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4X34
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BU of 4x34 by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K381acK382me2
Descriptor: THR-SER-ARG-HIS-ALY-MLY-LEU-MET-PHE-LYS, Tumor suppressor p53-binding protein 1
Authors:Tong, Q, Kutateladze, T.G.
Deposit date:2014-11-27
Release date:2015-03-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:An Acetyl-Methyl Switch Drives a Conformational Change in p53.
Structure, 23, 2015
3RCP
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BU of 3rcp by Molmil
Crystal structure of the FAPP1 pleckstrin homology domain
Descriptor: GLYCEROL, Pleckstrin homology domain-containing family A member 3
Authors:Roy, S, He, J, Kutateladze, T.G.
Deposit date:2011-03-31
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain.
J.Biol.Chem., 286, 2011
7K7T
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BU of 7k7t by Molmil
Crystal structure of human MORC4 ATPase-CW in complex with AMPPNP
Descriptor: Isoform 3 of MORC family CW-type zinc finger protein 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Klein, B.J, Tencer, A.H, Kutateladze, T.G.
Deposit date:2020-09-24
Release date:2020-11-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Molecular mechanism of the MORC4 ATPase activation.
Nat Commun, 11, 2020
1R48
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BU of 1r48 by Molmil
Solution structure of the C-terminal cytoplasmic domain residues 468-497 of Escherichia coli protein ProP
Descriptor: Proline/betaine transporter
Authors:Zoetewey, D.L, Tripet, B.P, Kutateladze, T.G, Overduin, M.J, Wood, J.M, Hodges, R.S.
Deposit date:2003-10-03
Release date:2003-12-23
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution Structure of the C-terminal Antiparallel Coiled-coil Domain from Escherichia coli Osmosensor ProP.
J.Mol.Biol., 334, 2003
3C6W
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BU of 3c6w by Molmil
Crystal structure of the ING5 PHD finger in complex with H3K4me3 peptide
Descriptor: H3K4me3 histone peptide, Inhibitor of growth protein 5, ZINC ION
Authors:Champagne, K.S, Pena, P.V, Johnson, K, Kutateladze, T.G.
Deposit date:2008-02-05
Release date:2008-06-03
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide.
Proteins, 72, 2008
8GDX
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BU of 8gdx by Molmil
Crystal structure of JADE1 PZP domain
Descriptor: GLYCEROL, Protein Jade-1, ZINC ION
Authors:Klein, B.J, Liu, J, Kutateladze, T.G.
Deposit date:2023-03-06
Release date:2024-03-13
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Guiding the HBO1 complex function through the JADE subunit.
Nat.Struct.Mol.Biol., 2024
8GE0
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BU of 8ge0 by Molmil
Crystal structure of JADE1 PZP domain in complex with Histone H3
Descriptor: Histone H3.1,Protein Jade-1, ZINC ION
Authors:Klein, B.J, Liu, J, Kutateladze, T.G.
Deposit date:2023-03-06
Release date:2024-03-13
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Guiding the HBO1 complex function through the JADE subunit.
Nat.Struct.Mol.Biol., 2024
6U04
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BU of 6u04 by Molmil
Crystal structure of human BRPF1 PZP bound to histone H3 tail
Descriptor: Histone H3.3,BRPF1, Peregrin, PRASEODYMIUM ION, ...
Authors:Klein, B.J, Kutateladze, T.G.
Deposit date:2019-08-13
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.
Structure, 28, 2020
4HCZ
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BU of 4hcz by Molmil
PHF1 Tudor in complex with H3K36me3
Descriptor: H3L-like histone, PHD finger protein 1
Authors:Musselman, C.A, Roy, S, Nunez, J, Kutateladze, T.G.
Deposit date:2012-10-01
Release date:2012-11-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1.
Nat.Struct.Mol.Biol., 19, 2012
6AXJ
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BU of 6axj by Molmil
Crystal structure of the Yaf9 YEATS domain bound to H3K27ac
Descriptor: ALY-SER-ALA-PRO-ALA, GLYCEROL, Protein AF-9 homolog, ...
Authors:Klein, B.J, Kutateladze, T.G.
Deposit date:2017-09-06
Release date:2017-11-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.379 Å)
Cite:Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.
Nucleic Acids Res., 46, 2018
3LGF
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BU of 3lgf by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K370me2
Descriptor: DIMETHYLATED p53 Lysine 370 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Roy, S, Kutateladze, T.G.
Deposit date:2010-01-20
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
J.Mol.Biol., 398, 2010
3LGL
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BU of 3lgl by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K382me2
Descriptor: DIMETHYLATED p53 LYSINE 382 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Roy, S, Kutateladze, T.G.
Deposit date:2010-01-20
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
J.Mol.Biol., 398, 2010
3MDF
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BU of 3mdf by Molmil
Crystal structure of the RRM domain of Cyclophilin 33
Descriptor: Peptidyl-prolyl cis-trans isomerase E
Authors:Hom, R.A, Chang, P.Y, Roy, S, Mussleman, C.A, Glass, K.C, Seleznevia, A.I, Gozani, O, Ismagilov, R.F, Cleary, M.L, Kutateladze, T.G.
