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5UGG
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BU of 5ugg by Molmil
Protease Inhibitor
Descriptor: Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)methyl]-L-tyrosinamide, Plasminogen
Authors:Law, R.H.P, Wu, G, Whisstock, J.C.
Deposit date:2017-01-08
Release date:2017-05-31
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Blood Adv, 1, 2017
5UGD
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BU of 5ugd by Molmil
Protease Inhibitor
Descriptor: Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(pyridin-4-yl)methyl]-L-tyrosinamide, Plasminogen
Authors:Law, R.H.P, Wu, G, Whisstock, J.C.
Deposit date:2017-01-08
Release date:2017-05-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Blood Adv, 1, 2017
2R9Y
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BU of 2r9y by Molmil
Structure of antiplasmin
Descriptor: Alpha-2-antiplasmin
Authors:Law, R.H.P, Sofian, T, Kan, W.T, Horvath, A.J, Hitchen, C.R, Langendorf, C.G, Buckle, A.M, Whisstock, J.C, Coughlin, P.B.
Deposit date:2007-09-14
Release date:2007-12-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin
Blood, 111, 2008
4DUR
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BU of 4dur by Molmil
The X-ray Crystal Structure of Full-Length type II Human Plasminogen
Descriptor: ACETATE ION, BICARBONATE ION, CHLORIDE ION, ...
Authors:Law, R.H.P, Caradoc-Davies, T, Whisstock, J.C.
Deposit date:2012-02-22
Release date:2012-03-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The X-ray crystal structure of full-length human plasminogen
Cell Rep, 1, 2012
4DUU
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BU of 4duu by Molmil
The X-ray Crystal Structure of Full-Length type I Human Plasminogen
Descriptor: Plasminogen
Authors:Law, R.H.P, Caradoc-Davies, T, Whisstock, J.C.
Deposit date:2012-02-22
Release date:2012-03-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (5.2 Å)
Cite:The X-ray crystal structure of full-length human plasminogen
Cell Rep, 1, 2012
6NMB
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BU of 6nmb by Molmil
Tranexamic Acid is an Active Site Inhibitor of Urokinase Plasminogen Activator
Descriptor: NITRATE ION, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID, Urokinase-type plasminogen activator
Authors:Law, R.H.P, Wu, G.
Deposit date:2019-01-10
Release date:2019-03-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.
Blood Adv, 3, 2019
5UG6
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BU of 5ug6 by Molmil
Perforin C2 Domain - T431D
Descriptor: IODIDE ION, Perforin-1
Authors:Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C.
Deposit date:2017-01-07
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
5UG7
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BU of 5ug7 by Molmil
Calcium bound Perforin C2 Domain - T431D
Descriptor: CALCIUM ION, Perforin-1
Authors:Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C.
Deposit date:2017-01-07
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
6OG4
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BU of 6og4 by Molmil
plasminogen binding group A streptococcal M protein
Descriptor: Plasminogen, Plasminogen-binding group A streptococcal M-like protein PAM, SULFATE ION
Authors:Law, R.H.P, Quek, A.J, Whisstock, J.C, Caradoc-Davies, T.T.
Deposit date:2019-04-01
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.
J.Mol.Biol., 431, 2019
6CXO
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BU of 6cxo by Molmil
Complement component-9
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement component C9, ...
Authors:Law, R.H.P, Spicer, B.A, Caradoc-Davies, T.T.
Deposit date:2018-04-03
Release date:2018-09-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Nat Commun, 9, 2018
6D3Z
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BU of 6d3z by Molmil
Protease SFTI complex
Descriptor: Plasminogen, Trypsin inhibitor 1
Authors:Law, R.H.P, Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
6DN7
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BU of 6dn7 by Molmil
SPRY domain-containing SOCS box protein 2 complexed with WDINNN(BAL) Cyclic peptide inhibitor
Descriptor: CHLORIDE ION, SPRY domain-containing SOCS box protein 4, WDINNN(BAL) Cyclic peptide inhibitor
Authors:Law, R.H.P, Caradoc-Davies, T.T, Norton, R.S.
Deposit date:2018-06-06
Release date:2019-04-17
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.
