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4WVP
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BU of 4wvp by Molmil
Crystal structure of an activity-based probe HNE complex
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BTN-3V3-NLB-OMT-OIC-3V2, ...
Authors:Lechtenberg, B.C, Kasperkiewicz, P, Robinson, H.R, Drag, M, Riedl, S.J.
Deposit date:2014-11-06
Release date:2015-02-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:The Elastase-PK101 Structure: Mechanism of an Ultrasensitive Activity-based Probe Revealed.
Acs Chem.Biol., 10, 2015
2W0T
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BU of 2w0t by Molmil
Solution structure of the FCS zinc finger domain of human LMBL2
Descriptor: LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE 2 PROTEIN, ZINC ION
Authors:Lechtenberg, B.C, Allen, M.D, Bycroft, M.
Deposit date:2008-10-10
Release date:2009-01-20
Last modified:2017-04-19
Method:SOLUTION NMR
Cite:Solution Structure of the Fcs Zinc Finger Domain of the Human Polycomb Group Protein L(3)Mbt-Like 2.
Protein Sci., 18, 2009
5EDV
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BU of 5edv by Molmil
Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex
Descriptor: E3 ubiquitin-protein ligase RNF31, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ...
Authors:Lechtenberg, B.C, Mace, P.D, Sanishvili, R, Riedl, S.J.
Deposit date:2015-10-22
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.
Nature, 529, 2016
5V60
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BU of 5v60 by Molmil
Phospho-ERK2 bound to AMP-PCP
Descriptor: GLYCEROL, MAGNESIUM ION, Mitogen-activated protein kinase 1, ...
Authors:Lechtenberg, B.C, Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
5V61
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BU of 5v61 by Molmil
Phospho-ERK2 bound to bivalent inhibitor SBP2
Descriptor: 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, ...
Authors:Lechtenberg, B.C, Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
5V62
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BU of 5v62 by Molmil
Phospho-ERK2 bound to bivalent inhibitor SBP3
Descriptor: 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, Mitogen-activated protein kinase 1, ...
Authors:Lechtenberg, B.C, Riedl, S.J.
Deposit date:2017-03-15
Release date:2017-07-26
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
4BXS
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BU of 4bxs by Molmil
Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A.
Deposit date:2013-07-15
Release date:2013-07-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
4BXW
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BU of 4bxw by Molmil
Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis
Descriptor: COAGULATION FACTOR V, FACTOR XA, GLYCEROL, ...
Authors:Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A.
Deposit date:2013-07-16
Release date:2013-07-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
4CH2
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BU of 4ch2 by Molmil
Low-salt crystal structure of a thrombin-GpIbalpha peptide complex
Descriptor: D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, GLYCEROL, PLATELET GLYCOPROTEIN IB ALPHA CHAIN, ...
Authors:Lechtenberg, B.C, Freund, S.M.V, Huntington, J.A.
Deposit date:2013-11-28
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Gpibalpha Interacts Exclusively with Exosite II of Thrombin
J.Mol.Biol., 426, 2014
4CH8
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BU of 4ch8 by Molmil
High-salt crystal structure of a thrombin-GpIbalpha peptide complex
Descriptor: D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, GLYCEROL, PLATELET GLYCOPROTEIN IB ALPHA CHAIN, ...
Authors:Lechtenberg, B.C, Freund, S.M.V, Huntington, J.A.
Deposit date:2013-11-29
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Gpibalpha Interacts Exclusively with Exosite II of Thrombin
J.Mol.Biol., 426, 2014
7KJC
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BU of 7kjc by Molmil
Crystal structure of the EphA2 S901E mutant intracellular KD-SAM domains
Descriptor: Ephrin type-A receptor 2, GLYCEROL, MAGNESIUM ION, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2020-10-26
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
Nat Commun, 12, 2021
7KJB
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BU of 7kjb by Molmil
Crystal structure of the EphA2 S897E/S901E mutant intracellular KD-SAM domains
Descriptor: CESIUM ION, Ephrin type-A receptor 2
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2020-10-26
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
Nat Commun, 12, 2021
7KJA
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BU of 7kja by Molmil
Crystal structure of the EphA2 intracellular KD-SAM domains
Descriptor: Ephrin type-A receptor 2, GLYCEROL, MAGNESIUM ION, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2020-10-26
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.
