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1Y6Q
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CYRSTAL STRUCTURE OF MTA/ADOHCY NUCLEOSIDASE COMPLEXED WITH MT-DADME-IMMA
Descriptor:MTA/SAH nucleosidase, CHLORIDE ION, (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL
Authors:Lee, J.E., Singh, V., Evans, G.B., Tyler, P.C., Furneaux, R.H., Cornell, K.A., Riscoe, M.K., Schramm, V.L., Howell, P.L.
Deposit date:2004-12-06
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
J.Biol.Chem., 280, 2005
1Y6R
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CRYSTAL STRUCTURE OF MTA/ADOHCY NUCLEOSIDASE COMPLEXED WITH MT-IMMA.
Descriptor:MTA/SAH nucleosidase, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL
Authors:Lee, J.E., Singh, V., Evans, G.B., Tyler, P.C., Furneaux, R.H., Cornell, K.A., Riscoe, M.K., Schramm, V.L., Howell, P.L.
Deposit date:2004-12-06
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
J.Biol.Chem., 280, 2005
1JYS
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CRYSTAL STRUCTURE OF E. COLI MTA/ADOHCY NUCLEOSIDASE
Descriptor:MTA/SAH nucleosidase, ADENINE
Authors:Lee, J.E., Cornell, K.A., Riscoe, M.K., Howell, P.L.
Deposit date:2001-09-13
Release date:2002-10-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases.
Structure, 9, 2001
1NC1
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CRYSTAL STRUCTURE OF E. COLI MTA/ADOHCY NUCLEOSIDASE COMPLEXED WITH 5'-METHYLTHIOTUBERCIDIN (MTH)
Descriptor:MTA/SAH nucleosidase, 2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL
Authors:Lee, J.E., Cornell, K.A., Riscoe, M.K., Howell, P.L.
Deposit date:2002-12-04
Release date:2003-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.
J.Biol.Chem., 278, 2003
1NC3
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CRYSTAL STRUCTURE OF E. COLI MTA/ADOHCY NUCLEOSIDASE COMPLEXED WITH FORMYCIN A (FMA)
Descriptor:MTA/SAH nucleosidase, (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol
Authors:Lee, J.E., Cornell, K.A., Riscoe, M.K., Howell, P.L.
Deposit date:2002-12-04
Release date:2003-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.
J.Biol.Chem., 278, 2003
1SD1
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STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH FORMYCIN A
Descriptor:5'-methylthioadenosine phosphorylase, (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol
Authors:Lee, J.E., Settembre, E.C., Cornell, K.A., Riscoe, M.K., Sufrin, J.R., Ealick, S.E., Howell, P.L.
Deposit date:2004-02-12
Release date:2004-05-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design.
Biochemistry, 43, 2004
1SD2
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STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-METHYLTHIOTUBERCIDIN
Descriptor:5'-methylthioadenosine phosphorylase, SULFATE ION, 2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL
Authors:Lee, J.E., Settembre, E.C., Cornell, K.A., Riscoe, M.K., Sufrin, J.R., Ealick, S.E., Howell, P.L.
Deposit date:2004-02-12
Release date:2004-05-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design.
Biochemistry, 43, 2004
1Z5N
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CRYSTAL STRUCTURE OF MTA/ADOHCY NUCLEOSIDASE GLU12GLN MUTANT COMPLEXED WITH 5-METHYLTHIORIBOSE AND ADENINE
Descriptor:MTA/SAH nucleosidase, 5-S-METHYL-5-THIO-ALPHA-D-RIBOFURANOSE, ADENINE
Authors:Lee, J.E., Smith, G.D., Horvatin, C., Huang, D.J.T., Cornell, K.A., Riscoe, M.K., Howell, P.L.
Deposit date:2005-03-18
Release date:2005-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis
J.Mol.Biol., 352, 2005
1Z5O
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CRYSTAL STRUCTURE OF MTA/ADOHCY NUCLEOSIDASE ASP197ASN MUTANT COMPLEXED WITH 5'-METHYLTHIOADENOSINE
Descriptor:MTA/SAH nucleosidase, 5'-DEOXY-5'-METHYLTHIOADENOSINE
Authors:Lee, J.E., Smith, G.D., Horvatin, C., Huang, D.J.T., Cornell, K.A., Riscoe, M.K., Howell, P.L.