ACS Chem. Biol., 13, 2018
6D40
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BU of 6d40 by Molmil
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Descriptor: Plasminogen, SULFATE ION, Trypsin inhibitor 1
Authors:Law, R.H.P, Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
6D3Y
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BU of 6d3y by Molmil
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Descriptor: GLYCEROL, Plasminogen, SULFATE ION, ...
Authors:Law, R.H.P, Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
6DN6
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BU of 6dn6 by Molmil
SPRY domain-containing SOCS box protein 2 complexed with INNN(ABU) cyclic peptide inhibitor
Descriptor: INNN(ABU) cyclic peptide inhibitor, SPRY domain-containing SOCS box protein 2
Authors:Law, R.H.P, Caradoc-Davies, T.T, Norton, R.S.
Deposit date:2018-06-06
Release date:2019-04-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.
ACS Chem. Biol., 13, 2018
6D3X
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BU of 6d3x by Molmil
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Descriptor: Plasminogen, Trypsin inhibitor 1
Authors:Law, R.H.P, Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
6DN5
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BU of 6dn5 by Molmil
SPRY domain-containing SOCS box protein 2 complexed with WDINNN(BAL) cyclic peptide inhibitor
Descriptor: SPRY domain-containing SOCS box protein 2, SULFATE ION, WDINNN(BAL) cyclic peptide inhibitor
Authors:Law, R.H.P, Caradoc-Davies, T.T, Norton, R.S.
Deposit date:2018-06-06
Release date:2019-04-17
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.
ACS Chem. Biol., 13, 2018
6DN8
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BU of 6dn8 by Molmil
SPRY domain-containing SOCS box protein 2 complexed with (GZJ)VDINNN(CY3) Cyclic peptide inhibitor
Descriptor: (GZJ)VDINNN(CY3) Cyclic peptide inhibitor, ACETATE ION, SPRY domain-containing SOCS box protein 4, ...
Authors:Law, R.H.P, Caradoc-Davies, T.T, Norton, R.S.
Deposit date:2018-06-06
Release date:2019-04-17
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.
ACS Chem. Biol., 13, 2018
4V3N
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BU of 4v3n by Molmil
Membrane bound pleurotolysin prepore (TMH2 strand lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V2T
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BU of 4v2t by Molmil
Membrane embedded pleurotolysin pore with 13 fold symmetry
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-15
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3A
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BU of 4v3a by Molmil
Membrane bound pleurotolysin prepore (TMH1 lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, CaradocDavies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-17
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (15 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3M
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BU of 4v3m by Molmil
Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
5FMW
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BU of 5fmw by Molmil
The poly-C9 component of the Complement Membrane Attack Complex
Descriptor: POLYC9
Authors:Dudkina, N.V, Spicer, B.A, Reboul, C.F, Conroy, P.J, Lukoyanova, N, Elmlund, H, Law, R.H.P, Ekkel, S.M, Kondos, S.C, Goode, R.J.A, Ramm, G, Whisstock, J.C, Saibil, H.R, Dunstone, M.A.
Deposit date:2015-11-10
Release date:2016-02-17
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Structure of the Poly-C9 Component of the Complement Membrane Attack Complex
Nat.Commun., 7, 2016
3VP6
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BU of 3vp6 by Molmil
Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation
Descriptor: 4-oxo-4H-pyran-2,6-dicarboxylic acid, GLYCEROL, Glutamate decarboxylase 1
Authors:Langendorf, C.G, Tuck, K.L, Key, T.L.G, Rosado, C.J, Wong, A.S.M, Fenalti, G, Buckle, A.M, Law, R.H.P, Whisstock, J.C.
Deposit date:2012-02-27
Release date:2013-01-16
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates
Biosci.Rep., 33, 2013
6Q1U
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BU of 6q1u by Molmil
Structure of plasmin and peptide complex
Descriptor: 1-methyl-1H-1,2,3-triazole, GLY-ARG-ALA-TYR-LYS-SER-LYS-PRO-PRO-ILE-ALA-PHE-PRO-ASP, Plasminogen
Authors:Wu, G, Law, R.H.P.
Deposit date:2019-08-06
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3467 Å)
Cite:Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.
Angew.Chem.Int.Ed.Engl., 59, 2020

 

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