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4ADY
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BU of 4ady by Molmil
Crystal structure of 26S proteasome subunit Rpn2
Descriptor: 26S PROTEASOME REGULATORY SUBUNIT RPN2
Authors:Kulkarni, K, He, J, Da Fonseca, P.C.A, Krutauz, D, Glickman, M.H, Barford, D, Morris, E.P.
Deposit date:2012-01-04
Release date:2012-03-14
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings
Structure, 20, 2012
4CAD
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BU of 4cad by Molmil
Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Kulkarni, K, Manolaridis, I, Dodd, R.B, Cronin, N, Ogasawara, S, Iwata, S, Barford, D.
Deposit date:2013-10-08
Release date:2013-11-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism of Farnesylated Caax Protein Processing by the Intramembrane Protease Rce1
Nature, 504, 2013
5BPW
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BU of 5bpw by Molmil
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain
Descriptor: Anaphase-promoting complex subunit 4
Authors:Kulkarni, K, Yang, J, Zhang, Z, Barford, D.
Deposit date:2015-05-28
Release date:2015-09-02
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
1NXU
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BU of 1nxu by Molmil
CRYSTAL STRUCTURE OF E. COLI HYPOTHETICAL OXIDOREDUCTASE YIAK NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER82.
Descriptor: Hypothetical oxidoreductase yiaK, SULFATE ION
Authors:Forouhar, F, Lee, I, Benach, J, Kulkarni, K, Xiao, R, Acton, T.B, Shastry, R, Rost, B, Montelione, G.T, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2003-02-11
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
J.Biol.Chem., 279, 2004
1S20
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BU of 1s20 by Molmil
A novel NAD binding protein revealed by the crystal structure of E. Coli 2,3-diketogulonate reductase (YiaK) NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER82
Descriptor: Hypothetical oxidoreductase yiaK, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Forouhar, F, Lee, I, Benach, J, Kulkarni, K, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-01-07
Release date:2004-01-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
J.Biol.Chem., 279, 2004
4A2N
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BU of 4a2n by Molmil
Crystal Structure of Ma-ICMT
Descriptor: CARDIOLIPIN, ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE, PALMITIC ACID, ...
Authors:Yang, J, Kulkarni, K, Manolaridis, I, Zhang, Z, Dodd, R.B, Mas-Droux, C, Barford, D.
Deposit date:2011-09-27
Release date:2012-01-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase Icmt.
Mol.Cell, 44, 2011
6A8M
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BU of 6a8m by Molmil
N-terminal domain of FACT complex subunit SPT16 from Eremothecium gossypii (Ashbya gossypii)
Descriptor: FACT complex subunit SPT16
Authors:Gaur, N.K, Are, V.N, Durani, V, Ghosh, B, Kumar, A, Kulkarni, K, Makde, R.D.
Deposit date:2018-07-09
Release date:2018-08-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Evolutionary conservation of protein dynamics: insights from all-atom molecular dynamics simulations of 'peptidase' domain of Spt16.
J.Biomol.Struct.Dyn., 2021
2YIN
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BU of 2yin by Molmil
STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.
Descriptor: DEDICATOR OF CYTOKINESIS PROTEIN 2, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
Authors:Kulkarni, K.A, Yang, J, Zhang, Z, Barford, D.
Deposit date:2011-05-16
Release date:2011-05-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (Dock) Nucleotide Exchange Factors.
J.Biol.Chem., 286, 2011
4WWQ
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BU of 4wwq by Molmil
Apo structure of the Grb7 SH2 domain
Descriptor: Growth factor receptor-bound protein 7, MALONIC ACID
Authors:Watson, G.M, Ambaye, N.D, Wilce, M.C, Wilce, J.A.
Deposit date:2014-11-12
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
6K3G
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BU of 6k3g by Molmil
Crystal structure of 10-Hydroxygeraniol Dehydrogenase from Cantharanthus roseus in complex with NADP+
Descriptor: 10-hydroxygeraniol oxidoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ZINC ION
Authors:Sandholu, A.S, Sharmila, P.M, Thulasiram, H.V, Kulkarni, K.A.
Deposit date:2019-05-18
Release date:2020-03-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structural studies on 10-hydroxygeraniol dehydrogenase: A novel linear substrate-specific dehydrogenase from Catharanthus roseus.