Deposit date:2005-03-18
Release date:2005-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis
J.Mol.Biol., 352, 2005
1Z5P
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CRYSTAL STRUCTURE OF MTA/ADOHCY NUCLEOSIDASE WITH A LIGAND-FREE PURINE BINDING SITE
Descriptor:MTA/SAH nucleosidase, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, GLYCEROL, ...
Authors:Lee, J.E., Smith, G.D., Horvatin, C., Huang, D.J.T., Cornell, K.A., Riscoe, M.K., Howell, P.L.
Deposit date:2005-03-18
Release date:2005-10-04
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis
J.Mol.Biol., 352, 2005
2QHR
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CRYSTAL STRUCTURE OF THE 13F6-1-2 FAB FRAGMENT BOUND TO ITS EBOLA VIRUS GLYCOPROTEIN PEPTIDE EPITOPE.
Descriptor:13F6-1-2 Fab fragment heavy chain, 13F6-1-2 Fab fragment V lambda x light chain, Envelope glycoprotein peptide
Authors:Lee, J.E., Kuehne, A., Abelson, D.M., Fusco, M.L., Hart, M.K., Saphire, E.O.
Deposit date:2007-07-02
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain.
J.Mol.Biol., 375, 2008
3CSY
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CRYSTAL STRUCTURE OF THE TRIMERIC PREFUSION EBOLA VIRUS GLYCOPROTEIN IN COMPLEX WITH A NEUTRALIZING ANTIBODY FROM A HUMAN SURVIVOR
Descriptor:Fab KZ52 heavy chain, Fab KZ52 light chain, Envelope glycoprotein GP1, ...
Authors:Lee, J.E., Fusco, M.L., Hessell, A.J., Oswald, W.B., Burton, D.R., Saphire, E.O.
Deposit date:2008-04-10
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.
Nature, 454, 2008
3INU
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CRYSTAL STRUCTURE OF AN UNBOUND KZ52 NEUTRALIZING ANTI-EBOLAVIRUS ANTIBODY.
Descriptor:KZ52 antibody fragment heavy chain, KZ52 antibody fragment light chain, SULFATE ION, ...
Authors:Lee, J.E., Fusco, M.L., Abelson, D.M., Hessell, A.J., Burton, D.R., Saphire, E.O.
Deposit date:2009-08-12
Release date:2009-10-27
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.
Acta Crystallogr.,Sect.D, 65, 2009
2GMK
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CRYSTAL STRUCTURE OF ONCONASE DOUBLE MUTANT WITH SPONTANEOUSLY-ASSEMBLED (AMP) 4 STACK
Descriptor:P-30 protein, ADENOSINE MONOPHOSPHATE
Authors:Bae, E., Lee, J.E., Raines, R.T., Wesenberg, G.E., Phillips Jr., G.N., Bitto, E., Bingman, C.A., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2006-04-06
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for catalysis by onconase.
J.Mol.Biol., 375, 2008
2I5S
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CRYSTAL STRUCTURE OF ONCONASE WITH BOUND NUCLEIC ACID
Descriptor:P-30 protein, 5'-D(*A*(DU)P*GP*A)-3'
Authors:Bae, E., Lee, J.E., Raines, R.T., Wesenberg, G.E., Phillips Jr., G.N., Bitto, E., Bingman, C.A., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2006-08-25
Release date:2006-09-05
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for catalysis by onconase.
J.Mol.Biol., 375, 2008
5UQY
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CRYSTAL STRUCTURE OF MARBURG VIRUS GP IN COMPLEX WITH THE HUMAN SURVIVOR ANTIBODY MR78
Descriptor:ENVELOPE GLYCOPROTEIN GP1, ENVELOPE GLYCOPROTEIN GP2, MR78 Fab light chain, ...
Authors:Hashiguchi, T., Fusco, M.L., Hastie, K.M., Bomholdt, Z.A., Lee, J.E., Flyak, A.I., Matsuoka, R., Kohda, D., Yanagi, Y., Hammel, M., Crowe, J.E., Saphire, E.O.
Deposit date:2017-02-08
Release date:2017-03-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Cell, 160, 2015
1JDI
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CRYSTAL STRUCTURE OF L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE
Descriptor:L-RIBULOSE 5 PHOSPHATE 4-EPIMERASE, ZINC ION
Authors:Luo, Y., Samuel, J., Mosimann, S.C., Lee, J.E., Tanner, M.E., Strynadka, N.C.J.
Deposit date:2001-06-13
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of L-ribulose-5-phosphate 4-epimerase: an aldolase-like platform for epimerization.
