Author results

1L8G
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CRYSTAL STRUCTURE OF PTP1B COMPLEXED WITH 7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, 7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Authors:Iversen, L.F., Andersen, H.S., Moller, K.B., Olsen, O.H., Peters, G.H., Branner, S., Mortensen, S.B., Hansen, T.K., Lau, J., Ge, Y., Holsworth, D.D., Newman, M.J., Moller, N.P.H.
Deposit date:2002-03-20
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.
Biochemistry, 40, 2001
4L6R
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STRUCTURE OF THE CLASS B HUMAN GLUCAGON G PROTEIN COUPLED RECEPTOR
Descriptor:Soluble cytochrome b562 and Glucagon receptor chimera, DI(HYDROXYETHYL)ETHER
Authors:Siu, F.Y., He, M., de Graaf, C., Han, G.W., Yang, D., Zhang, Z., Zhou, C., Xu, Q., Wacker, D., Joseph, J.S., Liu, W., Lau, J., Cherezov, V., Katritch, V., Wang, M.W., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2013-06-12
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the human glucagon class B G-protein-coupled receptor.
Nature, 499, 2013
5VEW
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STRUCTURE OF THE HUMAN GLP-1 RECEPTOR COMPLEX WITH PF-06372222
Descriptor:Glucagon-like peptide 1 receptor,Endolysin chimera, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Song, G., Yang, D., Wang, Y., Graaf, C.D., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z.-J., Wang, M.-W., Stevens, R.C.
Deposit date:2017-04-05
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546, 2017
5VEX
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STRUCTURE OF THE HUMAN GLP-1 RECEPTOR COMPLEX WITH NNC0640
Descriptor:Glucagon-like peptide 1 receptor, Endolysin chimera, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide
Authors:Song, G., Yang, D., Wang, Y., Graaf, C.D., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z.-J., Wang, M.-W., Stevens, R.C.
Deposit date:2017-04-05
Release date:2017-05-17
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546, 2017
5XEZ
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody, mAb1, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5XF1
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody mAb1 Heavy chain, Antibody mAb1 Light chain, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5YQZ
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STRUCTURE OF THE GLUCAGON RECEPTOR IN COMPLEX WITH A GLUCAGON ANALOGUE
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Glucagon analogue, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhang, H., Qiao, A., Yang, L., VAN EPS, N., Frederiksen, K., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Can, C., He, L., Yang, H., Lau, J., Ernst, O., Hanson, M., Stevens, R., Wang, M., Seedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B.
Deposit date:2017-11-08
Release date:2018-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
4ZGM
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CRYSTAL STRUCTURE OF SEMAGLUTIDE PEPTIDE BACKBONE IN COMPLEX WITH THE GLP-1 RECEPTOR EXTRACELLULAR DOMAIN
Descriptor:Glucagon-like peptide 1 receptor, Semaglutide peptide backbone; 8Aib,34R-GLP-1(7-37)-OH, 3,6,9,12,15,18-hexaoxahexacosan-1-ol
Authors:Reedtz-Runge, S.
Deposit date:2015-04-23
Release date:2015-09-09
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
J.Med.Chem., 58, 2015
5GL6
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MSMEG RIMP
Descriptor:Ribosome maturation factor RimP
Authors:Chu, T., Lau, T.C.K.
Deposit date:2016-07-08
Release date:2017-07-12
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The ribosomal maturation factor P fromMycobacterium smegmatisfacilitates the ribosomal biogenesis by binding to the small ribosomal protein S12.
J. Biol. Chem., 294, 2019
6AY2
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STRUCTURE OF CATHB WITH COVALENTLY LINKED COMPOUND 28
Descriptor:Cathepsin B, N~1~-[(2S)-1-amino-5-(carbamoylamino)pentan-2-yl]-N'~1~-[(1R)-1-(thiophen-3-yl)ethyl]cyclobutane-1,1-dicarboxamide
Authors:Kiefer, J.R., Steinbacher, S.
Deposit date:2017-09-07
Release date:2017-12-27
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J. Med. Chem., 61, 2018
5CQ2
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CRYSTAL STRUCTURE OF TANDEM WW DOMAINS OF ITCH IN COMPLEX WITH TXNIP PEPTIDE
Descriptor:E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2015-07-21
Release date:2015-09-16
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
Biochem.J., 473, 2016
5DF6
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CRYSTAL STRUCTURE OF PTPN11 TANDEM SH2 DOMAINS IN COMPLEX WITH A TXNIP PEPTIDE
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, txnip, UNKNOWN ATOM OR ION
Authors:Dong, A., Li, W., Tempel, W., Liu, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2015-08-26
Release date:2015-09-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
Biochem.J., 473, 2016
3C59
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CRYSTAL STRUCTURE OF THE LIGAND-BOUND GLUCAGON-LIKE PEPTIDE-1 RECEPTOR EXTRACELLULAR DOMAIN
Descriptor:Glucagon-like peptide 1 receptor, Exendin-4, decyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside
Authors:Runge, S.
Deposit date:2008-01-31
Release date:2008-02-19
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain
J.Biol.Chem., 283, 2008
3C5T
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CRYSTAL STRUCTURE OF THE LIGAND-BOUND GLUCAGON-LIKE PEPTIDE-1 RECEPTOR EXTRACELLULAR DOMAIN
Descriptor:Glucagon-like peptide 1 receptor, Exendin-4, decyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside
Authors:Runge, S.
Deposit date:2008-02-01
Release date:2008-02-19
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain
J.Biol.Chem., 283, 2008