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2GDO
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BU of 2gdo by Molmil
4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors
Descriptor: 4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE, SULFATE ION, Serine/threonine-protein kinase Chk1
Authors:Le, V, Dove, J, Fang, E, Bussiere, D.E.
Deposit date:2006-03-16
Release date:2007-03-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
1B9F
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BU of 1b9f by Molmil
MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
Descriptor: CACODYLATE ION, PROTEIN (INTEGRASE), SULFATE ION
Authors:Greenwald, J, Le, V, Butler, S.L, Bushman, F.D, Choe, S.
Deposit date:1999-02-11
Release date:1999-07-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
Biochemistry, 38, 1999
1B92
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BU of 1b92 by Molmil
MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
Descriptor: CACODYLATE ION, PROTEIN (INTEGRASE), SULFATE ION
Authors:Greenwald, J, Le, V, Butler, S.L, Bushman, F.D, Choe, S.
Deposit date:1999-02-19
Release date:1999-07-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
Biochemistry, 38, 1999
1B9D
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BU of 1b9d by Molmil
MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
Descriptor: CACODYLATE ION, PROTEIN (INTEGRASE), SULFATE ION
Authors:Greenwald, J, Le, V, Butler, S.L, Bushman, F.D, Choe, S.
Deposit date:1999-02-11
Release date:1999-07-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
Biochemistry, 38, 1999
6VFM
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BU of 6vfm by Molmil
Crystal structure of SpeG allosteric polyamine acetyltransferase from Bacillus thuringiensis
Descriptor: Spermidine N1-acetyltransferase
Authors:Tsimbalyuk, S, Shornikov, A, Le, V.T.B, Kuhn, M.L, Forwood, J.K.
Deposit date:2020-01-05
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:SpeG polyamine acetyltransferase enzyme from Bacillus thuringiensis forms a dodecameric structure and exhibits high catalytic efficiency.
J.Struct.Biol., 210, 2020
6VFN
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BU of 6vfn by Molmil
Crystal structure of SpeG allosteric polyamine acetyltransferase from Bacillus thuringiensis in complex with spermine
Descriptor: SPERMINE, Spermidine N1-acetyltransferase
Authors:Tsimbalyuk, S, Shornikov, A, Le, V.T.B, Kuhn, M.L, Forwood, J.K.
Deposit date:2020-01-05
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:SpeG polyamine acetyltransferase enzyme from Bacillus thuringiensis forms a dodecameric structure and exhibits high catalytic efficiency.
J.Struct.Biol., 210, 2020
4YCG
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BU of 4ycg by Molmil
Pro-bone morphogenetic protein 9
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone Morphogenetic Protein 9 Growth Factor Domain, Bone Morphogenetic Protein 9 Prodomain, ...
Authors:Mi, L.-Z, Brown, C.T, Gao, Y, Tian, Y, Le, V, Walz, T, Springer, T.A.
Deposit date:2015-02-20
Release date:2015-03-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of bone morphogenetic protein 9 procomplex.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YCI
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BU of 4yci by Molmil
non-latent pro-bone morphogenetic protein 9
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone Morphogenetic Protein 9 Growth Factor Domain, ...
Authors:Mi, L.Z, Brown, C.T, Gao, Y, Tian, Y, Le, V, Walz, T, Springer, T.A.
Deposit date:2015-02-20
Release date:2015-03-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of bone morphogenetic protein 9 procomplex.
Proc.Natl.Acad.Sci.USA, 112, 2015
4N6Z
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BU of 4n6z by Molmil
Pim1 Complexed with a pyridylcarboxamide
Descriptor: 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}pyrazine-2-carboxamide, GLYCEROL, Serine/threonine-protein kinase pim-1
Authors:Bellamacina, C.R, Le, V, Shu, W, Burger, M.T, Bussiere, D.
Deposit date:2013-10-14
Release date:2013-11-06
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
ACS Med Chem Lett, 4, 2013
4N70
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BU of 4n70 by Molmil
Pim1 Complexed with a pyridylcarboxamide
Descriptor: N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, Serine/threonine-protein kinase pim-1
Authors:Bellamacina, C.R, Le, V, Shu, W, Burger, M.T, Bussiere, D.
Deposit date:2013-10-14
Release date:2013-11-06
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
ACS Med Chem Lett, 4, 2013
4N6Y
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BU of 4n6y by Molmil
Pim1 Complexed with a phenylcarboxamide
Descriptor: 2-(acetylamino)-N-[2-(piperidin-1-yl)phenyl]-1,3-thiazole-4-carboxamide, Serine/threonine-protein kinase pim-1
Authors:Bellamacina, C.R, Le, V, Shu, W, Burger, M.T, Bussiere, D.
Deposit date:2013-10-14
Release date:2013-11-06
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
ACS Med Chem Lett, 4, 2013
3T9I
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BU of 3t9i by Molmil
Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution
Descriptor: 2-methoxy-4-(3-phenyl-2H-pyrazolo[3,4-b]pyridin-6-yl)phenol, Proto-oncogene serine/threonine-protein kinase pim-1
Authors:Bellamacina, C, Shu, W, Le, V, Nishiguchi, G, Bussiere, D.
Deposit date:2011-08-02
Release date:2011-10-12
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases.
Bioorg.Med.Chem.Lett., 21, 2011
3K3B
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BU of 3k3b by Molmil
Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline
Descriptor: 3-[(1R)-2-acetyl-6-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl]phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Bussiere, D.E, Bellamacina, C, Le, V.
Deposit date:2009-10-02
Release date:2009-12-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
Bioorg.Med.Chem.Lett., 20, 2010

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