Biochemistry, 40, 2001
1K0W
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CRYSTAL STRUCTURE OF L-RIBULOSE-5-PHOSPHATE 4-EPIMERASE
Descriptor:L-RIBULOSE 5 PHOSPHATE 4-EPIMERASE, ZINC ION
Authors:Luo, Y., Samuel, J., Mosimann, S.C., Lee, J.E., Strynadka, N.C.J.
Deposit date:2001-09-21
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of L-ribulose-5-phosphate 4-epimerase: an aldolase-like platform for epimerization
Biochemistry, 40, 2001
2Y6S
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STRUCTURE OF AN EBOLAVIRUS-PROTECTIVE ANTIBODY IN COMPLEX WITH ITS MUCIN-DOMAIN LINEAR EPITOPE
Descriptor:LIGHT CHAIN, HEAVY CHAIN, ENVELOPE GLYCOPROTEIN
Authors:Olal, D.O., Kuehne, A., Lee, J.E., Bale, S., Dye, J.M., Saphire, E.O.
Deposit date:2011-01-25
Release date:2012-01-11
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of an Ebola Virus-Protective Antibody in Complex with its Mucin-Domain Linear Epitope.
J.Virol., 86, 2012
3BL6
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE IN COMPLEX WITH FORMYCIN A
Descriptor:5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase, (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol
Authors:Siu, K.K.W., Lee, J.E., Smith, G.D., Horvatin, C., Howell, P.L.
Deposit date:2007-12-10
Release date:2008-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Acta Crystallogr.,Sect.F, 64, 2008
3MMS
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CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE MTA/SAH NUCLEOSIDASE IN COMPLEX WITH 8-AMINOADENINE
Descriptor:5'-methylthioadenosine / S-adenosylhomocysteine nucleosidase, 9H-purine-6,8-diamine, GLYCEROL
Authors:Siu, K.K.W., Lee, J.E., Horvatin-Mrakovcic, C., Howell, P.L.
Deposit date:2010-04-20
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of Streptococcus pneumoniae MTA/SAH nucleosidase in complex with 8-aminoadenine
TO BE PUBLISHED
3TIO
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CRYSTAL STRUCTURES OF YRDA FROM ESCHERICHIA COLI, A HOMOLOGOUS PROTEIN OF GAMMA-CLASS CARBONIC ANHYDRASE, SHOW POSSIBLE ALLOSTERIC CONFORMATIONS
Descriptor:Protein YrdA, ZINC ION, PHOSPHATE ION
Authors:Park, H.M., Choi, J.W., Lee, J.E., Jung, C.H., Kim, B.Y., Kim, J.S.
Deposit date:2011-08-21
Release date:2012-08-01
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Structures of the gamma-class carbonic anhydrase homologue YrdA suggest a possible allosteric switch
Acta Crystallogr.,Sect.D, 68, 2012
3TIS
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CRYSTAL STRUCTURES OF YRDA FROM ESCHERICHIA COLI, A HOMOLOGOUS PROTEIN OF GAMMA-CLASS CARBONIC ANHYDRASES, SHOW POSSIBLE ALLOSTERIC CONFORMATIONS
Descriptor:Protein YrdA, ZINC ION
Authors:Park, H.M., Chio, J.W., Lee, J.E., Jung, J.H., Kim, B.Y., Kim, J.S.
Deposit date:2011-08-21
Release date:2012-08-01
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the gamma-class carbonic anhydrase homologue YrdA suggest a possible allosteric switch
Acta Crystallogr.,Sect.D, 68, 2012
4J4J
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CRYSTAL STRUCTURE OF THE APOBEC3F VIF BINDING DOMAIN
Descriptor:DNA dC->dU-editing enzyme APOBEC-3F, ZINC ION
Authors:Siu, K.K., Sultana, A., Lee, J.E.
Deposit date:2013-02-06
Release date:2013-11-06
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F.
Nat Commun, 4, 2013
4JF3
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CRYSTAL STRUCTURE OF THE MPMV TM RETROVIRAL FUSION CORE
Descriptor:Envelope glycoprotein, CHLORIDE ION
Authors:Cook, J.D., Aydin, H., Lee, J.E.
Deposit date:2013-02-27
Release date:2013-10-23
Last modified:2014-01-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of Beta- and gammaretrovirus fusion proteins reveal a role for electrostatic stapling in viral entry.
J.Virol., 88, 2014
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