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1I1Z
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MUTANT HUMAN LYSOZYME (Q86D)
Descriptor:LYSOZYME C
Authors:Kuroki, R.
Deposit date:2001-02-05
Release date:2001-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and thermodynamic responses of mutations at a Ca2+ binding site engineered into human lysozyme.
J.Biol.Chem., 273, 1998
1I20
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MUTANT HUMAN LYSOZYME (A92D)
Descriptor:LYSOZYME C
Authors:Kuroki, R.
Deposit date:2001-02-05
Release date:2001-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and thermodynamic responses of mutations at a Ca2+ binding site engineered into human lysozyme.
J.Biol.Chem., 273, 1998
1I22
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MUTANT HUMAN LYSOZYME (A83K/Q86D/A92D)
Descriptor:LYSOZYME C, CALCIUM ION
Authors:Kuroki, R.
Deposit date:2001-02-05
Release date:2001-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and thermodynamic responses of mutations at a Ca2+ binding site engineered into human lysozyme.
J.Biol.Chem., 273, 1998
1QT3
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T26D MUTANT OF T4 LYSOZYME
Descriptor:PROTEIN (T4 Lysozyme), CHLORIDE ION, 2-HYDROXYETHYL DISULFIDE
Authors:Kuroki, R., Weaver, L.H., Matthews, B.W.
Deposit date:1999-06-30
Release date:1999-07-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QT4
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T26Q MUTANT OF T4 LYSOZYME
Descriptor:PROTEIN (T4 LYSOZYME), CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:Kuroki, R., Weaver, L.H., Matthews, B.W.
Deposit date:1999-06-30
Release date:1999-07-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QT5
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D20E MUTANT STRUCTURE OF T4 LYSOZYME
Descriptor:PROTEIN (T4 LYSOZYME), 2-HYDROXYETHYL DISULFIDE
Authors:Kuroki, R., Weaver, L.H., Matthews, B.W.
Deposit date:1999-06-30
Release date:1999-07-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QT6
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E11H MUTANT OF T4 LYSOZYME
Descriptor:PROTEIN (T4 LYSOZYME), CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:Kuroki, R., Weaver, L.H., Matthews, B.W.
Deposit date:1999-06-30
Release date:1999-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QT7
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E11N MUTANT OF T4 LYSOZYME
Descriptor:PROTEIN (T4 LYSOZYME), CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:Kuroki, R., Weaver, L.H., Matthews, B.W.
Deposit date:1999-06-30
Release date:1999-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QT8
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T26H MUTANT OF T4 LYSOZYME
Descriptor:PROTEIN (T4 LYSOZYME), 2-HYDROXYETHYL DISULFIDE
Authors:Kuroki, R., Weaver, L.H., Matthews, B.W.
Deposit date:1999-06-30
Release date:1999-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QTV
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T26E APO STRUCTURE OF T4 LYSOZYME
Descriptor:PROTEIN (T4 LYSOZYME), CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:Kuroki, R., Weaver, L.H., Matthews, B.W.
Deposit date:1999-06-29
Release date:1999-07-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QTZ
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D20C MUTANT OF T4 LYSOZYME
Descriptor:PROTEIN (T4 LYSOZYME), BETA-MERCAPTOETHANOL
Authors:Kuroki, R., Weaver, L.H., Matthews, B.W.
Deposit date:1999-06-29
Release date:1999-07-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site.
Proc.Natl.Acad.Sci.USA, 96, 1999
148L
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A COVALENT ENZYME-SUBSTRATE INTERMEDIATE WITH SACCHARIDE DISTORTION IN A MUTANT T4 LYSOZYME
Descriptor:T4 LYSOZYME, SUBSTRATE CLEAVED FROM CELL WALL OF ESCHERICHIA COLI, BETA-MERCAPTOETHANOL, ...
Authors:Kuroki, R., Weaver, L.H., Matthews, B.W.
Deposit date:1993-10-27
Release date:1994-04-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A covalent enzyme-substrate intermediate with saccharide distortion in a mutant T4 lysozyme.
Science, 262, 1993
253L
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LYSOZYME
Descriptor:LYSOZYME, CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:Kuroki, R., Shoichet, B., Weaver, L.H., Matthews, B.W.
Deposit date:1997-11-10
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A relationship between protein stability and protein function.
Proc.Natl.Acad.Sci.USA, 92, 1995
254L
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LYSOZYME
Descriptor:LYSOZYME, CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:Kuroki, R., Shoichet, B., Weaver, L.H., Matthews, B.W.
Deposit date:1997-11-10
Release date:1998-01-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A relationship between protein stability and protein function.
Proc.Natl.Acad.Sci.USA, 92, 1995
255L
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HYDROLASE
Descriptor:LYSOZYME, CHLORIDE ION, BETA-MERCAPTOETHANOL
Authors:Kuroki, R., Shoichet, B., Weaver, L.H., Matthews, B.W.
