Author results

5F21
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HUMAN CD38 IN COMPLEX WITH NANOBODY MU375
Descriptor:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, nanobody MU375, SULFATE ION, ...
Authors:Hao, Q., Zhang, H.
Deposit date:2015-12-01
Release date:2016-06-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Immuno-targeting the multifunctional CD38 using nanobody
Sci Rep, 6, 2016
5F1O
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HUMAN CD38 IN COMPLEX WITH NANOBODY MU551
Descriptor:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, nanobody MU551
Authors:Zhang, H., Hao, Q.
Deposit date:2015-11-30
Release date:2016-06-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Immuno-targeting the multifunctional CD38 using nanobody
Sci Rep, 6, 2016
5F1K
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HUMAN CD38 IN COMPLEX WITH NANOBODY MU1053
Descriptor:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, nanobody MU1053
Authors:Zhang, H., Hao, Q.
Deposit date:2015-11-30
Release date:2016-06-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Immuno-targeting the multifunctional CD38 using nanobody
Sci Rep, 6, 2016
5BNI
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PORCINE CD38 COMPLEXED WITH COMPLEXED WITH A COVALENT INTERMEDIATE, RIBO-F-RIBOSE-5'-PHOSPHATE
Descriptor:Uncharacterized protein, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Ting, K.Y., Leung, C.F.P., Graeff, R.M., Lee, H.C., Hao, Q., Kotaka, M.
Deposit date:2015-05-26
Release date:2016-05-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Porcine CD38 exhibits prominent secondary NAD(+) cyclase activity.
Protein Sci., 25, 2016
5BNF
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APO STRUCTURE OF PORCINE CD38
Descriptor:Uncharacterized protein
Authors:Ting, K.Y., Leung, C.P.F., Graeff, R.M., Lee, H.C., Hao, Q., Kotaka, M.
Deposit date:2015-05-26
Release date:2016-05-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Porcine CD38 exhibits prominent secondary NAD(+) cyclase activity.
Protein Sci., 25, 2016
5AI1
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CRYSTAL STRUCTURE OF KETOSTEROID ISOMERASE CONTAINING Y32F, D40N, Y57F AND Y119F MUTATIONS IN THE EQUILENIN-BOUND FORM
Descriptor:KETOSTEROID ISOMERASE, EQUILENIN
Authors:Cha, H.J., Jeong, J.H., Kim, Y.G.
Deposit date:2015-02-11
Release date:2015-05-20
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Contribution of a Low-Barrier Hydrogen Bond to Catalysis is not Significant in Ketosteroid Isomerase.
Mol.Cells, 38, 2015
4F46
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CRYSTAL STRUCTURE OF WILD TYPE HUMAN CD38 IN COMPLEX WITH NAADP AND ADPRP
Descriptor:ADP-ribosyl cyclase 1, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5S)-3,4,5-tris(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2012-05-10
Release date:2013-04-03
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal Structures of Human CD38 in Complex with NAADP and ADPRP
MESSENGER, 2, 2013
4F45
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CRYSTAL STRUCTURE OF HUMAN CD38 E226Q MUTANT IN COMPLEX WITH NAADP
Descriptor:ADP-ribosyl cyclase 1, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2012-05-10
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Human CD38 in Complex with NAADP and ADPRP
MESSENGER, 2, 2013
3ZWY
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CRYSTAL STRUCTURE OF ADP-RIBOSYL CYCLASE COMPLEXED WITH 8-BROMO-ADP- RIBOSE AND CYCLIC 8-BROMO-CYCLIC-ADP-RIBOSE
Descriptor:ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide
Authors:Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Deposit date:2011-08-03
Release date:2012-08-22
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
To be Published
3ZWX
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CRYSTAL STRUCTURE OF ADP-RIBOSYL CYCLASE COMPLEXED WITH 8-BROMO-ADP- RIBOSE
Descriptor:ADP-RIBOSYL CYCLASE, CHLORIDE ION, [(2R,3S,4R,5R)-5-(6-amino-8-bromo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4S)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Deposit date:2011-08-03
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
To be Published
3ZWW
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CRYSTAL STRUCTURE OF ADP-RIBOSYL CYCLASE COMPLEXED WITH ARA-2'F-ADP- RIBOSE AT 2.3 ANGSTROM
Descriptor:ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Deposit date:2011-08-03
Release date:2011-11-30
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWV
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CRYSTAL STRUCTURE OF ADP-RIBOSYL CYCLASE COMPLEXED WITH ARA-2'F-ADP- RIBOSE AT 2.3 ANGSTROM
Descriptor:ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Deposit date:2011-08-03
Release date:2011-11-30
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of intermediates along the cyclization pathway of Aplysia ADP-ribosyl cyclase.
