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6DCN
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BU of 6dcn by Molmil
Bcl-xL complex with Beclin 1 BH3 domain T108pThr
Descriptor: BCL-xl protein, Beclin-1
Authors:Lee, E.F, Smith, B.J, Smith, N.A, Yao, S, Fairlie, W.D.
Deposit date:2018-05-07
Release date:2018-05-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.444 Å)
Cite:Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Autophagy, 15, 2019
6DCO
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BU of 6dco by Molmil
Bcl-xL complex with Beclin 1 BH3 domain T108D
Descriptor: Bcl-2-like protein 1,Bcl-2-like protein 1, Beclin-1, CHLORIDE ION
Authors:Lee, E.F, Smith, B.J, Smith, N.A, Yao, S, Fairlie, W.D.
Deposit date:2018-05-07
Release date:2018-05-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1.
Autophagy, 15, 2019
2YJ1
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BU of 2yj1 by Molmil
Puma BH3 foldamer in complex with Bcl-xL
Descriptor: ALPHA-BETA-PUMA BH3 FOLDAMER, BCL-2-LIKE PROTEIN 1
Authors:Lee, E.F, Smith, B.J, Horne, W.S, Mayer, K.N, Evangelista, M, Colman, P.M, Gellman, S.H, Fairlie, W.D.
Deposit date:2011-05-18
Release date:2011-10-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural Basis of Bcl-Xl Recognition by a Bh3-Mimetic Alpha-Beta-Peptide Generated Via Sequence-Based Design
Chembiochem, 12, 2011
2Y6W
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BU of 2y6w by Molmil
Structure of a Bcl-w dimer
Descriptor: BCL-2-LIKE PROTEIN 2, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL
Authors:Lee, E.F, Evangelista, M, Pettikiriarachchi, A, Dogovski, C, Perugini, M.A, Colman, P.M, Fairlie, W.D.
Deposit date:2011-01-27
Release date:2011-10-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a Bcl-W Domain-Swapped Dimer: Implications for the Function of Bcl-2 Family Proteins.
Structure, 19, 2011
3D7V
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BU of 3d7v by Molmil
Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand
Descriptor: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Lee, E.F, Czabotar, P.E, Colman, P.M, Fairlie, W.D.
Deposit date:2008-05-22
Release date:2008-06-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
5VAY
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BU of 5vay by Molmil
Bcl-2 complex with Beclin 1 T108D BH3 domain
Descriptor: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1
Authors:Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D.
Deposit date:2017-03-28
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:Bcl-2 complex with Beclin 1 pT108 BH3 domain
To Be Published
5VAX
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BU of 5vax by Molmil
Bcl-2 complex with Beclin 1 BH3 domain
Descriptor: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1
Authors:Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D.
Deposit date:2017-03-28
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bcl-2 complex with Beclin 1 pT108 BH3 domain
To Be Published
5VAU
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BU of 5vau by Molmil
Bcl-2 complex with Beclin 1 BH3 domain
Descriptor: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1
Authors:Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D.
Deposit date:2017-03-28
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.754 Å)
Cite:Bcl-2 complex with Beclin 1 BH3 domain
To Be Published
3QBR
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BU of 3qbr by Molmil
BakBH3 in complex with sjA
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Bcl-2 homologous antagonist/killer, SJCHGC06286 protein
Authors:Lee, E.F, Clarke, O.B, Fairlie, W.D, Colman, P.M, Evangelista, M, Feng, Z, Speed, T.P, Tchoubrieva, E, Strasser, A, Kalinna, B.
Deposit date:2011-01-13
Release date:2011-04-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proc.Natl.Acad.Sci.USA, 108, 2011
4CIN
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BU of 4cin by Molmil
Complex of Bcl-xL with its BH3 domain
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BCL-2-LIKE PROTEIN 1, ...
Authors:Colman, P.M, Lee, E.F, Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
4CIM
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BU of 4cim by Molmil
Complex of a Bcl-w BH3 mutant with a BH3 domain
Descriptor: 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 2
Authors:Colman, P.M, Lee, E.F, Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
2YXJ
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BU of 2yxj by Molmil
Crystal structure of Bcl-xL in complex with ABT-737
Descriptor: 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, Apoptosis regulator Bcl-X, CHLORIDE ION, ...