Deposit date:1997-11-10
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A relationship between protein stability and protein function.
Proc.Natl.Acad.Sci.USA, 92, 1995
1LZ4
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ENTHALPIC DESTABILIZATION OF A MUTANT HUMAN LYSOZYME LACKING A DISULFIDE BRIDGE BETWEEN CYSTEINE-77 AND CYSTEINE-95
Descriptor:HUMAN LYSOZYME
Authors:Inaka, K., Matsushima, M., Kuroki, R., Taniyama, Y., Kikuchi, M.
Deposit date:1993-02-03
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enthalpic destabilization of a mutant human lysozyme lacking a disulfide bridge between cysteine-77 and cysteine-95.
Biochemistry, 31, 1992
1LHJ
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ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
Descriptor:HUMAN LYSOZYME
Authors:Inaka, K., Matsushima, M., Herning, T., Kuroki, R., Yutani, K., Kikuchi, M.
Deposit date:1992-03-27
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with X-ray structure analysis of proline mutants.
Biochemistry, 31, 1992
2D9Q
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CRYSTAL STRUCTURE OF THE HUMAN GCSF-RECEPTOR SIGNALING COMPLEX
Descriptor:CSF3, Granulocyte colony-stimulating factor receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Tamada, T., Kuroki, R.
Deposit date:2005-12-12
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex
Proc.Natl.Acad.Sci.Usa, 103, 2006
1LHH
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ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
Descriptor:HUMAN LYSOZYME
Authors:Inaka, K., Matsushima, M., Herning, T., Kuroki, R., Yutani, K., Kikuchi, M.
Deposit date:1992-03-27
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with X-ray structure analysis of proline mutants.
Biochemistry, 31, 1992
1LHI
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ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
Descriptor:HUMAN LYSOZYME
Authors:Inaka, K., Matsushima, M., Herning, T., Kuroki, R., Yutani, K., Kikuchi, M.
Deposit date:1992-03-27
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with X-ray structure analysis of proline mutants.
Biochemistry, 31, 1992
1LHK
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ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
Descriptor:HUMAN LYSOZYME
Authors:Inaka, K., Matsushima, M., Herning, T., Kuroki, R., Yutani, K., Kikuchi, M.
Deposit date:1992-03-27
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with X-ray structure analysis of proline mutants.
Biochemistry, 31, 1992
1LHL
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ROLE OF PROLINE RESIDUES IN HUMAN LYSOZYME STABILITY: A SCANNING CALORIMETRIC STUDY COMBINED WITH X-RAY STRUCTURE ANALYSIS OF PROLINE MUTANTS
Descriptor:HUMAN LYSOZYME
Authors:Inaka, K., Matsushima, M., Herning, T., Kuroki, R., Yutani, K., Kikuchi, M.
Deposit date:1992-03-27
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of proline residues in human lysozyme stability: a scanning calorimetric study combined with X-ray structure analysis of proline mutants.
Biochemistry, 31, 1992
1V7M
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HUMAN THROMBOPOIETIN FUNCTIONAL DOMAIN COMPLEXED TO NEUTRALIZING ANTIBODY TN1 FAB
Descriptor:Monoclonal TN1 Fab Light Chain, Monoclonal TN1 Fab Heavy Chain, Thrombopoietin
Authors:Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R.
Deposit date:2003-12-18
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
Proc.Natl.Acad.Sci.USA, 101, 2004
1V7N
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HUMAN THROMBOPOIETIN FUNCTIONAL DOMAIN COMPLEXED TO NEUTRALIZING ANTIBODY TN1 FAB
Descriptor:Monoclonal TN1 Fab Light Chain, Monoclonal TN1 Fab Heavy Chain, Thrombopoietin
Authors:Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R.
Deposit date:2003-12-18
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
Proc.Natl.Acad.Sci.USA, 101, 2004
3HGN
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STRUCTURE OF PORCINE PANCREATIC ELASTASE COMPLEXED WITH A POTENT PEPTIDYL INHIBITOR FR130180 DETERMINED BY NEUTRON CRYSTALLOGRAPHY
Descriptor:Elastase-1, 4-[[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-pentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamoyl]benzoic acid, CALCIUM ION, ...
Authors:Tamada, T., Kinoshita, T., Kuroki, R., Tada, T.
Deposit date:2009-05-14
Release date:2009-07-28
Last modified:2011-07-13
Method:NEUTRON DIFFRACTION (1.65 Å), X-RAY DIFFRACTION
Cite:Combined High-Resolution Neutron and X-ray Analysis of Inhibited Elastase Confirms the Active-Site Oxyanion Hole but Rules against a Low-Barrier Hydrogen Bond
J.Am.Chem.Soc., 131, 2009