1K4R
| Structure of Dengue Virus | Descriptor: | MAJOR ENVELOPE PROTEIN E | Authors: | Kuhn, R.J, Zhang, W, Rossmann, M.G, Pletnev, S.V, Corver, J, Lenches, E, Jones, C.T, Mukhopadhyay, S, Chipman, P.R, Strauss, E.G, Baker, T.S, Strauss, J.H. | Deposit date: | 2001-10-08 | Release date: | 2002-03-13 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (24 Å) | Cite: | Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell(Cambridge,Mass.), 108, 2002
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1DGI
| Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155 | Descriptor: | POLIOVIRUS RECEPTOR, VP1, VP2, ... | Authors: | He, Y, Bowman, V.D, Mueller, S, Bator, C.M, Bella, J, Peng, X, Baker, T.S, Wimmer, E, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 1999-11-24 | Release date: | 2000-01-24 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (22 Å) | Cite: | Interaction of the poliovirus receptor with poliovirus. Proc.Natl.Acad.Sci.USA, 97, 2000
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8FE4
| Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody | Descriptor: | Envelope protein E, prM protein, prM13 Fab Heavy Chain, ... | Authors: | Dowd, A.D, Sirohi, D, Speer, S, Mukherjee, S, Govero, J, Aleshnick, M, Larman, B, Sukupolvi-Petty, S, Sevvana, M, Miller, A.S, Klose, T, Zheng, A, Kielian, M, Kuhn, R.J, Diamond, M.S, Pierson, T.C. | Deposit date: | 2022-12-05 | Release date: | 2023-02-01 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis. Proc.Natl.Acad.Sci.USA, 120, 2023
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8FE3
| Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody | Descriptor: | Envelope protein E, prM protein, prM12 Fab Heavy Chain, ... | Authors: | Dowd, A.D, Sirohi, D, Speer, S, Mukherjee, S, Govero, J, Aleshnick, M, Larman, B, Sukupolvi-Petty, S, Sevvana, M, Miller, A.S, Klose, T, Zheng, A, Kielian, M, Kuhn, R.J, Diamond, M.S, Pierson, T.C. | Deposit date: | 2022-12-05 | Release date: | 2023-02-01 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (10.2 Å) | Cite: | prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis. Proc.Natl.Acad.Sci.USA, 120, 2023
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6CO8
| Structure of Zika virus at a resolution of 3.1 Angstrom | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E protein, M protein | Authors: | Sevvana, M, Long, F, Miller, A.J, Klose, T, Buda, G, Sun, L, Kuhn, R.J, Rossmann, M.R. | Deposit date: | 2018-03-12 | Release date: | 2018-07-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 angstrom Resolution. Structure, 26, 2018
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7T17
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4WM7
| Crystal Structure of Human Enterovirus D68 in Complex with Pleconaril | Descriptor: | 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE, VP1, VP2, ... | Authors: | Liu, Y, Sheng, J, Fokine, A, Meng, G, Long, F, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2014-10-08 | Release date: | 2015-01-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. Science, 347, 2015
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4WM8
| Crystal Structure of Human Enterovirus D68 | Descriptor: | DECANOIC ACID, VP1, VP2, ... | Authors: | Liu, Y, Sheng, J, Fokine, A, Meng, G, Long, F, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2014-10-08 | Release date: | 2015-01-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Virus structure. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. Science, 347, 2015
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5U4W
| Cryo-EM Structure of Immature Zika Virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, E protein, M protein, ... | Authors: | Mangala Prasad, V, Miller, A.S, Klose, T, Sirohi, D, Buda, G, Jiang, W, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2016-12-06 | Release date: | 2017-01-11 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (9.1 Å) | Cite: | Structure of the immature Zika virus at 9 angstrom resolution. Nat. Struct. Mol. Biol., 24, 2017
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5UHY
| A Human Antibody Against Zika Virus Crosslinks the E Protein to Prevent Infection | Descriptor: | ZV67 Fab chain 1, ZV67 Fab chain 2, envelope protein | Authors: | Hasan, S.S, Miller, A, Sapparapu, G, Fernandez, E, Klose, T, Long, F, Fokine, A, Porta, J.C, Jiang, W, Diamond, M.S, Crowe Jr, J.E, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2017-01-12 | Release date: | 2017-03-29 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | A human antibody against Zika virus crosslinks the E protein to prevent infection. Nat Commun, 8, 2017
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4UOM
| Electron Cryo-microscopy of Venezuelan Equine Encephalitis Virus TC- 83 in complex with neutralizing antibody Fab F5 | Descriptor: | FAB FRAGMENT HEAVY CHAIN, FAB FRAGMENT LIGHT CHAIN | Authors: | Porta, J, Jose, J, Roehrig, J.T, Blair, C.D, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2014-06-05 | Release date: | 2014-10-15 | Last modified: | 2017-08-23 | Method: | ELECTRON MICROSCOPY (17 Å) | Cite: | Locking and Blocking the Viral Landscape of an Alphavirus with Neutralizing Antibodies. J.Virol., 88, 2014