Nat Commun, 12, 2021
5JR2
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BU of 5jr2 by Molmil
Crystal structure of the EphA4 LBD in complex with APYd3 peptide inhibitor
Descriptor: APYd3 peptide, Ephrin type-A receptor 4, GLYCEROL, ...
Authors:Lechtenberg, B.C, Olson, E.J, Pasquale, E.B, Dawson, P.E, Riedl, S.J.
Deposit date:2016-05-05
Release date:2016-07-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability.
Acs Med.Chem.Lett., 7, 2016
6O5E
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BU of 6o5e by Molmil
Crystal structure of the Vitronectin hemopexin-like domain
Descriptor: CHLORIDE ION, IMIDAZOLE, NITRATE ION, ...
Authors:Lechtenberg, B.C, Shin, K, Marassi, F.M.
Deposit date:2019-03-01
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of human Vitronectin C-terminal domain and interaction withYersinia pestisouter membrane protein Ail.
Sci Adv, 5, 2019
4W50
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BU of 4w50 by Molmil
Structure of the EphA4 LBD in complex with peptide
Descriptor: 1,3-BUTANEDIOL, APY peptide, Ephrin type-A receptor 4, ...
Authors:Lechtenberg, B.C, Mace, P.D, Riedl, S.J.
Deposit date:2014-08-16
Release date:2014-10-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
4W4Z
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BU of 4w4z by Molmil
Structure of the EphA4 LBD in complex with peptide
Descriptor: APY-bAla8.am peptide, Ephrin type-A receptor 4, GLYCEROL, ...
Authors:Lechtenberg, B.C, Mace, P.D, Riedl, S.J.
Deposit date:2014-08-15
Release date:2014-10-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
6NK0
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BU of 6nk0 by Molmil
EphA2 LBD in complex with bA-WLA-Yam peptide
Descriptor: 1,2-ETHANEDIOL, 6-AMINOHEXANOIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NKP
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BU of 6nkp by Molmil
EphA2 LBD in complex with bA-WLA-YSKbio peptide
Descriptor: BIOTIN, Ephrin type-A receptor 2, bA-WLA-YSKbio peptide
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-07
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.033 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NJZ
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BU of 6njz by Molmil
EphA2 LBD in complex with YSA-GSGSK-bio peptide
Descriptor: BIOTIN, Ephrin type-A receptor 2, GLYCEROL, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NK1
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BU of 6nk1 by Molmil
EphA2 LBD in complex with bA-WLA-YRPKbio peptide
Descriptor: ACETATE ION, Ephrin type-A receptor 2, GLYCEROL, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NK2
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BU of 6nk2 by Molmil
EphA2 LBD in complex with bA-WLA-YRPK bio peptide
Descriptor: DI(HYDROXYETHYL)ETHER, Ephrin type-A receptor 2, bA-WLA-YPRKbio peptide
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
7M4O
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BU of 7m4o by Molmil
Crystal structure of phosphorylated RBR E3 ligase RNF216 in complex with K63-linked di-ubiquitin
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, E3 ubiquitin-protein ligase RNF216, GLYCEROL, ...
Authors:Cotton, T.R, Lechtenberg, B.C.
Deposit date:2021-03-21
Release date:2022-01-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
Mol.Cell, 82, 2022
8EAZ
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BU of 8eaz by Molmil
HOIL-1/E2-Ub/Ub transthiolation complex
Descriptor: RanBP-type and C3HC4-type zinc finger-containing protein 1, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ...
Authors:Wang, X.S, Cotton, T.R, Lechtenberg, B.C.
Deposit date:2022-08-30
Release date:2023-01-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family.
Nat Commun, 14, 2023
8EB0
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BU of 8eb0 by Molmil
RNF216/E2-Ub/Ub transthiolation complex
Descriptor: E3 ubiquitin-protein ligase RNF216, SULFATE ION, Ubiquitin, ...
Authors:Cotton, T.R, Wang, X.S, Lechtenberg, B.C.
Deposit date:2022-08-30
Release date:2023-01-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family.
Nat Commun, 14, 2023

 

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