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6Z6V
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BU of 6z6v by Molmil
Globular head of C1q in complex with the nanobody C1qNb75
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, ...
Authors:Laursen, N.S, Andersen, G.R.
Deposit date:2020-05-29
Release date:2020-06-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System.
Front Immunol, 11, 2020
3KLS
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BU of 3kls by Molmil
Structure of complement C5 in complex with SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
Deposit date:2009-11-09
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3KM9
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BU of 3km9 by Molmil
Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
Authors:Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
Deposit date:2009-11-10
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3PRX
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BU of 3prx by Molmil
Structure of Complement C5 in Complex with CVF and SSL7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ...
Authors:Laursen, N.S, Andersen, G.R, Sottrup-Jensen, L, Andersen, K.R, Spillner, E, Braren, I.
Deposit date:2010-11-30
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
3PVM
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BU of 3pvm by Molmil
Structure of Complement C5 in Complex with CVF
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, Complement C5
Authors:Laursen, N.S, Andersen, K.R, Braren, I, Sottrup-Jensen, L, Spillner, E, Andersen, G.R.
Deposit date:2010-12-07
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
6FYW
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BU of 6fyw by Molmil
Structure of B/Brisbane/60/2008 Influenza Hemagglutinin in complex with SD83
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Laursen, N.S, Wilson, I.A.
Deposit date:2018-03-12
Release date:2018-11-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
6FYU
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BU of 6fyu by Molmil
Structure of H7(A/Shanghai/2/2013) Influenza Hemagglutinin in complex SD36
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:Laursen, N.S, Wilson, I.A.
Deposit date:2018-03-12
Release date:2018-11-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.643 Å)
Cite:Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
6FYS
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BU of 6fys by Molmil
Structure of single domain antibody SD83
Descriptor: 1,2-ETHANEDIOL, Single domain antibody SD83
Authors:Laursen, N.S, Wilson, I.A.
Deposit date:2018-03-12
Release date:2018-11-07
Last modified:2022-03-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
6FYT
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BU of 6fyt by Molmil
Structure of H1 (A/solomon Islands/3/06) Influenza Hemagglutinin in complex with SD38
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:Laursen, N.S, Wilson, I.A.
Deposit date:2018-03-12
Release date:2018-11-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
5NQW
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BU of 5nqw by Molmil
IgE-Fc in complex with single domain antibody 026
Descriptor: 026, GLYCEROL, Immunoglobulin heavy constant epsilon, ...
Authors:Laursen, N.S, Jabs, F, Spillner, E, Andersen, G.R.
Deposit date:2017-04-21
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts Fc epsilon RI interaction.
Nat Commun, 9, 2018
6YSQ
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BU of 6ysq by Molmil
The hC4Nb8 complement inhibitory nanobody in complex with C4b
Descriptor: Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A alpha chain, ...
Authors:Zarantonello, A, Laursen, N.S, Andersen, G.R.
Deposit date:2020-04-23
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase.
J Immunol., 205, 2020
6QUP
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BU of 6qup by Molmil
Structural signatures in EPR3 define a unique class of plant carbohydrate receptors
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ISOPROPYL ALCOHOL, ...
Authors:Wong, J.E, Gysel, K, Birkefeldt, T.G, Vinther, M, Muszynski, A, Azadi, P, Laursen, N.S, Sullivan, J.T, Ronson, C.W, Stougaard, J, Andersen, K.R.
Deposit date:2019-02-28
Release date:2020-08-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.871 Å)
Cite:Structural signatures in EPR3 define a unique class of plant carbohydrate receptors.
Nat Commun, 11, 2020
6RU3
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BU of 6ru3 by Molmil
Crystal structure of the FP specific nanobody hFPNb1
Descriptor: hFP1Nb1
Authors:Mazarakis, S.M.M, Pedersen, D.V, Laursen, N.S, Andersen, G.R.