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4UOK
| Electron Cryo-microscopy of Venezuelan Equine Encephalitis Virus TC-83 in complex with neutralizing antibody Fab 3B4C-4 | Descriptor: | FAB FRAGMENT HEAVY CHAIN, FAB FRAGMENT LIGHT CHAIN | Authors: | Porta, J, Jose, J, Roehrig, J.T, Blair, C.D, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2014-06-04 | Release date: | 2014-09-17 | Last modified: | 2019-05-29 | Method: | ELECTRON MICROSCOPY (18 Å) | Cite: | Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies. J.Virol., 88, 2014
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7TAG
| Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain virion in complex with pleconaril | Descriptor: | 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE, viral protein 1, viral protein 2, ... | Authors: | Fu, J, Klose, T, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2021-12-20 | Release date: | 2023-01-25 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Isoxazole-3-Carboxamide Derivatives of Pleconaril Destabilize the Viral Capsid of Enterovirus-D68 To Be Published
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7TAH
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7TAJ
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7TAF
| Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain virion in complex with inhibitor 11526092 | Descriptor: | N,N-dimethyl-5-(3-{2-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenoxy}propyl)-1,2-oxazole-3-carboxamide, viral protein 1, viral protein 2, ... | Authors: | Fu, J, Klose, T, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2021-12-20 | Release date: | 2023-01-25 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | Isoxazole-3-Carboxamide Derivatives of Pleconaril Destabilize the Viral Capsid of Enterovirus-D68 To Be Published
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7T9P
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7N69
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7N6A
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7V0P
| Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a potently neutralizing human antibody IgG-106 | Descriptor: | IgG 106 Fab heavy chain, IgG 106 Fab light chain, Spike glycoprotein E1, ... | Authors: | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | Deposit date: | 2022-05-10 | Release date: | 2023-04-05 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 120, 2023
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7V0N
| Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a moderately/weakly neutralizing human antibody IgG-21 | Descriptor: | IgG 21 Fab heavy chain, IgG 21 Fab light chain, Spike glycoprotein E1, ... | Authors: | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | Deposit date: | 2022-05-10 | Release date: | 2023-04-05 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 120, 2023
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7V0O
| Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a moderately/weakly neutralizing human antibody IgG-94 | Descriptor: | IgG 94 Fab heavy chain, IgG 94 Fab light chain, Spike glycoprotein E1, ... | Authors: | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | Deposit date: | 2022-05-10 | Release date: | 2023-04-05 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 120, 2023
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2SNW
| SINDBIS VIRUS CAPSID PROTEIN, TYPE3 CRYSTAL FORM | Descriptor: | COAT PROTEIN C | Authors: | Choi, H.-K, Lee, S, Zhang, Y.-P, Mckinney, B.R, Wengler, G, Rossmann, M.G, Kuhn, R.J. | Deposit date: | 1998-02-17 | Release date: | 1998-04-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural analysis of Sindbis virus capsid mutants involving assembly and catalysis. J.Mol.Biol., 262, 1996
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2B6B
| Cryo EM structure of Dengue complexed with CRD of DC-SIGN | Descriptor: | CD209 antigen, envelope glycoprotein | Authors: | Pokidysheva, E, Zhang, Y, Battisti, A.J, Bator-Kelly, C.M, Chipman, P.R, Gregorio, G, Hendrickson, W.A, Kuhn, R.J, Rossmann, M.G. | Deposit date: | 2005-09-30 | Release date: | 2006-03-07 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (25 Å) | Cite: | Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN Cell(Cambridge,Mass.), 124, 2006
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3IYA
| Association of the pr peptides with dengue virus blocks membrane fusion at acidic pH | Descriptor: | Envelope protein, prM protein | Authors: | Yu, I, Holdaway, H.A, Chipman, P.R, Kuhn, R.J, Rossmann, M.G, Chen, J. | Deposit date: | 2009-06-01 | Release date: | 2010-04-14 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (22 Å) | Cite: | Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion. J.Virol., 83, 2009
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