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4GMS
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CRYSTAL STRUCTURE OF HETEROSUBTYPIC FAB S139/1 IN COMPLEX WITH INFLUENZA A H3 HEMAGGLUTININ
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, Fab S139/1 light chain, ...
Authors:Lee, P.S., Ekiert, D.C., Wilson, I.A.
Deposit date:2012-08-16
Release date:2012-10-03
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GMT
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CRYSTAL STRUCTURE OF HETEROSUBTYPIC FAB S139/1
Descriptor:Fab S139/1 light chain, Fab S139/1 heavy chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lee, P.S., Ekiert, D.C., Wilson, I.A.
Deposit date:2012-08-16
Release date:2012-10-03
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity.
Proc.Natl.Acad.Sci.USA, 109, 2012
4O58
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY F045-092 IN COMPLEX WITH A/VICTORIA/3/1975 (H3N2) INFLUENZA HEMAGGLUTININ
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, Fab F045-092 light chain, ...
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2013-12-19
Release date:2014-04-16
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.7501 Å)
Cite:Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.
Nat Commun, 5, 2014
4O5I
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY F045-092 IN COMPLEX WITH A/VICTORIA/361/2011 (H3N2) INFLUENZA HEMAGGLUTININ
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, Fab F045-092 heavy chain, ...
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2013-12-19
Release date:2014-04-16
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (6.501 Å)
Cite:Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.
Nat Commun, 5, 2014
4O5L
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY F045-092
Descriptor:Fab F045-092 light chain, Fab F045-092 heavy chain, PHOSPHATE ION
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2013-12-19
Release date:2014-04-16
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (1.5045 Å)
Cite:Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.
Nat Commun, 5, 2014
4O5N
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CRYSTAL STRUCTURE OF A/VICTORIA/361/2011 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2013-12-19
Release date:2014-04-16
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.
Nat Commun, 5, 2014
4WUK
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CRYSTAL STRUCTURE OF APO CH65 FAB
Descriptor:CH65 heavy chain, CH65 light chain, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2014-11-01
Release date:2015-02-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the apo anti-influenza CH65 Fab.
Acta Crystallogr.,Sect.F, 71, 2015
4ZCJ
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CRYSTAL STRUCTURE OF THE A/HONG KONG/1/1968 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ HA1 CYS30, HA2 CYS47 MUTANT
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2015-04-16
Release date:2015-05-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer.
J.Virol., 89, 2015
5KUX
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DESIGNED INFLUENZA HEMAGGLUTININ BINDING PROTEIN HSB.2
Descriptor:Designed influenza inhibitor protein HSB.2
Authors:Lee, P.S., Bernard, S.M., Wilson, I.A.
Deposit date:2016-07-13
Release date:2017-06-14
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.
Nat. Biotechnol., 35, 2017
4M5Y
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING FAB 5J8
Descriptor:Fab 5J8 heavy chain, Fab 5J8 light chain, DI(HYDROXYETHYL)ETHER, ...
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2013-08-08
Release date:2013-09-25
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site.
J.Virol., 87, 2013
4NM4
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CR8043
Descriptor:Antibody CR8043, Light Chain, Heavy Chain, ...
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2013-11-14
Release date:2013-12-25
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A common solution to group 2 influenza virus neutralization.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NM8
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CR8043 BOUND TO H3 INFLUENZA HEMAGGLUTININ
Descriptor:Hemagglutinin HA1 Chain, Hemagglutinin HA2 Chain, Antibody CR8043, ...
Authors:Lee, P.S., Wilson, I.A.
Deposit date:2013-11-14
Release date:2013-12-25
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (4.0041 Å)
Cite:A common solution to group 2 influenza virus neutralization.
Proc.Natl.Acad.Sci.USA, 111, 2014
2O8K
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NMR STRUCTURE OF THE SIGMA-54 RPON DOMAIN BOUND TO THE-24 PROMOTER ELEMENT
Descriptor:5'-D(*TP*TP*TP*TP*GP*GP*CP*AP*CP*GP*TP*TP*TP*C)-3', 5'-D(*GP*AP*AP*AP*CP*GP*TP*GP*CP*CP*AP*AP*AP*A)-3', RNA polymerase sigma factor RpoN
Authors:Doucleff, M., Pelton, J.G., Lee, P.S., Wemmer, D.E.
Deposit date:2006-12-12
Release date:2007-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of DNA recognition by the alternative sigma-factor, sigma54.
J.Mol.Biol., 369, 2007
2O9L
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AMBER REFINED NMR STRUCTURE OF THE SIGMA-54 RPON DOMAIN BOUND TO THE-24 PROMOTER ELEMENT
Descriptor:5'-D(*TP*TP*TP*TP*GP*GP*CP*AP*CP*GP*TP*TP*TP*C)-3', 5'-D(*GP*AP*AP*AP*CP*GP*TP*GP*CP*CP*AP*AP*AP*A)-3', RNA polymerase sigma factor RpoN
Authors:Doucleff, M., Pelton, J.G., Lee, P.S., Wemmer, D.E.
Deposit date:2006-12-13
Release date:2007-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of DNA recognition by the alternative sigma-factor, sigma54.
