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3GFK
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BU of 3gfk by Molmil
Crystal structure of Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex
Descriptor: DNA-directed RNA polymerase subunit alpha, Regulatory protein spx
Authors:Lamour, V, Westblade, L.F, Campbell, E.A, Darst, S.A.
Deposit date:2009-02-27
Release date:2009-03-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the in vivo-assembled Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex
J.Struct.Biol., 168, 2009
2ETN
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BU of 2etn by Molmil
Crystal structure of Thermus aquaticus Gfh1
Descriptor: anti-cleavage anti-GreA transcription factor Gfh1
Authors:Lamour, V, Hogan, B.P, Erie, D.A, Darst, S.A.
Deposit date:2005-10-27
Release date:2006-02-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of Thermus aquaticus Gfh1, a Gre-factor paralog that inhibits rather than stimulates transcript cleavage.
J.Mol.Biol., 356, 2006
1KIJ
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BU of 1kij by Molmil
Crystal structure of the 43K ATPase domain of Thermus thermophilus gyrase B in complex with novobiocin
Descriptor: DNA GYRASE SUBUNIT B, FORMIC ACID, NOVOBIOCIN
Authors:Lamour, V, Hoermann, L, Jeltsch, J.-M, Oudet, P, Moras, D.
Deposit date:2001-12-03
Release date:2002-06-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:An open conformation of the Thermus thermophilus gyrase B ATP-binding domain.
J.Biol.Chem., 277, 2002
3BMB
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BU of 3bmb by Molmil
Crystal structure of a new RNA polymerase interacting protein
Descriptor: CHLORIDE ION, Regulator of nucleoside diphosphate kinase, SULFATE ION
Authors:Darst, S.A, Lamour, V.
Deposit date:2007-12-12
Release date:2008-10-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of Escherichia coli Rnk, a new RNA polymerase-interacting protein.
J.Mol.Biol., 383, 2008
2GHO
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BU of 2gho by Molmil
Recombinant Thermus aquaticus RNA polymerase for Structural Studies
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta',DNA-directed RNA polymerase subunit beta'
Authors:Lamour, V, Darst, S.A.
Deposit date:2006-03-27
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (5 Å)
Cite:Recombinant Thermus aquaticus RNA Polymerase for Structural Studies.
J.Mol.Biol., 359, 2006
8A43
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BU of 8a43 by Molmil
Human RNA polymerase I
Descriptor: DNA-directed RNA polymerase I subunit RPA1, DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA2, ...
Authors:Daiss, J.L, Pilsl, M, Straub, K, Bleckmann, A, Hoecherl, M, Heiss, F.B, Abascal-Palacios, G, Ramsay, E, Tluckova, K, Mars, J.C, Fuertges, T, Bruckmann, A, Rudack, T, Bernecky, C, Lamour, V, Panov, K, Vannini, A, Moss, T, Engel, C.
Deposit date:2022-06-10
Release date:2022-08-31
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (4.09 Å)
Cite:The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.
Life Sci Alliance, 5, 2022
1US0
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BU of 1us0 by Molmil
Human Aldose Reductase in complex with NADP+ and the inhibitor IDD594 at 0.66 Angstrom
Descriptor: ALDOSE REDUCTASE, CITRIC ACID, IDD594, ...
Authors:Howard, E.I, Sanishvili, R, Cachau, R.E, Mitschler, A, Chevrier, B, Barth, P, Lamour, V, Van Zandt, M, Sibley, E, Bon, C, Moras, D, Schneider, T.R, Joachimiak, A, Podjarny, A.
Deposit date:2003-11-16
Release date:2004-05-07
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (0.66 Å)
Cite:Ultrahigh Resolution Drug Design I: Details of Interactions in Human Aldose Reductase-Inhibitor Complex at 0.66 A.
Proteins, 55, 2004
1PFJ
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BU of 1pfj by Molmil
Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit
Descriptor: TFIIH basal transcription factor complex p62 subunit
Authors:Gervais, V, Lamour, V, Jawhari, A, Frindel, F, Wasielewski, E, Thierry, J.C, Kieffer, B, Poterszman, A, Structural Proteomics in Europe (SPINE)
Deposit date:2003-05-27
Release date:2004-06-08
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:TFIIH contains a PH domain involved in DNA nucleotide excision repair.
Nat.Struct.Mol.Biol., 11, 2004
2P7V
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BU of 2p7v by Molmil
Crystal structure of the Escherichia coli regulator of sigma 70, Rsd, in complex with sigma 70 domain 4
Descriptor: MAGNESIUM ION, RNA polymerase sigma factor rpoD, Regulator of sigma D
Authors:Patikoglou, G.A, Westblade, L.F, Campbell, E.A, Lamour, V, Lane, W.J, Darst, S.A.
Deposit date:2007-03-20
Release date:2007-08-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4.
J.Mol.Biol., 372, 2007
6ENH
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BU of 6enh by Molmil
Crystal structure of the 43K ATPase domain of Thermus thermophilus gyrase B in complex with an aminocoumarin
Descriptor: Coumermycin A1, DNA gyrase subunit B, IMIDAZOLE
Authors:Vanden Broeck, A, McEwen, A.G, Lamour, V.
Deposit date:2017-10-04
Release date:2019-04-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural Basis for DNA Gyrase Interaction with Coumermycin A1.
