Author results

5TZP
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CRYSTAL STRUCTURE OF FPV039:BIK BH3 COMPLEX
Descriptor:Bcl-2-like protein FPV039, Bik, 1,2-ETHANEDIOL, ...
Authors:Anasir, M.I., Kvansakul, M.
Deposit date:2016-11-22
Release date:2017-05-03
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural basis of apoptosis inhibition by the fowlpox virus protein FPV039.
J. Biol. Chem., 292, 2017
6MS1
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CRYSTAL STRUCTURE OF THE HUMAN SCRIBBLE PDZ1 DOMAIN BOUND TO THE PDZ-BINDING MOTIF OF APC
Descriptor:Protein scribble homolog, APC C-terminus peptide, 1,2-ETHANEDIOL
Authors:How, J.Y., Kvansakul, M., Caria, S., Humbert, P.O.
Deposit date:2018-10-16
Release date:2019-02-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC.
FEBS Lett., 2019
4AAZ
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X-RAY STRUCTURE OF NICOTIANA ALATA DEFENSIN 1 NAD1
Descriptor:FLOWER-SPECIFIC DEFENSIN, 1,2-ETHANEDIOL, PHOSPHATE ION
Authors:Lay, F.T., Mills, G.D., Hulett, M.D., Kvansakul, M.
Deposit date:2011-12-06
Release date:2012-04-25
Last modified:2012-08-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Dimerization of Plant Defensin Nad1 Enhances its Antifungal Activity.
J.Biol.Chem., 287, 2012
2WH6
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CRYSTAL STRUCTURE OF ANTI-APOPTOTIC BHRF1 IN COMPLEX WITH THE BIM BH3 DOMAIN
Descriptor:EARLY ANTIGEN PROTEIN R, BCL-2-LIKE PROTEIN 11, BROMIDE ION, ...
Authors:Kvansakul, M., Huang, D.C.S., Colman, P.M.
Deposit date:2009-05-01
Release date:2010-05-26
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS Pathog., 6, 2010
5WOU
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CRYSTAL STRUCTURE OF DROSOPHILA MELANOGASTER SCRIBBLE PDZ1 DOMAIN IN COMPLEX WITH GUK-HOLDER
Descriptor:Protein lap4, GUK-holder, isoform A, ...
Authors:Caria, S., Kvansakul, M.
Deposit date:2017-08-03
Release date:2018-02-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Drosophila melanogasterGuk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.
J. Biol. Chem., 293, 2018
2WUH
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CRYSTAL STRUCTURE OF THE DDR2 DISCOIDIN DOMAIN BOUND TO A TRIPLE- HELICAL COLLAGEN PEPTIDE
Descriptor:DISCOIDIN DOMAIN RECEPTOR 2, COLLAGEN PEPTIDE
Authors:Carafoli, F., Bihan, D., Stathopoulos, S., Konitsiotis, A.D., Kvansakul, M., Farndale, R.W., Leitinger, B., Hohenester, E.
Deposit date:2009-10-05
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic Insight Into Collagen Recognition by Discoidin Domain Receptor 2
Structure, 17, 2009
4CQK
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CRYSTAL STRUCTURE OF LIGAND-BOUND NAD1
Descriptor:FLOWER-SPECIFIC DEFENSIN, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, SULFATE ION, ...
Authors:Lay, F.T., Mills, G.M., Poon, I.K.H., Baxter, A.A., Hulett, M.D., Kvansakul, M.
Deposit date:2014-02-17
Release date:2014-04-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Phosphoinositide-Mediated Oligomerization of a Defensin Induces Cell Lysis.
Elife, 3, 2014
4AB0
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X-RAY CRYSTAL STRUCTURE OF NICOTIANA ALATA DEFENSIN NAD1
Descriptor:FLOWER-SPECIFIC DEFENSIN, PHOSPHATE ION
Authors:Mills, G.D., Lay, F.T., Hulett, M.D., Kvansakul, M.
Deposit date:2011-12-06
Release date:2012-04-25
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.636 Å)
Cite:Dimerization of Plant Defensin Nad1 Enhances its Antifungal Activity.