Authors:Czabotar, P.E, Lee, E.F, Smith, B.J, Deshayes, K, Zobel, K, Fairlie, W.D, Colman, P.M.
Deposit date:2007-04-26
Release date:2007-05-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family
Cell Death Differ., 14, 2007
5FMJ
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BU of 5fmj by Molmil
Bcl-xL with mouse Bak BH3 Q75L complex
Descriptor: 1,2-ETHANEDIOL, BAK1 PROTEIN, BCL-2-LIKE PROTEIN 1
Authors:Fairlie, W.D, Lee, E.F, Smith, B.J.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
5FMI
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BU of 5fmi by Molmil
Human Bak Q77L
Descriptor: BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, ZINC ION
Authors:Fairlie, W.D, Lee, E.F, Smith, B.J.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
5FMK
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BU of 5fmk by Molmil
Bcl-xL with Bak BH3 complex
Descriptor: BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, BCL-XL, GLYCEROL
Authors:Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M.
Deposit date:2015-11-06
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.731 Å)
Cite:Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
3INQ
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BU of 3inq by Molmil
Crystal structure of BCL-XL in complex with W1191542
Descriptor: 1,2-ETHANEDIOL, 4-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}benzamide, Bcl-2-like protein 1, ...
Authors:Fairlie, W.D, Smith, B.J, Colman, P.M, Czabotar, P.E, Lee, E.F.
Deposit date:2009-08-12
Release date:2009-09-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands
J. Biol. Chem., 284, 2009
3IO8
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BU of 3io8 by Molmil
BimL12F in complex with Bcl-xL
Descriptor: Bcl-2-like protein 1, Bcl-2-like protein 11, ZINC ION
Authors:Colman, P.M, Lee, E.F, Fairlie, W.D, Smith, B.J, Czabotar, P.E, Yang, H, Sleebs, B.E, Lessene, G.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
3IO9
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BU of 3io9 by Molmil
BimL12Y in complex with Mcl-1
Descriptor: Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Czabotar, P.E, Lee, E.F, Yang, H, Sleebs, B.E, Lessene, G, Colman, P.M, Smith, B.J, Fairlie, W.D.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
3FDL
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BU of 3fdl by Molmil
Bim BH3 peptide in complex with Bcl-xL
Descriptor: Apoptosis regulator Bcl-X, Bcl-2-like protein 11
Authors:Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M.
Deposit date:2008-11-26
Release date:2009-03-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
3FDM
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BU of 3fdm by Molmil
alpha/beta foldamer in complex with Bcl-xL
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator Bcl-X, alpha/beta-peptide foldamer
Authors:Fairlie, W.D, Lee, E.F, Smith, B.J, Czabotar, P.E, Colman, P.M, Sadowsky, J.D, Peterson-Kaufman, K.J, Gellman, S.H.
Deposit date:2008-11-26
Release date:2009-03-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Angew.Chem.Int.Ed.Engl., 48, 2009
6V4M
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BU of 6v4m by Molmil
Trichuris suis BCL-2
Descriptor: BCL-2, CHLORIDE ION, SULFATE ION
Authors:Fairlie, W.D, Lee, E.F, Smith, B.J.
Deposit date:2019-11-28
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Diversity in the intrinsic apoptosis pathway of nematodes.
Commun Biol, 3, 2020
7JGV
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BU of 7jgv by Molmil
CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH COMPOUND 1620116, CRYSTAL FORM 2
Descriptor: 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1
Authors:Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F.
Deposit date:2020-07-19
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Acs Infect Dis., 7, 2021
7JGW
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BU of 7jgw by Molmil
Crystal structure of BCL-XL in complex with COMPOUND 1620116, CRYSTAL FORM 1
Descriptor: 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1
Authors:Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F.
Deposit date:2020-07-19
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Acs Infect Dis., 7, 2021
7JMT
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BU of 7jmt by Molmil
Crystal structure of schistosome BCL-2 bound to ABT-737
Descriptor: 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, BCL-2 protein
Authors:Smith, N.A, Smith, B.J, Lee, E.F, Colman, P.M, Fairlie, W.D.
Deposit date:2020-08-02
Release date:2021-02-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Acs Infect Dis., 7, 2021
4A1U
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BU of 4a1u by Molmil
Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL
Descriptor: ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ...
Authors:Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D.
Deposit date:2011-09-20
Release date:2011-12-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012

 

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