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2N0A
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BU of 2n0a by Molmil
Atomic-resolution structure of alpha-synuclein fibrils
Descriptor: Alpha-synuclein
Authors:Tuttle, M.D, Comellas, G, Nieuwkoop, A.J, Covell, D.J, Berthold, D.A, Kloepper, K.D, Courtney, J.M, Kim, J.K, Schwieters, C.D, Lee, V.M, George, J.M, Rienstra, C.M.
Deposit date:2015-03-04
Release date:2016-03-23
Last modified:2023-06-14
Method:SOLID-STATE NMR
Cite:Solid-state NMR structure of a pathogenic fibril of full-length human alpha-synuclein.
Nat.Struct.Mol.Biol., 23, 2016
8GF7
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BU of 8gf7 by Molmil
Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein
Authors:Balana, J.A, Nguyen, A.B, Saelices, L, Pratt, R.M.
Deposit date:2023-03-07
Release date:2023-11-08
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology.
Nat.Chem.Biol., 2024
7Q3U
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BU of 7q3u by Molmil
Cryo-EM structure of TDP43 core peptide amyloid fiber
Descriptor: TAR DNA-binding protein 43
Authors:Nazarov, S.
Deposit date:2021-10-28
Release date:2023-03-22
Last modified:2023-10-04
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage.
Nat.Neurosci., 26, 2023

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