J. Mol. Biol., 415, 2012
3ZWP
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH ARA-2'F-ADP- RIBOSE AT 2.1 ANGSTROM
Descriptor:ADP-RIBOSYL CYCLASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, GLYCEROL
Authors:Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWO
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH REACTION INTERMEDIATE
Descriptor:ADP-RIBOSYL CYCLASE, GUANOSINE DIPHOSPHATE RIBOSE, 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]PYRIDINIUM
Authors:Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWN
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CRYSTAL STRUCTURE OF APLYSIA CYCLASE COMPLEXED WITH SUBSTRATE NGD AND PRODUCT CGDPR
Descriptor:ADP-RIBOSYL CYCLASE, CYCLIC GUANOSINE DIPHOSPHATE-RIBOSE, 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]PYRIDINIUM
Authors:Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3ZWM
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH SUBSTRATE NAD AND PRODUCT CADPR
Descriptor:ADP-RIBOSYL CYLCASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE
Authors:Kotaka, M., Graeff, R., Zhang, L.H., Lee, H.C., Hao, Q.
Deposit date:2011-08-02
Release date:2011-11-30
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Studies of Intermediates Along the Cyclization Pathway of Aplysia Adp-Ribosyl Cyclase.
J.Mol.Biol., 415, 2012
3U4I
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CD38 STRUCTURE-BASED INHIBITOR DESIGN USING THE N1-CYCLIC INOSINE 5'-DIPHOSPHATE RIBOSE TEMPLATE
Descriptor:ADP-ribosyl cyclase 1, Cyclic adenosine 5'-diphosphocarbocyclic ribose
Authors:Liu, Q., Hao, Q., Lee, H.C., Graeff, R.
Deposit date:2011-10-08
Release date:2012-10-10
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.118 Å)
Cite:CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013
3U4H
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CD38 STRUCTURE-BASED INHIBITOR DESIGN USING THE N1-CYCLIC INOSINE 5'-DIPHOSPHATE RIBOSE TEMPLATE
Descriptor:ADP-ribosyl cyclase 1, 8-Amino-N1-Cyclic Inosine 5'-Diphosphoribose
Authors:Liu, Q., Hao, Q., Lee, H.C., Graeff, R.
Deposit date:2011-10-08
Release date:2012-10-10
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (1.878 Å)
Cite:CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template
Plos One, 8, 2013
3ROQ
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH COMPOUND CZ-46
Descriptor:ADP-ribosyl cyclase 1, (2R,3R,4S,5S)-4-fluoro-3,5-dihydroxytetrahydrofuran-2-yl 2-phenylethyl hydrogen (S)-phosphate
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2011-04-26
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3ROP
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH COMPOUND CZ-50B
Descriptor:ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-ribofuranose, NICOTINAMIDE
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2011-04-26
Release date:2011-12-21
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3ROM
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH COMPOUND CZ-48
Descriptor:ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-thiophosphono-alpha-D-arabinofuranose
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2011-04-26
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3ROK
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH COMPOUND CZ-27
Descriptor:ADP-ribosyl cyclase 1, 5-O-[(S)-butoxy(hydroxy)phosphoryl]-2-deoxy-2-fluoro-alpha-D-arabinofuranose
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2011-04-26
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Catalysis-based inhibitors of the calcium signaling function of CD38.
Biochemistry, 51, 2012
3RAJ
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH THE FAB FRAGMENT OF ANTIBODY HB7
Descriptor:ADP-ribosyl cyclase 1, heavy chain of the Fab fragment of antibody HB7, light chain of the Fab fragment of antibody HB7
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2011-03-28
Release date:2011-04-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.044 Å)
Cite:Engineering a novel cytosolic form of CD38 for cyclic ADP-ribose dependent signaling
To be Published
3OFS
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DYNAMIC CONFORMATIONS OF THE CD38-MEDIATED NAD CYCLIZATION CAPTURED USING MULTI-COPY CRYSTALLOGRAPHY
Descriptor:ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2010-08-16
Release date:2010-12-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal
J.Mol.Biol., 405, 2011
3I9O
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CRYSTAL STRUCTURE OF ADP RIBOSYL CYCLASE COMPLEXED WITH RIBO-2'F-ADP RIBOSE
Descriptor:ADP-ribosyl cyclase, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Graeff, R., Liu, Q., Kriksunov, I.A., Kotaka, M., Oppenheimer, N., Hao, Q., Lee, H.C.
Deposit date:2009-07-12
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38
J.Biol.Chem., 284, 2009
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