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6NYY
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BU of 6nyy by Molmil
human m-AAA protease AFG3L2, substrate-bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, AFG3-like protein 2, MAGNESIUM ION, ...
Authors:Lander, G.C, Puchades, C.
Deposit date:2019-02-12
Release date:2019-05-22
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.
Mol.Cell, 75, 2019
5AN8
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BU of 5an8 by Molmil
Cryo-electron microscopy structure of rabbit TRPV2 ion channel
Descriptor: TRPV2
Authors:Zubcevic, L, Herzik, M.A.J, Chung, B.C, Lander, G.C, Lee, S.Y.
Deposit date:2015-09-04
Release date:2015-12-23
Last modified:2019-04-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-Electron Microscopy of the Trpv2 Ion Channel
Nat.Struct.Mol.Biol., 23, 2016
8VE0
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BU of 8ve0 by Molmil
Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation
Descriptor: 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid, Transthyretin
Authors:Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C.
Deposit date:2023-12-18
Release date:2024-01-31
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The conformational landscape of human transthyretin revealed by cryo-EM
To Be Published
8D9X
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BU of 8d9x by Molmil
Cryo-EM structure of human DELE1 in oligomeric form
Descriptor: Maltodextrin-binding protein,DAP3-binding cell death enhancer 1 short form
Authors:Yang, J, Lander, G.C.
Deposit date:2022-06-11
Release date:2023-06-14
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:DELE1 oligomerization promotes integrated stress response activation.
Nat.Struct.Mol.Biol., 30, 2023
6V20
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BU of 6v20 by Molmil
Rabbit muscle aldolase determined using single-particle cryo-EM at 200 keV
Descriptor: Fructose-bisphosphate aldolase A
Authors:Wu, M, Lander, G.C, Herzik, M.A.
Deposit date:2019-11-21
Release date:2020-02-12
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (2.13 Å)
Cite:Sub-2 Angstrom resolution structure determination using single-particle cryo-EM at 200 keV.
J Struct Biol X, 4, 2020
6V11
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BU of 6v11 by Molmil
Lon Protease from Yersinia pestis
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease
Authors:Shin, M, Puchades, C, Asmita, A, Puri, N, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C.
Deposit date:2019-11-19
Release date:2020-01-22
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for distinct operational modes and protease activation in AAA+ protease Lon.
Sci Adv, 6, 2020
6V21
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BU of 6v21 by Molmil
Mouse heavy chain apoferritin determined using single-particle cryo-EM at 200 keV
Descriptor: Ferritin heavy chain
Authors:Wu, M, Lander, G.C, Herzik, M.A.
Deposit date:2019-11-21
Release date:2020-02-12
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (1.75 Å)
Cite:Sub-2 Angstrom resolution structure determination using single-particle cryo-EM at 200 keV.
J Struct Biol X, 4, 2020
8FLJ
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BU of 8flj by Molmil
Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA
Descriptor: CRISPR leader and repeat, anti-sense strand of DNA, CRISPR leader, ...
Authors:Santiago-Frangos, A, Henriques, W.S, Wiegand, T, Gauvin, C, Buyukyoruk, M, Neselu, K, Eng, E.T, Lander, G.C, Wiedenheft, B.
Deposit date:2022-12-21
Release date:2023-09-06
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays.
Nat.Struct.Mol.Biol., 30, 2023
8D7X
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BU of 8d7x by Molmil
Cereblon~DDB1 in the Apo form with DDB1 in the hinged conformation
Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION
Authors:Watson, E.R, Lander, G.C.
Deposit date:2022-06-07
Release date:2022-07-20
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
8D7Y
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BU of 8d7y by Molmil
Cereblon-DDB1 in the Apo form with DDB1 in the twisted conformation
Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION
Authors:Watson, E.R, Lander, G.C.
Deposit date:2022-06-07
Release date:2022-07-20
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022
6AZ0
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BU of 6az0 by Molmil
Mitochondrial ATPase Protease YME1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Puchades, C, Rampello, A.J, Shin, M, Giuliano, C, Wiseman, R.L, Glynn, S.E, Lander, G.C.
