Author results

2RSG
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SOLUTION STRUCTURE OF THE CERT PH DOMAIN
Descriptor:Collagen type IV alpha-3-binding protein
Authors:Sugiki, T., Takeuchi, K., Tokunaga, Y., Kumagai, K., Kawano, M., Nishijima, M., Hanada, K., Takahashi, H., Shimada, I.
Deposit date:2012-02-25
Release date:2012-08-15
Last modified:2013-10-16
Method:SOLUTION NMR
Cite:Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)
J.Biol.Chem., 287, 2012
2E3M
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CRYSTAL STRUCTURE OF CERT START DOMAIN
Descriptor:Lipid-transfer protein CERT
Authors:Kudo, N., Kumagai, K., Wakatsuki, S., Nishijima, M., Hanada, K., Kato, R.
Deposit date:2006-11-28
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2E3N
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH C6-CERAMIDE (P212121)
Descriptor:Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)HEXANAMIDE
Authors:Kudo, N., Kumagai, K., Wakatsuki, S., Nishijima, M., Hanada, K., Kato, R.
Deposit date:2006-11-28
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2E3O
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH C16-CERAMIDE (P212121)
Descriptor:Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE, DIMETHYL SULFOXIDE
Authors:Kudo, N., Kumagai, K., Wakatsuki, S., Nishijima, M., Hanada, K., Kato, R.
Deposit date:2006-11-28
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2E3P
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH C16-CEARMIDE (P1)
Descriptor:Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE
Authors:Kudo, N., Kumagai, K., Wakatsuki, S., Nishijima, M., Hanada, K., Kato, R.
Deposit date:2006-11-28
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2E3Q
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH C18-CERAMIDE (P212121)
Descriptor:Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE, DIMETHYL SULFOXIDE
Authors:Kudo, N., Kumagai, K., Wakatsuki, S., Nishijima, M., Hanada, K., Kato, R.
Deposit date:2006-11-28
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2E3R
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH C18-CERAMIDE (P1)
Descriptor:Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE
Authors:Kudo, N., Kumagai, K., Wakatsuki, S., Nishijima, M., Hanada, K., Kato, R.
Deposit date:2006-11-28
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2E3S
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CRYSTAL STRUCTURE OF CERT START DOMAIN CO-CRYSTALLIZED WITH C24-CERAMIDE (P21)
Descriptor:Lipid-transfer protein CERT
Authors:Kudo, N., Kumagai, K., Wakatsuki, S., Nishijima, M., Hanada, K., Kato, R.
Deposit date:2006-11-28
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2Z9Y
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH C10-DIACYLGLYCEROL
Descriptor:Lipid-transfer protein CERT, (2S)-3-hydroxypropane-1,2-diyl didecanoate
Authors:Kudo, N., Kumagai, K., Wakatsuki, S., Nishijima, M., Hanada, K., Kato, R.
Deposit date:2007-09-26
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2Z9Z
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CRYSTAL STRUCTURE OF CERT START DOMAIN(N504A MUTANT), IN COMPLEX WITH C10-DIACYLGLYCEROL
Descriptor:Lipid-transfer protein CERT, (2S)-3-hydroxypropane-1,2-diyl didecanoate
Authors:Kudo, N., Kumagai, K., Wakatsuki, S., Nishijima, M., Hanada, K., Kato, R.
Deposit date:2007-09-26
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
5XE8
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CRYSTAL STRUCTURE OF THE PEPTIDASE DOMAIN OF STREPTOCOCCUS MUTANS COMA
Descriptor:Putative ABC transporter, ATP-binding protein ComA, DI(HYDROXYETHYL)ETHER
Authors:Ishii, S., Fukui, K., Yokoshima, S., Kumagai, K., Beniyama, Y., Kodama, T., Fukuyama, T., Okabe, T., Nagano, T., Kojima, H., Yano, T.
Deposit date:2017-04-03
Release date:2017-06-28
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway
Sci Rep, 7, 2017
5XE9
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CRYSTAL STRUCTURE OF THE COMPLEX OF THE PEPTIDASE DOMAIN OF STREPTOCOCCUS MUTANS COMA WITH A SMALL MOLECULE INHIBITOR.
Descriptor:Putative ABC transporter, ATP-binding protein ComA, [(1~{S},2~{R},4~{S},5~{R})-5-[5-(4-methoxyphenyl)-2-methyl-pyrazol-3-yl]-1-azabicyclo[2.2.2]octan-2-yl]methyl ~{N}-propylcarbamate
Authors:Ishii, S., Fukui, K., Yokoshima, S., Kumagai, K., Beniyama, Y., Kodama, T., Fukuyama, T., Okabe, T., Nagano, T., Kojima, H., Yano, T.
Deposit date:2017-04-03
Release date:2017-06-28
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway
Sci Rep, 7, 2017
5ZYG
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND B5
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[3-~{tert}-butyl-5-(2-pyridin-2-ylethyl)phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYH
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E5
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[3-~{tert}-butyl-5-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYI
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E16
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-pentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYJ
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E16A
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-pentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYK
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E25
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-cyclopentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYL
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E25A
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-cyclopentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYM
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E25B
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-cyclopentyl-3-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6IEZ
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND B16
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-({4'-pentyl-3'-[2-(pyridin-2-yl)ethyl][1,1'-biphenyl]-4-yl}sulfonyl)ethan-1-ol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-09-18
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6IF0
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND D16
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-({4'-pentyl-3'-[(Z)-2-(pyridin-2-yl)ethenyl][1,1'-biphenyl]-4-yl}sulfonyl)ethan-1-ol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-09-18
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6J0O
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND SC1
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[2-fluoranyl-5-[3-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]phenyl]phenyl]sulfonylethanol, UNKNOWN ATOM OR ION
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-12-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6J81
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E14
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-propyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2019-01-18
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
3H3Q
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CRYSTAL STRUCTURE OF THE CERT START DOMAIN IN COMPLEX WITH HPA-13
Descriptor:Goodpasture antigen binding protein, N-[(1R,3R)-3-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]tridecanamide
Authors:Kudo, N., Wakatsuki, S., Kato, R.
Deposit date:2009-04-17
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer.
J.Mol.Biol., 396, 2010
3H3R
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CRYSTAL STRUCTURE OF THE CERT START DOMAIN IN COMPLEX WITH HPA-14
Descriptor:Goodpasture antigen binding protein, N-[(1R,3R)-3-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]tetradecanamide
Authors:Kudo, N., Wakatsuki, S., Kato, R.
Deposit date:2009-04-17
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer.
J.Mol.Biol., 396, 2010
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