Author results

2R9Y
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STRUCTURE OF ANTIPLASMIN
Descriptor:Alpha-2-antiplasmin
Authors:Law, R.H.P., Sofian, T., Kan, W.T., Horvath, A.J., Hitchen, C.R., Langendorf, C.G., Buckle, A.M., Whisstock, J.C., Coughlin, P.B.
Deposit date:2007-09-14
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin
Blood, 111, 2008
4DUR
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THE X-RAY CRYSTAL STRUCTURE OF FULL-LENGTH TYPE II HUMAN PLASMINOGEN
Descriptor:Plasminogen, CHLORIDE ION, POTASSIUM ION, ...
Authors:Law, R.H.P., Caradoc-Davies, T., Whisstock, J.C.
Deposit date:2012-02-22
Release date:2012-03-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The X-ray crystal structure of full-length human plasminogen
Cell Rep, 1, 2012
4DUU
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THE X-RAY CRYSTAL STRUCTURE OF FULL-LENGTH TYPE I HUMAN PLASMINOGEN
Descriptor:Plasminogen
Authors:Law, R.H.P., Caradoc-Davies, T., Whisstock, J.C.
Deposit date:2012-02-22
Release date:2012-03-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (5.2 Å)
Cite:The X-ray crystal structure of full-length human plasminogen
Cell Rep, 1, 2012
5UGD
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PROTEASE INHIBITOR
Descriptor:Plasminogen, Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(pyridin-4-yl)methyl]-L-tyrosinamide
Authors:Law, R.H.P., Wu, G., Whisstock, J.C.
Deposit date:2017-01-08
Release date:2017-05-31
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Blood Adv, 1, 2017
5UGG
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PROTEASE INHIBITOR
Descriptor:Plasminogen, Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)methyl]-L-tyrosinamide
Authors:Law, R.H.P., Wu, G., Whisstock, J.C.
Deposit date:2017-01-08
Release date:2017-05-31
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Blood Adv, 1, 2017
5UG6
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PERFORIN C2 DOMAIN - T431D
Descriptor:Perforin-1, IODIDE ION
Authors:Law, R.H.P., Conroy, P.J., Voskoboinik, I., Whisstock, J.C.
Deposit date:2017-01-07
Release date:2018-02-07
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
5UG7
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CALCIUM BOUND PERFORIN C2 DOMAIN - T431D
Descriptor:Perforin-1, CALCIUM ION
Authors:Law, R.H.P., Conroy, P.J., Voskoboinik, I., Whisstock, J.C.
Deposit date:2017-01-07
Release date:2018-02-07
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
6CXO
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COMPLEMENT COMPONENT-9
Descriptor:Complement component C9, ZINC ION, CALCIUM ION, ...
Authors:Law, R.H.P., Spicer, B.A., Caradoc-Davies, T.T.
Deposit date:2018-04-03
Release date:2018-09-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Nat Commun, 9, 2018
2OKJ
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THE X-RAY CRYSTAL STRUCTURE OF THE 67KDA ISOFORM OF GLUTAMIC ACID DECARBOXYLASE (GAD67)
Descriptor:Glutamate decarboxylase 1, GAMMA-AMINO-BUTANOIC ACID, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID
Authors:Buckle, A.M., Fenalti, G., Law, R.H.P., Whisstock, J.C.
Deposit date:2007-01-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Nat.Struct.Mol.Biol., 14, 2007
3VP6
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STRUCTURAL CHARACTERIZATION OF GLUTAMIC ACID DECARBOXYLASE; INSIGHTS INTO THE MECHANISM OF AUTOINACTIVATION
Descriptor:Glutamate decarboxylase 1, 4-oxo-4H-pyran-2,6-dicarboxylic acid, GLYCEROL
Authors:Langendorf, C.G., Tuck, K.L., Key, T.L.G., Rosado, C.J., Wong, A.S.M., Fenalti, G., Buckle, A.M., Law, R.H.P., Whisstock, J.C.
Deposit date:2012-02-27
Release date:2013-01-16
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates
Biosci.Rep., 33, 2013
3ZLF
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STRUCTURE OF GROUP A STREPTOCOCCAL ENOLASE K312A MUTANT
Descriptor:ENOLASE, PHOSPHATE ION
Authors:Cork, A.J., Ericsson, D.J., Law, R.H.P., Casey, L.W., Valkov, E., Bertozzi, C., Stamp, A., Aquilina, J.A., Whisstock, J.C., Walker, M.J., Kobe, B.
Deposit date:2013-01-31
Release date:2014-02-05
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Stability of the Octameric Structure Affects Plasminogen-Binding Capacity of Streptococcal Enolase.
Plos One, 10, 2015
3ZLG
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STRUCTURE OF GROUP A STREPTOCOCCAL ENOLASE K362A MUTANT
Descriptor:ENOLASE, PHOSPHATE ION
Authors:Cork, A.J., Ericsson, D.J., Law, R.H.P., Casey, L.W., Valkov, E., Bertozzi, C., Stamp, A., Aquilina, J.A., Whisstock, J.C., Walker, M.J., Kobe, B.
Deposit date:2013-01-31
Release date:2014-02-05
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Stability of the Octameric Structure Affects Plasminogen-Binding Capacity of Streptococcal Enolase.
Plos One, 10, 2015
3ZLH
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STRUCTURE OF GROUP A STREPTOCOCCAL ENOLASE
Descriptor:ENOLASE
Authors:Cork, A.J., Ericsson, D.J., Law, R.H.P., Casey, L.W., Valkov, E., Bertozzi, C., Stamp, A., Aquilina, J.A., Whisstock, J.C., Walker, M.J., Kobe, B.
