authors:Saraboji, K., Hakansson, M., Diehl, C., Nilsson, U.J., Leffler, H., Akke, M., Logan, D.T.
Deposit date:2011-06-28
Release date:2011-12-14
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:The Carbohydrate-Binding Site in Galectin-3 is Pre-Organized to Recognize a Sugar-Like Framework of Oxygens: Ultra-High Resolution Structures and Water Dynamics.
Biochemistry, 51, 2012
3ZSM
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CRYSTAL STRUCTURE OF APO HUMAN GALECTIN-3 CRD AT 1.25 ANGSTROM RESOLUTION, AT ROOM TEMPERATURE
Descriptor:GALECTIN-3
Authors:Saraboji, K., Hakansson, M., Diehl, C., Nilsson, U.J., Leffler, H., Akke, M., Logan, D.T.
Deposit date:2011-06-28
Release date:2011-12-14
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The Carbohydrate-Binding Site in Galectin-3 is Pre-Organized to Recognize a Sugar-Like Framework of Oxygens: Ultra-High Resolution Structures and Water Dynamics.
Biochemistry, 51, 2012
3ZXE
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH A GALACTOSE- BENZYLPHOSPHATE INHIBITOR
Descriptor:GALECTIN-7, METHYL 2-O-[(S)-(BENZYLOXY)(HYDROXY)PHOSPHORYL]-3-DEOXY-3-{[(4-METHYLPHENYL)CARBONYL]AMINO}-1-THIO-BETA-D-GALACTOPYRANOSIDE
Authors:Masuyer, G., Oberg, C.T., Leffler, H., Nilsson, U.J., Acharya, K.R.
Deposit date:2011-08-10
Release date:2011-11-30
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Inhibition Mechanism of Human Galectin-7 by a Novel Galactose-Benzylphosphate Inhibitor.
FEBS J., 279, 2012
3ZXF
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HIGH RESOLUTION STRUCTURE OF HUMAN GALECTIN-7
Descriptor:GALECTIN-7, ACETATE ION
Authors:Masuyer, G., Oberg, C.T., Leffler, H., Nilsson, U.J., Acharya, K.R.
Deposit date:2011-08-10
Release date:2011-11-30
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Inhibition Mechanism of Human Galectin-7 by a Novel Galactose-Benzylphosphate Inhibitor.
FEBS J., 279, 2012
4BLI
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GALECTIN-3C IN COMPLEX WITH BISAMIDO-THIOGALACTOSIDE DERIVATE 1
Descriptor:GALECTIN-3, (3-Deoxy-3-(3-methoxy-benzamido)-b-D-galactopyranosyl)-(3-deoxy-3-(3-methoxy-benzamido)-2-O-sulfo-b-D-galactopyranosyl)-sulfide
Authors:Noresson, A.L., Oberg, C.T., Engstrom, O., Hakansson, M., Logan, D.T., Leffler, H., Nilsson, U.J.
Deposit date:2013-05-03
Release date:2014-05-21
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Controlling Protein Conformation Through Electronic Fine-Tuning of Arginine-Arene Interactions: Synthetic, Structural, and Biological Studies
To be Published
4BLJ
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GALECTIN-3C IN COMPLEX WITH BISAMIDO-THIOGALACTOSIDE DERIVATE 2
Descriptor:GALECTIN-3, Bis-(3-deoxy-3-(3-methoxy-benzamido)-b-D-galactopyranosyl)-sulfide
Authors:Noresson, A.L., Oberg, C.T., Engstrom, O., Hakansson, M., Logan, D.T., Leffler, H., Nilsson, U.J.
Deposit date:2013-05-03
Release date:2014-05-14
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Controlling Protein Conformation Through Electronic Fine-Tuning of Arginine-Arene Interactions: Synthetic, Structural, and Biological Studies
To be Published
4BM8
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GALECTIN-3C IN COMPLEX WITH BISAMIDO-THIOGALACTOSIDE DERIVATE 3
Descriptor:GALECTIN-3, (3-Deoxy-3-(2,3,5,6-tetra-fluoro-4-methoxy-benzamido)-b-D-galactopyranosyl)-(3-deoxy-3-(2,3,5,6-tetra-fluoro-4-methoxy-benzamido)-2-O-sulfo-b-D-galactopyranosyl)-sulfide
Authors:Noresson, A.L., Oberg, C.T., Engstrom, O., Hakansson, M., Logan, D.T., Leffler, H., Nilsson, U.J.
