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3A38
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CRYSTAL STRUCTURE OF HIGH-POTENTIAL IRON-SULFUR PROTEIN FROM THERMOCHROMATIUM TEPIDUM AT 0.7 ANGSTROM RESOLUTION
Descriptor:High-potential iron-sulfur protein, IRON/SULFUR CLUSTER, SULFATE ION, ...
Authors:Takeda, K., Kusumoto, K., Hirano, Y., Miki, K.
Deposit date:2009-06-10
Release date:2010-01-26
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (0.7 Å)
Cite:Detailed assessment of X-ray induced structural perturbation in a crystalline state protein.
J.Struct.Biol., 169, 2010
3A39
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CRYSTAL STRUCTURE OF HIGH-POTENTIAL IRON-SULFUR PROTEIN FROM THERMOCHROMATIUM TEPIDUM AT 0.72 ANGSTROM RESOLUTION
Descriptor:High-potential iron-sulfur protein, IRON/SULFUR CLUSTER, SULFATE ION, ...
Authors:Takeda, K., Kusumoto, K., Hirano, Y., Miki, K.
Deposit date:2009-06-11
Release date:2009-10-27
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (0.72 Å)
Cite:Detailed assessment of X-ray induced structural perturbation in a crystalline state protein.
J.Struct.Biol., 169, 2010
5TMG
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OPTIMIZATION OF 3,5-DISUBSTITUED PIPERIDINE: DISCOVERY OF NON-PEPTIDE MIMETICS AS AN ORALLY ACTIVE RENIN INHIBITOR
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, 5-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl]-1-phenyl-1H-1,2,3-triazole-4-carboxamide, ...
Authors:Snell, G.P., Behnke, C.A., Okada, K., Hideyuki, O., Sang, B.C., Lane, W.
Deposit date:2016-10-12
Release date:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor
To be published
5TMK
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OPTIMIZATION OF 3,5-DISUBSTITUED PIPERIDINE: DISCOVERY OF NON-PEPTIDE MIMETICS AS AN ORALLY ACTIVE RENIN INHIBITOR
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, 1-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholine-4-carbonyl)piperidin-3-yl]-5-phenyl-1H-pyrrole-2-carboxamide, ...
Authors:Snell, G.P., Behnke, C.A., Okada, K., Hideyuki, O., Sang, B.C., Lane, W.
Deposit date:2016-10-13
Release date:2017-10-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor
To be published
4PF3
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MINERALOCORTICOID RECEPTOR LIGAND-BINDING DOMAIN WITH COMPUOND 37A
Descriptor:Mineralocorticoid receptor, 6-[1-(2,2-difluoro-3-hydroxypropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one, 1,2-ETHANEDIOL
Authors:Sogabe, S., Habuka, N.
Deposit date:2014-04-28
Release date:2014-11-26
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists
Bioorg.Med.Chem., 22, 2014
5KOS
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DISCOVERY OF TAK-272: A NOVEL, POTENT AND ORALLY ACTIVE RENIN IN-HIBITOR
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, 2-~{tert}-butyl-4-(3-methoxypropylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]pyrimidine-5-carboxamide, ...
Authors:Snell, G.P., Behnke, C.A., Okada, K., Hideyuki, O., Sang, B.-C., Lane, W.
Deposit date:2016-07-01
Release date:2016-11-16
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.
Acs Med.Chem.Lett., 7, 2016
5KOT
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DISCOVERY OF TAK-272: A NOVEL, POTENT AND ORALLY ACTIVE RENIN IN-HIBITOR
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, 1-(4-methoxybutyl)-~{N}-(2-methylpropyl)-~{N}-[(3~{S},5~{R})-5-morpholin-4-ylcarbonylpiperidin-3-yl]benzimidazole-2-carboxamide, ...
Authors:Snell, G.P., Behnke, C.A., Okada, K., Hideyuki, O., Sang, B.-C., Lane, W.
Deposit date:2016-07-01
Release date:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of TAK-272: A Novel, Potent and Orally Active Renin Inhibitor
To be published
5KOQ
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DISCOVERY OF TAK-272: A NOVEL, POTENT AND ORALLY ACTIVE RENIN IN-HIBITOR
Descriptor:Renin, N-ACETYL-D-GLUCOSAMINE, 2-~{tert}-butyl-4-(furan-2-ylmethylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S})-piperidin-3-yl]pyrimidine-5-carboxamide, ...
Authors:Snell, G.P., Behnke, C.A., Okada, K., Hideyuki, O., Sang, B.-C., Lane, W.
Deposit date:2016-07-01
Release date:2016-11-02
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.
Bioorg.Med.Chem., 24, 2016