J.Biol.Chem., 287, 2012
5TZQ
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CRYSTAL STRUCTURE OF FPV039:BMF BH3 COMPLEX
Descriptor:Bcl-2-like protein FPV039, Bcl-2-modifying factor, 1,2-ETHANEDIOL
Authors:Anasir, M.I., Kvansakul, M.
Deposit date:2016-11-22
Release date:2017-05-03
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis of apoptosis inhibition by the fowlpox virus protein FPV039.
J. Biol. Chem., 292, 2017
5VMN
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CRYSTAL STRUCTURE OF GROUPER IRIDOVIRUS GIV66
Descriptor:Bak protein, NITRATE ION, 1,2-ETHANEDIOL
Authors:Banjara, S., Kvansakul, M.
Deposit date:2017-04-27
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim.
J. Biol. Chem., 293, 2018
4UJ0
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CRYSTAL STRUCTURE OF THE TOMATO DEFENSIN TPP3
Descriptor:FLOWER-SPECIFIC GAMMA-THIONIN-LIKE PROTEIN/ACIDIC PROTEIN, ACETATE ION
Authors:Richter, V., Lay, F.T., Hulett, M.D., Kvansakul, M.
Deposit date:2015-04-07
Release date:2015-04-15
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Tomato Defensin Tpp3 Binds Phosphatidylinositol (4,5)-Bisphosphate Via a Conserved Dimeric Cationic Grip Conformation to Mediate Cell Lysis.
Mol.Cell.Biol., 35, 2015
5KK4
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CRYSTAL STRUCTURE OF THE PLANT DEFENSIN NSD7 BOUND TO PHOSPHATIDIC ACID
Descriptor:NsD7, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Kvansakul, M., Hulett, M.D., Lay, F.T.
Deposit date:2016-06-21
Release date:2016-10-05
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization.
Proc.Natl.Acad.Sci.USA, 113, 2016
5VMO
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CRYSTAL STRUCTURE OF GROUPER IRIDOVIRUS GIV66:BIM COMPLEX
Descriptor:Bak protein, Bcl-2 interacting mediator of cell death, PENTAETHYLENE GLYCOL, ...
Authors:Banjara, S., Kvansakul, M.
Deposit date:2017-04-28
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim.
J. Biol. Chem., 293, 2018
5AJJ
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CRYSTAL STRUCTURE OF VARIOLA VIRUS VIRULENCE FACTOR F1L IN COMPLEX WITH HUMAN BID BH3 DOMAIN
Descriptor:HOMOLOG OF VACCINIA VIRUS CDS F1L PUTATIVE, BH3-INTERACTING DOMAIN DEATH AGONIST, GLYCEROL, ...
Authors:Kvansakul, M., Colman, P.M.
Deposit date:2015-02-25
Release date:2015-03-25
Last modified:2015-07-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Variola Virus F1L is a Bcl-2-Like Protein that Unlike its Vaccinia Virus Counterpart Inhibits Apoptosis Independent of Bim.
Cell Death Dis., 6, 2015
5VWI
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CRYSTAL STRUCTURE OF HUMAN SCRIBBLE PDZ1:BETA-PIX COMPLEX
Descriptor:Protein scribble homolog, beta-PIX
Authors:Lim, K.Y.B., Kvansakul, M.
Deposit date:2017-05-22
Release date:2017-11-08
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor beta-PIX.
J. Biol. Chem., 292, 2017
5TWA
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CRYSTAL STRUCTURE OF GEODIA CYDONIUM BHP2 IN COMPLEX WITH LUBOMIRSKIA BAICALENSIS BAK-2
Descriptor:Bcl-x homologous protein, BHP2, BAK-2 protein, ...
Authors:Caria, S., Hinds, M.G., Kvansakul, M.
Deposit date:2016-11-12
Release date:2017-01-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural insight into an evolutionarily ancient programmed cell death regulator - the crystal structure of marine sponge BHP2 bound to LB-Bak-2.
