Author results

4ZLV
  • Download 4zlv
  • View 4zlv
Molmil generated image of 4zlv
CRYSTAL STRUCTURE OF THE ORNITHINE AMINOTRANSFERASE FROM TOXOPLASMA GONDII ME49 IN A COMPLEX WITH THE SCHIFF BASE BETWEEN PLP AND LYS286
分子名称:Ornithine aminotransferase, mitochondrial, putative, ...
著者Filippova, E.V., Minasov, G., Flores, K., Van Le, H., Silverman, R.B., McLeod, R., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2015-05-01
公開日2015-05-20
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49 in a complex with the Schiff base between PLP and Lys286
To Be Published
4ZWM
  • Download 4zwm
  • View 4zwm
Molmil generated image of 4zwm
2.3 A RESOLUTION CRYSTAL STRUCTURE OF THE ORNITHINE AMINOTRANSFERASE FROM TOXOPLASMA GONDII ME49
分子名称:Ornithine aminotransferase, mitochondrial, putative, ...
著者Filippova, E.V., Minasov, G., Flores, K., Van Le, H., Silverman, R.B., McLeod, R., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2015-05-19
公開日2015-06-03
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献2.3 A resolution crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49
To Be Published
6MI6
  • Download 6mi6
  • View 6mi6
Molmil generated image of 6mi6
STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH AN ADP ANALOG
分子名称:Chemotaxis protein CheA, SULFATE ION, 5'-O-[(S)-hydroxy{[(S)-hydroxy{[(1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]disulfanyl}phosphoryl]oxy}phosphoryl]adenosine, ...
著者Crane, B.R., Muok, A.R., Chua, T.K., Le, H.
登録日2018-09-19
公開日2018-12-05
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Nucleotide spin-labeling for ESR spectroscopy of ATP-binding proteins
Appl.Magn.Reson., 49, 2018
3D85
  • Download 3d85
  • View 3d85
Molmil generated image of 3d85
CRYSTAL STRUCTURE OF IL-23 IN COMPLEX WITH NEUTRALIZING FAB
分子名称:FAB of antibody 7G10, light chain, heavy chain, ...
著者Beyer, B.M., Ingram, R., Ramanathan, L., Reichert, P., Le, H., Madison, V.
登録日2008-05-22
公開日2008-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
J.Mol.Biol., 382, 2008
3D87
  • Download 3d87
  • View 3d87
Molmil generated image of 3d87
CRYSTAL STRUCTURE OF INTERLEUKIN-23
分子名称:Interleukin-23 subunit p19, Interleukin-12 subunit p40, PHOSPHATE ION, ...
著者Beyer, B.M., Ingram, R., Ramanathan, L., Reichert, P., Le, H., Madison, V.
登録日2008-05-22
公開日2008-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
J.Mol.Biol., 382, 2008
5VWO
  • Download 5vwo
  • View 5vwo
Molmil generated image of 5vwo
ORNITHINE AMINOTRANSFERASE INACTIVATED BY (1R,3S,4S)-3-AMINO-4-FLUOROCYCLOPENTANE-1-CARBOXYLIC ACID (FCP)
分子名称:Ornithine aminotransferase, mitochondrial, (1S,3S,4E)-3-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-4-iminocyclopentane-1-carboxylic acid
著者Mascarenhas, R., Liu, D., Le, H., Silverman, R.
登録日2017-05-22
公開日2017-08-30
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.773 Å)
主引用文献Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.
Biochemistry, 56, 2017
5VWR
  • Download 5vwr
  • View 5vwr
Molmil generated image of 5vwr
E.COLI ASPARTATE AMINOTRANSFERASE-(1R,3S,4S)-3-AMINO-4-FLUOROCYCLOPENTANE-1-CARBOXYLIC ACID (FCP)-ALPHA-KETOGLUTARATE
分子名称:Aspartate aminotransferase, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-glutamic acid, GLYCEROL
著者Mascarenhas, R., Liu, D., Le, H., Silverman, R.
登録日2017-05-22
公開日2017-09-13
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.
Biochemistry, 56, 2017
6G4Z
  • Download 6g4z
  • View 6g4z
Molmil generated image of 6g4z
CRYSTAL STRUCTURE OF MURINE NF-KAPPAB INDUCING KINASE (NIK) IN COMPLEX WITH COMPOUND 2F
分子名称:Mitogen-activated protein kinase kinase kinase 14, 5-fluoranyl-1-[4-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrol-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide
著者Leonardo-Silvestre, H., McEwan, P.A., Hymowitz, S.G.
登録日2018-03-28
公開日2018-07-04
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase.
J. Med. Chem., 61, 2018
3FMZ
  • Download 3fmz
  • View 3fmz
Molmil generated image of 3fmz
CRYSTAL STRUCTURE OF RETINOL-BINDING PROTEIN 4 (RBP4) IN COMPLEX WITH NON-RETINOID LIGAND
分子名称:Retinol-binding protein 4, 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid
著者Wang, Z., Johnstone, S., Walker, N.P.
登録日2008-12-22
公開日2009-01-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo.
J.Biol.Chem., 284, 2009
4JI9
  • Download 4ji9
  • View 4ji9
Molmil generated image of 4ji9
JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH TG101209
分子名称:Tyrosine-protein kinase JAK2, N-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide
著者Eigenbrot, C., Ultsch, M.
登録日2013-03-05
公開日2013-08-07
最終更新日2013-08-21
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4JIA
  • Download 4jia
  • View 4jia
Molmil generated image of 4jia
JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 9
分子名称:Tyrosine-protein kinase JAK2, 5-(4-methoxyphenyl)-N-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine, GLYCEROL
著者Eigenbrot, C., Ultsch, M.
登録日2013-03-05
公開日2013-08-07
最終更新日2013-08-21
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
6G4Y
  • Download 6g4y
  • View 6g4y
Molmil generated image of 6g4y
CRYSTAL STRUCTURE OF MURINE NF-KAPPAB INDUCING KINASE (NIK) IN COMPLEX WITH COMPOUND 1A
分子名称:Mitogen-activated protein kinase kinase kinase 14, SULFATE ION, 10-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrolidin-3-yl]ethynyl]-~{N}3-(oxan-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide
著者Hole, A.J., Hymowitz, S.G., McEwan, P.A.
登録日2018-03-28
公開日2018-07-04
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase.
J. Med. Chem., 61, 2018
3R7Q
  • Download 3r7q
  • View 3r7q
Molmil generated image of 3r7q
STRUCTURE-BASED DESIGN OF THIENOBENZOXEPIN INHIBITORS OF PI3- KINASE
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-(2-chlorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide
著者Murray, J.M., Wiesmann, C.
登録日2011-03-22
公開日2011-08-03
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.
Bioorg.Med.Chem.Lett., 21, 2011
3R7R
  • Download 3r7r
  • View 3r7r
Molmil generated image of 3r7r
STRUCTURE-BASED DESIGN OF THIENOBENZOXEPIN INHIBITORS OF PI3-KINASE
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 8-(acetylamino)-N-(2-chlorophenyl)-N-methyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2-carboxamide
著者Murray, J.M., Wiesmann, C.
登録日2011-03-22
公開日2011-08-03
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.
Bioorg.Med.Chem.Lett., 21, 2011