Deposit date:2013-01-31
Release date:2014-02-05
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Stability of the Octameric Structure Affects Plasminogen-Binding Capacity of Streptococcal Enolase.
Plos One, 10, 2015
4OV8
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CRYSTAL STRUCTURE OF THE TMH1-LOCK MUTANT OF THE MATURE FORM OF PLEUROTOLYSIN B
Descriptor:Pleurotolysin B, SULFATE ION, CHLORIDE ION, ...
Authors:Kondos, S.C., Law, R.H.P., Whisstock, J.C., Dunstone, M.A.
Deposit date:2014-02-20
Release date:2015-02-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
Plos Biol., 13, 2015
4V2T
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MEMBRANE EMBEDDED PLEUROTOLYSIN PORE WITH 13 FOLD SYMMETRY
Descriptor:PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N., Kondos, S.C., Farabella, I., Law, R.H.P., Reboul, C.F., Caradoc-Davies, T.T., Spicer, B.A., Kleifeld, O., Perugini, M., Ekkel, S., Hatfaludi, T., Oliver, K., Hotze, E.M., Tweten, R.K., Whisstock, J.C., Topf, M., Dunstone, M.A., Saibil, H.R.
Deposit date:2014-10-15
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3A
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MEMBRANE BOUND PLEUROTOLYSIN PREPORE (TMH1 LOCK) TRAPPED WITH ENGINEERED DISULPHIDE CROSS-LINK
Descriptor:PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N., Kondos, S.C., Farabella, I., Law, R.H.P., Reboul, C.F., CaradocDavies, T.T., Spicer, B.A., Kleifeld, O., Perugini, M., Ekkel, S., Hatfaludi, T., Oliver, K., Hotze, E.M., Tweten, R.K., Whisstock, J.C., Topf, M., Dunstone, M.A., Saibil, H.R.
Deposit date:2014-10-17
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (15 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3M
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MEMBRANE BOUND PLEUROTOLYSIN PREPORE (TMH2 HELIX LOCK) TRAPPED WITH ENGINEERED DISULPHIDE CROSS-LINK
Descriptor:PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N., Kondos, S.C., Farabella, I., Law, R.H.P., Reboul, C.F., Caradoc-Davies, T.T., Spicer, B.A., Kleifeld, O., Perugini, M., Ekkel, S., Hatfaludi, T., Oliver, K., Hotze, E.M., Tweten, R.K., Whisstock, J.C., Topf, M., Dunstone, M.A., Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3N
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MEMBRANE BOUND PLEUROTOLYSIN PREPORE (TMH2 STRAND LOCK) TRAPPED WITH ENGINEERED DISULPHIDE CROSS-LINK
Descriptor:PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N., Kondos, S.C., Farabella, I., Law, R.H.P., Reboul, C.F., Caradoc-Davies, T.T., Spicer, B.A., Kleifeld, O., Perugini, M., Ekkel, S., Hatfaludi, T., Oliver, K., Hotze, E.M., Tweten, R.K., Whisstock, J.C., Topf, M., Dunstone, M.A., Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
5FMW
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THE POLY-C9 COMPONENT OF THE COMPLEMENT MEMBRANE ATTACK COMPLEX
Descriptor:POLYC9
Authors:Dudkina, N.V., Spicer, B.A., Reboul, C.F., Conroy, P.J., Lukoyanova, N., Elmlund, H., Law, R.H.P., Ekkel, S.M., Kondos, S.C., Goode, R.J.A., Ramm, G., Whisstock, J.C., Saibil, H.R., Dunstone, M.A.
Deposit date:2015-11-10
Release date:2016-02-17
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Structure of the Poly-C9 Component of the Complement Membrane Attack Complex
Nat.Commun., 7, 2016
6DLW
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COMPLEMENT COMPONENT POLYC9
Descriptor:Complement component C9, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Dunstone, M.A., Spicer, B.A., Law, R.H.P.
Deposit date:2018-06-03
Release date:2018-09-12
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Nat Commun, 9, 2018
6D3X
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HIGHLY POTENT AND SELECTIVE PLASMIN INHIBITORS BASED ON THE SUNFLOWER TRYPSIN INHIBITOR-1 SCAFFOLD ATTENUATE FIBRINOLYSIS IN PLASMA
Descriptor:Plasminogen, Trypsin inhibitor 1
Authors:Law, R.H.P., Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 2018
6D3Y
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HIGHLY POTENT AND SELECTIVE PLASMIN INHIBITORS BASED ON THE SUNFLOWER TRYPSIN INHIBITOR-1 SCAFFOLD ATTENUATE FIBRINOLYSIS IN PLASMA
Descriptor:Plasminogen, Trypsin inhibitor 1, SULFATE ION, ...
Authors:Law, R.H.P., Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 2018
6D3Z
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PROTEASE SFTI COMPLEX
Descriptor:Plasminogen, Trypsin inhibitor 1
Authors:Law, R.H.P., Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 2018
6D40
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HIGHLY POTENT AND SELECTIVE PLASMIN INHIBITORS BASED ON THE SUNFLOWER TRYPSIN INHIBITOR-1 SCAFFOLD ATTENUATE FIBRINOLYSIS IN PLASMA
Descriptor:Plasminogen, Trypsin inhibitor 1, SULFATE ION
Authors:Law, R.H.P., Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 2018
2OKK
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THE X-RAY CRYSTAL STRUCTURE OF THE 65KDA ISOFORM OF GLUTAMIC ACID DECARBOXYLASE (GAD65)
Descriptor:Glutamate decarboxylase 2, GAMMA-AMINO-BUTANOIC ACID, GLYCEROL
Authors:Buckle, A.M., Fenalti, G., Law, R.H.P., Whisstock, J.C.
Deposit date:2007-01-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Nat.Struct.Mol.Biol., 14, 2007
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