Cell Death Dis, 8, 2017
6CS9
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CRYSTAL STRUCTURE OF HUMAN BETA-DEFENSIN 2 IN COMPLEX WITH PIP2
Descriptor:Beta-defensin 4A, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Jarva, M., Phan, K., Lay, F.T., Humble, C., Hulett, M., Kvansakul, M.
Deposit date:2018-03-20
Release date:2018-07-25
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Human beta-defensin 2 killsCandida albicansthrough phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization.
Sci Adv, 4, 2018
1O91
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CRYSTAL STRUCTURE OF A COLLAGEN VIII NC1 DOMAIN TRIMER
Descriptor:COLLAGEN ALPHA 1(VIII) CHAIN, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, SULFATE ION
Authors:Kvansakul, M., Bogin, O., Hohenester, E., Yayon, A.
Deposit date:2002-12-10
Release date:2003-11-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Collagen Alpha1(Viii) Nc1 Trimer.
Matrix Biol., 22, 2003
1UX6
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STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENT REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATS
Descriptor:THROMBOSPONDIN-1, CALCIUM ION
Authors:Kvansakul, M., Adams, J.C., Hohenester, E.
Deposit date:2004-02-19
Release date:2004-03-18
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Thrombospondin C-Terminal Fragment Reveals a Novel Calcium Core in the Type 3 Repeats
Embo J., 23, 2004
4B4S
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CRYSTAL STRUCTURE OF A PRO-SURVIVAL BCL-2:BIM BH3 COMPLEX
Descriptor:BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL
Authors:Rautureau, G.J.P., Hinds, M.G., Kvansakul, M.
Deposit date:2012-08-01
Release date:2013-01-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist.
Cell Death Dis., 3, 2012
5AEA
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CRYSTAL STRUCTURE OF HUMAN NCAM DOMAIN 1
Descriptor:NEURAL CELL ADHESION MOLECULE 1, CITRATE ANION
Authors:Kvansakul, M., Griffiths, K., Foley, M.
Deposit date:2015-08-27
Release date:2016-04-13
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:I-Bodies, Human Single Domain Antibodies that Antagonize Chemokine Receptor Cxcr4.
J.Biol.Chem., 291, 2016
5VWC
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CRYSTAL STRUCTURE OF HUMAN SCRIBBLE PDZ1 DOMAIN
Descriptor:Protein scribble homolog, 1,2-ETHANEDIOL
Authors:Lim, K.Y.B., Kvansakul, M.
Deposit date:2017-05-21
Release date:2017-11-08
Last modified:2017-12-27
Method:X-RAY DIFFRACTION (1.911 Å)
Cite:Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor beta-PIX.
J. Biol. Chem., 292, 2017
1GL4
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NIDOGEN-1 G2/PERLECAN IG3 COMPLEX
Descriptor:NIDOGEN-1, BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN, ZINC ION, ...
Authors:Kvansakul, M., Hopf, M., Ries, A., Timpl, R., Hohenester, E.
Deposit date:2001-08-23
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the High-Affinity Interaction of Nidogen-1 with Immunoglobulin-Like Domain 3 of Perlecan
Embo J., 20, 2001
1GR3
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STRUCTURE OF THE HUMAN COLLAGEN X NC1 TRIMER
Descriptor:COLLAGEN X, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CALCIUM ION, ...
Authors:Bogin, O., Kvansakul, M., Rom, E., Singer, J., Yayon, A., Hohenester, E.
Deposit date:2001-12-12
Release date:2002-02-14
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insight Into Schmid Metaphyseal Chondrodysplasia from the Crystal Structure of the Collagen X Nc1 Domain Trimer.
Structure, 10, 2002
6H1N
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CRYSTAL STRUCTURE OF A ZEBRA-FISH PRO-SURVIVAL PROTEIN NRZ-APO
Descriptor:BCL2-like 10 (Apoptosis facilitator), SULFATE ION, ACETATE ION
Authors:Suraweera, C.D., Hinds, M.G., Kvansakul, M.
Deposit date:2018-07-12
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:A structural investigation of NRZ mediated apoptosis regulation in zebrafish.
Cell Death Dis, 9, 2018
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