Proteins, 88, 2020
6KJ5
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BU of 6kj5 by Molmil
Crystal structure of 10-Hydroxygeraniol Dehydrogenase apo form from Cantharanthus roseus
Descriptor: 10-hydroxygeraniol dehydrogenase, ZINC ION
Authors:Sandholu, A.S, Sharmila, P.M, Thulasiram, H.V, Kulkarni, K.A.
Deposit date:2019-07-21
Release date:2020-03-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structural studies on 10-hydroxygeraniol dehydrogenase: A novel linear substrate-specific dehydrogenase from Catharanthus roseus.
Proteins, 88, 2020
6K16
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BU of 6k16 by Molmil
Crystal Structure of Sesquisabinene B Synthase 1 from Santalum album
Descriptor: MAGNESIUM ION, Sesquisabinene B synthase 1
Authors:Singh, S, Thulasiram, H.V, Kulkarni, K.A.
Deposit date:2019-05-09
Release date:2019-06-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dynamic coupling analysis on plant sesquiterpene synthases provides leads for the identification of product specificity determinants
Biochem.Biophys.Res.Commun., 536, 2021
5U06
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BU of 5u06 by Molmil
Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic
Descriptor: Growth factor receptor-bound protein 7, POTASSIUM ION, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST
Authors:Watson, G.M, Wilce, J.A.
Deposit date:2016-11-22
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
5TYI
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BU of 5tyi by Molmil
Grb7 SH2 with bicyclic peptide containing pY mimetic
Descriptor: Growth factor receptor-bound protein 7, Peptide inhibitor
Authors:Watson, G.M, Wilce, M.C.J, Wilce, J.A.
Deposit date:2016-11-20
Release date:2017-11-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
5U1Q
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BU of 5u1q by Molmil
Grb7-SH2 with bicyclic peptide inhibitor
Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 7, LYS-PHE-GLU-GLY-TYR-ASP-ASN-GLU-CST
Authors:Watson, G.M, Wilce, M.C.J, Wilce, J.A.
Deposit date:2016-11-28
Release date:2017-11-15
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
5EMH
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BU of 5emh by Molmil
Crystal structure of Iridoid Synthase from Cantharanthus roseus in complex with NADP+
Descriptor: Iridoid synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sandholu, A, Thulasiram, H.V, Kulkarni, K.A.
Deposit date:2015-11-06
Release date:2015-11-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dynamics of loops at the substrate entry channel determine the specificity of iridoid synthases.
FEBS Lett., 592, 2018
4X6S
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BU of 4x6s by Molmil
Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide
Descriptor: Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1
Authors:Watson, G.M, Panjikar, S, Wilce, M.C, Wilce, J.A.
Deposit date:2014-12-09
Release date:2015-09-23
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
3ZN3
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BU of 3zn3 by Molmil
N-terminal domain of S. pombe Cdc23 APC subunit
Descriptor: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, MERCURY (II) ION
Authors:Zhang, Z, Yang, J, Conin, N, Kulkarni, K, Barford, D.
Deposit date:2013-02-13
Release date:2013-02-20
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Four Canonical Tpr Subunits of Human Apc/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a Tpr Suprahelix
J.Mol.Biol., 425, 2013
5BPT
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BU of 5bpt by Molmil
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain
Descriptor: MGC81278 protein
Authors:Cronin, N, Yang, J, Zhang, Z, Barford, D.
Deposit date:2015-05-28
Release date:2015-09-02
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
5BPZ
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BU of 5bpz by Molmil
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain
Descriptor: 1,2-ETHANEDIOL, Anapc5 protein
Authors:Cronin, N, Yang, J, Zhang, Z, Barford, D.
Deposit date:2015-05-28
Release date:2015-09-02
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
5D0J
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BU of 5d0j by Molmil
Grb7 SH2 with inhibitor peptide
Descriptor: G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION
Authors:Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J.
Deposit date:2015-08-03
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
5EEQ
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BU of 5eeq by Molmil
Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor
Descriptor: Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION
Authors:Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M.
Deposit date:2015-10-23
Release date:2016-06-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
5EEL
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BU of 5eel by Molmil
Grb7 SH2 with bicyclic peptide inhibitor
Descriptor: Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ...
Authors:Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A.
Deposit date:2015-10-23
Release date:2016-06-15
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016

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