Deposit date:2010-03-30
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.
J.Mol.Biol., 400, 2010
7LKY
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BU of 7lky by Molmil
Crystal Structure of PHF1 Tudor domain in complex with a peptidomimetic ligand UNC6641
Descriptor: DIMETHYL SULFOXIDE, Isoform 1 of PHD finger protein 1, Peptidomimetic inhibitor UNC6641, ...
Authors:Liu, J, Kutateladze, T.G.
Deposit date:2021-02-03
Release date:2021-12-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1).
J.Med.Chem., 64, 2021
7MJU
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BU of 7mju by Molmil
Crystal structure of human AF10 PZP bound to histone H3 tail
Descriptor: Histone H3.1,Protein AF-10, ZINC ION
Authors:Klein, B.J, Kutateladze, T.G.
Deposit date:2021-04-20
Release date:2021-08-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
Nat Commun, 12, 2021
3LH0
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BU of 3lh0 by Molmil
Crystal structure of the 53BP1 tandem tudor domain in complex with p53K372me2
Descriptor: DIMETHYLATED p53 LYSINE 372 PEPTIDE, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Roy, S, Kutateladze, T.G.
Deposit date:2010-01-21
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insight into p53 recognition by the 53BP1 tandem Tudor domain.
J.Mol.Biol., 398, 2010
7UHE
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BU of 7uhe by Molmil
Taf14 ET domain in complex with C-terminal tail of Taf2
Descriptor: C-terminal tail of Transcription initiation factor TFIID subunit 2, Transcription initiation factor TFIID subunit 14
Authors:Klein, B.J, Kutateladze, T.G.
Deposit date:2022-03-26
Release date:2022-08-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Taf2 mediates DNA binding of Taf14.
Nat Commun, 13, 2022
7TRL
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BU of 7trl by Molmil
Crystal structure of human BIRC2 BIR3 domain in complex with histone H3
Descriptor: 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 2, Histone H3, ...
Authors:Klein, B.J, Tencer, A.H, Kutateladze, T.G.
Deposit date:2022-01-29
Release date:2023-08-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.
Nat.Struct.Mol.Biol., 30, 2023
7TRM
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BU of 7trm by Molmil
Crystal structure of human BIRC2 BIR3 domain in complex with inhibitor LCL-161
Descriptor: 1,2-ETHANEDIOL, Baculoviral IAP repeat-containing protein 2, LCL-161, ...
Authors:Tencer, A.H, Klein, B.J, Kutateladze, T.G.
Deposit date:2022-01-29
Release date:2023-08-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.
Nat.Struct.Mol.Biol., 30, 2023
4L7X
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BU of 4l7x by Molmil
Crystal structure of the DIDO PHD finger in complex with H3K4me3
Descriptor: Death-inducer obliterator 1, Histone H3 peptide, ZINC ION
Authors:Tong, Q, Gatchalian, J, Kutateladze, T.G.
Deposit date:2013-06-14
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Dido3 PHD Modulates Cell Differentiation and Division.
Cell Rep, 4, 2013
4L58
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BU of 4l58 by Molmil
Crystal structure of the MLL5 PHD finger in complex with H3K4me3
Descriptor: Histone H3 peptide, Histone-lysine N-methyltransferase MLL5, ZINC ION
Authors:Tong, Q, Ali, M, Kutateladze, T.G.
Deposit date:2013-06-10
Release date:2013-06-26
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Molecular basis for chromatin binding and regulation of MLL5.
Proc.Natl.Acad.Sci.USA, 110, 2013
4OUF
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BU of 4ouf by Molmil
Crystal Structure of CBP bromodomain
Descriptor: 1,2-ETHANEDIOL, CREB-binding protein, DI(HYDROXYETHYL)ETHER
Authors:Roy, S, Das, C, Tyler, J.K, Kutateladze, T.G.
Deposit date:2014-02-17
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.
Proc.Natl.Acad.Sci.USA, 111, 2014
8E4V
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BU of 8e4v by Molmil
Solution structure of the WH domain of MORF
Descriptor: Isoform 3 of Histone acetyltransferase KAT6B
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2022-08-19
Release date:2023-05-10
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.
Nat Commun, 14, 2023
6DS6
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BU of 6ds6 by Molmil
Crystal structure of p300 ZZ domain in complex with histone H3 peptide
Descriptor: CHLORIDE ION, Histone H3 peptide-Histone acetyltransferase p300 Chimeric protein, ZINC ION
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3.
Nat. Struct. Mol. Biol., 25, 2018
6E86
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BU of 6e86 by Molmil
Solution structure of ZZZ3 ZZ domain in complex with histone H3K4ac peptide
Descriptor: H3K4ac, ZINC ION, ZZ-type zinc finger-containing protein 3
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2018-07-27
Release date:2018-09-19
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation.
Nat Commun, 9, 2018

 

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