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3UZA
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BU of 3uza by Molmil
Thermostabilised Adenosine A2A receptor in complex with 6-(2,6-Dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine
Descriptor: 6-(2,6-dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine, Adenosine receptor A2a
Authors:Congreve, M, Andrews, S.P, Dore, A.S, Hollenstein, K, Hurrell, E, Langmead, C.J, Mason, J.S, Ng, I.W, Tehan, B, Zhukov, A, Weir, M, Marshall, F.H.
Deposit date:2011-12-07
Release date:2012-03-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.273 Å)
Cite:Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55, 2012
3UZC
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BU of 3uzc by Molmil
Thermostabilised Adenosine A2A receptor in complex with 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
Descriptor: 4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol, Adenosine A2A Receptor
Authors:Congreve, M, Andrews, S.P, Dore, A.S, Hollenstein, K, Hurrell, E, Langmead, C.J, Mason, J.S, Ng, I.W, Zhukov, A, Weir, M, Marshall, F.H.
Deposit date:2011-12-07
Release date:2012-03-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.341 Å)
Cite:Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
J.Med.Chem., 55, 2012
2YDV
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BU of 2ydv by Molmil
Thermostabilised HUMAN A2a Receptor with NECA bound
Descriptor: ADENOSINE RECEPTOR A2A, N-ETHYL-5'-CARBOXAMIDO ADENOSINE, octyl 1-thio-beta-D-glucopyranoside
Authors:Lebon, G, Warne, T, Edwards, P.C, Bennett, K, Langmead, C.J, Leslie, A.G.W, Tate, C.G.
Deposit date:2011-03-24
Release date:2011-05-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
2YDO
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BU of 2ydo by Molmil
Thermostabilised HUMAN A2a Receptor with adenosine bound
Descriptor: ADENOSINE, ADENOSINE RECEPTOR A2A, octyl 1-thio-beta-D-glucopyranoside
Authors:Lebon, G, Warne, T, Edwards, P.C, Bennett, K, Langmead, C.J, Leslie, A.G.W, Tate, C.G.
Deposit date:2011-03-23
Release date:2011-05-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Agonist-Bound Adenosine A(2A) Receptor Structures Reveal Common Features of Gpcr Activation.
Nature, 474, 2011
6X1A
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BU of 6x1a by Molmil
Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Zhang, X, Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
6X19
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BU of 6x19 by Molmil
Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Zhang, X, Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
6X18
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BU of 6x18 by Molmil
GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Descriptor: Glucagon, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Zhang, X, Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 80, 2020
6OL9
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BU of 6ol9 by Molmil
Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium
Descriptor: (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ...
Authors:Vuckovic, Z, Christopoulos, A, Thal, D.M.
Deposit date:2019-04-16
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.541 Å)
Cite:Crystal structure of the M5muscarinic acetylcholine receptor.
Proc.Natl.Acad.Sci.USA, 116, 2019
6V9S
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BU of 6v9s by Molmil
Structure-based development of subtype-selective orexin 1 receptor antagonists
Descriptor: CHOLESTEROL, OLEIC ACID, Orexin receptor type 1,GlgA glycogen synthase chimera, ...
Authors:Hellmann, J, Drabek, M, Yin, J, Huebner, H, Kraus, F, Proell, T, Weikert, D, Kolb, P, Rosenbaum, D.M, Gmeiner, P.
Deposit date:2019-12-16
Release date:2020-07-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure-based development of a subtype-selective orexin 1 receptor antagonist.
Proc.Natl.Acad.Sci.USA, 117, 2020
7RTB
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BU of 7rtb by Molmil
Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R)
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Johnson, R.M, Danev, R, Sexton, P.M, Wootten, D.
Deposit date:2021-08-12
Release date:2021-10-06
Method:ELECTRON MICROSCOPY (2.14 Å)
Cite:Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor.
Biochem.Biophys.Res.Commun., 578, 2021
6ZG4
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BU of 6zg4 by Molmil
Structure of M1-StaR-T4L in complex with HTL0009936 at 2.35A
Descriptor: Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, OLEIC ACID, PHOSPHATE ION, ...
Authors:Rucktooa, P, Cooke, R.M.
Deposit date:2020-06-18
Release date:2021-10-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell, 184, 2021
6ZFZ
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BU of 6zfz by Molmil
Structure of M1-StaR-T4L in complex with 77-LH-28-1 at 2.17A
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Rucktooa, P, Cooke, R.M.
Deposit date:2020-06-18
Release date:2021-10-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell, 184, 2021
6ZG9
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BU of 6zg9 by Molmil
Structure of M1-StaR-T4L in complex with GSK1034702 at 2.5A
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 7-fluoranyl-5-methyl-3-[1-(oxan-4-yl)piperidin-4-yl]-1~{H}-benzimidazol-2-one, Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, ...
Authors:Rucktooa, P, Cooke, R.M.
Deposit date:2020-06-18
Release date:2021-10-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell, 184, 2021
5G53
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BU of 5g53 by Molmil
Structure of the adenosine A2A receptor bound to an engineered G protein
Descriptor: ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Carpenter, B, Nehme, R, Warne, T, Leslie, A.G.W, Tate, C.G.
Deposit date:2016-05-19
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein
Nature, 536, 2016

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