Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
5DBO
DownloadVisualize
BU of 5dbo by Molmil
Crystal structure of the tetrameric eIF2B-beta2-delta2 complex from C. thermophilum
Descriptor: Translation initiation factor eIF2b-like protein,Translation initiation factor eIF2b-like protein, Translation initiation factor eif-2b-like protein
Authors:Kuhle, B, Ficner, R.
Deposit date:2015-08-21
Release date:2015-10-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
4ZEM
DownloadVisualize
BU of 4zem by Molmil
Crystal structure of eIF2B beta from Chaetomium thermophilum
Descriptor: Translation initiation factor eIF2b-like protein,Translation initiation factor eIF2b-like protein
Authors:Kuhle, B, Ficner, R.
Deposit date:2015-04-20
Release date:2015-09-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
4ZEO
DownloadVisualize
BU of 4zeo by Molmil
Crystal structure of eIF2B delta from Chaetomium thermophilum
Descriptor: Translation initiation factor eif-2b-like protein
Authors:Kuhle, B, Ficner, R.
Deposit date:2015-04-20
Release date:2015-09-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
6NLY
DownloadVisualize
BU of 6nly by Molmil
Fragment of human mitochondrial Alanyl-tRNA Synthetase C-Ala domain
Descriptor: Alanine--tRNA ligase, mitochondrial
Authors:Kuhle, B, Schimmel, P.
Deposit date:2019-01-09
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.307 Å)
Cite:Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
6NLQ
DownloadVisualize
BU of 6nlq by Molmil
Human Mitochondrial Alanyl-tRNA Synthetase C-terminal domain
Descriptor: Alanine--tRNA ligase, mitochondrial, CALCIUM ION
Authors:Kuhle, B, Schimmel, P.
Deposit date:2019-01-08
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
6NOW
DownloadVisualize
BU of 6now by Molmil
Human Mitochondrial Alanyl-tRNA Synthetase C-Ala domain
Descriptor: Alanine--tRNA ligase, mitochondrial
Authors:Kuhle, B, Schimmel, P.
Deposit date:2019-01-16
Release date:2020-01-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4.099 Å)
Cite:Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs.
Nat Commun, 11, 2020
7TZB
DownloadVisualize
BU of 7tzb by Molmil
Crystal structure of the human mitochondrial seryl-tRNA synthetase (mt SerRS) bound with a seryl-adenylate analogue
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial
Authors:Kuhle, B, Hirschi, M, Doerfel, L, Lander, G, Schimmel, P.
Deposit date:2022-02-15
Release date:2022-09-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
4TMZ
DownloadVisualize
BU of 4tmz by Molmil
Translation initiation factor eIF5B (517-858) from C. thermophilum, bound to GTPgammaS and potassium
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHLORIDE ION, GLYCEROL, ...
Authors:Kuhle, B, Ficner, R.
Deposit date:2014-06-02
Release date:2014-09-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TN1
DownloadVisualize
BU of 4tn1 by Molmil
Translation initiation factor eIF5B (517-858) mutant D533R from C. thermophilum, bound to GTPgammaS
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, eIF5B
Authors:Kuhle, B, Ficner, R.
Deposit date:2014-06-02
Release date:2014-09-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TMW
DownloadVisualize
BU of 4tmw by Molmil
Translation initiation factor eIF5B (517-858) from C. thermophilum, bound to GTP and Sodium
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SODIUM ION, ...
Authors:Kuhle, B, Ficner, R.
Deposit date:2014-06-02
Release date:2014-09-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TMV
DownloadVisualize
BU of 4tmv by Molmil
Translation initiation factor eIF5B (517-858) from C. thermophilum, bound to GTPgammaS and Sodium
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Kuhle, B, Ficner, R.
Deposit date:2014-06-02
Release date:2014-09-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TMT
DownloadVisualize
BU of 4tmt by Molmil
Translation initiation factor eIF5B (517-858) mutant D533A from C. thermophilum, bound to GTPgammaS
Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
Authors:Kuhle, B, Ficner, R.
Deposit date:2014-06-02
Release date:2014-09-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4TMX
DownloadVisualize
BU of 4tmx by Molmil
Translation initiation factor eIF5B (517-858) mutant D533N from C. thermophilum, bound to GTP and sodium
Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Kuhle, B, Ficner, R.
