Author results

4GXO
  • Download 4gxo
  • View 4gxo
Molmil generated image of 4gxo
CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS PROTEIN SARZ MUTANT C13E
Descriptor:MarR family regulatory protein, GLYCEROL
Authors:Sun, F., Ding, Y., Ji, Q., Liang, Z., Deng, X., Wong, C.C., Yi, C., Zhang, L., Xie, S., Alvarez, S., Hicks, L.M., Luo, C., Jiang, H., Lan, L., He, C.
Deposit date:2012-09-04
Release date:2012-09-26
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
Proc.Natl.Acad.Sci.USA, 109, 2012
4HQM
  • Download 4hqm
  • View 4hqm
Molmil generated image of 4hqm
THE CRYSTAL STRUCTURE OF QSRR-MENADIONE COMPLEX
Descriptor:QsrR protein, 2-methylnaphthalene-1,4-diol
Authors:Ji, Q., Zhang, L., Jones, M.B., Sun, F., Deng, X., Liang, H., Brugarolas, P., Gao, N., Peterson, S.N., Lan, L., Bae, T., He, C.
Deposit date:2012-10-25
Release date:2013-03-06
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Proc.Natl.Acad.Sci.USA, 110, 2013
4WJA
  • Download 4wja
  • View 4wja
Molmil generated image of 4wja
CRYSTAL STRUCTURE OF PAXX
Descriptor:Uncharacterized protein C9orf142
Authors:Xing, M., Yang, M., Huo, W., Feng, F., Wei, L., Ning, S., Yan, Z., Li, W., Wang, Q., Hou, M., Dong, C., Guo, R., Gao, G., Ji, J., Lan, L., Liang, H., Xu, D.
Deposit date:2014-09-29
Release date:2015-03-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Nat Commun, 6, 2015
6C8U
  • Download 6c8u
  • View 6c8u
Molmil generated image of 6c8u
SOLUTION STRUCTURE OF MUSASHI2 RRM1
Descriptor:RNA-binding protein Musashi homolog 2
Authors:Xing, M., Lan, L., Douglas, J.T., Gao, P., Hanzlik, R.P., Xu, L.
Deposit date:2018-01-25
Release date:2019-01-30
Last modified:2019-02-20
Method:SOLUTION NMR
Cite:Solution structure of Musashi2 RRM1
To be Published
4QBA
  • Download 4qba
  • View 4qba
Molmil generated image of 4qba
CRYSTAL STRUCTURE OF THE EFFECTOR-BINDING DOMAIN OF S. AUREUS CCPE
Descriptor:LysR family regulatory protein, CHLORIDE ION
Authors:Liu, X., Lan, L., Yang, C.G.
Deposit date:2014-05-06
Release date:2014-11-19
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Metabolic sensor governing bacterial virulence in Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 2014
3ST9
  • Download 3st9
  • View 3st9
Molmil generated image of 3st9
CRYSTAL STRUCTURE OF CLPP IN HEPTAMERIC FORM FROM STAPHYLOCOCCUS AUREUS
Descriptor:ATP-dependent Clp protease proteolytic subunit, SULFATE ION, CALCIUM ION, ...
Authors:Zhang, J., Ye, F., Lan, L., Jiang, H., Luo, C., Yang, C.-G.
Deposit date:2011-07-09
Release date:2011-09-07
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural switching of Staphylococcus aureus Clp protease: a key to understanding protease dynamics
J.Biol.Chem., 286, 2011
3STA
  • Download 3sta
  • View 3sta
Molmil generated image of 3sta
CRYSTAL STRUCTURE OF CLPP IN TETRADECAMERIC FORM FROM STAPHYLOCOCCUS AUREUS
Descriptor:ATP-dependent Clp protease proteolytic subunit
Authors:Zhang, J., Ye, F., Lan, L., Jiang, H., Luo, C., Yang, C.-G.
Deposit date:2011-07-09
Release date:2011-09-07
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural switching of Staphylococcus aureus Clp protease: a key to understanding protease dynamics
J.Biol.Chem., 286, 2011
4HBL
  • Download 4hbl
  • View 4hbl
Molmil generated image of 4hbl
CRYSTAL STRUCTURE OF ABFR OF STAPHYLOCOCCUS EPIDERMIDIS
Descriptor:Transcriptional regulator, MarR family
Authors:Liu, X., Sun, X., Gan, J., Lan, L., Yang, C.-G.
Deposit date:2012-09-28
Release date:2013-01-02
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis.
J.Biol.Chem., 288, 2013
4HQE
  • Download 4hqe
  • View 4hqe
Molmil generated image of 4hqe
THE CRYSTAL STRUCTURE OF QSRR-DNA COMPLEX
Descriptor:Transcriptional regulator QsrR, DNA (5'-D(*GP*GP*TP*AP*TP*AP*AP*TP*AP*AP*TP*TP*AP*TP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*TP*AP*AP*TP*TP*AP*TP*TP*AP*TP*AP*CP*C)-3')
Authors:He, C., Ji, Q., Zhang, L.
Deposit date:2012-10-25
Release date:2013-03-06
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Proc.Natl.Acad.Sci.USA, 110, 2013
5XPD
  • Download 5xpd
  • View 5xpd
Molmil generated image of 5xpd
SUGAR TRANSPORTER OF ATSWEET13 IN INWARD-FACING STATE WITH A SUBSTRATE ANALOG
Descriptor:sugar transporter, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE
Authors:Han, L., Zhang, X.J.