Deposit date:2013-05-07
Release date:2014-05-21
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Controlling Protein Conformation Through Electronic Fine-Tuning of Arginine-Arene Interactions: Synthetic, Structural, and Biological Studies
To be Published
5IUQ
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GALECTIN-3C IN COMPLEX WITH BISAMIDO-THIOGALACTOSIDE DERIVATIVE 4
Descriptor:Galectin-3, 3-deoxy-3-[(2,3,5,6-tetrafluoro-4-methoxybenzene-1-carbonyl)amino]-beta-D-galactopyranosyl 3-deoxy-3-[(2,3,5,6-tetrafluoro-4-methoxybenzene-1-carbonyl)amino]-1-thio-beta-D-galactopyranoside
Authors:Noresson, A.-L., Aurelius, O., Oberg, C.T., Engstrom, O., Sundin, A.P., Hakansson, M., Logan, D.T., Leffler, H., Nilsson, U.J.
Deposit date:2016-03-18
Release date:2017-03-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.121 Å)
Cite:Controlling protein:ligand complex conformation through tuning of arginine-arene interactions: Synthetic and structural studies with 3-benzamido-2-sulfo-galactosides as galectin-3 ligands
To Be Published
5E88
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH THIENYL-1,2,3-TRIAZOLYL THIODIGALACTOSIDE INHIBITOR
Descriptor:Galectin-3, CHLORIDE ION, 3-deoxy-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-1-thio-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranoside
Authors:Collins, P.M., Blanchard, H.
Deposit date:2015-10-13
Release date:2016-08-24
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.
Chembiochem, 17, 2016
5E89
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH 3-FLUOPHENYL-1,2,3-TRIAZOLYL THIODIGALACTOSIDE INHIBITOR
Descriptor:Galectin-3, CHLORIDE ION, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
Authors:Collins, P.M., Blanchard, H.
Deposit date:2015-10-13
Release date:2016-08-24
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.
Chembiochem, 17, 2016
5E8A
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH 4-FLUOPHENYL-1,2,3-TRIAZOLYL THIODIGALACTOSIDE INHIBITOR
Descriptor:Galectin-3, CHLORIDE ION, 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
Authors:Collins, P.M., Blanchard, H.
Deposit date:2015-10-13
Release date:2016-08-24
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.
Chembiochem, 17, 2016
5EXO
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH METHYL 2-O-ACETYL-3-O-(2H-CHROMENE-3-YL-METHYL)-A-D-GALACTOPYRANOSIDE INHIBITOR
Descriptor:Galectin-3, CHLORIDE ION, [(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2-methoxy-5-oxidanyl-4-[(2-oxidanylidenechromen-3-yl)methoxy]oxan-3-yl] ethanoate
Authors:Collins, P.M., Blanchard, H.
Deposit date:2015-11-23
Release date:2016-10-05
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model.
J.Med.Chem., 59, 2016
3OY8
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH LACTOBIONIC ACID
Descriptor:Galectin-1, BETA-D-GALACTOSE, GLUCONIC ACID
Authors:Blanchard, H., Collins, P.M.
Deposit date:2010-09-23
Release date:2010-11-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model
CANCER LETT., 2010
3OYW
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH THIODIGALACTOSIDE
Descriptor:Galectin-1, THIODIGALACTOSIDE
Authors:Blanchard, H., Collins, P.M.
Deposit date:2010-09-23
Release date:2010-11-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model
CANCER LETT., 2010
3T1L
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 IN COMPLEX WITH METHYL 2-O-ACETYL-3-O-TOLUOYL-BETA-D-TALOPYRANOSIDE
Descriptor:Galectin-3, CHLORIDE ION, methyl 2-O-acetyl-3-O-(4-methylbenzoyl)-beta-D-talopyranoside
Authors:Blanchard, H., Collins, P.M.
Deposit date:2011-07-22
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Taloside inhibitors of galectin-1 and galectin-3
Chem.Biol.Drug Des., 79, 2012
3T1M
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN IN COMPLEX WITH METHYL 3-DEOXY-2-O-TOLUOYL-3-N-TOLUOYL-BETA-D-TALOPYRANOSIDE
Descriptor:Galectin-3, CHLORIDE ION, methyl 3-deoxy-2-O-(4-methylbenzoyl)-3-[(4-methylbenzoyl)amino]-beta-D-talopyranoside
Authors:Blanchard, H., Collins, P.M.
Deposit date:2011-07-22
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Taloside inhibitors of galectin-1 and galectin-3
Chem.Biol.Drug Des., 79, 2012
3T2T
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH METHYL 2-O-ACETYL-3-O-TOLUOYL-BETA-D-TALOPYRANOSIDE
Descriptor:Galectin-1, methyl 2-O-acetyl-3-O-(4-methylbenzoyl)-beta-D-talopyranoside
Authors:Blanchard, H., Collins, P.M.
Deposit date:2011-07-23
Release date:2011-12-28
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Taloside inhibitors of galectin-1 and galectin-3
Chem.Biol.Drug Des., 79, 2012
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