Author results

1QYS
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CRYSTAL STRUCTURE OF TOP7: A COMPUTATIONALLY DESIGNED PROTEIN WITH A NOVEL FOLD
Descriptor:TOP7
Authors:Kuhlman, B., Dantas, G., Ireton, G.C., Varani, G., Stoddard, B.L., Baker, D.
Deposit date:2003-09-11
Release date:2003-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
Science, 302, 2003
1JML
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CONVERSION OF MONOMERIC PROTEIN L TO AN OBLIGATE DIMER BY COMPUTATIONAL PROTEIN DESIGN
Descriptor:Protein L, ZINC ION
Authors:O'Neill, J.W., Kuhlman, B., Kim, D.E., Zhang, K.Y.J., Baker, D.
Deposit date:2001-07-19
Release date:2001-10-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conversion of monomeric protein L to an obligate dimer by computational protein design.
Proc.Natl.Acad.Sci.USA, 98, 2001
1KH0
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ACCURATE COMPUTER BASE DESIGN OF A NEW BACKBONE CONFORMATION IN THE SECOND TURN OF PROTEIN L
Descriptor:protein L
Authors:O'Neill, J.W., Kuhlman, B., Kim, D.E., Zhang, K.Y., Baker, D.
Deposit date:2001-11-28
Release date:2002-01-23
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Accurate computer-based design of a new backbone conformation in the second turn of protein L.
J.Mol.Biol., 315, 2002
2XNS
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CRYSTAL STRUCTURE OF HUMAN G ALPHA I1 BOUND TO A DESIGNED HELICAL PEPTIDE DERIVED FROM THE GOLOCO MOTIF OF RGS14
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, REGULATOR OF G-PROTEIN SIGNALING 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Sammond, D.W., Butterfoss, G.L., Machius, M., Siderovski, D.P., Kuhlman, B.
Deposit date:2010-08-05
Release date:2011-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Computational Design of the Sequence and Structure of a Protein-Binding Peptide.
J.Am.Chem.Soc., 133, 2011
3ONW
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STRUCTURE OF A G-ALPHA-I1 MUTANT WITH ENHANCED AFFINITY FOR THE RGS14 GOLOCO MOTIF.
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Kimple, A.J., Sammond, D.W., Miley, M.J., Machius, M., Kuhlman, B., Willard, F.S., Siderovski, D.P.
Deposit date:2010-08-30
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
4WF0
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CRYSTAL STRUCTURE OF ILID - AN IMPROVED LIGHT-INDUCIBLE DIMER
Descriptor:NPH1-1, FLAVIN MONONUCLEOTIDE, CHLORIDE ION
Authors:Hallett, R., Williams, T., Kuhlman, B.
Deposit date:2014-09-11
Release date:2014-12-24
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins.
Proc.Natl.Acad.Sci.USA, 112, 2015
5KAY
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STRUCTURE OF SPELTER BOUND TO ZN2+
Descriptor:Spelter, ZINC ION, SODIUM ION
Authors:Guffy, S.L., Der, B.S., Kuhlman, B.
Deposit date:2016-06-02
Release date:2016-08-03
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Probing the minimal determinants of zinc binding with computational protein design.
Protein Eng.Des.Sel., 29, 2016
2LSE
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED FOUR HELIX BUNDLE PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR188
Descriptor:Four Helix Bundle Protein
Authors:Sathyamoorthy, B., Pulavarti, S., Murphy, G., Mills, J.L., Eletski, A., Der, B.S., Machius, M.C., Kuhlman, B., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-04-28
Release date:2012-06-27
Method:SOLUTION NMR
Cite:Solution NMR Structure of a Denovo Design Four Helix Bundle Protein, Northeast Structural Genomics Consortium Target OR188
To be Published
2N8I
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SOLUTION NMR STRUCTURE OF DESIGNED PROTEIN DA05, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR626
Descriptor:Designed Protein DA05
Authors:Xu, X., Eletsky, A., Federizon, J.F., Jacobs, T.M., Kuhlman, B., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2015-10-15
Release date:2016-01-20
Last modified:2016-05-18
Method:SOLUTION NMR
Cite:Design of structurally distinct proteins using strategies inspired by evolution.
Science, 352, 2016
2N8W
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SOLUTION NMR STRUCTURE OF DESIGNED PROTEIN DA05R1, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR690
Descriptor:Designed Protein DA05R1
Authors:Eletsky, A., Federizon, J.F., Xu, X., Pulavarti, S., Jacobs, T.M., Kuhlman, B., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2015-10-27
Release date:2015-11-25
Last modified:2016-05-18
Method:SOLUTION NMR
Cite:Design of structurally distinct proteins using strategies inspired by evolution.
Science, 352, 2016
5DI8
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FC KNOB-HOLE HETERODIMER T366W + T366S/L368A/Y407V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-08-31
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ0
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FC HETERODIMER DESIGN 11.2 Y349S/K370Y + E357D/S364Q
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ2
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FC HETERODIMER DESIGN 7.4 Y407A + T366V/K409V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ6
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FC HETERODIMER DESIGN 6.1 F405W/Y407A + T366M
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ8
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FC HETERODIMER DESIGN 7.7 D399M/Y407A + T366V/K409I
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJA
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FC HETERODIMER DESIGN 9.1 Y407M + T366I
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJC
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FC HETERODIMER DESIGN 8.1 L368V/Y407A + T366V/K409F
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJD
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FC HETERODIMER DESIGN 5.1 T366V + Y407F
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJX
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FC HETERODIMER DESIGN 2.9 L368M/K370E + E357A/S364G
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJY
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FC HETERODIMER DESIGN 20.8 Y349S/T366V/K370Y/K409V + E357D/S364Q/Y407A
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJZ
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FC HETERODIMER DESIGN 7.8 D399M/Y407A + T366V/K409V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DK0
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FC HETERODIMER DESIGN 20.8.34 Y349S/T366M/K370Y/K409V + E356G/E357D/S364Q/Y407A
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DK2
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FC HETERODIMER E356K/D399K + K392D/K409D
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVK
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FC DESIGN 7.7 B CHAIN HOMODIMER T366V/K409I
Descriptor:Ig gamma-1 chain C region
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-21
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVL
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FC DESIGN 20.8.37 A CHAIN HOMODIMER Y349S/T366M/K370Y/K409V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-21
Release date:2016-03-30
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
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