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1VYW
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STRUCTURE OF CDK2/CYCLIN A WITH PNU-292137
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, SULFATE ION, ...
Authors:Pevarello, P., Brasca, M.G., Amici, R., Orsini, P., Traquandi, G., Corti, L., Piutti, C., Sansonna, P., Villa, M., Pierce, B.S., Pulici, M., Giordano, P., Martina, K., Fritzen, E.L., Nugent, R.A., Casale, E., Cameron, A., Ciomei, M., Roletto, F., Isacchi, A., Fogliatto, G., Pesenti, E., Pastori, W., Marsiglio, A., Leach, K.L., Clare, P.M., Fiorentini, F., Varasi, M., Vulpetti, A., Warpehoski, M.A.
Deposit date:2004-05-07
Release date:2004-06-10
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:3-Aminopyrazole Inhibitors of Cdk2/Cyclin a as Antitumor Agents. Part 1. Lead Finding
J.Med.Chem., 47, 2004
1VYZ
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STRUCTURE OF CDK2 COMPLEXED WITH PNU-181227
Descriptor:CELL DIVISION PROTEIN KINASE 2, N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)BENZAMIDE
Authors:Pevarello, P., Brasca, M.G., Amici, R., Orsini, P., Traquandi, G., Corti, L., Piutti, C., Sansonna, P., Villa, M., Pierce, B.S., Pulici, M., Giordano, G., Martina, K., Lfritzen, E., Nugent, R.A., Casale, E., Cameron, A., Ciomei, M., Roletto, F., Isacchi, A., Fogliatto, G., Pesenti, E., Pastori, W., Marsiglio, W., Leach, K.L., Clare, P.M., Fiorentini, F., Varasi, M., Vulpetti, A., Warpehoski, M.A.
Deposit date:2004-05-07
Release date:2004-06-17
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:3-Aminopyrazole Inhibitors of Cdk2/Cyclin a as Antitumor Agents. 1. Lead Finding
J.Med.Chem., 47, 2004
1JSV
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THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH 4-[(6-AMINO-4-PYRIMIDINYL)AMINO]BENZENESULFONAMIDE
Descriptor:CELL DIVISION PROTEIN KINASE 2, 4-[(6-AMINO-4-PYRIMIDINYL)AMINO]BENZENESULFONAMIDE
Authors:Watenpaugh, K.D., Kelley, L.C.
Deposit date:2001-08-19
Release date:2001-08-29
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism
J.Biol.Chem., 276, 2001
3U1Y
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POTENT INHIBITORS OF LPXC FOR THE TREATMENT OF GRAM-NEGATIVE INFECTIONS
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide
Authors:Brown, M., Abramite, J., Liu, S.
Deposit date:2011-09-30
Release date:2012-01-04
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Potent inhibitors of LpxC for the treatment of Gram-negative infections.
J.Med.Chem., 55, 2012
3UHM
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UDP-3-O-[3-HYDROXYMYRISTOYL] N-ACETYLGLUCOSAMINE DEACETYLASE IN COMPLEX WITH INHIBITOR
Descriptor:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide, ...
Authors:Montgomery, J., Liu, S.
Deposit date:2011-11-03
Release date:2012-02-01
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.
J.Med.Chem., 55, 2012