J.Mol.Biol., 369, 2007
4M5Z
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY 5J8 BOUND TO 2009 PANDEMIC INFLUENZA HEMAGGLUTININ, HA1 SUBUNIT
Descriptor:Hemagglutinin HA1 chain, Fab 5J8 heavy chain, Fab 5J8 light chain
Authors:Hong, M., Lee, P.S., Wilson, I.A.
Deposit date:2013-08-08
Release date:2013-09-25
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site.
J.Virol., 87, 2013
5IC4
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CRYSTAL STRUCTURE OF CASPASE-3 DEVE PEPTIDE COMPLEX
Descriptor:Caspase-3 subunit p17, Caspase-3 subunit p12, DEVE peptide
Authors:Seaman, J.E., Julien, O., Lee, P.S., Rettenmaier, T.J., Thomsen, N.D., Wells, J.A.
Deposit date:2016-02-22
Release date:2016-07-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Cell Death Differ., 23, 2016
5IC6
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CRYSTAL STRUCTURE OF CASPASE-7 DEVE PEPTIDE COMPLEX
Descriptor:Caspase-7 subunit p20, Caspase-7 subunit p11, DEVE peptide
Authors:Seaman, J.E., Julien, O., Lee, P.S., Rettenmaier, T.J., Thomsen, N.D., Wells, J.A.
Deposit date:2016-02-22
Release date:2016-07-20
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Cell Death Differ., 23, 2016
5WKZ
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VH1-69 GERMLINE ANTIBODY PREDICTED FROM CR6261
Descriptor:Immunoglobulin heavy variable 1-69D,IgG H chain, Lambda-chain (AA -20 to 215), SULFATE ION
Authors:Lang, S., Lee, P.S.
Deposit date:2017-07-25
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Anti-idiotypic antibody K1-18 engages VH1-69 precursor and affinity-matured, anti-stem antibodies through mimicry of the HA stem
To Be Published
6MAE
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CHAIN A. UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE PA-LPXC COMPLEXED WITH (R)-3-((S)-3-(4-(CYCLOPROPYLETHYNYL)PHENYL)-2-OXOOXAZOLIDIN-5-YL)-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)PROPENAMIDE
Descriptor:UDP-3-O-acyl-N-acetylglucosamine deacetylase, (2R)-3-{(5S)-3-[4-(cyclopropylethynyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)propanamide, ZINC ION
Authors:Shu, W.
Deposit date:2018-08-27
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.
J. Med. Chem., 61, 2018
4G3K
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CRYSTAL STRUCTURE OF A. AEOLICUS NLH1 GAF DOMAIN IN AN INACTIVE STATE
Descriptor:Transcriptional regulator nlh1
Authors:Wemmer, D.E., Batchelor, J.D., Wang, A., Lee, P., Doucleff, M.
Deposit date:2012-07-14
Release date:2013-05-29
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural mechanism of GAF-regulated delta(54) activators from Aquifex aeolicus
J.Mol.Biol., 425, 2013
4G3V
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CRYSTAL STRUCTURE OF A. AEOLICUS NLH2 GAF DOMAIN IN AN INACTIVE STATE
Descriptor:Transcriptional regulator nlh2, CHLORIDE ION
Authors:Batchelor, J.D., Lee, P., Wang, A., Doucleff, M., Wemmer, D.E.
Deposit date:2012-07-15
Release date:2013-05-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural mechanism of GAF-regulated delta(54) activators from Aquifex aeolicus
J.Mol.Biol., 425, 2013
4G3W
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CRYSTAL STRUCTURE OF A. AEOLICUS NLH1 GAF DOMAIN IN AN INACTIVE STATE
Descriptor:Transcriptional regulator nlh1
Authors:Batchelor, J.D., Wang, A., Lee, P., Doucleff, M., Wemmer, D.E.
Deposit date:2012-07-15
Release date:2013-05-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural mechanism of GAF-regulated delta(54) activators from Aquifex aeolicus
J.Mol.Biol., 425, 2013
4NUG
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CRYSTAL STRUCTURE OF HIV-1 BROADLY NEUTRALIZING ANTIBODY PGT151
Descriptor:PGT151 light chain, PGT151 heavy chain, HEXAETHYLENE GLYCOL
Authors:Blattner, C., Wilson, I.A.
Deposit date:2013-12-03
Release date:2014-05-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.8617 Å)
Cite:Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers.
Immunity, 40, 2014
4NUJ
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CRYSTAL STRUCTURE OF HIV-1 BROADLY NEUTRALIZING ANTIBODY PGT152
Descriptor:PGT152 light chain, PGT152 heavy chain
Authors:Blattner, C., Wilson, I.A.
Deposit date:2013-12-03
Release date:2014-05-14
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (1.827 Å)
Cite:Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers.
Immunity, 40, 2014
4RQQ
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CRYSTAL STRUCTURE OF HUMAN FAB PGDM1400, A BROADLY REACTIVE AND POTENT HIV-1 NEUTRALIZING ANTIBODY
Descriptor:Human anti-HIV-1 antibody PGDM1400 light chain, Human anti-HIV-1 antibody PGDM1400 heavy chain
Authors:Julien, J.-P., Wilson, I.A.
Deposit date:2014-11-04
Release date:2014-11-19
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.
Proc.Natl.Acad.Sci.USA, 111, 2014
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