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6IEY
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BU of 6iey by Molmil
Crystal structure of Chloramphenicol-Metabolizaing Enzyme EstDL136-Chloramphenicol complex
Descriptor: CHLORAMPHENICOL, Esterase
Authors:Kim, S.H, Kang, P.A, Han, K.T, Lee, S.W, Rhee, S.K.
Deposit date:2018-09-18
Release date:2019-02-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome.
PLoS ONE, 14, 2019
1ULH
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BU of 1ulh by Molmil
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
Descriptor: Tryptophanyl-tRNA synthetase
Authors:Kise, Y, Sengoku, T, Ishii, R, Yokoyama, S, Park, S.G, Lee, S.W, Kim, S, Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-09-12
Release date:2004-02-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
Nat.Struct.Mol.Biol., 11, 2004
6AAE
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BU of 6aae by Molmil
Crystal structure of Chloramphenicol-Metabolizaing Enzyme EstDL136
Descriptor: DI(HYDROXYETHYL)ETHER, Esterase, PENTAETHYLENE GLYCOL
Authors:Kim, S.H, Kang, P.A, Han, K.T, Lee, S.W, Rhee, S.K.
Deposit date:2018-07-18
Release date:2019-02-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.641 Å)
Cite:Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome.
PLoS ONE, 14, 2019
5GPG
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BU of 5gpg by Molmil
Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP3, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, Serine/threonine-protein kinase mTOR
Authors:Lee, H.B, Lee, S.Y, Rhee, H.W, Lee, C.W.
Deposit date:2016-08-02
Release date:2016-10-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells
Acs Cent.Sci., 2, 2016
6OKX
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BU of 6okx by Molmil
Solution structure of VEK50RH1/AA
Descriptor: Plasminogen-binding group A streptococcal M-like protein PAM
Authors:Yuan, Y, Castellino, F.J.
Deposit date:2019-04-15
Release date:2020-02-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
6OQ9
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BU of 6oq9 by Molmil
Solution structure of VEK50 in the bound form with plasminogen kringle 2
Descriptor: Plasminogen-binding group A streptococcal M-like protein PAM
Authors:Yuan, Y, Castellino, F.J.
Deposit date:2019-04-25
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
6OQJ
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BU of 6oqj by Molmil
SOLUTION STRUCTURE OF THE COMPLEX OF MUTANT VEK50[RH1/AA] AND PLASMINOGEN KRINGLE 2
Descriptor: Plasminogen kringle 2, Plasminogen-binding group A streptococcal M-like protein PAM
Authors:Yuan, Y, Castellino, F.J.
Deposit date:2019-04-26
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
6OKW
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BU of 6okw by Molmil
Solution structure of VEK50
Descriptor: Plasminogen-binding group A streptococcal M-like protein PAM
Authors:Yuan, Y, Castellino, F.J.
Deposit date:2019-04-15
Release date:2020-02-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
6OQK
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BU of 6oqk by Molmil
SOLUTION STRUCTURE OF THE COMPLEX OF MUTANT VEK50[RH2/AA] AND PLASMINOGEN KRINGLE 2
Descriptor: Plasminogen Kringle 2, Plasminogen-binding group A streptococcal M-like protein PAM
Authors:Yuan, Y, Castellino, F.J.
Deposit date:2019-04-26
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
6O8R
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BU of 6o8r by Molmil
Syn-safencin 24
Descriptor: Circular bacteriocin, circularin A/uberolysin family
Authors:Fields, F.R, Lee, S.W.
Deposit date:2019-03-11
Release date:2020-05-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy.
Acs Pharmacol Transl Sci, 3, 2020
6O8P
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BU of 6o8p by Molmil
Syn-safencin 8
Descriptor: Circular bacteriocin, circularin A/uberolysin family
Authors:Fields, F.R, Lee, S.W.
Deposit date:2019-03-11
Release date:2020-05-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy.
Acs Pharmacol Transl Sci, 3, 2020
6O8S
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BU of 6o8s by Molmil
Syn-safencin 56
Descriptor: Circular bacteriocin, circularin A/uberolysin family
Authors:Fields, F.R, Lee, S.W.
Deposit date:2019-03-11
Release date:2020-05-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy.
Acs Pharmacol Transl Sci, 3, 2020
6A6K
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BU of 6a6k by Molmil
Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000
Descriptor: 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol, Estrogen-related receptor gamma
Authors:Yoon, H, Kim, J, Chin, J, Cho, S.J, Song, J.
