Author results

4LI5
  • Download 4li5
  • View 4li5
Molmil generated image of 4li5
EGFR-K IN COMPLEX WITH N-[3-[[5-CHLORO-4-(1H-INDOL-3-YL)PYRIMIDIN-2-YL]AMINO]-4-METHOXY-PHENYL] PROP-2-ENAMIDE
Descriptor:Epidermal growth factor receptor, N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide, SODIUM ION
Authors:Debreczeni, J.E., Seiffert, G.B., Kiefersauer, R., Augustin, M., Nagel, S., Ward, R., Anderton, M., Ashton, S., Bethel, P., Box, M., Butterworth, S., Colclough, N., Chroley, C., Chuaqui, C., Cross, D., Eberlein, C., Finlay, R., Hill, G., Grist, M., Klinowska, T., Lane, C., Martin, S., Orme, J., Smith, P., Wang, F., Waring, M.
Deposit date:2013-07-02
Release date:2013-08-28
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR).
J.Med.Chem., 56, 2013
4GV1
  • Download 4gv1
  • View 4gv1
Molmil generated image of 4gv1
PKB ALPHA IN COMPLEX WITH AZD5363
Descriptor:RAC-alpha serine/threonine-protein kinase, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, GLYCEROL
Authors:Addie, M., Ballard, P., Bird, G., Buttar, D., Currie, G., Davies, B., Debreczeni, J., Dry, H., Dudley, P., Greenwood, R., Hatter, G., Jestel, A., Johnson, P.D., Kettle, J.G., Lane, C., Lamont, G., Leach, A., Luke, R.W.A., Ogilvie, D., Page, K., Pass, M., Steinbacher, S., Steuber, H., Pearson, S., Ruston, L.
Deposit date:2012-08-30
Release date:2013-02-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases.
J.Med.Chem., 56, 2013