Deposit date:2014-06-02
Release date:2014-09-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
4N3S
DownloadVisualize
BU of 4n3s by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (399-852) from Saccharomyces cerevisiae, apo form
Descriptor: 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 5B, GLYCEROL
Authors:Kuhle, B, Ficner, R.
Deposit date:2013-10-07
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.832 Å)
Cite:eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4N3G
DownloadVisualize
BU of 4n3g by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (870-1116) from Chaetomium thermophilum, domains III and IV
Descriptor: CHLORIDE ION, Eukaryotic translation initiation factor 5B-like protein, eIF5B(870-C), ...
Authors:Kuhle, B, Ficner, R.
Deposit date:2013-10-07
Release date:2014-07-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.203 Å)
Cite:eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4N3N
DownloadVisualize
BU of 4n3n by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (517-1116) from Chaetomium thermophilum, apo form
Descriptor: Eukaryotic translation initiation factor 5B-like protein, eIF5B(517-C), LACTIC ACID
Authors:Kuhle, B, Ficner, R.
Deposit date:2013-10-07
Release date:2014-07-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.752 Å)
Cite:eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4NCN
DownloadVisualize
BU of 4ncn by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (517-858) from Chaetomium thermophilum in complex with GTP
Descriptor: ACETIC ACID, Eukaryotic translation initiation factor 5B-like protein, GLYCEROL, ...
Authors:Kuhle, B, Ficner, R.
Deposit date:2013-10-24
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4NCL
DownloadVisualize
BU of 4ncl by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (517-970) from Chaetomium thermophilum in complex with GDP
Descriptor: Eukaryotic translation initiation factor 5B-like protein, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Kuhle, B, Ficner, R.
Deposit date:2013-10-24
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.115 Å)
Cite:eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
4NCF
DownloadVisualize
BU of 4ncf by Molmil
Crystal structure of eukaryotic translation initiation factor eIF5B (399-852) from Saccharomyces cerevisiae in complex with GDP
Descriptor: Eukaryotic translation initiation factor 5B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Kuhle, B, Ficner, R.
Deposit date:2013-10-24
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.015 Å)
Cite:eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining.
Embo J., 33, 2014
6O76
DownloadVisualize
BU of 6o76 by Molmil
Human cytosolic Histidyl-tRNA synthetase (HisRS) with WHEP domain
Descriptor: CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic
Authors:Kuhle, B, Yang, X.L.
Deposit date:2019-03-07
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.787 Å)
Cite:CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 116, 2019
8FFY
DownloadVisualize
BU of 8ffy by Molmil
Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(UGA-TL)
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial, ...
Authors:Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G.
Deposit date:2022-12-11
Release date:2023-08-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for a degenerate tRNA identity code and the evolution of bimodal specificity in human mitochondrial tRNA recognition.
Nat Commun, 14, 2023
7U2A
DownloadVisualize
BU of 7u2a by Molmil
Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA (GCU)
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (38-MER), Serine--tRNA ligase, ...
Authors:Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G.
Deposit date:2022-02-23
Release date:2022-09-14
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
7U2B
DownloadVisualize
BU of 7u2b by Molmil
Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(GCU-TL)
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (53-MER), Serine--tRNA ligase, ...
Authors:Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G.
Deposit date:2022-02-23
Release date:2022-09-14
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
Nat Commun, 13, 2022
8P8X
DownloadVisualize
BU of 8p8x by Molmil
Crystal structure of a pathogenic mutant variant of human mitochodnrial PheRS
Descriptor: PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial
Authors:Chen, W, Kuhle, B.
Deposit date:2023-06-03
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Clinical and molecular characterization of novel FARS2 variants causing neonatal mitochondrial disease.
Mol.Genet.Metab., 140, 2023
4NOX
DownloadVisualize
BU of 4nox by Molmil
Structure of the nine-bladed beta-propeller of eIF3b
Descriptor: CHLORIDE ION, Eukaryotic translation initiation factor 3 subunit B
Authors:Liu, Y, Neumann, P, Kuhle, B, Monecke, T, Ficner, R.
Deposit date:2013-11-20
Release date:2014-09-17
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.722 Å)
Cite:Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit
Structure, 22, 2014

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon