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1I34
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BU of 1i34 by Molmil
SOLUTION DNA QUADRUPLEX WITH DOUBLE CHAIN REVERSAL LOOP AND TWO DIAGONAL LOOPS CONNECTING GGGG TETRADS FLANKED BY G-(T-T) TRIAD AND T-T-T TRIPLE
Descriptor: 5'-D(*GP*GP*TP*TP*TP*TP*GP*GP*CP*AP*GP*GP*GP*TP*TP*TP*TP*GP*GP*T)-3'
Authors:Kuryavyi, V, Majumdar, A, Shallop, A, Chernichenko, N, Skripkin, E, Jones, R, Patel, D.J.
Deposit date:2001-02-12
Release date:2001-06-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:A double chain reversal loop and two diagonal loops define the architecture of a unimolecular DNA quadruplex containing a pair of stacked G(syn)-G(syn)-G(anti)-G(anti) tetrads flanked by a G-(T-T) Triad and a T-T-T triple.
J.Mol.Biol., 310, 2001
2LXV
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BU of 2lxv by Molmil
Dimeric pil-e g-quadruplex dna from neisseria gonorrhoeae, NMR 11 structures
Descriptor: 5'-D(*GP*GP*GP*TP*GP*GP*GP*TP*TP*GP*GP*GP*TP*GP*GP
Authors:Kuryavyi, V, Patel, D.J.
Deposit date:2012-08-31
Release date:2012-11-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:RecA-Binding pilE G4 Sequence Essential for Pilin Antigenic Variation Forms Monomeric and 5' End-Stacked Dimeric Parallel G-Quadruplexes.
Structure, 20, 2012
2KYO
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BU of 2kyo by Molmil
Dimeric human ckit-2 proto-oncogene promoter quadruplex DNA NMR, 10 structures
Descriptor: 5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*GP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3'
Authors:Kuryavyi, V, Phan, A.T, Patel, D.J.
Deposit date:2010-06-05
Release date:2010-06-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter.
Nucleic Acids Res., 38, 2010
2KPR
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BU of 2kpr by Molmil
Monomeric intronic human chl1 gene quadruplex DNA NMR, 17 structures
Descriptor: 5'-D(*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*GP*GP*GP*TP*GP*GP*GP*T)-3'
Authors:Kuryavyi, V, Patel, D.J.
Deposit date:2009-10-19
Release date:2010-03-02
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution Structure of a Unique G-Quadruplex Scaffold Adopted by a Guanosine-Rich Human Intronic Sequence.
Structure, 18, 2010
2KYP
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BU of 2kyp by Molmil
Monomeric Human CKIT-2 proto-oncogene promoter quadruplex DNA NMR, 12 structures
Descriptor: 5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*GP*CP*TP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3'
Authors:Kuryavyi, V, Phan, A.T, Patel, D.J.
Deposit date:2010-06-06
Release date:2010-06-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter.
Nucleic Acids Res., 38, 2010
6MJW
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BU of 6mjw by Molmil
human cGAS catalytic domain bound with the inhibitor G150
Descriptor: 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, Cyclic GMP-AMP synthase, ZINC ION
Authors:Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T.
Deposit date:2018-09-23
Release date:2019-05-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Nat Commun, 10, 2019
6MJX
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BU of 6mjx by Molmil
human cGAS catalytic domain bound with cGAMP
Descriptor: Cyclic GMP-AMP synthase, ZINC ION, cGAMP
Authors:Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T.
Deposit date:2018-09-23
Release date:2019-05-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Nat Commun, 10, 2019
6MJU
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BU of 6mju by Molmil
human cGAS catalytic domain bound with the inhibitor G108
Descriptor: 1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, Cyclic GMP-AMP synthase, ZINC ION
Authors:Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T.
Deposit date:2018-09-22
Release date:2019-05-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Nat Commun, 10, 2019
7SHO
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BU of 7sho by Molmil
Crystal structure of hSTING in complex with c[2',3'-(ara-2'-G, ribo-3'-A)-MP] (RJ242)
Descriptor: (2R,5R,7R,8S,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
Authors:Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J.
Deposit date:2021-10-10
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.
Cell Chem Biol, 2023
7SHP
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BU of 7shp by Molmil
Crystal structure of hSTING in complex with c[2',3'-(ribo-2'-G, xylo-3'-A)-MP](RJ244)
Descriptor: (2S,5R,7R,8R,10S,12aR,14R,15R,15aR,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
Authors:Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J.
Deposit date:2021-10-11
Release date:2022-10-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.
Cell Chem Biol, 2023
2LA5
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BU of 2la5 by Molmil
RNA Duplex-Quadruplex Junction Complex with FMRP RGG peptide
Descriptor: Fragile X mental retardation 1 protein, RNA (36-MER)
Authors:Phan, A, Kuryavyi, V, Darnell, J, Serganov, A, Majumdar, A, Ilin, S, Darnell, R, Patel, D.
Deposit date:2011-03-03
Release date:2011-06-08
Last modified:2011-07-20
Method:SOLUTION NMR
Cite:Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction.
Nat.Struct.Mol.Biol., 18, 2011
1YVU
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BU of 1yvu by Molmil
Crystal structure of A. aeolicus Argonaute
Descriptor: CALCIUM ION, hypothetical protein aq_1447
Authors:Yuan, Y.R, Pei, Y, Ma, J.B, Kuryavyi, V, Zhadina, M, Meister, G, Chen, H.Y, Dauter, Z, Tuschl, T, Patel, D.J.