Deposit date:2017-09-09
Release date:2017-11-15
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.
Science, 358, 2017
6BPQ
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BU of 6bpq by Molmil
Structure of the cold- and menthol-sensing ion channel TRPM8
Descriptor: Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Wu, M, Zubcevic, L, Borschel, W.F, Lander, G.C, Lee, S.-Y.
Deposit date:2017-11-25
Release date:2017-12-13
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the cold- and menthol-sensing ion channel TRPM8.
Science, 359, 2018
4YLS
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BU of 4yls by Molmil
Tubulin Glutamylase
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tubulin polyglutamylase TTLL7
Authors:Garnham, C.P, Vemu, A, Wilson-Kubalek, E.M, Yu, I, Szyk, A, Lander, G.C, Milligan, R.A, Roll-Mecak, A.
Deposit date:2015-03-05
Release date:2015-06-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.
Cell, 161, 2015
4YLR
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BU of 4ylr by Molmil
Tubulin Glutamylase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Tubulin polyglutamylase TTLL7
Authors:Garnham, C.P, Vemu, A, Wilson-Kubalek, E.M, Yu, I, Szyk, A, Lander, G.C, Milligan, R.A, Roll-Mecak, A.
Deposit date:2015-03-05
Release date:2015-06-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.
Cell, 161, 2015
6PKW
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BU of 6pkw by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6P07
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BU of 6p07 by Molmil
Spastin hexamer in complex with substrate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sandate, C.R, Szyk, A, Zehr, E, Roll-Mecak, A, Lander, G.C.
Deposit date:2019-05-16
Release date:2019-06-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:An allosteric network in spastin couples multiple activities required for microtubule severing.
Nat.Struct.Mol.Biol., 26, 2019
6PKV
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BU of 6pkv by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6PKX
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BU of 6pkx by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6XMJ
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BU of 6xmj by Molmil
Human 20S proteasome bound to an engineered 11S (PA26) activator
Descriptor: Proteasome activator protein PA26, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ...
Authors:de la Pena, A.H, Opoku-Nsiah, K.A, Williams, S.K, Chopra, N, Sali, A, Gestwicki, J.E, Lander, G.C.
Deposit date:2020-06-30
Release date:2020-07-22
Last modified:2022-03-23
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The Y Phi motif defines the structure-activity relationships of human 20S proteasome activators.
Nat Commun, 13, 2022
3J6E
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BU of 3j6e by Molmil
Energy minimized average structure of Microtubules stabilized by GmpCpp
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
Authors:Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E.
Deposit date:2014-02-18
Release date:2014-06-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis.
Cell(Cambridge,Mass.), 157, 2014
3J6F
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BU of 3j6f by Molmil
Minimized average structure of GDP-bound dynamic microtubules
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E.
Deposit date:2014-02-19
Release date:2014-06-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis.
Cell(Cambridge,Mass.), 157, 2014
3J6G
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BU of 3j6g by Molmil
Minimized average structure of microtubules stabilized by taxol
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E.
Deposit date:2014-02-19
Release date:2014-06-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis.
Cell(Cambridge,Mass.), 157, 2014
3JCK
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BU of 3jck by Molmil
Structure of the yeast 26S proteasome lid sub-complex
Descriptor: 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit RPN12, 26S proteasome regulatory subunit RPN3, ...
Authors:Herzik Jr, M.A, Dambacher, C.M, Worden, E.J, Martin, A, Lander, G.C.
Deposit date:2015-12-20
Release date:2016-01-20
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.
Elife, 5, 2016
7SXO
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BU of 7sxo by Molmil
Yeast Lon (PIM1) with endogenous substrate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ...
Authors:Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C.
Deposit date:2021-11-24
Release date:2022-01-12
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements.
J.Biol.Chem., 298, 2022
8CVP
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BU of 8cvp by Molmil
Cereblon-DDB1 in the Apo form
Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION
Authors:Watson, E.R, Lander, G.C.
Deposit date:2022-05-18
Release date:2022-07-20
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular glue CELMoD compounds are regulators of cereblon conformation.
Science, 378, 2022

 

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