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4ADY
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CRYSTAL STRUCTURE OF 26S PROTEASOME SUBUNIT RPN2
Descriptor:26S PROTEASOME REGULATORY SUBUNIT RPN2
Authors:Kulkarni, K., He, J., Da Fonseca, P.C.A., Krutauz, D., Glickman, M.H., Barford, D., Morris, E.P.
Deposit date:2012-01-04
Release date:2012-03-14
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings
Structure, 20, 2012
4CAD
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MECHANISM OF FARNESYLATED CAAX PROTEIN PROCESSING BY THE INTEGRAL MEMBRANE PROTEASE RCE1
Descriptor:ANTIBODY FAB FRAGMENT LIGHT CHAIN, ANTIBODY FAB FRAGMENT HEAVY CHAIN, RAS AND A-FACTOR CONVERTING ENZYME 1, ...
Authors:Kulkarni, K., Manolaridis, I., Dodd, R.B., Cronin, N., Ogasawara, S., Iwata, S., Barford, D.
Deposit date:2013-10-08
Release date:2013-11-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanism of Farnesylated Caax Protein Processing by the Intramembrane Protease Rce1
Nature, 504, 2013
5BPW
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ATOMIC-RESOLUTION STRUCTURES OF THE APC/C SUBUNITS APC4 AND THE APC5 N-TERMINAL DOMAIN
Descriptor:Anaphase-promoting complex subunit 4
Authors:Kulkarni, K., Yang, J., Zhang, Z., Barford, D.
Deposit date:2015-05-28
Release date:2015-09-02
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
1NXU
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CRYSTAL STRUCTURE OF E. COLI HYPOTHETICAL OXIDOREDUCTASE YIAK NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER82.
Descriptor:Hypothetical oxidoreductase yiaK, SULFATE ION
Authors:Forouhar, F., Lee, I., Benach, J., Kulkarni, K., Xiao, R., Acton, T.B., Shastry, R., Rost, B., Montelione, G.T., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2003-02-11
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
J.Biol.Chem., 279, 2004
1S20
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A NOVEL NAD BINDING PROTEIN REVEALED BY THE CRYSTAL STRUCTURE OF E. COLI 2,3-DIKETOGULONATE REDUCTASE (YIAK) NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER82
Descriptor:Hypothetical oxidoreductase yiaK, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Forouhar, F., Lee, I., Benach, J., Kulkarni, K., Xiao, R., Acton, T.B., Montelione, G.T., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-01-07
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Novel NAD-binding Protein Revealed by the Crystal Structure of 2,3-Diketo-L-gulonate Reductase (YiaK).
J.Biol.Chem., 279, 2004
4A2N
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CRYSTAL STRUCTURE OF MA-ICMT
Descriptor:ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, PALMITIC ACID, ...
Authors:Yang, J., Kulkarni, K., Manolaridis, I., Zhang, Z., Dodd, R.B., Mas-Droux, C., Barford, D.
Deposit date:2011-09-27
Release date:2012-01-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase Icmt.
Mol.Cell, 44, 2011
6A8M
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N-TERMINAL DOMAIN OF FACT COMPLEX SUBUNIT SPT16 FROM EREMOTHECIUM GOSSYPII (ASHBYA GOSSYPII)
Descriptor:FACT complex subunit SPT16
Authors:Gaur, N.K., Are, V.N., Durani, V., Ghosh, B., Kumar, A., Kulkarni, K., Makde, R.D.
Deposit date:2018-07-09
Release date:2018-08-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:N-terminal domain of FACT complex subunit SPT16 from Eremothecium gossypii (Ashbya gossypii)
To Be Published
2YIN
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STRUCTURE OF THE COMPLEX BETWEEN DOCK2 AND RAC1.
Descriptor:DEDICATOR OF CYTOKINESIS PROTEIN 2, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1
Authors:Kulkarni, K.A., Yang, J., Zhang, Z., Barford, D.
Deposit date:2011-05-16
Release date:2011-05-25
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (Dock) Nucleotide Exchange Factors.
J.Biol.Chem., 286, 2011
5EMH
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CRYSTAL STRUCTURE OF IRIDOID SYNTHASE FROM CANTHARANTHUS ROSEUS IN COMPLEX WITH NADP+
Descriptor:Iridoid synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Sandholu, A., Thulasiram, H.V., Kulkarni, K.A.
Deposit date:2015-11-06
Release date:2015-11-25
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dynamics of loops at the substrate entry channel determine the specificity of iridoid synthases.
