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1SS9
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CRYSTAL STRUCTURAL ANALYSIS OF ACTIVE SITE MUTANT Q189E OF LGTC
Descriptor:alpha-1,4-galactosyl transferase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUOROGALACTOSE
Authors:Lairson, L.L., Chiu, C.P., Ly, H.D., He, S., Wakarchuk, W.W., Strynadka, N.C., Withers, S.G.
Deposit date:2004-03-23
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue.
J.Biol.Chem., 279, 2004
1RO7
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STRUCTURAL ANALYSIS OF THE SIALYLTRANSFERASE CSTII FROM CAMPYLOBACTER JEJUNI IN COMPLEX WITH A SUBSTRATE ANALOGUE, CMP-3FNEUAC.
Descriptor:alpha-2,3/8-sialyltransferase, (4S)-2-METHYL-2,4-PENTANEDIOL, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID
Authors:Chiu, C.P., Watts, A.G., Lairson, L.L., Gilbert, M., Lim, D., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.
Deposit date:2003-12-01
Release date:2004-02-03
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.
Nat.Struct.Mol.Biol., 11, 2004
1RO8
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STRUCTURAL ANALYSIS OF THE SIALYLTRANSFERASE CSTII FROM CAMPYLOBACTER JEJUNI IN COMPLEX WITH A SUBSTRATE ANALOGUE, CYTIDINE-5'-MONOPHOSPHATE
Descriptor:alpha-2,3/8-sialyltransferase, CYTIDINE-5'-MONOPHOSPHATE
Authors:Chiu, C.P., Watts, A.G., Lairson, L.L., Gilbert, M., Lim, D., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.
Deposit date:2003-12-01
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.
Nat.Struct.Mol.Biol., 11, 2004
2P2V
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CRYSTAL STRUCTURE ANALYSIS OF MONOFUNCTIONAL ALPHA-2,3-SIALYLTRANSFERASE CST-I FROM CAMPYLOBACTER JEJUNI
Descriptor:Alpha-2,3-sialyltransferase, CHLORIDE ION, 1,2-ETHANEDIOL, ...
Authors:Chiu, C.P., Lairson, L.L., Gilbert, M., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.
Deposit date:2007-03-07
Release date:2007-07-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Analysis of the alpha-2,3-Sialyltransferase Cst-I from Campylobacter jejuni in Apo and Substrate-Analogue Bound Forms.
Biochemistry, 46, 2007
2P56
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CRYSTAL STRUCTURE OF ALPHA-2,3-SIALYLTRANSFERASE FROM CAMPYLOBACTER JEJUNI IN APO FORM
Descriptor:Alpha-2,3-sialyltransferase, 1,2-ETHANEDIOL
Authors:Chiu, C.P., Lairson, L.L., Gilbert, M., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.
Deposit date:2007-03-14
Release date:2007-07-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of the alpha-2,3-Sialyltransferase Cst-I from Campylobacter jejuni in Apo and Substrate-Analogue Bound Forms.
Biochemistry, 46, 2007
2WQQ
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CRYSTALLOGRAPHIC ANALYSIS OF MONOMERIC CSTII
Descriptor:ALPHA-2,3-/2,8-SIALYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, DI(HYDROXYETHYL)ETHER
Authors:Chan, P.H.W., Lairson, L.L., Lee, H.J., Wakarchuk, W.W., Strynadka, N.C.J., Withers, S.G., McIntosh, L.P.
Deposit date:2009-08-25
Release date:2009-10-27
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:NMR Spectroscopic Characterization of the Sialyltransferase Cstii from Camplyobacter Jejuni: Histidine 188 is the General Base.
Biochemistry, 48, 2009
2X61
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CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE CST-II IN COMPLEX WITH TRISACCHARIDE ACCEPTOR AND CMP
Descriptor:ALPHA-2,3-/2,8-SIALYLTRANSFERASE, N-ACETYL-D-GALACTOSAMINE, BETA-D-GALACTOSE, ...
Authors:Lee, H.J., Lairson, L.L., Rich, J.R., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.J.