Deposit date:2017-06-01
Release date:2017-09-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.788 Å)
Cite:Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5YEW
  • Download 5yew
  • View 5yew
Molmil generated image of 5yew
STRUCTURAL BASIS FOR GTP HYDROLYSIS AND CONFORMATIONAL CHANGE OF MITOFUSIN 1 IN MEDIATING MITOCHONDRIAL FUSION
Descriptor:Mitofusin-1,Mitofusin-1 fusion protein, GUANOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Yan, L., Qi, Y., Huang, X., Yu, C.
Deposit date:2017-09-20
Release date:2018-01-31
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion
Nat. Struct. Mol. Biol., 25, 2018
4EYC
  • Download 4eyc
  • View 4eyc
Molmil generated image of 4eyc
CRYSTAL STRUCTURE OF THE CATHELIN-LIKE DOMAIN OF HUMAN CATHELICIDIN LL-37 (HCLD)
Descriptor:Cathelicidin antimicrobial peptide
Authors:Pazgier, M., Pozharski, E., Toth, E., Lu, W.
Deposit date:2012-05-01
Release date:2013-02-27
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Analysis of the Pro-Domain of Human Cathelicidin, LL-37.
Biochemistry, 52, 2013
5C90
  • Download 5c90
  • View 5c90
Molmil generated image of 5c90
STAPHYLOCOCCUS AUREUS CLPP MUTANT - Y63A
Descriptor:ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Ye, F., Liu, H., Zhang, J., Gan, J., Yang, C.-G.
Deposit date:2015-06-26
Release date:2016-05-25
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure
Acs Chem.Biol., 11, 2016
5DAJ
  • Download 5daj
  • View 5daj
Molmil generated image of 5daj
CRYSTAL STRUCTURE OF NALD, THE SECONDARY REPRESSOR OF MEXAB-OPRM MULTIDRUG EFFLUX PUMP IN PSEUDOMONAS AERUGINOSA
Descriptor:NalD
Authors:Chen, W.Z., Wang, D., Huang, S.Q., Hu, Q.Y., Liu, X.C., Gan, J.H., Chen, H.
Deposit date:2015-08-20
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa
Mol.Microbiol., 100, 2016
5H9T
  • Download 5h9t
  • View 5h9t
Molmil generated image of 5h9t
CRYSTAL STRUCTURE OF NATIVE NALD AT RESOLUTION OF 2.9, THE SECONDARY REPRESSOR OF MEXAB-OPRM MULTIDRUG EFFLUX PUMP IN PSEUDOMONAS AERUGINOSA
Descriptor:NalD
Authors:Chen, W.Z., Wang, D., Huang, S.Q., Hu, Q.Y., Liu, X.C., Gan, J.H., Chen, H.
Deposit date:2015-12-29
Release date:2016-04-20
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa.
Mol. Microbiol., 100, 2016
5HLG
  • Download 5hlg
  • View 5hlg
Molmil generated image of 5hlg
STRUCTURE OF REDUCED ABFR BOUND TO DNA
Descriptor:DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator
Authors:Liu, G., Liu, X., Gan, J., Yang, C.G.
Deposit date:2016-01-15
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
5HLH
  • Download 5hlh
  • View 5hlh
Molmil generated image of 5hlh
CRYSTAL STRUCTURE OF THE OVEROXIDIZED ABFR BOUND TO DNA
Descriptor:DNA (5'-D(*TP*AP*AP*CP*TP*CP*AP*AP*TP*CP*GP*CP*GP*CP*GP*CP*GP*AP*TP*TP*GP*AP*GP*T)-3'), MarR family transcriptional regulator
Authors:Liu, G., Liu, X., Gan, J., Yang, C.-G.
Deposit date:2016-01-15
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
5HLI
  • Download 5hli
  • View 5hli
Molmil generated image of 5hli
STRUCTURE OF DISULFIDE FORMED ABFR
Descriptor:MarR family transcriptional regulator, COPPER (II) ION, CHLORIDE ION
Authors:Liu, G., Liu, X., Gan, J., Yang, C.-G.
Deposit date:2016-01-15
Release date:2017-01-25
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR.
J. Am. Chem. Soc., 139, 2017
5VZ2
  • Download 5vz2
  • View 5vz2
Molmil generated image of 5vz2
STRUCTURE OF CLPP FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH ACYLDEPSIPEPTIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, Acyldepsipeptide
Authors:Griffith, E.C., Lee, R.E.
Deposit date:2017-05-26
Release date:2017-06-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Design and Synthesis of Urea Depsipeptides as ClpP Activators
To Be Published
5W18
  • Download 5w18
  • View 5w18
Molmil generated image of 5w18
STAPHYLOCOCCUS AUREUS CLPP IN COMPLEX WITH (S)-N-((2R,6S,8AS,14AS,20S,23AS)-2,6-DIMETHYL-5,8,14,19,23-PENTAOXOOCTADECAHYDRO-1H,5H,14H,19H-PYRIDO[2,1-I]DIPYRROLO[2,1-C:2',1'-L][1]OXA[4,7,10,13]TETRAAZACYCLOHEXADECIN-20-YL)-3-PHENYL-2-(3-PHENYLUREIDO)PROPANAMIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, 9V7-PHE-SER-PRO-YCP-ALA-MP8
Authors:Lee, R.E., Griffith, E.C.
Deposit date:2017-06-02
Release date:2017-08-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Design and Synthesis of Urea Depsipeptide as ClpP Activators
To Be Published
6CFD
  • Download 6cfd
  • View 6cfd
Molmil generated image of 6cfd
ADEP4 BOUND TO E. FAECIUM CLPP
Descriptor:ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide
Authors:Lee, R.E., Griffith, E.C.
Deposit date:2018-02-14
Release date:2018-05-16
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:In VivoandIn VitroEffects of a ClpP-Activating Antibiotic against Vancomycin-Resistant Enterococci.
Antimicrob. Agents Chemother., 62, 2018