FEBS Lett., 592, 2018
3ZN3
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N-TERMINAL DOMAIN OF S. POMBE CDC23 APC SUBUNIT
Descriptor:ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, MERCURY (II) ION
Authors:Zhang, Z., Yang, J., Conin, N., Kulkarni, K., Barford, D.
Deposit date:2013-02-13
Release date:2013-02-20
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Four Canonical Tpr Subunits of Human Apc/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a Tpr Suprahelix
J.Mol.Biol., 425, 2013
4WWQ
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APO STRUCTURE OF THE GRB7 SH2 DOMAIN
Descriptor:Growth factor receptor-bound protein 7, MALONIC ACID
Authors:Watson, G.M., Ambaye, N.D., Wilce, M.C., Wilce, J.A.
Deposit date:2014-11-12
Release date:2015-09-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
4X6S
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GRB7 SH2 DOMAIN WITH PHOSPHOTYROSINE MIMETIC INHIBITOR PEPTIDE
Descriptor:Growth factor receptor-bound protein 7, Phosphotyrosine mimetic inhibitor peptide G7-TEM1
Authors:Watson, G.M., Panjikar, S., Wilce, M.C., Wilce, J.A.
Deposit date:2014-12-09
Release date:2015-09-23
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
J.Med.Chem., 58, 2015
5BPT
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ATOMIC-RESOLUTION STRUCTURES OF THE APC/C SUBUNITS APC4 AND THE APC5 N-TERMINAL DOMAIN
Descriptor:MGC81278 protein
Authors:Cronin, N., Yang, J., Zhang, Z., Barford, D.
Deposit date:2015-05-28
Release date:2015-09-02
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
5BPZ
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ATOMIC-RESOLUTION STRUCTURES OF THE APC/C SUBUNITS APC4 AND THE APC5 N-TERMINAL DOMAIN
Descriptor:Anapc5 protein, 1,2-ETHANEDIOL
Authors:Cronin, N., Yang, J., Zhang, Z., Barford, D.
Deposit date:2015-05-28
Release date:2015-09-02
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain.
J.Mol.Biol., 427, 2015
5D0J
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GRB7 SH2 WITH INHIBITOR PEPTIDE
Descriptor:Growth factor receptor-bound protein 7, G7-TEdFP peptide, PHOSPHATE ION
Authors:Gunzburg, M.J., Watson, G.M., Wilce, J.A., Wilce, M.C.J.
Deposit date:2015-08-03
Release date:2016-06-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
5EEL
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GRB7 SH2 WITH BICYCLIC PEPTIDE INHIBITOR
Descriptor:Growth factor receptor-bound protein 7, Bicyclic Peptide Inhibitor, MALONIC ACID, ...
Authors:Watson, G.M., Gunzburg, M.J., Wilce, M.C.J., Wilce, J.A.
Deposit date:2015-10-23
Release date:2016-06-15
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
5EEQ
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GRB7 SH2 WITH THE G7-B1 BICYCLIC PEPTIDE INHIBITOR
Descriptor:Growth factor receptor-bound protein 7, Bicyclic Peptide Inhibitor, PHOSPHATE ION
Authors:Ambaye, N.D., Watson, G.M., Wilce, M.C.J., Wilce, G.M.
Deposit date:2015-10-23
Release date:2016-06-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
5TYI
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GRB7 SH2 WITH BICYCLIC PEPTIDE CONTAINING PY MIMETIC
Descriptor:Growth factor receptor-bound protein 7, Peptide inhibitor
Authors:Watson, G.M., Wilce, M.C.J., Wilce, J.A.
Deposit date:2016-11-20
Release date:2017-11-15
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
5U06
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GRB7-SH2 WITH BICYCLIC PEPTIDE INHIBITOR CONTAINING A PY MIMETIC
Descriptor:Growth factor receptor-bound protein 7, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST, POTASSIUM ION
Authors:Watson, G.M., Wilce, J.A.
Deposit date:2016-11-22
Release date:2017-11-15
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
5U1Q
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GRB7-SH2 WITH BICYCLIC PEPTIDE INHIBITOR
Descriptor:Growth factor receptor-bound protein 7, LYS-PHE-GLU-GLY-TYR-ASP-ASN-GLU-CST, CHLORIDE ION
Authors:Watson, G.M., Wilce, M.C.J., Wilce, J.A.
Deposit date:2016-11-28
Release date:2017-11-15
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.
J. Med. Chem., 60, 2017
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