Deposit date:2019-05-27
Release date:2019-08-21
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Front Immunol, 10, 2019
5NLW
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BU of 5nlw by Molmil
Structure of Nb36 crystal form 2
Descriptor: SULFATE ION, nanobody Nb36
Authors:Hansen, S.B, Andersen, K.R, Laursen, N.S, Andersen, G.R.
Deposit date:2017-04-05
Release date:2017-05-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Acta Crystallogr D Struct Biol, 73, 2017
5NM0
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BU of 5nm0 by Molmil
Nb36 Ser85Cys with Hg, crystal form 1
Descriptor: MERCURY (II) ION, Nb36
Authors:Hansen, S.B, Andersen, K.R, Laursen, N.S, Andersen, G.R.
Deposit date:2017-04-05
Release date:2017-06-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Acta Crystallogr D Struct Biol, 73, 2017
5NML
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BU of 5nml by Molmil
Nb36 Ser85Cys with Hg bound
Descriptor: 1,2-ETHANEDIOL, MERCURY (II) ION, Nanobody Nb36 Ser85Cys
Authors:Hansen, S.B, Andersen, K.R, Laursen, N.S, Andersen, G.R.
Deposit date:2017-04-06
Release date:2017-06-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Acta Crystallogr D Struct Biol, 73, 2017
5NLU
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BU of 5nlu by Molmil
Structure of Nb36 crystal form 1
Descriptor: SULFATE ION, single domain llama antibody Nb36
Authors:Hansen, S.B, Andersen, K.R, Laursen, N.S, Andersen, G.R.
Deposit date:2017-04-05
Release date:2017-05-31
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.193 Å)
Cite:Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures.
Acta Crystallogr D Struct Biol, 73, 2017
6EHG
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BU of 6ehg by Molmil
complement component C3b in complex with a nanobody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jensen, R.K, Andersen, K.R, Gadeberg, T.A.F, Laursen, N.S, Andersen, G.R.
Deposit date:2017-09-13
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
J. Biol. Chem., 293, 2018
4FQM
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BU of 4fqm by Molmil
Structure of B/Brisbane/60/2008 Influenza Hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ...
Authors:Dreyfus, C, Laursen, N.S, Wilson, I.A.
Deposit date:2012-06-25
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
4FQL
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BU of 4fql by Molmil
Influenza B HA Antibody (Fab) CR8033
Descriptor: monoclonal antibody CR8033 heavy chain, monoclonal antibody CR8033 light chain
Authors:Dreyfus, C, Laursen, N.S, Wilson, I.A.
Deposit date:2012-06-25
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
4FQK
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BU of 4fqk by Molmil
Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody CR8059 Heavy Chain, ...
Authors:Dreyfus, C, Laursen, N.S, Wilson, I.A.
Deposit date:2012-06-25
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (5.65 Å)
Cite:Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
4FQJ
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BU of 4fqj by Molmil
Influenza B/Florida/4/2006 hemagglutinin Fab CR8071 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, antibody CR8071 heavy chain, ...
Authors:Dreyfus, C, Laursen, N.S, Wilson, I.A.
Deposit date:2012-06-25
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
7ZMK
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BU of 7zmk by Molmil
Structure of human MFAP4 in complex with the Fab fragment of the AS0326 monoclonal antibody
Descriptor: CALCIUM ION, Light chain of AS0326, Microfibril-associated glycoprotein 4, ...
Authors:Laursen, N.S, Andersen, G.R.
Deposit date:2022-04-19
Release date:2023-03-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:MFAP4-targeted immunotherapy inhibits retinal neovascularization and vascular leakage
To Be Published
6CNW
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BU of 6cnw by Molmil
STRUCTURE OF HUMANIZED SINGLE DOMAIN ANTIBODY SD84
Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, humanized antibody SD84h
Authors:Luo, J, Obmolova, O.
Deposit date:2018-03-09
Release date:2018-11-14
Method:X-RAY DIFFRACTION (0.92 Å)
Cite:Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
6CNV
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BU of 6cnv by Molmil
INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR9114 Fab heavy chain, ...
Authors:Luo, J, Obmolova, G.
Deposit date:2018-03-09
Release date:2018-11-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018

 

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