J.Med.Chem., 62, 2019
6ENG
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BU of 6eng by Molmil
Crystal structure of the 43K ATPase domain of Escherichia coli gyrase B in complex with an aminocoumarin
Descriptor: CHLORIDE ION, Coumermycin A1, DNA gyrase subunit B, ...
Authors:Vanden Broeck, A, McEwen, A.G, Lamour, V.
Deposit date:2017-10-04
Release date:2019-04-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for DNA Gyrase Interaction with Coumermycin A1.
J.Med.Chem., 62, 2019
3D36
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BU of 3d36 by Molmil
How to Switch Off a Histidine Kinase: Crystal Structure of Geobacillus stearothermophilus KinB with the Inhibitor Sda
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bick, M.J, Lamour, V, Rajashankar, K.R, Gordiyenko, Y, Robinson, C.V, Darst, S.A.
Deposit date:2008-05-09
Release date:2009-01-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:How to switch off a histidine kinase: crystal structure of Geobacillus stearothermophilus KinB with the inhibitor Sda
J.Mol.Biol., 386, 2009
6ZY7
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BU of 6zy7 by Molmil
Cryo-EM structure of the entire Human topoisomerase II alpha in State 1
Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ...
Authors:Vanden Broeck, A, Lamour, V.
Deposit date:2020-07-30
Release date:2021-05-26
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (4.64 Å)
Cite:Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Nat Commun, 12, 2021
6ZY6
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BU of 6zy6 by Molmil
Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2
Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ...
Authors:Vanden Broeck, A, Lamour, V.
Deposit date:2020-07-30
Release date:2021-05-26
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Nat Commun, 12, 2021
6ZY8
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BU of 6zy8 by Molmil
Cryo-EM structure of the entire Human topoisomerase II alpha in State 2
Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ...
Authors:Vanden Broeck, A, Lamour, V.
Deposit date:2020-07-30
Release date:2021-05-26
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Nat Commun, 12, 2021
6ZY5
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BU of 6zy5 by Molmil
Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1
Descriptor: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ...
Authors:Vanden Broeck, A, Lamour, V.
Deposit date:2020-07-30
Release date:2021-05-26
Last modified:2021-06-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Nat Commun, 12, 2021
6RKW
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BU of 6rkw by Molmil
CryoEM structure of the complete E. coli DNA Gyrase complex bound to a 130 bp DNA duplex
Descriptor: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA (58-MER), DNA (62-MER), ...
Authors:Vanden Broeck, A, Lamour, V.
Deposit date:2019-04-30
Release date:2019-11-06
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Nat Commun, 10, 2019
6RKS
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BU of 6rks by Molmil
E. coli DNA Gyrase - DNA binding and cleavage domain in State 1 without TOPRIM insertion
Descriptor: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA Strand 1, DNA Strand 2, ...
Authors:Vanden Broeck, A, Lamour, V.
Deposit date:2019-04-30
Release date:2019-11-06
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Nat Commun, 10, 2019
6RKV
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BU of 6rkv by Molmil
E. coli DNA Gyrase - DNA binding and cleavage domain in State 2
Descriptor: DNA Strand 1, DNA Strand 2, DNA gyrase subunit A, ...
Authors:Vanden Broeck, A, Lamour, V.
Deposit date:2019-04-30
Release date:2019-11-06
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Nat Commun, 10, 2019
6RKU
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BU of 6rku by Molmil
E. coli DNA Gyrase - DNA binding and cleavage domain in State 1
Descriptor: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA Strand 1, DNA Strand 2, ...
Authors:Vanden Broeck, A, Lamour, V.
Deposit date:2019-04-30
Release date:2019-11-06
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Nat Commun, 10, 2019
1KZN
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BU of 1kzn by Molmil
Crystal Structure of E. coli 24kDa Domain in Complex with Clorobiocin
Descriptor: CLOROBIOCIN, DNA GYRASE SUBUNIT B
Authors:Lafitte, D, Lamour, V, Tsvetkov, P.O, Makarov, A.A, Klich, M, Deprez, P, Moras, D, Briand, C, Gilli, R.
Deposit date:2002-02-07
Release date:2002-06-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose.
Biochemistry, 41, 2002
1EKO
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BU of 1eko by Molmil
PIG ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
Descriptor: ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE
Authors:Podjarny, A.
Deposit date:2000-03-09
Release date:2000-05-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of human aldose reductase bound to the inhibitor IDD384.
Acta Crystallogr.,Sect.D, 56, 2000
1EL3
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BU of 1el3 by Molmil
HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
Descriptor: ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE
Authors:Podjarny, A.
Deposit date:2000-03-13
Release date:2000-05-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure of human aldose reductase bound to the inhibitor IDD384.
Acta Crystallogr.,Sect.D, 56, 2000
3MLQ
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BU of 3mlq by Molmil
Crystal structure of the Thermus thermophilus transcription-repair coupling factor RNA polymerase interacting domain with the Thermus aquaticus RNA polymerase beta1 domain
Descriptor: DNA-directed RNA polymerase subunit beta, PHOSPHATE ION, Transcription-repair coupling factor
Authors:Darst, S.A, Westblade, L.F, Campbell, E.A.
Deposit date:2010-04-18
Release date:2010-10-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction.
Nucleic Acids Res., 38, 2010

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