Author results

1IIO
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NMR-BASED STRUCTURE OF THE CONSERVED PROTEIN MTH865 FROM THE ARCHEA METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor:conserved hypothetical protein MTH865
Authors:Lee, G.M., Edwards, A.M., Arrowsmith, C.H., McIntosh, L.P.
Deposit date:2001-04-23
Release date:2001-10-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum.
J.Biomol.NMR, 21, 2001
1R36
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NMR-BASED STRUCTURE OF AUTOINHIBITED MURINE ETS-1 DELTAN301
Descriptor:C-ets-1 protein
Authors:Lee, G.M., Donaldson, L.W., Pufall, M.A., Kang, H.-S., Pot, I., Graves, B.J., McIntosh, L.P.
Deposit date:2003-09-30
Release date:2004-11-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structural and Dynamic Basis of Ets-1 DNA Binding Autoinhibition
J.Biol.Chem., 280, 2005
2JV3
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ETS-1 PNT DOMAIN (29-138) NMR STRUCTURE ENSEMBLE
Descriptor:ETS1 proto-oncogene
Authors:Lee, G.M., Kang, H., Schaerpf, M., Slupsky, C.M., Lawrence, M.P.
Deposit date:2007-09-11
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Ets-1 PNT domain (29-138) NMR structure ensemble
To be Published
1RYJ
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SOLUTION NMR STRUCTURE OF PROTEIN MTH1743 FROM METHANOBACTERIUM THERMOAUTOTROPHICUM. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET MTH1743_1_70; NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET TT526.
Descriptor:unknown
Authors:Yee, A., Chang, X., Pineda-Lucena, A., Wu, B., Semesi, A., Le, B., Ramelot, T., Lee, G.M., Bhattacharyya, S., Gutierrez, P., Denisov, A., Lee, C.H., Cort, J.R., Kozlov, G., Liao, J., Finak, G., Chen, L., Wishart, D., Lee, W., McIntosh, L.P., Gehring, K., Kennedy, M.A., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2003-12-22
Release date:2004-02-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:AN NMR APPROACH TO STRUCTURAL PROTEOMICS
Proc.Natl.Acad.Sci.USA, 99, 2002
2HF5
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THE STRUCTURE AND FUNCTION OF A NOVEL TWO-SITE CALCIUM-BINDING FRAGMENT OF CALMODULIN
Descriptor:Calmodulin, CALCIUM ION
Authors:Lakowski, T.M., Lee, G.M., Reid, R.E., McIntosh, L.P.
Deposit date:2006-06-23
Release date:2007-05-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Calcium-induced folding of a fragment of calmodulin composed of EF-hands 2 and 3
Protein Sci., 16, 2007
2KMD
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RAS SIGNALING REQUIRES DYNAMIC PROPERTIES OF ETS1 FOR PHOSPHORYLATION-ENHANCED BINDING TO CO-ACTIVATOR CBP
Descriptor:Protein C-ets-1
Authors:Nelson, M.L., Kang, H., Lee, G.M., Blaszczak, A.G., Lau, D.K.W., McIntosh, L.P., Graves, B.J.
Deposit date:2009-07-27
Release date:2010-05-05
Last modified:2012-03-21
Method:SOLUTION NMR
Cite:Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.
Proc.Natl.Acad.Sci.USA, 107, 2010
3NJQ
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CRYSTAL STRUCTURE OF KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS PROTEASE IN COMPLEX WITH DIMER DISRUPTOR
Descriptor:ORF 17, ACETATE ION, 3-benzyl-4-({[6-(cyclohexylmethyl)pyridin-2-yl]carbonyl}amino)benzoic acid, ...
Authors:Baharuddin, A.
Deposit date:2010-06-17
Release date:2011-08-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzyme inhibition by allosteric capture of an inactive conformation.
J.Mol.Biol., 411, 2011
1JCU
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SOLUTION STRUCTURE OF MTH1692 PROTEIN FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor:conserved protein MTH1692
Authors:Kozlov, G., Ekiel, I., Gehring, K.
Deposit date:2001-06-11
Release date:2002-07-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JDQ
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SOLUTION STRUCTURE OF TM006 PROTEIN FROM THERMOTOGA MARITIMA
Descriptor:HYPOTHETICAL PROTEIN TM0983
Authors:Denisov, A.Y., Finak, G., Yee, A., Kozlov, G., Gehring, K., Arrowsmith, C.H.