Deposit date:2018-06-28
Release date:2019-04-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
J. Med. Chem., 62, 2019
6KNR
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BU of 6knr by Molmil
Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699
Descriptor: (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol, Estrogen-related receptor gamma
Authors:Yoon, H, Kim, J, Chin, J, Song, J, Cho, S.J.
Deposit date:2019-08-07
Release date:2020-08-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Eur.J.Med.Chem., 205, 2020
5YSO
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BU of 5yso by Molmil
Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434
Descriptor: 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol, Estrogen-related receptor gamma
Authors:Cho, S.J, Chin, J.W, Yoon, H.S, Jeon, Y.H, Bae, J.H, Song, J.Y.
Deposit date:2017-11-14
Release date:2018-12-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:A Novel Orally Active Inverse Agonist of Estrogen-related Receptor Gamma (ERR gamma ), DN200434, A Booster of NIS in Anaplastic Thyroid Cancer.
Clin.Cancer Res., 25, 2019
4CKR
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BU of 4ckr by Molmil
Crystal structure of the human DDR1 kinase domain in complex with DDR1-IN-1
Descriptor: 1,2-ETHANEDIOL, 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide, EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1
Authors:Canning, P, Elkins, J.M, Goubin, S, Mahajan, P, Krojer, T, Newman, J.A, Dixon-Clarke, S, Chaikuad, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.
Deposit date:2014-01-07
Release date:2014-01-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a Potent and Selective Ddr1 Receptor Tyrosine Kinase Inhibitor.
Acs Chem.Biol., 8, 2013
5V4U
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BU of 5v4u by Molmil
Solution structure of VKK38 bound to plasminogen kringle 2
Descriptor: M protein
Authors:Yuan, Y, Castellino, F.
Deposit date:2017-03-10
Release date:2017-07-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen.
J. Biol. Chem., 292, 2017
2OIB
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BU of 2oib by Molmil
Crystal structure of IRAK4 kinase domain apo form
Descriptor: Interleukin-1 receptor-associated kinase 4
Authors:Kuglstatter, A, Villasenor, A.G, Browner, M.F.
Deposit date:2007-01-10
Release date:2007-03-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
2OIC
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BU of 2oic by Molmil
Crystal structure of IRAK4 kinase domain complexed with staurosporine
Descriptor: Interleukin-1 receptor-associated kinase 4, STAUROSPORINE
Authors:Kuglstatter, A, Villasenor, A.G, Browner, M.F.
Deposit date:2007-01-10
Release date:2007-03-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
2OID
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BU of 2oid by Molmil
Crystal structure of IRAK4 kinase domain complexed with AMPPNP
Descriptor: Interleukin-1 receptor-associated kinase 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Kuglstatter, A, Villasenor, A.G, Browner, M.F.
Deposit date:2007-01-10
Release date:2007-03-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
J.Immunol., 178, 2007
3PIY
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BU of 3piy by Molmil
Crystal structure of BTK kinase domain complexed with R406
Descriptor: 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, Tyrosine-protein kinase BTK
Authors:Kuglstatter, A, Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PIZ
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BU of 3piz by Molmil
Crystal structure of BTK kinase domain complexed with (5-Amino-1-o-tolyl-1H-pyrazol-4-yl)-[3-(1-methanesulfonyl-piperidin-4-yl)-phenyl]-methanone
Descriptor: Tyrosine-protein kinase BTK, [5-amino-1-(2-methylphenyl)-1H-pyrazol-4-yl]{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}methanone
Authors:Kuglstatter, A, Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PJ3
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BU of 3pj3 by Molmil
Crystal structure of BTK kinase domain complexed with 2-Methyl-5-[(E)-(3-phenyl-acryloyl)amino]-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-benzamide
Descriptor: 2-methyl-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-5-{[(2E)-3-phenylprop-2-enoyl]amino}benzamide, Tyrosine-protein kinase BTK
Authors:Kuglstatter, A, Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PJ1
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BU of 3pj1 by Molmil
Crystal structure of BTK kinase domain complexed with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
Descriptor: 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, Tyrosine-protein kinase BTK
Authors:Kuglstatter, A, Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011
3PIX
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BU of 3pix by Molmil
Crystal structure of BTK kinase domain complexed with 2-Isopropyl-7-(4-methyl-piperazin-1-yl)-4-(5-methyl-2H-pyrazol-3-ylamino)-2H-phthalazin-1-one
Descriptor: 7-(4-methylpiperazin-1-yl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-(propan-2-yl)phthalazin-1(2H)-one, Tyrosine-protein kinase BTK
Authors:Kuglstatter, A, Wong, A.
Deposit date:2010-11-08
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
Protein Sci., 20, 2011

 

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