Author results

2GDO
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4-(AMINOALKYLAMINO)-3-BENZIMIDAZOLE-QUINOLINONES AS POTENT CHK1 INHIBITORS
Descriptor:Serine/threonine-protein kinase Chk1, SULFATE ION, 4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE
Authors:Le, V., Dove, J., Fang, E., Bussiere, D.E.
Deposit date:2006-03-16
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
1B92
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MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
Descriptor:PROTEIN (INTEGRASE), CACODYLATE ION, SULFATE ION
Authors:Greenwald, J., Le, V., Butler, S.L., Bushman, F.D., Choe, S.
Deposit date:1999-02-19
Release date:1999-07-19
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
Biochemistry, 38, 1999
1B9D
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MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
Descriptor:PROTEIN (INTEGRASE), CACODYLATE ION, SULFATE ION
Authors:Greenwald, J., Le, V., Butler, S.L., Bushman, F.D., Choe, S.
Deposit date:1999-02-11
Release date:1999-07-19
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
Biochemistry, 38, 1999
1B9F
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MOBILITY OF AN HIV-1 INTEGRASE ACTIVE SITE LOOP IS CORRELATED WITH CATALYTIC ACTIVITY
Descriptor:PROTEIN (INTEGRASE), CACODYLATE ION, SULFATE ION
Authors:Greenwald, J., Le, V., Butler, S.L., Bushman, F.D., Choe, S.
Deposit date:1999-02-11
Release date:1999-07-19
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity.
Biochemistry, 38, 1999
4YCG
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PRO-BONE MORPHOGENETIC PROTEIN 9
Descriptor:Bone Morphogenetic Protein 9 Growth Factor Domain, Bone Morphogenetic Protein 9 Prodomain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mi, L.-Z., Brown, C.T., Gao, Y., Tian, Y., Le, V., Walz, T., Springer, T.A.
Deposit date:2015-02-20
Release date:2015-03-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of bone morphogenetic protein 9 procomplex.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YCI
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NON-LATENT PRO-BONE MORPHOGENETIC PROTEIN 9
Descriptor:Bone Morphogenetic Protein 9 Growth Factor Domain, Bone Morphogenetic Protein 9 Prodomain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mi, L.Z., Brown, C.T., Gao, Y., Tian, Y., Le, V., Walz, T., Springer, T.A.
Deposit date:2015-02-20
Release date:2015-03-04
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of bone morphogenetic protein 9 procomplex.
Proc.Natl.Acad.Sci.USA, 112, 2015
4N6Y
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PIM1 COMPLEXED WITH A PHENYLCARBOXAMIDE
Descriptor:Serine/threonine-protein kinase pim-1, 2-(acetylamino)-N-[2-(piperidin-1-yl)phenyl]-1,3-thiazole-4-carboxamide
Authors:Bellamacina, C.R., Le, V., Shu, W., Burger, M.T., Bussiere, D.
Deposit date:2013-10-14
Release date:2013-11-06
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
ACS Med Chem Lett, 4, 2013
4N6Z
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PIM1 COMPLEXED WITH A PYRIDYLCARBOXAMIDE
Descriptor:Serine/threonine-protein kinase pim-1, 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]pyridin-3-yl}pyrazine-2-carboxamide, GLYCEROL
Authors:Bellamacina, C.R., Le, V., Shu, W., Burger, M.T., Bussiere, D.
Deposit date:2013-10-14
Release date:2013-11-06
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
ACS Med Chem Lett, 4, 2013
4N70
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PIM1 COMPLEXED WITH A PYRIDYLCARBOXAMIDE
Descriptor:Serine/threonine-protein kinase pim-1, N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
Authors:Bellamacina, C.R., Le, V., Shu, W., Burger, M.T., Bussiere, D.
Deposit date:2013-10-14
Release date:2013-11-06
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
ACS Med Chem Lett, 4, 2013
3K3B
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CO-CRYSTAL STRUCTURE OF THE HUMAN KINESIN EG5 WITH A NOVEL TETRAHYDRO-BETA-CARBOLINE
Descriptor:Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Bussiere, D.E., Bellamacina, C., Le, V.
Deposit date:2009-10-02
Release date:2009-12-15
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
Bioorg.Med.Chem.Lett., 20, 2010
3T9I
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PIM1 COMPLEXED WITH A NOVEL 3,6-DISUBSTITUTED INDOLE AT 2.6 ANG RESOLUTION
Descriptor:Proto-oncogene serine/threonine-protein kinase pim-1, 2-methoxy-4-(3-phenyl-2H-pyrazolo[3,4-b]pyridin-6-yl)phenol
Authors:Bellamacina, C., Shu, W., Le, V., Nishiguchi, G., Bussiere, D.
Deposit date:2011-08-02
Release date:2011-10-12
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases.
Bioorg.Med.Chem.Lett., 21, 2011