Deposit date:2005-02-16
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of A. aeolicus Argonaute provides unique perspectives into the mechanism of guide strand-mediated mRNA cleavage
Mol.Cell, 19, 2005
2ASL
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BU of 2asl by Molmil
oxoG-modified Postinsertion Binary Complex
Descriptor: 5'-D(*CP*T*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(DOC))-3', CALCIUM ION, ...
Authors:Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J.
Deposit date:2005-08-23
Release date:2006-01-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
2ASD
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BU of 2asd by Molmil
oxoG-modified Insertion Ternary Complex
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*T*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', ...
Authors:Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J.
Deposit date:2005-08-23
Release date:2006-01-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
2AU0
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BU of 2au0 by Molmil
Unmodified preinsertion binary complex
Descriptor: 5'-D(*CP*TP*AP*AP*CP*G*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', CALCIUM ION, ...
Authors:Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J.
Deposit date:2005-08-26
Release date:2006-01-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
2ASJ
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BU of 2asj by Molmil
oxoG-modified Preinsertion Binary Complex
Descriptor: 5'-D(*CP*TP*AP*AP*CP*(8OG)*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', CALCIUM ION, ...
Authors:Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J.
Deposit date:2005-08-23
Release date:2006-01-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
2ATL
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BU of 2atl by Molmil
Unmodified Insertion Ternary Complex
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*T*AP*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', ...
Authors:Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J.
Deposit date:2005-08-25
Release date:2006-01-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
1D6D
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BU of 1d6d by Molmil
SOLUTION DNA STRUCTURE CONTAINING (A-A)-T TRIADS INTERDIGITATED BETWEEN A-T BASE PAIRS AND GGGG TETRADS; NMR, 8 STRUCT.
Descriptor: 5'-D(*AP*AP*GP*GP*TP*TP*TP*TP*AP*AP*GP*G)-3'
Authors:Kuryavyi, V.V, Kettani, A, Wang, W, Jones, R, Patel, D.J.
Deposit date:1999-10-13
Release date:2000-01-17
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:A diamond-shaped zipper-like DNA architecture containing triads sandwiched between mismatches and tetrads.
J.Mol.Biol., 295, 2000
2LXQ
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BU of 2lxq by Molmil
Monomeric PilE G-Quadruplex DNA from Neisseria Gonorrhoeae
Descriptor: DNA (5'-D(*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*TP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*T)-3')
Authors:Kuryavyi, V.V, Patel, D.J.
Deposit date:2012-08-30
Release date:2012-11-28
Last modified:2012-12-26
Method:SOLUTION NMR
Cite:RecA-Binding pilE G4 Sequence Essential for Pilin Antigenic Variation Forms Monomeric and 5' End-Stacked Dimeric Parallel G-Quadruplexes.
Structure, 20, 2012
5YEY
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BU of 5yey by Molmil
The structure of a chair-type G-quadruplex of the human telomeric variant in K+ solution
Descriptor: DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3')
Authors:Liu, C, Zhou, B, Kuryavyi, V.V, Zhu, G.
Deposit date:2017-09-20
Release date:2018-09-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+solution.
Chem Sci, 10, 2019
2A5P
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BU of 2a5p by Molmil
Monomeric parallel-stranded DNA tetraplex with snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, NMR, 8 struct.
Descriptor: 5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*IP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3'
Authors:Phan, A.T, Kuryavyi, V.V, Gaw, H.Y, Patel, D.J.
Deposit date:2005-06-30
Release date:2005-07-26
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.
Nat.Chem.Biol., 1, 2005
2A5R
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BU of 2a5r by Molmil
Complex of tetra-(4-n-methylpyridyl) porphin with monomeric parallel-stranded DNA tetraplex, snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, C-MYC promoter, NMR, 6 struct.
Descriptor: (1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin, 5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*IP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3'
Authors:Phan, A.T, Kuryavyi, V.V, Gaw, H.Y, Patel, D.J.
Deposit date:2005-06-30
Release date:2005-07-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.
Nat.Chem.Biol., 1, 2005
2JSK
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BU of 2jsk by Molmil
Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, 16 G Form 1, NMR, 10 Structures
Descriptor: HUMAN TELOMERE DNA
Authors:Kuryavyi, V.V, Phan, A.T, Luu, K.N, Patel, D.J.
Deposit date:2007-07-07
Release date:2008-07-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.
Nucleic Acids Res., 35, 2007
2JSM
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BU of 2jsm by Molmil
MONOMERIC HUMAN TELOMERE DNA TETRAPLEX WITH 3+1 STRAND FOLD TOPOLOGY, TWO EDGEWISE LOOPS AND DOUBLE-CHAIN REVERSAL LOOP, NMR, 10 STRUCTURES, Form 1 Natural
Descriptor: HUMAN TELOMERE DNA
Authors:Kuryavyi, V.V, Phan, A.T, Luu, K.N, Patel, D.J.
Deposit date:2007-07-09
Release date:2008-07-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution
Nucleic Acids Res., 35, 2007
2JSL
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BU of 2jsl by Molmil
Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, Form 2 Natural, NMR, 10 Structures
Descriptor: HUMAN TELOMERE DNA
Authors:Kuryavyi, V.V, Phan, A.T, Luu, K.N, Patel, D.J.
Deposit date:2007-07-08
Release date:2008-07-15
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.
Nucleic Acids Res., 35, 2007

 

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