Deposit date:2001-06-14
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JE3
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SOLUTION STRUCTURE OF EC005 FROM ESCHERICHIA COLI
Descriptor:HYPOTHETICAL 8.6 KDA PROTEIN IN AMYA-FLIE INTERGENIC REGION
Authors:Yee, A., Gutierrez, P., Kozlov, G., Denisov, A., Gehring, K., Arrowsmith, C.
Deposit date:2001-06-15
Release date:2002-03-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JRM
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NMR STRUCTURE OF MTH0637. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET MTH0637_1_104; NORTHEAST STRUCTURAL GENOMICS TARGET TT135
Descriptor:CONSERVED HYPOTHETICAL PROTEIN mth637
Authors:Pineda-Lucena, A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-08-14
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JW2
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SOLUTION STRUCTURE OF HEMOLYSIN EXPRESSION MODULATING PROTEIN HHA FROM ESCHERICHIA COLI. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET EC0308_1_72; NORTHEAST STRUCTURAL GENOMICS TARGET ET88
Descriptor:HEMOLYSIN EXPRESSION MODULATING PROTEIN Hha
Authors:Chang, X., Yee, A., Savchenko, A., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-09-02
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics
Proc.Natl.Acad.Sci.USA, 99, 2002
1JW3
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SOLUTION STRUCTURE OF METHANOBACTERIUM THERMOAUTOTROPHICUM PROTEIN 1598. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET MTH1598_1_140; NORTHEAST STRUCTURAL GENOMICS TARGET TT6
Descriptor:Conserved Hypothetical Protein MTH1598
Authors:Chang, X., Connelly, G., Yee, A., Kennedy, M.A., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-09-02
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
4P2T
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CRYSTAL STRUCTURE OF KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) PROTEASE IN COMPLEX WITH A DIMER DISRUPTOR
Descriptor:KSHV Protease, 6-(cyclohexylmethyl)-N-[4-(methylsulfonylcarbamoyl)-2-(phenylmethyl)phenyl]pyridine-2-carboxamide, DIMETHYL SULFOXIDE
Authors:Gable, J.E.
Deposit date:2014-03-04
Release date:2014-07-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Broad-spectrum allosteric inhibition of herpesvirus proteases.
Biochemistry, 53, 2014
4P3H
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CRYSTAL STRUCTURE OF KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) PROTEASE IN COMPLEX WITH DIMER DISRUPTOR
Descriptor:KSHV protease, N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide, GLYCEROL, ...
Authors:Gable, J.E.
Deposit date:2014-03-07
Release date:2014-07-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Broad-spectrum allosteric inhibition of herpesvirus proteases.
Biochemistry, 53, 2014
4W5B
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CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN WITH FRAGMENT 1 (N-(1H-BENZIMIDAZOL-2-YL)-1,3-DIMETHYL-PYRAZOLE-4-CARBOXAMIDE)
Descriptor:Cruzipain, N-(1H-benzimidazol-2-yl)-1,3-dimethyl-1H-pyrazole-4-carboxamide
Authors:Tochowicz, A., McKerrow, J.H., Craik, C.S.
Deposit date:2014-08-17
Release date:2015-03-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Applying Fragments Based- Drug Design to identify multiple binding modes on cysteine protease.
To Be Published
4W5C
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CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN WITH THREE FRAGMENTS: 1 (N-(1H-BENZIMIDAZOL-2-YL)-1,3-DIMETHYL-PYRAZOLE-4-CARBOXAMIDE), 6 (2-AMINO-4,6-DIFLUOROBENZOTHIAZOLE) AND 9 (N-(1H-BENZIMIDAZOL-2-YL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE).
Descriptor:Cruzipain, N-(1H-benzimidazol-2-yl)-1,3-dimethyl-1H-pyrazole-4-carboxamide, N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-pyrazole-4-carboxamide, ...
Authors:Tochowicz, A., McKerrow, J.H., Craik, C.S.
Deposit date:2014-08-17
Release date:2015-04-08
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Applying Fragments Based- Drug Design to identify multiple binding modes on cysteine protease.
To Be Published
1JJG
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SOLUTION STRUCTURE OF MYXOMA VIRUS PROTEIN M156R
Descriptor:M156R
Authors:Ramelot, T.A., Cort, J.R., Yee, A.A., Arrowsmith, C.H., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-07-05
Release date:2002-03-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha.
J.Mol.Biol., 322, 2002