Deposit date:2010-02-16
Release date:2011-03-02
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter Jejuni.
J.Biol.Chem., 286, 2011
2X62
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CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE CST-II Y81F IN COMPLEX WITH CMP
Descriptor:ALPHA-2,3-/2,8-SIALYLTRANSFERASE, 1,2-ETHANEDIOL, N3-PROTONATED CYTIDINE-5'-MONOPHOSPHATE
Authors:Lee, H.J., Lairson, L.L., Rich, J.R., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.J.
Deposit date:2010-02-14
Release date:2011-02-23
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter Jejuni.
J.Biol.Chem., 286, 2011
2X63
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CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE CST-II N51A IN COMPLEX WITH CMP
Descriptor:ALPHA-2,3-/2,8-SIALYLTRANSFERASE, 1,2-ETHANEDIOL, CYTIDINE-5'-MONOPHOSPHATE
Authors:Lee, H.J., Lairson, L.L., Rich, J.R., Wakarchuk, W.W., Withers, S.G., Strynadka, N.C.J.
Deposit date:2010-02-14
Release date:2011-02-23
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter Jejuni.
J.Biol.Chem., 286, 2011
6DNA
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CRYSTAL STRUCTURE OF T110A MUTANT HUMAN GLUTAMATE OXALOACETATE TRANSAMINASE 1 (GOT1)
Descriptor:Aspartate aminotransferase, cytoplasmic, TETRAETHYLENE GLYCOL, ...
Authors:Assar, Z., Holt, M.C., Stein, A.J., Lairson, L., Lyssiotis, C.A.
Deposit date:2018-06-06
Release date:2018-11-14
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry, 57, 2018
6DNB
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CRYSTAL STRUCTURE OF T110A:S256A MUTANT HUMAN GLUTAMATE OXALOACETATE TRANSAMINASE 1 (GOT1)
Descriptor:Aspartate aminotransferase, cytoplasmic, TETRAETHYLENE GLYCOL, ...
Authors:Assar, Z., Holt, M.C., Stein, A.J., Lairson, L., Lyssiotis, C.A.
Deposit date:2018-06-06
Release date:2018-11-14
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry, 57, 2018
6DND
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CRYSTAL STRUCTURE OF WILD-TYPE (WT) HUMAN GLUTAMATE OXALOACETATE TRANSAMINASE 1 (GOT1)
Descriptor:Aspartate aminotransferase, cytoplasmic, TETRAETHYLENE GLYCOL, ...
Authors:Assar, Z., Holt, M.C., Stein, A.J., Lairson, L., Lyssiotis, C.A.
Deposit date:2018-06-06
Release date:2018-11-14
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry, 57, 2018
2DRJ
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XRAY STRUCTURE OF ALPHA-2,3/8-SIALYLTRANSFERASE CSTII F91Y MUTANT
Descriptor:Alpha-2,3/8-sialyltransferase, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, ISOPROPYL ALCOHOL
Authors:Chiu, C.P.C., Strynadka, N.C.J.
Deposit date:2006-06-09
Release date:2007-04-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:High-throughput screening methodology for the directed evolution of glycosyltransferases
Nat.Methods, 3, 2006
2C83
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CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE PM0188
Descriptor:HYPOTHETICAL PROTEIN PM0188
Authors:Kim, D.U., Cho, H.S.
Deposit date:2005-12-01
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of Sialyltransferase Pm0188 from Pasteurella Multocida Complexed with Donor Analogue and Acceptor Sugar.
Bmb Rep., 41, 2008
2C84
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CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE PM0188 WITH CMP
Descriptor:ALPHA-2,3/2,6-SIALYLTRANSFERASE/SIALIDASE, CYTIDINE-5'-MONOPHOSPHATE
Authors:Kim, D.U., Cho, H.S.
Deposit date:2005-12-01
Release date:2007-03-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural Analysis of Sialyltransferase Pm0188 from Pasteurella Multocida Complexed with Donor Analogue and Acceptor Sugar.
Bmb Rep., 41, 2008